$868 Cheap Flights from Santiago Island (RAI) to São Tomé Island (TMS)

View $868 flight on Wed, Nov 19, 2025Opens in a new window

Popular airlines from Santiago Island (RAI-Praia Intl.) to São Tomé Island (TMS-São Tomé Intl.)

Cheap Flights from Santiago Island to São Tomé Island (RAI-TMS)

Prices were available within the past 7 days and start at $868 for one-way flights and $1,719 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

TAP Portugal
Fri, Dec 5 - Fri, Dec 12
RAI
Santiago
TMS
São Tomé Island
$1,719 Roundtrip, found 3 days ago
$1,719
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Fri, Dec 5 from Santiago to São Tomé Island, returning Fri, Dec 12, priced at $1,719 found 3 days ago
TAP Portugal
Fri, Dec 5 - Fri, Dec 12
RAI
Santiago
TMS
São Tomé Island
$1,814 Roundtrip, found 3 days ago
$1,814
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Fri, Dec 5 from Santiago to São Tomé Island, returning Fri, Dec 12, priced at $1,814 found 3 days ago
TAP Portugal
Fri, Dec 5 - Fri, Dec 12
RAI
Santiago
TMS
São Tomé Island
$1,909 Roundtrip, found 3 days ago
$1,909
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Fri, Dec 5 from Santiago to São Tomé Island, returning Fri, Dec 12, priced at $1,909 found 3 days ago
TAP Portugal
Sun, Oct 26 - Mon, Nov 3
RAI
Santiago
TMS
São Tomé Island
$1,911 Roundtrip, found 3 days ago
$1,911
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Oct 26 from Santiago to São Tomé Island, returning Mon, Nov 3, priced at $1,911 found 3 days ago

Frequently asked questions

How much does a flight from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS) cost?
Secure a cheap one-way flight from $868 or cheap return flight from $1,719 from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS)?
Traveling in December is a great way to save, as it's the cheapest month for flights between RAI and TMS. You'll usually find the lowest prices during the off-season.
What is the cheapest airline that flies from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest RAI to TMS flight.
How many flights per day from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS)?
There aren't any daily direct flights departing from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from RAI to TMS?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary depending on a number of factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS)?
To reach Sao Tome Intl. Airport (TMS) on time, pick a flight that leaves Praia Intl. Airport (RAI) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS) last-minute?
Last-minute bookings from RAI to TMS are usually more expensive. To secure the lowest rates, start looking for flights early. That being said, if you're flexible with your travel plans, you may score a cheap fare right before your trip.
Is it cheaper to book a RAI to TMS flight and hotel package?
You'll typically save money by securing a RAI to TMS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. After selecting your preferred flights and accommodations, consider adding extras including car rentals, tours and activities.
Can I cancel or change the date of my flight from Praia Intl. Airport (RAI) to Sao Tome Intl. Airport (TMS)?
Typically, you're able to reschedule or cancel your RAI to TMS flight. However, additional charges may apply, especially if you booked over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you want further information, head to our Customer Service portal.

Travel information

Origin airport
Praia Intl.
Destination airport
São Tomé Intl.
Roundtrip price
$1,719
Distance
2294 mi

Book with confidence

Santiago Island to São Tomé Island Flights

The cheapest times to fly from Santiago Island to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago Island to São Tomé Island are during the month of December. You can find some of the cheapest flights from Santiago Island to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santiago Island to São Tomé Island

Sunday is one of the best days to book for cheap flights from Santiago Island to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santiago Island to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago Island to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $868 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago Island to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago Island to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Santiago Island to São Tomé Island Flights
*Available to One Key members.