$168 Cheap Flights from Cusco (CUZ) to Santiago (SCL)

View $168 flight on Fri, Aug 28, 2026Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Santiago Intl. Airport (SCL)

Cheap Flights from Cusco to Santiago (CUZ-SCL)

Prices were available within the past 7 days and start at $168 for one-way flights and $324 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

SKY AIRLINE
Wed, May 6 - Sun, May 10
CUZ
Cusco
SCL
Santiago
$324 Roundtrip, found 6 days ago
$324
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Wed, May 6 from Cusco to Santiago, returning Sun, May 10, priced at $324 found 6 days ago
SKY AIRLINE
Thu, May 7 - Mon, May 11
CUZ
Cusco
SCL
Santiago
$344 Roundtrip, found 13 hours ago
$344
Roundtrip
found 13 hours ago
Select SKY AIRLINE flight, departing Thu, May 7 from Cusco to Santiago, returning Mon, May 11, priced at $344 found 13 hours ago
LATAM Airlines Group
Fri, Jun 5 - Thu, Jun 11
CUZ
Cusco
SCL
Santiago
$348 Roundtrip, found 1 day ago
$348
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Fri, Jun 5 from Cusco to Santiago, returning Thu, Jun 11, priced at $348 found 1 day ago
SKY AIRLINE
Fri, Jun 5 - Thu, Jun 11
CUZ
Cusco
SCL
Santiago
$350 Roundtrip, found 1 day ago
$350
Roundtrip
found 1 day ago
Select SKY AIRLINE flight, departing Fri, Jun 5 from Cusco to Santiago, returning Thu, Jun 11, priced at $350 found 1 day ago
SKY AIRLINE
Tue, Aug 18 - Sun, Aug 23
CUZ
Cusco
SCL
Santiago
$351 Roundtrip, found 2 days ago
$351
Roundtrip
found 2 days ago
Select SKY AIRLINE flight, departing Tue, Aug 18 from Cusco to Santiago, returning Sun, Aug 23, priced at $351 found 2 days ago
LATAM Airlines Group
Fri, Jun 5 - Thu, Jun 11
CUZ
Cusco
SCL
Santiago
$354 Roundtrip, found 1 day ago
$354
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Fri, Jun 5 from Cusco to Santiago, returning Thu, Jun 11, priced at $354 found 1 day ago
LATAM Airlines Group
Tue, May 5 - Tue, May 12
CUZ
Cusco
SCL
Santiago
$356 Roundtrip, found 12 hours ago
$356
Roundtrip
found 12 hours ago
Select LATAM Airlines Group flight, departing Tue, May 5 from Cusco to Santiago, returning Tue, May 12, priced at $356 found 12 hours ago
SKY AIRLINE
Tue, Aug 18 - Sun, Aug 23
CUZ
Cusco
SCL
Santiago
$357 Roundtrip, found 2 days ago
$357
Roundtrip
found 2 days ago
Select SKY AIRLINE flight, departing Tue, Aug 18 from Cusco to Santiago, returning Sun, Aug 23, priced at $357 found 2 days ago
SKY AIRLINE
Fri, Jun 5 - Thu, Jun 11
CUZ
Cusco
SCL
Santiago
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select SKY AIRLINE flight, departing Fri, Jun 5 from Cusco to Santiago, returning Thu, Jun 11, priced at $359 found 1 day ago
avianca
Thu, Oct 1 - Thu, Oct 8
CUZ
Cusco
SCL
Santiago
$370 Roundtrip, found 13 hours ago
$370
Roundtrip
found 13 hours ago
Select avianca flight, departing Thu, Oct 1 from Cusco to Santiago, returning Thu, Oct 8, priced at $370 found 13 hours ago

Frequently asked questions

How much does a flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) cost?
You can find cheap one-way flights and cheap return flights from $324 Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) with Expedia. One-way flights typically cost between $140 and $505, and return flights often range between $576 and $1110. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The cheapest month to fly from CUZ to SCL is May when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
There are 1 airlines offering direct flights from CUZ to SCL:

  • LATAM Airlines Group operates around 10 direct flights from CUZ to SCL every week
  • LAN Airlines operates around 10 direct flights from CUZ to SCL every week

What is the cheapest airline that flies from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
LAN Airlines is one of the cheapest airlines offering nonstop flights from Cusco (CUZ) to Santiago (SCL) starting from around $367. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
To find a cheap flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best airline to fly with from Cusco (CUZ) to Santiago (SCL) will differ from traveler to traveler. If you like to fly early, LAN Airlines offers early morning flights. If price is the most important factor, LAN Airlines typically offers the lowest fares. LATAM Airlines Group offers the most daily flights from Cusco to Santiago, which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
On average, there are around 1 nonstop flights per day from Alejandro Velasco Astete Intl. (CUZ) to Arturo Merino Benitez (SCL). For more options, look at flights that include layovers.
What is the earliest flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The earliest flight from Cusco (CUZ) to Santiago (SCL) typically departs at around 12:05 AM local time, operated by LATAM Airlines Group. This is a seasonal service active in February, October, and November, allowing you to start your journey early and make the most of your time in Santiago. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The most popular departure times for flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) are late at night, from 9pm to midnight. About 29% of passengers prefer this time window. LATAM Airlines is a key carrier during this period. This timing is favored as it allows you to enjoy a full day in Cusco before your flight.
How long does it take to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Direct flights from CUZ to SCL usually take about 3 hours 20 minutes, traveling roughly 1,374 miles. If you opt for a connecting flight, expect to add around 3 hours 30 minutes to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Business class seats are offered on the CUZ to SCL route with Avianca.
How do I earn miles on a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) flight with Expedia?
It's easy to earn miles on a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Santiago from Alejandro Velasco Astete Intl. (CUZ)?
If you're planning to travel to Santiago from Alejandro Velasco Astete Intl. (CUZ), you can fly into Arturo Merino Benitez (SCL) Some flights may connect through major hubs like Jorge Chavez Intl. (LIM), Rodriguez Ballon Intl. (AQP), Padre Aldamiz Intl. (PEM) before reaching Santiago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) at the last minute?
Typically, booking a last minute flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package?
Securing a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) Santiago Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
If you booked your Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
LATAM Airlines Group, SKY AIRLINE, avianca
Roundtrip price
$324
Distance
1373 mi
Average flight time
4 hours 20 mins

Book with confidence

Cusco to Santiago Flights

The cheapest times to fly from Cusco to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Santiago are during the month of May. You can find some of the cheapest flights from Cusco to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Santiago

Sunday is one of the best days to book for cheap flights from Cusco to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Santiago in 2026. You can also book with separate airlines for your outbound and return journeys, from $168 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to Santiago Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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