Find 4 Star Hotels in Depew, NY from $111
Check availability on Depew 4 Star Hotels
Our top choices for Depew 4-star hotels
9.0 out of 10, Wonderful, (1,002 reviews)
"Great stay"
Brittany
$129 nightly
The price is $147
Feb 1 - Feb 2
Total with taxes and fees
9.4 out of 10, Exceptional, (1,001 reviews)
"great staff!"
Stephen
$167 nightly
The price is $192
Feb 9 - Feb 10
Total with taxes and fees
7.8 out of 10, Good, (1,001 reviews)
"Everything look great we will come back again😀"
Cheekeong
$98 nightly
The price is $111
Feb 17 - Feb 18
Total with taxes and fees
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton
The Mosey Buffalo Williamsville, Tapestry Collection by HiltonBuffalo
9.4 out of 10, Exceptional, (1,001 reviews)
"Really enjoyed this hotel. Very very very clean and tidy. Great staff and very quiet. Would definitely stay again "
Naomi
$151 nightly
The price is $172
Feb 8 - Feb 9
Total with taxes and fees
Reikart House, Buffalo, a Tribute Portfolio Hotel
Reikart House, Buffalo, a Tribute Portfolio HotelBuffalo
9.6 out of 10, Exceptional, (689 reviews)
"Very nice hotel, well maintained, clean and high class. "
Brian
$197 nightly
The price is $224
Feb 15 - Feb 16
Total with taxes and fees
9.2 out of 10, Wonderful, (407 reviews)
"Immaculate hotel. All around good service."
Prince
$269 nightly
The price is $314
Feb 8 - Feb 9
Total with taxes and fees
10.0 out of 10, Exceptional, (47 reviews)
"Amazing breakfasts!"
David
$263 nightly
The price is $302
Feb 5 - Feb 6
Total with taxes and fees
10.0 out of 10, Exceptional, (76 reviews)
"Will definitely recommend and stay again. "
Carly
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Depew.
Curtiss Hotel, an Ascend Collection Hotel
210 Franklin St Buffalo NY
$218 nightly
The price is $254 total per night from Feb 9 to Feb 10
$254 total
Feb 9 - Feb 10
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
Still don't see what you're looking for?
See all properties in Depew.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Depew Hotel Reviews
Find out more about Depew
Depew Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Depew, Buffalo are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Depew 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Depew. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Depew, Buffalo, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Depew hotels offer everything your heart desires.
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near Reinstein Woods Nature Preserve and Environmental Education Center
- Hotels near Buffalo-Depew Station
- Hotels near Buffalo Niagara Intl.
- Hotels near Stiglmeier Park
- Hotels near Lancaster Opera House
- Hotels near Diamond Hawk Golf Course
- 4 Star Hotels in Cheektowaga
- 5 Star Hotels in Cheektowaga
- Hotels near Holiday Twin Rinks
- Cheektowaga Hotels
- Cheap Hotels in Cheektowaga
- 3 Star Hotels in Bowmansville
- Motels in Cheektowaga
- Hotels with an Indoor Pool in Cheektowaga
- Hotels with Restaurants in Cheektowaga
- Marriott Hotels & Resorts in Cheektowaga
- Pet-friendly Hotels in Cheektowaga
- Red Roof Inn Hotels in Cheektowaga
- B&B in Cheektowaga
- Extended Stay Hotels in Cheektowaga
- Luxury Hotels in Cheektowaga
- Hotel Wedding Venues Hotels in Cheektowaga
- Hotels with Kitchenettes in Cheektowaga
- Casino Hotels in Cheektowaga
- Hotels with Hot Tubs in Cheektowaga
- Hotels with Connecting Rooms in Cheektowaga
- Historic Hotels in Cheektowaga
- Romantic Hotels in Cheektowaga
- Cabin Rentals in Cheektowaga
- La Quinta Inn & Suites Hotels in Cheektowaga
- Hotels with Free Breakfast in Cheektowaga
- Hotels with an Outdoor Pool in Cheektowaga
- Flights from New York (JFK) to Buffalo (BUF)
- Flights from Buffalo Niagara Intl.
