Title: The Best 4 Star Hotels in Depew, NY from $111 | Expedia.com [Depew Travel Guide](https://expedia.com/Depew.dx6338362)[Hotels in Depew](https://expedia.com/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.com/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Flights to Depew](https://expedia.com/Cheap-Flights-To-Depew.d6338362.Travel-Guide-Flights)[Things to do in Depew](https://expedia.com/Things-To-Do-In-Depew.d6338362.Travel-Guide-Activities)[Car Rentals in Depew](https://expedia.com/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.com/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Depew 4 Star Hotels Tonight [Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Depew 4-star hotels ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/c468db44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/f6195d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds | Premium bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/bde63631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/14f70c6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Delavan Hotel & Spa [](https://www.expedia.com/Buffalo-Hotels-The-Delavan-Hotel-Spa.h15031117.Hotel-Information) Bowmansville 9.0/10 Wonderful (1,001 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brittany $129 nightly $147 total Feb 9 - Feb 10 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-The-Delavan-Hotel-Spa.h15031117.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/700000/692700/692610/1225a495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 1 Queen Bed (Premium Room (Fireplace Grand Queen)) | Hypo-allergenic bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/1000000/700000/692700/692610/37ec72a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/700000/692700/692610/28123e2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily cooked-to-order breakfast](https://images.trvl-media.com/lodging/1000000/700000/692700/692610/78ed955c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mansion On Delaware Ave [](https://www.expedia.com/Buffalo-Hotels-The-Mansion-On-Delaware-Ave.h692610.Hotel-Information) Downtown Buffalo 9.4/10 Exceptional (1,001 reviews) "great staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen $167 nightly $192 total Feb 15 - Feb 16 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-The-Mansion-On-Delaware-Ave.h692610.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3000/2914/3d573cc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/3000/2914/06b0b650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3000/2914/8bfec9e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3000/2914/8c69bec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel Buffalo - Amherst [](https://www.expedia.com/Buffalo-Hotels-DoubleTree-By-Hilton-Hotel-Buffalo-Amherst.h2914.Hotel-Information) Buffalo 7.8/10 Good (1,000 reviews) "Everything look great we will come back again😀" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cheekeong $98 nightly $111 total Feb 24 - Feb 25 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-DoubleTree-By-Hilton-Hotel-Buffalo-Amherst.h2914.Hotel-Information) ![Breakfast and dinner served, seafood](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/69eab7ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/729fa626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/2a49ee3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/680cb22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mosey Buffalo Williamsville, Tapestry Collection by Hilton [](https://www.expedia.com/Buffalo-Hotels-The-Mosey-Buffalo-Williamsville.h6290133.Hotel-Information) Buffalo 9.4/10 Exceptional (1,000 reviews) "Really enjoyed this hotel. Very very very clean and tidy. Great staff and very quiet. Would definitely stay again " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Naomi $151 nightly $172 total Feb 15 - Feb 16 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-The-Mosey-Buffalo-Williamsville.h6290133.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/39700/39605/d1f34efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/40000/39700/39605/f1eaba86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![American cuisine](https://images.trvl-media.com/lodging/1000000/40000/39700/39605/6cfba307.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![American cuisine](https://images.trvl-media.com/lodging/1000000/40000/39700/39605/05bfac67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reikart House, Buffalo, a Tribute Portfolio Hotel [](https://www.expedia.com/Buffalo-Hotels-Reikart-House.h39605.Hotel-Information) Buffalo 9.6/10 Exceptional (690 reviews) "Very nice hotel, well maintained, clean and high class. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian $197 nightly $224 total Feb 15 - Feb 16 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Reikart-House.h39605.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/14000000/13460000/13451300/13451237/841778b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness studio](https://images.trvl-media.com/lodging/14000000/13460000/13451300/13451237/9e9840d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13460000/13451300/13451237/6f487a3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/14000000/13460000/13451300/13451237/26451150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Buffalo [](https://www.expedia.com/Buffalo-Hotels-The-Westin-Buffalo.h13451237.Hotel-Information) Downtown Buffalo 9.2/10 Wonderful (407 reviews) "Immaculate hotel. All around good service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Prince $250 nightly $292 total Feb 12 - Feb 13 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-The-Westin-Buffalo.h13451237.