$348 Cheap Flights from Cape Town (CPT) to São Tomé Island (TMS)

View $348 flight on Sun, Dec 7, 2025Opens in a new window

Popular airlines from Cape Town Intl. Airport (CPT) to São Tomé Island (TMS-São Tomé Intl.)

Cheap Flights from Cape Town to São Tomé Island (CPT-TMS)

Prices were available within the past 7 days and start at $348 for one-way flights and $1,398 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Ethiopian Airlines
Fri, Nov 7 - Wed, Nov 19
CPT
Cape Town
TMS
São Tomé Island
$1,398 Roundtrip, found 1 hour ago
$1,398
Roundtrip
found 1 hour ago
Select Ethiopian Airlines flight, departing Fri, Nov 7 from Cape Town to São Tomé Island, returning Wed, Nov 19, priced at $1,398 found 1 hour ago
Ethiopian Airlines
Fri, Feb 13 - Fri, Feb 27
CPT
Cape Town
TMS
São Tomé Island
$1,595 Roundtrip, found 2 hours ago
$1,595
Roundtrip
found 2 hours ago
Select Ethiopian Airlines flight, departing Fri, Feb 13 from Cape Town to São Tomé Island, returning Fri, Feb 27, priced at $1,595 found 2 hours ago
Ethiopian Airlines
Fri, Feb 13 - Fri, Feb 27
CPT
Cape Town
TMS
São Tomé Island
$1,676 Roundtrip, found 2 hours ago
$1,676
Roundtrip
found 2 hours ago
Select Ethiopian Airlines flight, departing Fri, Feb 13 from Cape Town to São Tomé Island, returning Fri, Feb 27, priced at $1,676 found 2 hours ago
TAAG Angola Airlines
Sun, Dec 7 - Sun, Dec 14
CPT
Cape Town
TMS
São Tomé Island
$1,853 Roundtrip, found 3 hours ago
$1,853
Roundtrip
found 3 hours ago
Select TAAG Angola Airlines flight, departing Sun, Dec 7 from Cape Town to São Tomé Island, returning Sun, Dec 14, priced at $1,853 found 3 hours ago
Air France
Fri, Feb 13 - Fri, Feb 27
CPT
Cape Town
TMS
São Tomé Island
$2,518 Roundtrip, found 2 hours ago
$2,518
Roundtrip
found 2 hours ago
Select Air France flight, departing Fri, Feb 13 from Cape Town to São Tomé Island, returning Fri, Feb 27, priced at $2,518 found 2 hours ago

Frequently asked questions

How much does a flight from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS) cost?
Snag a cheap one-way flight from $348 or cheap return flight from $1,398 from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS)?
The cheapest month to fly from CPT to TMS is November, when there's less demand. Off-peak season is typically when airlines offer better prices between these airports.
What is the cheapest airline that flies from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest CPT to TMS flight.
How many flights per day from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS)?
You'll need to catch a flight with a layover if you're traveling from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from CPT to TMS?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS)?
To avoid potential delays on the Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS) route, aim to travel before 3 PM. Departures after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS) last-minute?
Last-minute bookings from CPT to TMS are usually more expensive. For the lowest rates, start looking for flights ahead of time. That being said, if you can play around with your travel dates, you may find a cheap ticket just before your departure.
Is it cheaper to book a CPT to TMS flight and hotel package?
Opting for a CPT to TMS flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Choose from our wide range of accommodations and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Cape Town Intl. Airport (CPT) to Sao Tome Intl. Airport (TMS)?
You can usually cancel or reschedule your CPT to TMS flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Cape Town Intl.
Destination airport
São Tomé Intl.
Airlines serving
Ethiopian Airlines
Roundtrip price
$1,398
Distance
2494 mi

Book with confidence

Cape Town to São Tomé Island Flights

The cheapest times to fly from Cape Town to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cape Town to São Tomé Island are during the month of November. You can find some of the cheapest flights from Cape Town to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cape Town to São Tomé Island

Sunday is one of the best days to book for cheap flights from Cape Town to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cape Town to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cape Town to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $348 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cape Town to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cape Town to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cape Town to São Tomé Island Flights
*Available to One Key members.