$103 Cheap Flights from Cusco (CUZ) to Santiago (SCL)

Cusco (CUZ) to Santiago (SCL) at a glance

Travel to Santiago (SCL) from Cusco (CUZ) with a selection of airlines operating on this international short-haul route. Evaluate various options from full-service carriers to discover the flight that aligns with your budget, schedule, and travel plans as you prepare to explore the iconic sights and neighborhoods of Santiago. Find essential information for flights departing from Alejandro Velasco Astete International Airport (CUZ) to Arturo Merino Benitez Airport (SCL).

• Fastest flight duration: around 3h 15m non-stop
• Route distance: roughly 1,400 miles (2,250 km)
• Flights per week: around 8 departures on average
• Typical fares (one-way): economy tickets often range from $140–$485, depending on seasonality and how far ahead you book

Flights from Alejandro Velasco Astete International Airport (CUZ) to Arturo Merino Benitez Airport (SCL)

Based on recent traveler bookings, here are the top airlines favored for flights from Cusco to Santiago, focusing on non-stop and one-stop options. Many travelers opt for itineraries with a popular layover at Jorge Chávez International Airport (LIM), which offers about a 2-hour and 45-minute stop. This flexibility allows you to balance price, total travel time, and cabin class to find your ideal travel plan.

• LATAM Airlines Group: This comprehensive airline provides both non-stop and one-stop flights, with one-way ticket prices generally falling between $165 and $555. It dominates the route, handling about 90% of departures, and typical non-stop flight durations are around 3 hours and 15 minutes.
• Sky Airlines: Offering one-stop services, this full-service airline features one-way fares usually ranging from $140 to $255. It represents roughly 10% of the departures on this route, with an in-flight duration of 5 hours and 15 minutes, leading to a total travel time of approximately 8 hours when including layovers.

Travelers can enhance their journey from Cusco to Santiago by upgrading to premium economy class, available through LATAM Airlines Group on this route for a more comfortable experience.

Best time to fly from Cusco (CUZ) to Santiago (SCL)

The most popular months for travelers flying from Cusco to Santiago are March, April, and December, when peak temperatures in Santiago reach up to 65.5°F in March. If you prefer quieter travel, consider June, the least busy time to visit with temperatures around 46.6°F and typically the lowest average one-way fare (around $209). Flight availability peaks in September, with approximately 9 flights per week, making it easier to find convenient departure times.

• Cheapest time to fly: June usually offers good deals with average one-way fare around $209, roughly 25% cheaper than the yearly average.
• More budget-friendly months to fly: May and August typically offer average one-way fares of around $226.
• Most flight options: September has the highest number of flights from Cusco to Santiago, with approximately 9 flights per week, giving you more flexibility in scheduling your trip.

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

How to find the best prices for flights from Cusco (CUZ) to Santiago (SCL)

Getting some of the best deals on flights from Cusco to Santiago is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are usually found when booking 2 to 8 weeks in advance, although most travelers tend to book at least 2 months ahead. Evening departures between 6 PM and 12 AM often provide lower prices, while morning flights from 5 AM to 12 PM are the most popular. Additionally, flying on Fridays typically offers cheaper rates, even though Wednesday is the most common travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Arturo Merino Benitez Airport from Alejandro Velasco Astete International Airport

Santiago welcomes travelers from Cusco with a range of transport options based on price, convenience, and proximity. Here's how to reach Santiago efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Santiago, with private rides that can be arranged in advance.
• Car rental: Renting a car from Arturo Merino Benitez Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Arturo Merino Benitez Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From Arturo Merino Benitez Airport, Barrancas Station, a metro station, is located about 6.6 miles away by car, while Lo Cruzat Metro Station, a train station, is about 8.3 miles away by car, providing convenient access to public transport options for travelers.

Cusco to Santiago Flights

The cheapest times to fly from Cusco to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Santiago are during the month of January. You can find some of the cheapest flights from Cusco to Santiago with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Cusco to Santiago

Sunday is one of the best days to book for cheap flights from Cusco to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Cusco to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Santiago in 2026. You can also book with separate airlines for your outbound and return journeys, from $103 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.