Title: The Best 5 Star Hotels in Santo Angelo  | Expedia.com

[Santo Angelo Travel Guide](https://expedia.com/Santo-Angelo.dx1304)[Hotels in Santo Angelo](https://expedia.com/Santo-Angelo-Hotels.d1304.Travel-Guide-Hotels)[Vacation Rentals in Santo Angelo](https://expedia.com/Santo-Angelo-Vacation-Rentals.d1304.Travel-Guide-VacationRentals)[Flights to Santo Angelo](https://expedia.com/Cheap-Flights-To-Santo-Angelo.d1304.Travel-Guide-Flights)[Car Rentals in Santo Angelo](https://expedia.com/Car-Rentals-In-Santo-Angelo.d1304.Car-Rental-Guide)[Santo Angelo Vacation Packages](https://expedia.com/Santo-Angelo.d1304.Destination-Travel-Guides)

![Santo Ângelo](https://images.trvl-media.com/place/1304/c5067e05-15b2-47b8-bbdf-3daff73959b7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Santo Angelo 5 Star Hotels

Tonight

[Feb 15 - Feb 16](https://www.expedia.com/Hotel-Search?regionId=1304&startDate=2026-02-15&endDate=2026-02-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 16 - Feb 17](https://www.expedia.com/Hotel-Search?regionId=1304&startDate=2026-02-16&endDate=2026-02-17&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=1304&startDate=2026-02-20&endDate=2026-02-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=1304&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Learn more about Santo Angelo

Explore the Catedral Angelopolitana's striking architecture before sampling local cuisine at the bustling Praça Ricardo Leônidas Ribas market. The Mission Route connects Santo Ângelo to other historic Jesuit ruins, where guided tours reveal fascinating indigenous and colonial history.

[See all hotels in Santo Angelo](https://www.expedia.com/Hotel-Search?startDate=2026-03-01&endDate=2026-03-02&adults=2&regionId=1304)

![Santo Ângelo](https://images.trvl-media.com/place/1304/c5067e05-15b2-47b8-bbdf-3daff73959b7.jpg?impolicy=fcrop&w=900&h=597&p=1&q=high)

## Top Santo Angelo Hotel Reviews

## Find out more about Santo Angelo

Indulge your every whim on your upcoming escape. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Santo Angelo so popular in the last year. There's no reason to delay a getaway to Santo Angelo any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Reserve one of our 5-star hotels in Santo Angelo and indulge in the finer things in life for a while. What are you waiting for?

### Get a Great Deal on 5-Star Hotels in Santo Angelo

You'll have a wonderful time at one of these 5-star hotels. Excellent service, delicious meals, and attentive guest service are all waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. How do you want to relax? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, delectable chocolate desserts, and even a hot tub in the bathroom...these hotels have it all. 

But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Santo Angelo are the perfect place to relax after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. 

### Make Your Escape

The results are in, and Santo Angelo 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- Expedia can help you land a great deal on accommodation. Opt for one of our Santo Angelo 5-star hotels today and decompress in the lap of luxury when you're ready.

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- [Book 5 Star Hotels in Santo Angelo on Expedia.com.br ](https://www.expedia.com.br/5estrelas-Santo-Angelo-Hoteis.s50-0-d1304.Guia-de-Viagem-Filtrar-Hoteis)