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/91000000/90770000/90762900/90762810/7bda029a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Robin Room | Premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/91000000/90770000/90762900/90762810/091461c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90770000/90762900/90762810/33860f43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90770000/90762900/90762810/27518664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Buffalo Harmony House [](https://www.expedia.com/Buffalo-Hotels-Buffalo-Harmony-House.h90762810.Hotel-Information) Downtown Buffalo 10/10 Exceptional (47 reviews) "Amazing breakfasts!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David $261 nightly $299 total Feb 8 - Feb 9 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Buffalo-Harmony-House.h90762810.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/17000000/16210000/16201000/16200927/cbf5b2b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, soundproofing](https://images.trvl-media.com/lodging/17000000/16210000/16201000/16200927/761e8af2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner served](https://images.trvl-media.com/lodging/17000000/16210000/16201000/16200927/9a62e340.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Separate tub and shower, deep soaking tub, hair dryer, bathrobes](https://images.trvl-media.com/lodging/17000000/16210000/16201000/16200927/490dcc21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### River Spring Lodge [](https://www.expedia.com/Attica-Hotels-River-Spring-Lodge.h16200927.Hotel-Information) Darien Center 10/10 Exceptional (76 reviews) "Will definitely recommend and stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carly [](https://www.expedia.com/Attica-Hotels-River-Spring-Lodge.h16200927.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/6000000/5790000/5789500/5789437/816eaa06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/6000000/5790000/5789500/5789437/ffbe42b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5790000/5789500/5789437/899c75f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/6000000/5790000/5789500/5789437/40a013a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lofts on Pearl Trademark Collection by Wyndham [](https://www.expedia.com/Buffalo-Hotels-Lofts-On-Pearl-Trademark-Collection-By-Wyndham.h5789437.Hotel-Information) Downtown Buffalo 9.2/10 Wonderful (520 reviews) "Very easy and fast check in. Property manager managed to find ways to connect with me after unable to contact Expedia that our original property is closed on Sunday and we have to move to another property. The info provided was accurate. The location is really good. Close to city and easy access to metro even though due to COVID we didn’t take public transportation. We will definitely try the metro next time we are here." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy T. [](https://www.expedia.com/Buffalo-Hotels-Lofts-On-Pearl-Trademark-Collection-By-Wyndham.h5789437.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Depew-Hotels.s40-0-d6338362.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Depew-Hotels.s40-0-d6338362.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Depew. ![Curtiss Hotel, an Ascend Collection Hotel](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/1b8dbb7d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Curtiss Hotel, an Ascend Collection Hotel 210 Franklin St Buffalo NY $218 nightly $254 total Feb 9 - Feb 10 Total with taxes and fees 9.2/10 Wonderful! (1,006 reviews) [](https://expedia.com/Buffalo-Hotels-Curtiss-Hotel.h17038248.Hotel-Information) Still don't see what you're looking for? [See all properties in Depew.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=6338362&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=6338362&star=40&star=40&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=6338362&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=6338362&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=6338362&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026®ionId=6338362&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Depew Hotel Reviews ## Find out more about Depew ## Depew Four Star Hotel Information When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Depew, Buffalo are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Depew 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service. Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Depew. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Depew, Buffalo, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop. Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Depew hotels offer everything your heart desires. ## Frequently asked questions ### What are the best 4-star hotels in Depew? ### How much does it cost to stay in a 4-star hotel in Depew? > - Search for the lowest price from $254 ### What's the difference between 5-star and 4-star hotels in Depew? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Reinstein Woods Nature Preserve and Environmental Education Center ](https://www.expedia.com/Reinstein-Woods-Nature-Preserve-And-Environmental-Education-Center-Hotels.0-l553248621561173660-0.Travel-Guide-Filter-Hotels) - [Hotels near Buffalo-Depew Station ](https://www.expedia.com/Buffalo-Depew-Station-Hotels.d6194293.Travel-Guide-Hotels) - [Hotels near Buffalo Niagara Intl. ](https://www.expedia.com/Buffalo-Niagara-Intl-Airport-Hotels.0-aBUF-0.Travel-Guide-Filter-Hotels) - 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