Cherokee Seneca Vacations from $446

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Your Cherokee Seneca Vacation

Whether you're coming for its history or walking, the neighborhood of Cherokee Seneca has plenty to keep you busy. Experience all of this and more with ease by booking a Cherokee Seneca vacation package. Some leading nearby attractions to see during your trip to Cherokee Seneca include Louisville Mega Cavern, Louisville Zoo and Louisville Waterfront Park. Expedia can help turn your ideal Cherokee Seneca vacation into reality, whatever your budget or travel plans.

The Latest Cherokee Seneca Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
Downtown Louisville
per person
Oct 31 - Nov 2
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Louisville (SDF)
9/10 Wonderful! (1,003 reviews)
Closed drapes, but couldn't open in morning. I got a handicap room, didn't request it but i assume check in person saw i had a walking stick and gave me one. Great. It was at the end of hall, as far away from elevators as possible. Why would you put handicap room there.

Reviewed on Aug 12, 2025

5 Bd/3 Ba-Near Expo/UL/Fair/YUM/Zoo

5 Bd/3 Ba-Near Expo/UL/Fair/YUM/Zoo

3 out of 5
per person
Sep 26 - Sep 28
found 2 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
No reviews
Fairfield Inn By Marriott Louisville North

Fairfield Inn By Marriott Louisville North

2.5 out of 5
per person
Nov 7 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Louisville (SDF)
8/10 Very Good! (536 reviews)
Property was pleasant. It had a little bit of a smell in hallways. The rooms were clean and a nice area out of the way. Good staff that called me so I could check in early.

Reviewed on Jul 18, 2025

Comfort Inn & Suites Clarksville - Louisville North

Comfort Inn & Suites Clarksville - Louisville North

2.5 out of 5
per person
Nov 7 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Louisville (SDF)
9/10 Wonderful! (952 reviews)
The presidential suite was huge! Definitely will stay again.

Reviewed on Aug 15, 2025

Bourbon Barrel Inn Bed & Breakfast

Bourbon Barrel Inn Bed & Breakfast

3 out of 5
Old Louisville
per person
Nov 7 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Louisville (SDF)
No reviews

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Cherokee Seneca
Louisville showing signage and street scenes as well as a small group of people

Downtown Louisville

3 out of top 10 points of interest in this area
4/5(1,812 area reviews)

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

Find hotels in Downtown Louisville

Cherokee Seneca Hotel Deals

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $161 total per night from Aug 31 to Sep 1
$161 total
Aug 31 - Sep 1
Total includes taxes and fees
8.8/10 Excellent! (3,527 reviews)
"Always have loved the Galt House Hotel. They are so good to us. Clean and friendly."

Reviewed on Aug 16, 2025

Galt House Hotel Trademark Collection by Wyndham
Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG

3.5 out of 5
830 Phillips Lane, Louisville, KY
Fully refundable
$111 nightly
The price is $131 total per night from Aug 24 to Aug 25
$131 total
Aug 24 - Aug 25
Total includes taxes and fees
8.6/10 Excellent! (746 reviews)
"Hotel is clean, staff was great and breakfast was very good. Didn't like: room was not cleaned well - hair, stains on the floor and empty water bottles left from previous guest. Safe was locked when we checked in security asked for a couple of hours to come open it"

Reviewed on Aug 14, 2025

Crowne Plaza Louisville Airport Expo Ctr by IHG
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $187 total per night from Aug 31 to Sep 1
$187 total
Aug 31 - Sep 1
Total includes taxes and fees
9.2/10 Wonderful! (1,556 reviews)
Great Anniversary Trip
"Upon checking in, I told Sharone it was our 44th Anniversary and we come to The Omni after spending the day at the KY State Fair. This was our 6th year returning. Not long after we were in our room, we heard a knock on the door. It was Sharone with a gift bag and two 4 gold balloons, denoting our ..."

Reviewed on Aug 15, 2025

Omni Louisville Hotel
See all 1,989 properties in Cherokee Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Cherokee Seneca

Kissing trees in Cherokee Park

Cherokee Park

Cherokee Park is just one of the places to see in Louisville, so why not enjoy the other things to explore during your travels? Stroll along the area's riverfront or experience its acclaimed art scene.

Cherokee Park
Ky Derby festival balloon glow.

Kentucky Exposition Center

Learn about the events happening at Kentucky Exposition Center during your trip to Louisville. Experience the area's great live music and acclaimed art scene.

Kentucky Exposition Center
Churchill Downs showing horseriding and land animals as well as a small group of people

Churchill Downs

Find more than mint juleps to enjoy at this iconic racetrack, best known as the annual host of the Kentucky Derby.

Churchill Downs

Things to do

Derby City Ghosts: Louisville Hauntings Tour

Derby City Ghosts: Louisville Hauntings Tour

$26
per adult
Derby City Ghosts: Louisville Hauntings Tour
Louisville: NuLu District Food and History Tour

Louisville: 3-Hour Food and History Tour of NuLu District

$129
per adult
80% of travellers recommend
Louisville: 3-Hour Food and History Tour of NuLu District
Whispers on Whiskey Row: Murder, Crime, & Ghost Tour

Whispers on Whiskey Row: Murder, Crime, & Ghost Tour w/Cocktail

$65
per adult
80% of travellers recommend
Whispers on Whiskey Row: Murder, Crime, & Ghost Tour w/Cocktail
See all activities in Louisville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.