$641 Cheap Flights from Lyon (LYS) to Medellín (MDE)

View $641 flight on Sat, Jan 17, 2026Opens in a new window

Popular airlines from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE)

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Cheap Flights from Lyon to Medellín (LYS-MDE)

Prices were available within the past 7 days and start at $641 for one-way flights and $1,908 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LOT-Polish Airlines
Fri, Dec 26 - Sat, Jan 10
LYS
Lyon
MDE
Medellin
$1,908 Roundtrip, found 3 days ago
$1,908
Roundtrip
found 3 days ago
Select LOT-Polish Airlines flight, departing Fri, Dec 26 from Lyon to Medellin, returning Sat, Jan 10, priced at $1,908 found 3 days ago
Lufthansa
Fri, Dec 26 - Sat, Jan 10
LYS
Lyon
MDE
Medellin
$2,252 Roundtrip, found 3 days ago
$2,252
Roundtrip
found 3 days ago
Select Lufthansa flight, departing Fri, Dec 26 from Lyon to Medellin, returning Sat, Jan 10, priced at $2,252 found 3 days ago

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE) cost?
Lock in a cheap one-way flight from $641 or cheap return flight from $1,908 from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE)?
Flying in December can help you save, as it's the cheapest month for flights between LYS and MDE. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest LYS to MDE flight.
How many flights per day from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE)?
There are no daily direct flights available from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way before you know it.
What day of the week has the most flights from LYS to MDE?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE)?
Book a flight from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Last-minute fares from LYS to MDE are usually more expensive. To lock in the lowest rates, start searching for flights as soon as possible. That said, if you're flexible with your travel plans, it's possible to find a cheap ticket just before your departure.
Is it cheaper to book a LYS to MDE flight and hotel package?
Compared with arranging hotels and flights separately, booking a LYS to MDE flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one easy place will take the stress out of planning your trip. Just secure your flights and select from our wide range of hotels, then customize your trip with other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to Jose Maria Cordova Intl. Airport (MDE)?
Typically, you can cancel or reschedule your LYS to MDE flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you need more details, visit our Customer Service portal.

Travel information

Origin airport
Saint-Exupery
Destination airport
José María Córdova Intl.
Roundtrip price
$1,908
Distance
5455 mi

Book with confidence

Lyon to Medellín Flights

The cheapest times to fly from Lyon to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to Medellín are during the month of December. You can find some of the cheapest flights from Lyon to Medellín with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to Medellín

Sunday is one of the best days to book for cheap flights from Lyon to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to Medellín in 2025. You can also book with separate airlines for your outbound and return journeys, from $641 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Lyon to Medellín Flights

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*Available to One Key members.