Depew Vacations from $345

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

The Latest Depew vacation packages

Price found within the past 48 hours. Click for updated prices.
Old Library Inn

Old Library Inn

2 out of 5
Price was $458, price is now $345 per person
$345
per person
Mar 15 - Mar 19
just found
Roundtrip flight included
New York (NYC) to Buffalo (BUF)
9.2/10 Wonderful! (19 reviews)
Beautiful home located in the next to the Old Library Restaurant. About a 30 minutes drive to Art Roscoe Park for cross country skiing.

Reviewed on Jan 7, 2026

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Price was $713, price is now $488 per person
$488
per person
May 2 - May 7
found 13 hours ago
Roundtrip flight included
Denver (DEN) to Buffalo (BUF)
8/10 Very Good! (2,709 reviews)
Customer service was great. Room was clean and spacious and the shuttle service was great. We had dinner at the attached restaurant which was great

Reviewed on Feb 8, 2026

The Richardson Hotel

The Richardson Hotel

3.5 out of 5
Elmwood Bidwell
Price was $947, price is now $700 per person
$700
per person
Mar 19 - Mar 22
found 24 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Buffalo (BUF)
9/10 Wonderful! (1,002 reviews)
The only real issue was you could only connect to one devise at a time for WiFi. Room was spotless, staff were very nice

Reviewed on Feb 3, 2026

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Downtown Buffalo
Price was $814, price is now $619 per person
$619
per person
May 2 - May 7
found 13 hours ago
Roundtrip flight included
Denver (DEN) to Buffalo (BUF)
8/10 Very Good! (1,617 reviews)
Great check in experience, clean rooms, close to everything downtown and the pool on the 11th floor with great views is a bonus.

Reviewed on Feb 8, 2026

The Mansion On Delaware Ave

The Mansion On Delaware Ave

4 out of 5
Downtown Buffalo
Price was $941, price is now $717 per person
$717
per person
May 2 - May 7
found 13 hours ago
Roundtrip flight included
Denver (DEN) to Buffalo (BUF)
9.4/10 Exceptional! (1,002 reviews)
Room upgrade. Pleasant staff.

Reviewed on Feb 3, 2026

Don't see what you're looking for?
See all available trips from Columbus to Depew
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Discover the most popular places to visit in Depew

A beautiful sunset today at ub! At least there is one perk to being stuck on campus for 12 hours! 🌅🌅🌅 #ub #universityatbuffalo #buffalo #sunset #baridpoint #oozefestpits #springsemester #academicspine #campuslife

University At Buffalo - North Campus

Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's great live music and acclaimed theater scene.

University At Buffalo - North Campus
Downtown Buffalo NY

KeyBank Center

Catch an event at KeyBank Center during your trip to Buffalo. Experience the area's entertainment choices and acclaimed theater scene.

KeyBank Center
NFL Salute to Service Buffalo Bills Ralph Wilson Stadium

Highmark Stadium

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's great live music and entertainment choices.

Highmark Stadium

What to do in Depew

TR is waiting to greet you!

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

$13
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Niagara Falls Self-Guided Driving Audio Tour from Toronto

Niagara Falls Self-Guided Driving Audio Tour from Toronto

$17
per traveler
Niagara Falls Self-Guided Driving Audio Tour from Toronto
Niagara Falls USA: Full-Day Scenic Tour from Buffalo!

Niagara Falls USA: Full-Day Scenic Tour from Buffalo!

$151
per adult
Niagara Falls USA: Full-Day Scenic Tour from Buffalo!
See all activities in Depew

Depew Hotel Deals

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Feb 10 to Feb 11
$102 total
Feb 10 - Feb 11
Total with taxes and fees
7.8/10 Good! (2,875 reviews)
Customer service was great. Room was clean and spacious and the shuttle service was great. We had dinner at the attached restaurant which was great

Reviewed on Feb 8, 2026

Buffalo Airport Hotel
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Fully refundable
$80 nightly
The price is $91 total per night from Mar 8 to Mar 9
$91 total
Mar 8 - Mar 9
Total with taxes and fees
7.8/10 Good! (1,984 reviews)
The room was nice, you can tell that there has been water damage in the room, the microwave wasn't balanced I had to wedge a soap holder under it, and the shower did leak I just used towels to maintain. Overall the stay was nice the bed was very comfortable.

Reviewed on Feb 6, 2026

Sleep Inn & Suites Buffalo Airport
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Feb 10 to Feb 11
$108 total
Feb 10 - Feb 11
Total with taxes and fees
7.6/10 Good! (2,258 reviews)
great room, fantastic front desk and airport shuttle driver.

Reviewed on Feb 8, 2026

Garden Place Hotel
See all 879 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Depew Vacation Packages

Depew Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Buffalo Niagara Intl. Airport (BUF)
Population
15,100
Max Temp Winter
30ºF
Max Temp Summer
75ºF
Top Sights
Buffalo Zoo, Buffalo Museum of Science and Albright - Knox Art Gallery

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Frequently asked questions

How much does a Depew vacation package cost?
You can pick up a vacation package to this destination from $345 on Expedia. But how much your vacation to Depew costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Depew?
If you'd like to snag a cheap Depew vacation package, consider traveling in December, January and February. You'll typically find lower rates on flights and accommodations during these quieter months — ideal for a budget-friendly break.
How many days is enough for Depew?
With a well-organized schedule, you can easily tick off the top Depew attractions in a few days. But if you want to explore off the beaten track or go on day tours, consider booking your Depew vacation for longer.
How to find the best Depew package deals?
Finding a cheap Depew package deal is a breeze with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget range, add a couple of filters and browse what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Depew package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Depew vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a customized Depew vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Depew?
If you're considering a spur-of-the-moment Depew adventure, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can score amazing deals on your hotels and flights by booking ahead.
How to plan a trip to Depew?

  1. Choose when to get away: Check your schedule and get your bags packed. Your preferred time of year and the type of activities available will also help you decide when to escape to Depew.
  2. Plan your budget wisely: On top of the cost of your accommodations, you should factor in other expenses too. These include flights, food and transportation. Also, set aside some extra funds for unexpected costs that may crop up during your trip to Depew.
  3. Organize your Depew escape with our trip planning tool: Look for and book accommodations and experiences all in one place. You can also collaborate with your group to plan an unforgettable trip to Depew together.
  4. Decide how many days away: Start by compiling a list of the attractions you'd like to get to in Depew. Then, estimate how long you'll need at each, as well as any travel time.
  5. Combine your flights and hotel: Awesome destination, check. Length of stay, check. All that's left is to choose a Depew vacation package that brings all your bookings together.
  6. Book any day trips or activities: Here's the fun part — organizing everything you want to see and do. Check out some of the top things to do in Depew in Depew and reserve your tickets early to save time (and maybe some money too!).

Does Expedia offer Book Now, Pay Later Depew vacation packages?
Your Depew break should be an escape from your busy life, not a source of money-related stress. So to give you that extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.