Cherokee Seneca Vacations from $382

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Cherokee Seneca Vacation

Whether you're coming for its history or walking, the neighborhood of Cherokee Seneca has plenty to keep you busy. Experience all of this and more with ease by booking a Cherokee Seneca vacation package. Some leading nearby attractions to see during your trip to Cherokee Seneca include Louisville Mega Cavern, Louisville Zoo and Louisville Waterfront Park. Expedia can help turn your ideal Cherokee Seneca vacation into reality, whatever your budget or travel plans.

The Latest Cherokee Seneca Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
Downtown Louisville
Price was $493, price is now $382 per person
$382
per person
Mar 21 - Mar 24
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
9/10 Wonderful! (3,770 reviews)
Staff was great but the room had no drawers for clothes, our heater did not work on the first night and there was no blanket on the bed, just a sheet with a thin topper.

Reviewed on Feb 1, 2026

Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
Downtown Louisville
Price was $638, price is now $462 per person
$462
per person
Mar 21 - Mar 24
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
9/10 Wonderful! (1,003 reviews)
Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again!

Reviewed on Jan 16, 2026

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
Downtown Louisville
Price was $748, price is now $560 per person
$560
per person
Mar 21 - Mar 24
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
9.6/10 Exceptional! (422 reviews)
Beautiful room! Clean and the service at the front desk was great! So kind!

Reviewed on Jan 28, 2026

Holiday Inn Louisville Airport South by IHG

Holiday Inn Louisville Airport South by IHG

3 out of 5
Price was $676, price is now $511 per person
$511
per person
Apr 7 - Apr 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
8.8/10 Excellent! (765 reviews)
Very nice hotel. Well maintained. Easy access to most of the city via I65!

Reviewed on Jan 22, 2026

Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
Downtown Louisville
Price was $796, price is now $622 per person
$622
per person
Apr 7 - Apr 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
8.8/10 Excellent! (1,005 reviews)
Delicious Old Fashion. Great location.

Reviewed on Jan 21, 2026

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Cherokee Seneca
Landscape of Louisville

Downtown Louisville

3 out of top 10 points of interest in this area
4/5(1,812 area reviews)

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

Find hotels in Downtown Louisville

Cherokee Seneca Hotel Deals

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $166 total per night from Feb 3 to Feb 4
$166 total
Feb 3 - Feb 4
Total with taxes and fees
8.8/10 Excellent! (4,010 reviews)
Great

Reviewed on Jan 25, 2026

Galt House Hotel Trademark Collection by Wyndham
Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG

3.5 out of 5
830 Phillips Lane Louisville KY
$104 nightly
The price is $122 total per night from Mar 3 to Mar 4
$122 total
Mar 3 - Mar 4
Total with taxes and fees
8.8/10 Excellent! (1,133 reviews)
The room is nice. But we didn’t have a trashcan and some utilities in the washroom. But in the rest 4/5.

Reviewed on Jan 27, 2026

Crowne Plaza Louisville Airport Expo Ctr by IHG
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $244 total per night from Feb 8 to Feb 9
$244 total
Feb 8 - Feb 9
Total with taxes and fees
9.2/10 Wonderful! (1,766 reviews)
Amazing stay!

Reviewed on Jan 27, 2026

Omni Louisville Hotel
See all 2,118 properties in Cherokee Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Cherokee Seneca

Kissing trees in Cherokee Park

Cherokee Park

Cherokee Park is just one of the places to see in Louisville, so why not enjoy the other things to explore during your travels? Stroll along the area's riverfront or experience its great live music.

Cherokee Park
Ky Derby festival balloon glow.

Kentucky Exposition Center

Learn about the events happening at Kentucky Exposition Center during your trip to Louisville. Experience the area's lively festivals and acclaimed art scene.

Kentucky Exposition Center
Churchill Downs showing horseriding and land animals as well as a small group of people

Churchill Downs

Find more than mint juleps to enjoy at this iconic racetrack, best known as the annual host of the Kentucky Derby.

Churchill Downs

Things to do

Kentucky Derby Museum

Kentucky Derby Museum - General Admission and Guided Track Visit

$22
per adult
90% of travellers recommend
Kentucky Derby Museum - General Admission and Guided Track Visit
Derby City Ghosts: Louisville Hauntings Tour

Lace, Lunacy, and Loss: Louisville Ghost Tours

$32
per adult
Lace, Lunacy, and Loss: Louisville Ghost Tours
Kentucky Derby Museum - Admission with Guided Track Visit

Kentucky Derby Museum - Admission with Guided Track Visit

$22
per adult
100% of travellers recommend
Kentucky Derby Museum - Admission with Guided Track Visit
See all activities in Louisville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.