$281 Cheap Flights from Florence (FLO) to Melbourne (MLB)

View $281 flight on Sun, Mar 15, 2026Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Melbourne Orlando Intl. Airport (MLB)

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Cheap Flights from Florence to Melbourne (FLO-MLB)

Prices were available within the past 7 days and start at $281 for one-way flights and $435 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sun, Feb 15 - Sun, Feb 22
FLO
Florence
MLB
Melbourne
$435 Roundtrip, found 6 days ago
$435
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Feb 15 from Florence to Melbourne, returning Sun, Feb 22, priced at $435 found 6 days ago
American Airlines
Tue, Feb 10 - Sat, Feb 28
FLO
Florence
MLB
Melbourne
$447 Roundtrip, found 3 days ago
$447
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Feb 10 from Florence to Melbourne, returning Sat, Feb 28, priced at $447 found 3 days ago
American Airlines
Sun, Mar 15 - Sat, Mar 21
FLO
Florence
MLB
Melbourne
$461 Roundtrip, found 2 days ago
$461
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Mar 15 from Florence to Melbourne, returning Sat, Mar 21, priced at $461 found 2 days ago
American Airlines
Mon, Feb 9 - Sat, Feb 21
FLO
Florence
MLB
Melbourne
$471 Roundtrip, found 3 days ago
$471
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Feb 9 from Florence to Melbourne, returning Sat, Feb 21, priced at $471 found 3 days ago
American Airlines
Tue, Feb 3 - Sat, Feb 21
FLO
Florence
MLB
Melbourne
$477 Roundtrip, found 3 days ago
$477
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Feb 3 from Florence to Melbourne, returning Sat, Feb 21, priced at $477 found 3 days ago
American Airlines
Sun, Feb 8 - Sat, Feb 21
FLO
Florence
MLB
Melbourne
$482 Roundtrip, found 3 days ago
$482
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Feb 8 from Florence to Melbourne, returning Sat, Feb 21, priced at $482 found 3 days ago
American Airlines
Tue, Feb 10 - Tue, Feb 24
FLO
Florence
MLB
Melbourne
$486 Roundtrip, found 3 days ago
$486
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Feb 10 from Florence to Melbourne, returning Tue, Feb 24, priced at $486 found 3 days ago
American Airlines
Mon, Feb 9 - Fri, Feb 20
FLO
Florence
MLB
Melbourne
$495 Roundtrip, found 3 days ago
$495
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Feb 9 from Florence to Melbourne, returning Fri, Feb 20, priced at $495 found 3 days ago
American Airlines
Mon, Feb 9 - Tue, Feb 17
FLO
Florence
MLB
Melbourne
$501 Roundtrip, found 3 days ago
$501
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Feb 9 from Florence to Melbourne, returning Tue, Feb 17, priced at $501 found 3 days ago
American Airlines
Sun, Mar 15 - Sat, Mar 21
FLO
Florence
MLB
Melbourne
$504 Roundtrip, found 2 days ago
$504
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Mar 15 from Florence to Melbourne, returning Sat, Mar 21, priced at $504 found 2 days ago
American Airlines
Mon, Feb 9 - Mon, Feb 23
FLO
Florence
MLB
Melbourne
$506 Roundtrip, found 3 days ago
$506
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Feb 9 from Florence to Melbourne, returning Mon, Feb 23, priced at $506 found 3 days ago

Alternative airports near Melbourne

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Orlando Melbourne Intl. MLB. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $477
MLB
Orlando Melbourne Intl.
CheapestClosest
Average driving time to city center5 min
Flights from $477

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) cost?
Secure a cheap one-way flight from $281 or cheap return flight from $435 from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)?
February is the most affordable month to fly from FLO to MLB. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll fly you from FLO to MLB. Then, sort your results by "Price (lowest to highest)" to pick up the best deal available.
How many flights per day from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)?
Direct flights from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from FLO to MLB?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)?
To avoid possible delays on the Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) route, aim to travel before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) last-minute?
Last-minute fares from FLO to MLB are typically more expensive. To secure the cheapest rates, start searching for flights as soon as possible. That being said, if your travel plans are flexible, you may land a cheap fare right before your journey.
Is it cheaper to book a FLO to MLB flight and hotel package?
Securing a FLO to MLB flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of accommodations and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)?
In most instances, you can cancel or modify your FLO to MLB flight. However, additional charges may apply, especially if your booking was made over 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you'd like more information, head to our Customer Service portal.

Travel information

Origin airport
Florence Regional
Destination airport
Orlando Melbourne Intl.
Roundtrip price
$435
Distance
424 mi

Book with confidence

Florence to Melbourne Flights

The cheapest times to fly from Florence to Melbourne

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Melbourne are during the month of February. You can find some of the cheapest flights from Florence to Melbourne with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Melbourne

Sunday is one of the best days to book for cheap flights from Florence to Melbourne: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Melbourne

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Melbourne in 2026. You can also book with separate airlines for your outbound and return journeys, from $281 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Melbourne flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Melbourne airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Melbourne Flights

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*Available to One Key members.