$427 Cheap Flights from Des Moines (DSM) to Prague (PRG)

View $427 flight on Mon, Mar 16, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Vaclav Havel Airport (PRG)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Des Moines to Prague (DSM-PRG)

Prices were available within the past 7 days and start at $427 for one-way flights and $535 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Sun, Nov 9 - Tue, Nov 18
DSM
Des Moines
PRG
Prague
$535 Roundtrip, found 22 hours ago
$535
Roundtrip
found 22 hours ago
Select British Airways flight, departing Sun, Nov 9 from Des Moines to Prague, returning Tue, Nov 18, priced at $535 found 22 hours ago
British Airways
Sun, Nov 9 - Tue, Nov 18
DSM
Des Moines
PRG
Prague
$544 Roundtrip, found 22 hours ago
$544
Roundtrip
found 22 hours ago
Select British Airways flight, departing Sun, Nov 9 from Des Moines to Prague, returning Tue, Nov 18, priced at $544 found 22 hours ago
Iberia
Sun, Nov 9 - Tue, Nov 18
DSM
Des Moines
PRG
Prague
$545 Roundtrip, found 22 hours ago
$545
Roundtrip
found 22 hours ago
Select Iberia flight, departing Sun, Nov 9 from Des Moines to Prague, returning Tue, Nov 18, priced at $545 found 22 hours ago
Scandinavian Airlines
Thu, Oct 30 - Thu, Nov 6
DSM
Des Moines
PRG
Prague
$546 Roundtrip, found 2 days ago
$546
Roundtrip
found 2 days ago
Select Scandinavian Airlines flight, departing Thu, Oct 30 from Des Moines to Prague, returning Thu, Nov 6, priced at $546 found 2 days ago
British Airways
Mon, Oct 27 - Mon, Nov 3
DSM
Des Moines
PRG
Prague
$563 Roundtrip, found 5 days ago
$563
Roundtrip
found 5 days ago
Select British Airways flight, departing Mon, Oct 27 from Des Moines to Prague, returning Mon, Nov 3, priced at $563 found 5 days ago
British Airways
Mon, Oct 27 - Tue, Nov 4
DSM
Des Moines
PRG
Prague
$569 Roundtrip, found 15 hours ago
$569
Roundtrip
found 15 hours ago
Select British Airways flight, departing Mon, Oct 27 from Des Moines to Prague, returning Tue, Nov 4, priced at $569 found 15 hours ago
British Airways
Mon, Oct 27 - Wed, Nov 5
DSM
Des Moines
PRG
Prague
$574 Roundtrip, found 2 days ago
$574
Roundtrip
found 2 days ago
Select British Airways flight, departing Mon, Oct 27 from Des Moines to Prague, returning Wed, Nov 5, priced at $574 found 2 days ago
British Airways
Mon, Oct 27 - Mon, Nov 3
DSM
Des Moines
PRG
Prague
$575 Roundtrip, found 5 days ago
$575
Roundtrip
found 5 days ago
Select British Airways flight, departing Mon, Oct 27 from Des Moines to Prague, returning Mon, Nov 3, priced at $575 found 5 days ago
American Airlines
Fri, May 1 - Fri, May 29
DSM
Des Moines
PRG
Prague
$622 Roundtrip, found 2 days ago
$622
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, May 1 from Des Moines to Prague, returning Fri, May 29, priced at $622 found 2 days ago
Lufthansa
Mon, Oct 27 - Tue, Nov 4
DSM
Des Moines
PRG
Prague
$628 Roundtrip, found 15 hours ago
$628
Roundtrip
found 15 hours ago
Select Lufthansa flight, departing Mon, Oct 27 from Des Moines to Prague, returning Tue, Nov 4, priced at $628 found 15 hours ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG) cost?
Snag a cheap one-way flight from $427 or cheap return flight from $535 from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG)?
Traveling in November is a good way to save, as it's the cheapest month for flights between DSM and PRG. You'll typically find the lowest fares during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to PRG flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG)?
Direct flights from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to PRG?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary based on a number of factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG)?
To touch down at Vaclav Havel Airport (PRG) on schedule, opt for a flight that leaves from Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG) last-minute?
Booking your plane ticket from DSM to PRG right before your journey is generally more expensive. However, if you're flexible with your travel times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a DSM to PRG flight and hotel package?
Booking a DSM to PRG flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our wide range of accommodations and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Vaclav Havel Airport (PRG)?
Typically, you can modify or cancel your DSM to PRG flight. However, there may be additional charges, especially if your booking was made over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you'd like more information, visit our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Vaclav Havel
Airlines serving
Aer Lingus, Air France, American Airlines, British Airways, Delta, Finnair, Iberia, KLM, Lufthansa, Scandinavian Airlines, United
Roundtrip price
$535
Distance
4755 mi

Book with confidence

Book with confidence

Des Moines to Prague Flights

The cheapest times to fly from Des Moines to Prague

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Prague are during the month of November. You can find some of the cheapest flights from Des Moines to Prague with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Prague

Sunday is one of the best days to book for cheap flights from Des Moines to Prague: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Prague

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Prague in 2025. You can also book with separate airlines for your outbound and return journeys, from $427 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Prague flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Prague airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Prague Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.