Depew Vacations from $346

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

The Latest Depew vacation packages

Price found within the past 48 hours. Click for updated prices.
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Price was $455, price is now $346 per person
$346
per person
Dec 27 - Dec 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (2,681 reviews)
Very good driver on shittle

Reviewed on Oct 23, 2025

Holiday Inn Express Buffalo NE Lockport by IHG

Holiday Inn Express Buffalo NE Lockport by IHG

2.5 out of 5
Price was $536, price is now $403 per person
$403
per person
Dec 26 - Dec 30
found 1 day ago
Roundtrip flight included
Tampa (TPA) to Buffalo (BUF)
9.2/10 Wonderful! (701 reviews)
This hotel was really nice. The room was very clean and layed out very good. All the staff members were very polite and helpful. The breakfast had a good variety of choices including healthy options. The breakfast worker was very helpful and kept the food area very clean. The only downside were the beds. They were a bit high for shorter people to get onto.

Reviewed on Oct 18, 2025

Niagara Crossing Hotel & Spa

Niagara Crossing Hotel & Spa

3.5 out of 5
Price was $587, price is now $444 per person
$444
per person
Dec 28 - Jan 1
found 1 day ago
Roundtrip flight included
Tampa (TPA) to Buffalo (BUF)
9/10 Wonderful! (1,505 reviews)
Great area, restaurants nearby, great staff

Reviewed on Oct 24, 2025

Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham

3.5 out of 5
Downtown Buffalo
Price was $758, price is now $595 per person
$595
per person
Jan 16 - Jan 19
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Buffalo (BUF)
8.6/10 Excellent! (1,008 reviews)
This hotel was a beautiful old building with unique architecture and comfortable, high-ceiling rooms. It was in a great location, allowing for easy walking to the arena, waterfront, and free tram. The only thing to be aware of is that there is a large population of homeless in the area that can make one feel unsafe, especially at night. It is not the fault of the hotel just an unfortunate reality of the times.

Reviewed on Oct 16, 2025

Red Coach Inn

Red Coach Inn

3 out of 5
Downtown Niagara Falls
Price was $891, price is now $709 per person
$709
per person
Dec 28 - Jan 1
found 1 day ago
Roundtrip flight included
Tampa (TPA) to Buffalo (BUF)
9.4/10 Exceptional! (1,006 reviews)
The Nottingham Suite was lovely. It is very well appointed, exceptionally clean and had everything we needed for our two-night stay. We were able to see the NY rapids from this room (directly across the street). The staff were very accommodating, professional and friendly. In addition, the Red Coach Inn is located within walking distance to most attractions - and they have on-site parking. Having a made-to-order breakfast each morning was wonderful.

Reviewed on Oct 20, 2025

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Discover the most popular places to visit in Depew

A nice day for a walk in the fall by the pillars. #universityatbuffalo#buffalo #ub #college #hiking #lake #berries #fall

University At Buffalo - North Campus

Explore the campus of University At Buffalo - North Campus, a top college in Amherst. Experience the area's acclaimed theater scene and entertainment choices.

University At Buffalo - North Campus
NFL Salute to Service Buffalo Bills Ralph Wilson Stadium

Highmark Stadium

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music.

Highmark Stadium
Buffalo Zoo

Buffalo Zoo

See more than 1,200 animals at this small zoo in Buffalo’s Delaware Park. Explore the rainforest building or see the big cats of the African plains.

Buffalo Zoo

What to do in Depew

Welcome to the Pan-American Exposition.

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

$13
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Morning American Tour with Maid of the Mist

The iconic Boat Ride- Maid of the Mist ticket- Best selling Tour! Get Tickets

$57
per adult
84% of travellers recommend
The iconic Boat Ride- Maid of the Mist ticket- Best selling Tour! Get Tickets
American Falls Adventure with Maid of the Mist & Cave of the Winds from USA

Niagara Falls USA: Maid of the Mist & Cave Adventure

$129
per adult
94% of travellers recommend
Niagara Falls USA: Maid of the Mist & Cave Adventure
See all activities in Depew

Depew Hotel Deals

M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave, Buffalo, NY
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $107 total per night from Nov 16 to Nov 17
$107 total
Nov 16 - Nov 17
Total with taxes and fees
7.2/10 Good! (2,343 reviews)
Close to shopping and a variety of other activities.

Reviewed on Oct 24, 2025

M Hotel Buffalo
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St, Buffalo, NY
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $113 total per night from Oct 26 to Oct 27
$113 total
Oct 26 - Oct 27
Total with taxes and fees
7.8/10 Good! (2,660 reviews)
Very good driver on shittle

Reviewed on Oct 23, 2025

Buffalo Airport Hotel
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr, Buffalo, NY
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $82 total per night from Nov 10 to Nov 11
$82 total
Nov 10 - Nov 11
Total with taxes and fees
7.8/10 Good! (1,807 reviews)
Close to the airport. Staff is great.Good choices for breakfast.

Reviewed on Oct 24, 2025

Sleep Inn & Suites Buffalo Airport
See all 847 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Depew Vacation Packages

Depew Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Buffalo Niagara Intl. Airport (BUF)
Population
15,100
Max Temp Winter
30ºF
Max Temp Summer
75ºF
Top Sights
Buffalo Zoo, Buffalo Museum of Science and Albright - Knox Art Gallery

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Frequently asked questions

How much does a Depew vacation package cost?
You can pick up a vacation package to this destination from $346 on Expedia. But how much your vacation to Depew costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Depew?
If you'd like to snag a cheap Depew vacation package, consider traveling in December, January and February. You'll typically find lower rates on flights and accommodations during these quieter months — ideal for a budget-friendly break.
How many days is enough for Depew?
With a well-organized schedule, you can easily tick off the top Depew attractions in a few days. But if you want to explore off the beaten track or go on day tours, consider booking your Depew vacation for longer.
How to find the best Depew package deals?
Finding a cheap Depew package deal is a breeze with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget range, add a couple of filters and browse what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Depew package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Depew vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a customized Depew vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Depew?
If you're considering a spur-of-the-moment Depew adventure, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can score amazing deals on your hotels and flights by booking ahead.
How to plan a trip to Depew?

  1. Choose when to get away: Check your schedule and get your bags packed. Your preferred time of year and the type of activities available will also help you decide when to escape to Depew.
  2. Plan your budget wisely: On top of the cost of your accommodations, you should factor in other expenses too. These include flights, food and transportation. Also, set aside some extra funds for unexpected costs that may crop up during your trip to Depew.
  3. Organize your Depew escape with our trip planning tool: Look for and book accommodations and experiences all in one place. You can also collaborate with your group to plan an unforgettable trip to Depew together.
  4. Decide how many days away: Start by compiling a list of the attractions you'd like to get to in Depew. Then, estimate how long you'll need at each, as well as any travel time.
  5. Combine your flights and hotel: Awesome destination, check. Length of stay, check. All that's left is to choose a Depew vacation package that brings all your bookings together.
  6. Book any day trips or activities: Here's the fun part — organizing everything you want to see and do. Check out some of the top things to do in Depew in Depew and reserve your tickets early to save time (and maybe some money too!).

Does Expedia offer Book Now, Pay Later Depew vacation packages?
Your Depew break should be an escape from your busy life, not a source of money-related stress. So to give you that extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.