San Francisco Vacations from $755
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Your San Francisco Vacation
When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.
The Latest San Francisco Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Las Clementinas
Casco Viejo
Price was $1,399, price is now $972 per person
$972
per person
Jan 4 - Jan 7
found 6 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.4/10 Exceptional! (206 reviews)
Beautiful property and great restaurant! Also awesome customer service
Reviewed on Nov 7, 2026
Casa Mallet by Wynwood House
Casco Viejo
Price was $2,451, price is now $1,710 per person
$1,710
per person
Jan 14 - Jan 18
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (30 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect.
The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us.
I would stay here again in a heart beat.
It’s a must stay!
Reviewed on Sep 16, 2026
Where to stay in San Francisco
Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
San Francisco Hotel Deals
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco Panama City Panama
$111 nightly
The price is $122 total per night from Nov 10 to Nov 11
$122 total
Nov 10 - Nov 11
Total with taxes and fees
9.6/10 Exceptional! (1,427 reviews)
"Buffet breakfast was pretty good. Hotel is in a good location for restaurants and bars as well. Staff were generally friendly and welcoming. My main concern is that I was not offered a room upgrade as per my VIP status perk l, and when I asked about it as well as a late checkout, the front desk person ..."
Reviewed on Nov 8, 2026
Megapolis Hotel Panamá
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $145 total per night from Nov 25 to Nov 26
$145 total
Nov 25 - Nov 26
Total with taxes and fees
Decapolis Hotel Panama City
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $112 total per night from Nov 10 to Nov 11
$112 total
Nov 10 - Nov 11
Total with taxes and fees
8.6/10 Excellent! (1,739 reviews)
"Stay was ok for what we paid just need to be updated it’s a bit outdated"
Reviewed on Nov 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular San Francisco attractions
Things to do
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
$99
per adult
94% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
$36
per adult
100% of travellers recommend
Panama City: Embera Native Village & Waterfall Tour & Lunch
$65
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.