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$274 Cheap Flights from Moline (MLI) to Roanoke (ROA)

View $274 flight on Sun, Aug 30, 2026Opens in a new window

Popular airlines from Quad City Intl. Airport (MLI) to Roanoke Regional Airport (ROA)

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Cheap Flights from Moline to Roanoke (MLI-ROA)

Prices were available within the past 7 days and start at $274 for one-way flights and $319 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Oct 2 - Sun, Oct 11
MLI
Moline
ROA
Roanoke
$319 Roundtrip, found 1 day ago
$319
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 2 from Moline to Roanoke, returning Sun, Oct 11, priced at $319 found 1 day ago
Delta
Fri, Oct 2 - Sun, Oct 11
MLI
Moline
ROA
Roanoke
$399 Roundtrip, found 1 day ago
$399
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 2 from Moline to Roanoke, returning Sun, Oct 11, priced at $399 found 1 day ago
Delta
Fri, Oct 23 - Mon, Oct 26
MLI
Moline
ROA
Roanoke
$403 Roundtrip, found 1 day ago
$403
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 23 from Moline to Roanoke, returning Mon, Oct 26, priced at $403 found 1 day ago
Delta
Fri, Oct 23 - Mon, Oct 26
MLI
Moline
ROA
Roanoke
$419 Roundtrip, found 1 day ago
$419
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 23 from Moline to Roanoke, returning Mon, Oct 26, priced at $419 found 1 day ago
American Airlines
Thu, Jul 30 - Sun, Aug 2
MLI
Moline
ROA
Roanoke
$439 Roundtrip, found 11 hours ago
$439
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Thu, Jul 30 from Moline to Roanoke, returning Sun, Aug 2, priced at $439 found 11 hours ago
Delta
Thu, Oct 15 - Mon, Oct 19
MLI
Moline
ROA
Roanoke
$444 Roundtrip, found 6 days ago
$444
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Oct 15 from Moline to Roanoke, returning Mon, Oct 19, priced at $444 found 6 days ago
United
Thu, Jul 30 - Sun, Aug 2
MLI
Moline
ROA
Roanoke
$459 Roundtrip, found 11 hours ago
$459
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Jul 30 from Moline to Roanoke, returning Sun, Aug 2, priced at $459 found 11 hours ago
American Airlines
Fri, Sep 25 - Mon, Sep 28
MLI
Moline
ROA
Roanoke
$467 Roundtrip, found 1 day ago
$467
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 25 from Moline to Roanoke, returning Mon, Sep 28, priced at $467 found 1 day ago
United
Thu, Jul 30 - Sun, Aug 2
MLI
Moline
ROA
Roanoke
$472 Roundtrip, found 11 hours ago
$472
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Jul 30 from Moline to Roanoke, returning Sun, Aug 2, priced at $472 found 11 hours ago
Delta
Fri, Oct 23 - Mon, Oct 26
MLI
Moline
ROA
Roanoke
$473 Roundtrip, found 1 day ago
$473
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 23 from Moline to Roanoke, returning Mon, Oct 26, priced at $473 found 1 day ago

What you need to know for your flight from Quad City Intl. to Roanoke Regional

Moline (MLI) to Roanoke (ROA) at a glance

Discover a range of airlines offering flights between Moline (MLI) and Roanoke (ROA) on this domestic short-haul route. Evaluate choices from both full-service and budget carriers to find the itinerary that aligns with your budget, schedule, and travel aspirations while you uncover the attractions and neighborhoods of Roanoke. Get all the essential details for flights from Quad City International Airport (MLI) to Roanoke Regional Airport (ROA).

  • Fastest flight duration: around 3h 30m in-flight, plus roughly 2 hours layover with one stop
  • Route distance: roughly 600 miles (970 km)
  • Flights per week: around 7 departures on average
  • Typical fares (one-way): economy tickets often range from $120–$575, depending on seasonality and how far ahead you book

Flights from Quad City International Airport (MLI) to Roanoke Regional Airport (ROA)

Based on recent traveler bookings, here are the top airlines chosen for flights from Moline to Roanoke, usually featuring one-stop service. Common layover options include O'Hare International Airport, ORD, with an approximate 2-hour layover, and Charlotte-Douglas International Airport, CLT, offering around a 3-hour layover. This variety allows you to balance price, total travel time, and cabin class to secure the best itinerary for your journey.

