Barrio Sur Vacations from $1,016

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

The Latest Barrio Sur Vacation Packages

Price found within the past 48 hours. Click for updated prices.
MARINN PLACE Financial District
La Coralina Island House
Central Hotel Bocas del Toro
Coral Bay Bungalows
The Gray by Wynwood House

Where to stay in Barrio Sur

Find the best Barrio Sur areas and neighborhoods for the activities you enjoy most. Learn more about Barrio Sur

Barrio Sur Hotel Deals

Radisson Colon 2,000 Hotel & Casino

Radisson Colon 2,000 Hotel & Casino

4 out of 5
Paseo Gorgas, Calle 13, Colon, Colon
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $120 total per night from Jul 31 to Aug 1
$120 total
Jul 31 - Aug 1
Total includes taxes and fees
8/10 Very Good! (765 reviews)
Beat hotel near the 2000 Free Trade Zone
"This was an excellent hotel to stay in. Walking distance to 2000 Free Trade Zone. Restaurant and bar at hotel if you desire to go. Staff was friendly, check-in was fast and efficient. I would recommend you stay at this hotel."

Reviewed on Jul 29, 2025

Radisson Colon 2,000 Hotel & Casino
Hotel Andros

Hotel Andros

3 out of 5
Ave. Herrera, entre Calles 9 y 10, Colon, Colon
Fully refundableReserve now, pay when you stay
$37 nightly
The price is $42 total per night from Aug 7 to Aug 8
$42 total
Aug 7 - Aug 8
Total includes taxes and fees
7.6/10 Good! (133 reviews)
"Good"

Reviewed on Jun 20, 2025

Hotel Andros
Hotel Sotelo

Hotel Sotelo

3 out of 5
Calle 11, Ave. Amador, Colon, Panama
Fully refundableReserve now, pay when you stay
$36 nightly
The price is $40 total per night from Jul 31 to Aug 1
$40 total
Jul 31 - Aug 1
Total includes taxes and fees
7.8/10 Good! (37 reviews)
"The hotel room was clean however the paint on the walls is dirty. The bedhead is discolored, bathroom mirror old and discolored. Air conditioner is very dirty. Bed is not comfortable. I ask front desk for ticker bedsheets buy there don't have. I booked for 6 days but leaves on the third day. The ..."

Reviewed on Jul 11, 2024

Hotel Sotelo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Barrio Sur

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.