Barrio Sur Vacations
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- La Moderna Downtown Nights by Wynwood
Aug 25 - Sep 5La Moderna Downtown Nights by Wynwood + Flight
Casco Viejo11 nights7.0/10 - Good (48 reviews)"Unit had multiple problems. Constantly reaching out to customer service for maintenance. Ended up having to move to another room. Won’t be staying there again!"Reviewed May 29, 2026Roundtrip • Georgetown (GEO) - Panama City (PTY)GEO - PTY • Nonstop PTY - GEO • Nonstop - Megapolis Hotel Panamá
Jul 24 - Jul 27Megapolis Hotel Panamá + Flight
San Francisco3 nights8.4/10 - Very Good (1,547 reviews)"El bufet ay muy poco personal de trabajadores para prestar un buen servicio"Reviewed June 4, 2026Roundtrip • New York (JFK) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,789$1,120found 2 days agoper traveler - Casa La Costa By Wynwood House
Aug 25 - Sep 5Casa La Costa By Wynwood House + Flight
Casco Viejo11 nights8.4/10 - Very Good (30 reviews)"Very nice place, clean and big, location is very good to walk around restaurants."Reviewed April 30, 2026Roundtrip • Georgetown (GEO) - Panama City (PTY)GEO - PTY • Nonstop PTY - GEO • Nonstop - Central Hotel Panama Casco Viejo
Jul 24 - Jul 27Central Hotel Panama Casco Viejo + Flight
Casco Viejo3 nights9.2/10 - Wonderful (1,007 reviews)"We thoroughly enjoyed our stay. Relaxing, clean and sophisticated vibe there. Central location can’t be beat. So comfortable! We liked the breakfast buffet as well. Staff was friendly. Would stay again! Very pleased :)"Reviewed June 7, 2026Roundtrip • New York (JFK) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,436$926found 2 days agoper traveler
Where to stay in Barrio Sur
Find the best Barrio Sur areas and neighborhoods for the activities you enjoy most. Learn more about Barrio Sur
Cristobal
Travelers enjoy Cristobal for its churches and seaside views. Consider checking out Limon Bay while you're in the area.
Barrio Sur Hotel Deals
Radisson Colon 2000 Hotel & Casino at Cruise Port & Duty Free Mall
Paseo Gorgas, Calle 13 Colon Colon
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $120 total per night from Jun 13 to Jun 14
$120 total
Jun 13 - Jun 14
Total with taxes and fees
8.2/10 Very Good! (935 reviews)
"The hotel is ok but rooms smell humid"
Reviewed on Jun 4, 2026
Hotel Sotelo
Calle 11, Ave. Amador Colon Panama
Fully refundableReserve now, pay when you stay
$32 nightly
The price is $35 total per night from Jun 8 to Jun 9
$35 total
Jun 8 - Jun 9
Total with taxes and fees
Hotel Internacional de Colón
Calle 11 con Avenida Bolivar Colon Colón Province
9.8/10 Exceptional! (11 reviews)
"It does not have breakfast facilities"
Reviewed on Nov 12, 2024
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Barrio Sur
Colon Free Zone
During your trip to Colon, you can search for that perfect souvenir at Colon Free Zone.
Colon 2000
During your visit to Colon, you can search for that perfect souvenir at Colon 2000. Stroll along this relaxing area's lakeside, or simply enjoy its restaurants.
Things to do
Panama Canal Tour: New Locks Agua Clara, Gatun & Atlantic Bridge
$49
per adult
Colon City tour: Exploring Caribbean roots, food and Afro culture
$105
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.