Title: Car Rental San Francisco - Expedia.com [San Francisco Travel Guide](https://expedia.com/Panama-City-San-Francisco.dx553248623199112076)[Hotels in San Francisco](https://expedia.com/San-Francisco-Panama-City-Hotels.0-n553248623199112076-0.Travel-Guide-Filter-Hotels)[Flights to Panama City](https://expedia.com/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights)[Things to do in Panama City](https://expedia.com/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities)[San Francisco Vacations](https://expedia.com/San-Francisco.d553248623199112076.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/553248623199112076/b14d4c65-cc25-49b4-aad3-c708d5b994fc.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rental San Francisco ## Search and Compare from Car Companies in San Francisco ## Featured car rental suppliers Compare from agencies ![car suppliers logo](https://forever.travel-assets.com/flex/flexmanager/images/2022/02/16/car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car rentals [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Car Deals in San Francisco \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Panama City, Panamá Province, PAN ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=San%20Francisco,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199112076&date1=4/14/2026&date2=4/16/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Panama City, Panamá Province, PAN ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=San%20Francisco,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199112076&date1=4/14/2026&date2=4/16/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Panama City, Panamá Province, PAN ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=San%20Francisco,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199112076&date1=4/14/2026&date2=4/16/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Panama City, Panamá Province, PAN ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=San%20Francisco,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199112076&date1=4/14/2026&date2=4/16/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in San Francisco [View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=San%20Francisco,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199112076&date1=4/14/2026&date2=4/16/2026&crfrr=defaultFlex&SearchType=Place) ## What you need to know for your San Francisco car rental ## Car Rental Information | Popular car types | [SUV](https://www.expedia.com/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.com/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.com/lp/b/car-rental/economy?rfrr=car.table.Economy) | | ------------------------------------------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available | | | Our best deal of the day | | | Our second best deal of the day | | | Our third best deal of the day | | | From the airport to your hotel | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) | | From popular domestic and international airports | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport) | ## Frequently asked questions ### How much is a rental car per day in San Francisco? ### What happens if I need to cancel my San Francisco car reservation? ### Where can I go on a road trip from San Francisco? > - Make your way to Colon for a fun-filled sightseeing experience. Approximately 35 miles from San Francisco, it has lots of inspiring sights, including Gatun Locks. > - Your next pit stop? Santiago, which is around 120 miles away. Escuela Normal Juan Demostenes Arosemena is one local hot spot you really shouldn't miss. > - Venture into the outdoors and take in the serenity at Starfish Beach. It's approximately 190 miles from San Francisco. ### How do I find the best car rental deals in San Francisco with Expedia? ### What do you need to rent a car in San Francisco? ### What is the cheapest car rental in San Francisco? ### Can I rent a car for a month or longer in San Francisco? ### Where can I find a San Francisco car rental if I am younger than 25? ### What insurance should I choose for my car rental in San Francisco? ### Can I drive in San Francisco with my current driver's license? > - Age restrictions: You'll need to be 25 or over in most places to rent a car. If you're younger, it may still be possible to rent a car but you'll have to pay a Young Driver's Surcharge. Additional restrictions may also apply to the types of vehicles you can rent. > - Driving limitations: Be sure to read the fine print before sliding behind the wheel. Usually, you can't cross country borders, drive onto ferries or go off-roading with a rental car. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - [Hotels near ATLAPA Conventions Center ](https://www.expedia.com/ATLAPA-Conventions-Center-Hotels.0-l6286123-0.Travel-Guide-Filter-Hotels) - [Hotels near Omar Torrijos Recreational Park ](https://www.expedia.com/Omar-Torrijos-Recreational-Park-Hotels.0-l553248621532964848-0.Travel-Guide-Filter-Hotels) - [Hotels near Multiplaza Pacific Mall ](https://www.expedia.com/Multiplaza-Pacific-Mall-Hotels.0-l6158227-0.Travel-Guide-Filter-Hotels) - [Hotels near Hospital Punta Pacífica ](https://www.expedia.com/Hospital-Punta-Pacifica-Hotels.0-l553248635976653100-0.Travel-Guide-Filter-Hotels) - [Hotels near Obarrio ](https://www.expedia.com/Obarrio-Panama-City-Hotels.0-n3000663487-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Obarrio ](https://www.expedia.com/Obarrio-Panama-City-Hotels-Cheap-Hotels.0-n3000663487-0-tCheapHotels.Travel-Guide-Filter-Hotels) - 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