Depew Vacations from $315

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

The Latest Depew vacation packages

Price found within the past 48 hours. Click for updated prices.
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Save 100% on your flight
Price was $472, price is now $315 per person
$315
per person
Jun 9 - Jun 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (2,928 reviews)
The rooms are well kept smd the staff were wonderful..wish the beds were bigger

Reviewed on Mar 29, 2026

Holiday Inn Express Cheektowaga North East by IHG

Holiday Inn Express Cheektowaga North East by IHG

2.5 out of 5
Save 100% on your flight
Price was $523, price is now $353 per person
$353
per person
Jun 9 - Jun 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8.4/10 Very Good! (1,272 reviews)
The woman taking care of the free breakfast was amazing and helpful…. Does a great job… best aspect of our stay!!

Reviewed on Apr 3, 2026

The Mansion On Delaware Ave

The Mansion On Delaware Ave

4 out of 5
Downtown Buffalo
Save 100% on your flight
Price was $924, price is now $656 per person
$656
per person
Jun 9 - Jun 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
9.4/10 Exceptional! (1,006 reviews)
Thoroughly enjoyed our night at the Mansion on Delaware. Room was very clean, staff were amazing and the freshly made breakfast was a huge bonus. Enjoyed a drink at the bar chatting with other visitors and the staff and came back after the game to a pint in front of the fireplace. Highly recommended! Thanks

Reviewed on Mar 31, 2026

Garden Place Hotel

Garden Place Hotel

3.5 out of 5
Price was $456, price is now $335 per person
$335
per person
Jun 9 - Jun 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
7.8/10 Good! (2,313 reviews)
The breakfast options needed to accommodate people who have gluten, and dairy intolerance. More selections of tea would’ve been nice.

Reviewed on Apr 1, 2026

Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown

2.5 out of 5
Downtown Buffalo
Save 100% on your flight
Price was $1,144, price is now $843 per person
$843
per person
Jun 9 - Jun 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8.8/10 Excellent! (1,001 reviews)
Excellent location, and even on a frigid weekend, the hotel was cozy.

Reviewed on Mar 19, 2026

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Discover the most popular places to visit in Depew

University At Buffalo - North Campus

University At Buffalo - North Campus

4.5/5(110 reviews)

Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's acclaimed theater scene and great live music.

University At Buffalo - North Campus
Highmark Stadium

Highmark Stadium

4/5(409 reviews)

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's great live music and entertainment choices.

Highmark Stadium
Downtown Buffalo NY

KeyBank Center

4.5/5(527 reviews)

Catch an event at KeyBank Center during your trip to Buffalo. Experience the area's great live music and entertainment choices.

KeyBank Center

What to do in Depew

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

$13
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Niagara Falls Day Tour from Toronto

Niagara Falls Day Tour from Toronto

$52
per adult
96% of travellers recommend
Niagara Falls Day Tour from Toronto
Buffalo Sabres Ice Hockey Game at Keybank Center

Buffalo Sabres Ice Hockey Game at Keybank Center

$120
per adult
Buffalo Sabres Ice Hockey Game at Keybank Center
See all activities in Depew

Depew Hotel Deals

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Apr 12 to Apr 13
$97 total
Apr 12 - Apr 13
Total with taxes and fees
8/10 Very Good! (2,922 reviews)
Couldn’t close the curtains only a sheer cover closed and it was on a ground floor. It was noisy due to other people arguing during the night. It was a great location and they offered a shuttle to the airport!! The restaurant was great.

Reviewed on Mar 31, 2026

Buffalo Airport Hotel
Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
2761 Long Road Grand Island NY
Fully refundable
$109 nightly
The price is $124 total per night from Apr 5 to Apr 6
$124 total
Apr 5 - Apr 6
Total with taxes and fees
9/10 Wonderful! (1,743 reviews)
Was good

Reviewed on Apr 4, 2026

Holiday Inn Express Grand Island - Niagara Falls by IHG
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $142 total per night from Apr 12 to Apr 13
$142 total
Apr 12 - Apr 13
Total with taxes and fees
7.4/10 Good! (2,699 reviews)
They dont like to give you your downpayment back

Reviewed on Apr 3, 2026

M Hotel Buffalo
See all 884 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Depew Vacation Packages

Depew Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Buffalo Niagara Intl. Airport (BUF)
Population
15,100
Max Temp Winter
30ºF
Max Temp Summer
75ºF
Top Sights
Buffalo Zoo, Buffalo Museum of Science and Albright - Knox Art Gallery

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Frequently asked questions

How much does a Depew vacation package cost?
You can pick up a vacation package to this destination from $315 on Expedia. But how much your vacation to Depew costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Depew?
If you'd like to snag a cheap Depew vacation package, consider traveling in December, January and February. You'll typically find lower rates on flights and accommodations during these quieter months — ideal for a budget-friendly break.
How many days is enough for Depew?
With a well-organized schedule, you can easily tick off the top Depew attractions in a few days. But if you want to explore off the beaten track or go on day tours, consider booking your Depew vacation for longer.
How to find the best Depew package deals?
Finding a cheap Depew package deal is a breeze with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget range, add a couple of filters and browse what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Depew package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Depew vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a customized Depew vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Depew?
If you're considering a spur-of-the-moment Depew adventure, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can score amazing deals on your hotels and flights by booking ahead.
How to plan a trip to Depew?

  1. Choose when to get away: Check your schedule and get your bags packed. Your preferred time of year and the type of activities available will also help you decide when to escape to Depew.
  2. Plan your budget wisely: On top of the cost of your accommodations, you should factor in other expenses too. These include flights, food and transportation. Also, set aside some extra funds for unexpected costs that may crop up during your trip to Depew.
  3. Organize your Depew escape with our trip planning tool: Look for and book accommodations and experiences all in one place. You can also collaborate with your group to plan an unforgettable trip to Depew together.
  4. Decide how many days away: Start by compiling a list of the attractions you'd like to get to in Depew. Then, estimate how long you'll need at each, as well as any travel time.
  5. Combine your flights and hotel: Awesome destination, check. Length of stay, check. All that's left is to choose a Depew vacation package that brings all your bookings together.
  6. Book any day trips or activities: Here's the fun part — organizing everything you want to see and do. Check out some of the top things to do in Depew in Depew and reserve your tickets early to save time (and maybe some money too!).

Does Expedia offer Book Now, Pay Later Depew vacation packages?
Your Depew break should be an escape from your busy life, not a source of money-related stress. So to give you that extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.