A historic church with two towers and a large central dome, surrounded by parked cars and a street.

$271 Cheap Flights to Santiago

View $271 flight on Fri, Apr 23, 2027

Popular airlines to Santiago

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  • How much is the cheapest flight to Santiago?

    Prices were available within the past 7 days and start at $271 for one-way flights and $567 for roundtrip, for the period specified. Prices and availability are subject to change.

    All deals

    One way

    Roundtrip

    Select United flight, departing Thu, Jun 3 from Columbus to Panama City, returning Mon, Jun 14, priced at $687 Found 6 hours ago

    Thu, Jun 3 - Mon, Jun 14 · CMH · PTY · Roundtrip

    Select American Airlines flight, departing Tue, Mar 23 from Columbus to Panama City, returning Wed, Mar 31, priced at $687 Found 17 hours ago

    Tue, Mar 23 - Wed, Mar 31 · CMH · PTY · Roundtrip

    Select Delta flight, departing Tue, Apr 13 from Columbus to Panama City, returning Tue, Apr 20, priced at $687 Found 2 days ago

    Tue, Apr 13 - Tue, Apr 20 · CMH · PTY · Roundtrip

    Select United flight, departing Mon, Feb 8 from Columbus to Panama City, returning Mon, Feb 15, priced at $692 Found 16 hours ago

    Mon, Feb 8 - Mon, Feb 15 · CMH · PTY · Roundtrip

    Select Avianca flight, departing Fri, Mar 5 from Columbus to Panama City, returning Sun, Mar 14, priced at $1,188 Found 9 hours ago

    Fri, Mar 5 - Sun, Mar 14 · CMH · PTY · Roundtrip

    Book with confidence

    Tips to find the cheapest flights to Santiago

    The cheapest day to fly

    Get started finding a cheap flight to Santiago on Expedia by either choosing a deal on this page or entering into the search bar your travel dates, origin airport, and whether you want roundtrip or one-way airfare. You can filter for flexibility, number of stops, airline, and departure/arrival times to find the best flight for you.

    The cheapest month to fly

    February is the cheapest month to fly to Santiago. This coincides with the low season when fewer people travel. Whichever month you travel in, though, be sure to book at least a month in advance if you want to score cheap tickets to Santiago. ARC's data shows that domestic flights booked 28 days or more before departure are typically 24% cheaper than those booked last minute.

    The most affordable time to book a flight

    Typically, a Sunday can be the cheapest time to book a flight to Santiago, according to ARC’s data. On average, you could save between 6% and 13% by booking on a Sunday instead of a Friday, which is the most expensive day to make a reservation.

    The cheapest round-trip tickets to Santiago

    The lowest price for round-trip flights to Santiago in 2026 starts from $567, while one-way tickets start from from $271. Expedia's effective search tool is one of the best ways to find a budget airfare. Simply enter your dates, and within seconds, it'll show you a vast selection of the cheapest flights to Santiago. If you have a preferred departure time or airline, you can use the handy filters to customize your search.

    The cheapest airlines flying to Santiago

    Copa, American Airlines, Delta, United, Avianca are just some of the airlines that can typically offer cheap tickets to Santiago. You can find their most affordable flights by using the “airline” search filter and then sorting prices from low to high. As a trusted partner of the world's leading airlines, Expedia offers you some of the best airfare deals to Santiago and countless more destinations worldwide.

    The most affordable airports to fly into

    To view the cheapest airports to fly into for Santiago, simply order your search results from lowest to highest price. Expedia's search tool compares flight prices for all airports close to your destination, so you don't have to manually search them one by one to find the cheapest flight to Santiago. If you have a preferred place to fly into, take advantage of the “arrival airport” filter to narrow down your search on Expedia.

    Save with a package

    With Expedia's amazing package deals, you could save hundreds of dollars by booking your Santiago plane tickets together with your accommodations, car rental, or activities. Just select the search wizard's “package” option to view some of the cheapest deals. Look out for the green savings label to see how much you're saving.

    Date flexibility for the cheapest flights to Santiago

    If you can be flexible with your travel dates, it's a good idea to broaden your search by comparing prices on different days. This will open up more options, meaning you could uncover a less expensive flight to Santiago.

    Stopover savings

    The cheapest tickets to Santiago are sometimes those with a stopover. Book one of these flights, and you'll change planes at an airport en route to Santiago. While the overall travel time might be longer than a non-stop flight, you may decide it's worth it for the money saved.

    Get Expedia's Price Drop Protection

    Price Drop Protection means that if your flight gets cheaper after booking, you'll be credited the difference*. This gives you peace of mind that you're getting one of the cheapest flights to Santiago for your chosen departure. Expedia's Price Drop Protection is available for a small fee but is free to One Key Gold and Platinum tier members.

    *Terms apply.

