An aerial view of a coastal area with a large body of water, a bridge, and a solar power plant.

Barrio Sur Vacations from $647

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The Latest Barrio Sur Vacation Packages

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  • A wooden deck with a metal table and chairs, overlooking a body of water and a sunset.
    Dec 24 - Dec 29

    Hotel San Pedro de Taboga + Flight

    Taboga
    5 nights
    3.0 star property
    9.6/10 - Exceptional (5 reviews)
    "Peronal muy amable y dispuestos ayudar en todo momento."
    Reviewed September 21, 2026
    Roundtrip • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Nonstop PTY - GEO • Nonstop
    $985
    $647
    per traveler
    found 14 hours ago
    Hotel San Pedro de Taboga
  • A multi-story building with balconies, arched windows, and decorative railings.
    Dec 25 - Dec 31

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    6 nights
    4.0 star property
    9.2/10 - Wonderful (1,003 reviews)
    "In the heart of Casco Viejo, the first hotel built but you could not tell as it has been remodeled. A lot of history. The place is beautiful and well maintained. We went on a sailing trip for 2 days and the held our bags at no extra cost. The staff is great and the restaurant in the back is absolutely delicious! Lots of great restaurants around as well. There is a Speakeasy nearby called Villa Ana 1928, second floor above the restaurant, don’t miss it!"
    Reviewed November 5, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    Save 100% on your flight
    $4,365
    $2,158
    per traveler
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
    Jan 26 - Jan 31

    Megapolis Hotel Panamá + Flight

    San Francisco
    5 nights
    4.5 star property
    8.6/10 - Excellent (1,840 reviews)
    "Shops nearby"
    Reviewed November 6, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,865
    $1,067
    per traveler
    found 1 day ago
    Megapolis Hotel Panamá
  • A pool area with lounge chairs, umbrellas, and a bridge over the water.
    Jan 26 - Jan 31

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen Airport
    5 nights
    4.0 star property
    8.6/10 - Excellent (1,813 reviews)
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,450
    $958
    per traveler
    found 1 day ago
    Riande Aeropuerto Hotel & Casino
  • A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
    Jan 26 - Jan 31

    Hyatt Regency Panama City + Flight

    Bella Vista
    5 nights
    5.0 star property
    9.6/10 - Exceptional (499 reviews)
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,959
    $1,331
    per traveler
    found 1 day ago
    Hyatt Regency Panama City

Where to stay in Barrio Sur

Find the best Barrio Sur areas and neighborhoods for the activities you enjoy most.
A statue of a historical figure pointing upwards with a bird in hand, set against a backdrop of a clear blue sky with scattered clouds.

Barrio Norte

While visiting Barrio Norte, you might make a stop by sights like Monument to Christopher Columbus and Limon Bay.

A large cargo ship docked at a port with multiple containers stacked on its deck.

Cristobal

Travelers enjoy Cristobal for its churches and seaside views. Consider checking out Limon Bay while you're in the area.

Coco Solo

If you're spending some time in Coco Solo, Colon Free Zone and Limon Bay are top sights worth seeing.

Gatun

The museums and monuments are just a few features travelers like about Gatun. If you want to do some sightseeing nearby, Canal Expansion Observation Center and Gatún Dam are a few top places to visit.

Discover the most popular places to visit in Barrio Sur

Colon Free Zone

7.8/10 (127 reviews)
During your trip to Colon, you can search for that perfect souvenir at Colon Free Zone.
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What to do near Barrio Sur

Panama Canal Tour: New Locks Agua Clara, Gatun & Atlantic Bridge

Panama Canal Tour: New Locks Agua Clara, Gatun & Atlantic Bridge

$45
per adult
0% of travelers recommend
Panama Canal Tour: New Locks Agua Clara, Gatun & Atlantic Bridge
See all activities near Barrio Sur

Barrio Sur Hotel Deals

A rooftop pool area with lounge chairs and a view of a port with cranes.

Radisson Colon 2000 Hotel & Casino at Cruise Port & Duty Free Mall

Radisson Colon 2000 Hotel & Casino at Cruise Port & Duty Free Mall
4.0 star property
Barrio Sur
8.2 out of 10, Very good, (995 reviews)
$110 nightly
The price is $121
Nov 9 - Nov 10
Total with taxes and fees
Radisson Colon 2000 Hotel & Casino at Cruise Port & Duty Free Mall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Barrio Sur
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.