- Flights from Atlanta (ATL) to Buffalo (BUF)
- Flights from Boston (BOS) to Buffalo (BUF)
- Flights from Orlando (MCO) to Buffalo (BUF)
- Flights from Dallas (DFW) to Buffalo (BUF)
- Flights from Los Angeles (LAX) to Buffalo (BUF)
- Flights from Tampa (TPA) to Buffalo (BUF)
- Flights from Chicago (ORD) to Buffalo (BUF)
- Flights from Charlotte (CLT) to Buffalo (BUF)
- Flights from Philadelphia (PHL) to Buffalo (BUF)
- Flights from Washington (DCA) to Buffalo (BUF)
- Flights from Raleigh (RDU) to Buffalo (BUF)
- Flights from Houston (HOU) to Buffalo (BUF)
- Flights from Fort Lauderdale (FLL) to Buffalo (BUF)
- Flights from Phoenix (PHX) to Buffalo (BUF)
- Flights from Denver (DEN) to Buffalo (BUF)
- Flights from New York (LGA) to Buffalo (BUF)
- Flights from San Francisco (SFO) to Buffalo (BUF)
- Flights from Minneapolis (MSP) to Buffalo (BUF)
- Flights from Baltimore (BWI) to Buffalo (BUF)
- Flights from Pittsburgh (PIT) to Buffalo (BUF)
- Flights from Miami (MIA) to Buffalo (BUF)
- Flights from Las Vegas (LAS) to Buffalo (BUF)
- Flights from Detroit (DTW) to Buffalo (BUF)
- Flights from Seattle (SEA) to Buffalo (BUF)
- Flights from Albany (ALB) to Buffalo (BUF)
- Flights from New York (NYC) to Buffalo (BUF)
- Flights from Hartford (BDL) to Buffalo (BUF)
- Flights from Austin (AUS) to Buffalo (BUF)
- Flights from Jacksonville (JAX) to Buffalo (BUF)
- Flights from Toronto (YYZ) to Buffalo (BUF)
- Flights from Fort Myers (RSW) to Buffalo (BUF)
- Flights from San Diego (SAN) to Buffalo (BUF)
- Flights from Nashville (BNA) to Buffalo (BUF)
- Flights from Rochester (ROC) to Buffalo (BUF)
- Flights from Cleveland (CLE) to Buffalo (BUF)
- Flights from Salt Lake City (SLC) to Buffalo (BUF)
- Flights from Kansas City (MCI) to Buffalo (BUF)
- Flights from Columbus (CMH) to Buffalo (BUF)
- Flights from Syracuse (SYR) to Buffalo (BUF)
- Flights from Cincinnati (CVG) to Buffalo (BUF)
- Flights from Indianapolis (IND) to Buffalo (BUF)
- Flights from White Plains (HPN) to Buffalo (BUF)
- Flights from Richmond (RIC) to Buffalo (BUF)
- Flights to Cheektowaga
- Flights from West Palm Beach (PBI) to Buffalo (BUF)
- Flights from Islip (ISP) to Buffalo (BUF)
- Flights from Washington (IAD) to Buffalo (BUF)
- Flights from St. Louis (STL) to Buffalo (BUF)
- Flights from Cheektowaga
- Car rental Buffalo Airport (BUF)
- Car rentals near Bellevue
- Car rentals near Cheektowaga
- Budget Rental Cars in Buffalo Niagara Intl.
- Hertz Rental Cars in Buffalo Niagara Intl.
- Enterprise Rental Cars in Cheektowaga
- Hertz Rental Cars in Cheektowaga
- Budget Rental Cars in Cheektowaga
- Advantage Rent-A-Car Rental Cars in Cheektowaga