    Use our Price Tracking feature

    Expedia's Price Tracking feature is another great tool that removes the guesswork from finding cheap flights to Santiago. Simply download the free Expedia app to your smart device and activate Santiago flight price alerts for your travel dates. There's even a price predictor tool that uses historical data to indicate the best time to book, giving you peace of mind that you'll nab the lowest prices.

    Book with Expedia

    As well as Price Drop Protection and Price Tracking, Expedia's close partnership with a vast selection of the world's leading airlines means you're sure to find cheap flights to Santiago. Plus, the One Key rewards program lets you earn real cash rewards on most bookings that you can use to save money on future trips. Best of all, it's free to join, and members often unlock exclusive discounts, too.

    Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

    Frequently Asked Questions

    What month is the cheapest to fly to Santiago?

    The cheapest month to fly to Santiago is February when there's less demand. Off-peak months are usually when you'll find cheap fares. To save money, steer clear of flying during school breaks and major holidays.

    Which US cities fly direct to Santiago?

    There are 17 US destinations you're able to fly to Santiago directly from. Compare your options by using the "Direct flights only" box on Expedia and choose the ideal starting point for you. Here are a few of the major cities to set off from:

    • Miami
    • Orlando
    • Los Angeles
    • Washington
    • New York

    How to find a cheap flight to Santiago?

    Book early or search for cheap flights to Santiago during off-peak months like September and October. Jetting off on a Thursday could also save you 16% on average compared to a Sunday departure.* The Expedia app makes it even easier to know the right time to book. Just activate the toggle for "Watch prices" and get notified when fares drop.

    *Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.

    How to get a cheap last-minute flight to Santiago?

    Being flexible about your travel plans can help you find last-minute offers on cheap flights to Santiago. To view all the available options, consider exploring different ticket types, changing your Santiago vacation dates, flying out of an alternative airport or going with another carrier.

    How far in advance should I book a flight to Santiago?

    To pick up some of the best deals on domestic journeys, book your flight to Santiago 28 days ahead of your travel dates. For international flights, search for your ticket two to four months in advance. This improves your chances of getting your preferred departure dates, times and seats.*

    *Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.

    Which day of the week is the cheapest day to buy a plane ticket to Santiago?

    Generally, you can find cheap flights to Santiago on Sundays. Travelers can save around 8% on average compared to those who book on a Friday, which is typically the most expensive day to buy tickets.*

    *Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.

    Which airlines fly to Santiago?

    When you're ready to book your ticket to Santiago, these leading airlines look forward to welcoming you aboard:

    • Copa Airlines - 932 flights to Santiago each month, including 932 flights to Tocumen Intl. Airport (PTY) per month.
    • United Airlines - 152 flights to Santiago each month, including 152 flights to Tocumen Intl. Airport (PTY) per month.
    • Delta Air Lines - 30 flights to Santiago each month, including 30 flights to Tocumen Intl. Airport (PTY) per month.

    Where do you fly into Santiago?

    If you're flying to Santiago, the main airport to arrive at is Santiago (SYP-Ruben Cantu). Alternatively, you could fly to Santiago via Chitre (CTD-Alonso Valderrama).

    How far is the airport from central Santiago?

    You'll be around 2 mi east of the center of Santiago after jetting into Santiago (SYP-Ruben Cantu).

    Can I save money by booking a Santiago trip package?

    Bundle your hotel and flight and you could save hundreds of dollars. Better still, you can add extras like tours and car rentals to your Santiago flight and hotel package deal. With Expedia, it's easy to organize all your Santiago travel arrangements in the same place.

    Can I change or cancel my flight to Santiago?

    You can usually change or cancel your flight to Santiago within 24 hours of booking. However, keep in mind that some flights are non-refundable. In those cases, you may be issued a credit toward a future trip instead of a direct refund. Make sure you check the airline's terms of service in your itinerary for exact details. You can use Expedia's "No cancel fee" or "Changes included" filters during your search to secure cheap flights to Santiago with flexible change policies. To learn more, visit our Customer Service Portal.

    Travel information

    Destination city namePanama City
    Destination airportTocumen Intl. Airport
    Destination airport IATA codePTY
    Airlines servingAvianca, American Airlines, Copa, Delta, United, Aeromexico, Air France, KLM, Turkish Airlines, Iberia, Air Europa, WestJet, Lufthansa, GOL Linhas Aereas S.A., British Airways, Cayman Airways, EVA Airways, Caribbean Airlines, Qatar Airways, Emirates, Korean Air, Etihad Airways, China Eastern Airlines, EL AL Israel Airlines, Azul
    Popular airlineAvianca
    Roundtrip price$687

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    Trending flights to Santiago

    Prices were available within the past 7 days and start at $271 for one-way flights and $567 for roundtrip, for the period specified. Prices and availability are subject to change.

    All deals

    One way

    Roundtrip

    Select Copa flight, departing Thu, Feb 11 from Miami to Panama City, returning Fri, Feb 12, priced at $567 Just found

    Thu, Feb 11 - Fri, Feb 12 · MIA · PTY · Roundtrip

    *Available to One Key members.