  • United: As a comprehensive airline, United provides a one-stop service, with one-way ticket prices generally falling between $145 and $530. This carrier represents about 48% of the flights on this route, featuring an in-flight duration of 3 hours and 30 minutes, resulting in a total travel time of approximately 5 hours and 15 minutes, including layover.
  • American Airlines: Another full-service option, American Airlines also offers one-stop flights with one-way fares usually ranging from $140 to $490. This airline accounts for roughly 43% of departures on this route, with a flight time of 3 hours and 30 minutes and an overall journey time of about 5 hours and 15 minutes, factoring in the layover.

Alternative route from Moline (MLI) to Roanoke (ROA)

  • Moline to Lynchburg (MLI-LYH): Lynchburg Regional Airport (LYH) is located approximately 43 miles from Roanoke Regional Airport (ROA).

How to find the best prices for flights from Moline (MLI) to Roanoke (ROA)

Getting some of the best deals on flights from Moline to Roanoke is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking 2-8 weeks in advance, even though most travelers book within 2 weeks. Afternoon departures from 12pm to 6pm often provide better prices, while morning flights from 5am to 12pm remain the most popular. Additionally, flying on Friday tends to be both cheaper and the preferred travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Roanoke hotel and flight deals.
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Roanoke Regional Airport from Quad City International Airport

Roanoke welcomes travelers from Moline with a range of transport options based on price, convenience, and proximity. Here's how to reach Roanoke efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Roanoke, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Roanoke Regional Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Roanoke Regional Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Roanoke Regional Airport, Roanoke Station, a train station, is located about 5.7 miles away by car.

Frequently asked questions

How much does a flight from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) cost?
You can find cheap one-way flights from $274 and cheap return flights from $319 Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) with Expedia. One-way flights generally range between $326 and $664, and roundtrip flights usually range from $418 to $1456. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
The cheapest month to fly from MLI to ROA is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
Enter MLI to ROA and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Moline, IL (MLI) to Roanoke, VA (ROA), with round-trip tickets starting from around $253. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
To find a cheap flight from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
The earliest flight from Moline (MLI) to Roanoke (ROA) typically departs at around 5:00 AM, operated by American Airlines. This seasonal service is active in May, providing an early start for your journey to Virginia. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
The most popular departure times for flights from Quad City International Airport (MLI) to Roanoke Regional Airport (ROA) are between 9am and 12pm. About 33% of passengers prefer this time window. Many major carriers, including United Airlines and Delta, offer flights during this window. This timing is convenient as it allows you to travel during the day, making connections easier.
How long does it take to fly from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
A flight from MLI to ROA with a layover takes around 5 hours, with the route covering approximately 630 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
First class seats are offered on the MLI to ROA route with Delta Air Lines and American Airlines.
How do I earn miles on a Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) flight with Expedia?
It's easy to earn miles on a Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Roanoke from Quad City Intl. (MLI)?
From Quad City Intl. (MLI), you can fly into Roanoke Regional (ROA) to reach Roanoke. Some flights may connect through major hubs like O'Hare Intl. (ORD), Hartsfield-Jackson Atlanta Intl. (ATL), Dallas-Fort Worth Intl. (DFW) before reaching Roanoke. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) at the last minute?
Typically, booking a last minute flight from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) flight and hotel package?
Securing a Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) Roanoke Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional)?
If you booked your Moline, IL (MLI-Quad City Intl.) to Roanoke, VA (ROA-Roanoke Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Quad City Intl.
Destination airport
Roanoke Regional
Airlines serving
American Airlines, Delta, United
Roundtrip price
$318
Distance
629 mi

Book with confidence

Moline to Roanoke Flights

The cheapest times to fly from Moline to Roanoke

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Moline to Roanoke are during the month of October. You can find some of the cheapest flights from Moline to Roanoke with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Moline to Roanoke

Sunday is one of the best days to book for cheap flights from Moline to Roanoke: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Moline to Roanoke

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Moline to Roanoke in 2026. You can also book with separate airlines for your outbound and return journeys, from $274 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Moline to Roanoke flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Moline to Roanoke airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Moline to Roanoke Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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