Find Cheap Cruises to South America

Great South America cruise deals now!

For expert cruise advice, call 1-866-403-9848.

Most cruises have enhanced cleanliness, safety & vaccinations protocols for a safer return to sea. More DetailsOpens in a new window

Questions about the cruise experience? Learn moreOpens in a new window in our Cruise Guide.

Online cruise vacation consultant Expedia cruise experts can help you plan your next cruise vacation. More detailsOpens in a new window

Best South America cruise deals

10 cruises found - Prices are per traveler, available within last 24 hours and valid for US and Canadian residents only. Taxes, fees, and port expenses are included. Fuel supplement may apply.
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Preziosa

3 night South America

MSC Cruises
MSC Cruises • MSC Preziosa
Oct 29, 2025 — Nov 1, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Preziosa

3 night South America

MSC Cruises
MSC Cruises • MSC Preziosa
Dec 7, 2025 — Dec 10, 2025
Santos, Brazil • Angra Dos Reis, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 4 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Lirica

3 night South America

MSC Cruises
MSC Cruises • MSC Lirica
Dec 12, 2025 — Dec 15, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Lirica

3 night South America

MSC Cruises
MSC Cruises • MSC Lirica
Nov 28, 2025 — Dec 1, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Preziosa

3 night South America

MSC Cruises
MSC Cruises • MSC Preziosa
Nov 1, 2025 — Nov 4, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Preziosa

3 night South America

MSC Cruises
MSC Cruises • MSC Preziosa
Nov 4, 2025 — Nov 7, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Preziosa

3 night South America

MSC Cruises
MSC Cruises • MSC Preziosa
Nov 7, 2025 — Nov 10, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Preziosa

3 night South America

MSC Cruises
MSC Cruises • MSC Preziosa
Oct 26, 2025 — Oct 29, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Lirica

3 night South America

MSC Cruises
MSC Cruises • MSC Lirica
Dec 5, 2025 — Dec 8, 2025
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Continue with ${nights} night ${destination} on ${cruise}, opens in new tab
MSC Lirica

3 night South America

MSC Cruises
MSC Cruises • MSC Lirica
Feb 3, 2026 — Feb 6, 2026
Santos, Brazil • Buzios, Brazil • Santos, BrazilDeparting from Santos, visiting 3 ports, select Itinerary details to review day by day itinerary

inside room per traveler
Don't see what you're looking for?
See all available South America sailings
View all sailings

Book a Vacation Cruise to South America

Why should I go on a cruise to South America?

Popular 4-day or 5-day cruises to South America in 2025, like the ones offered by Celebrity and MSC, allow you to explore some of the most beautiful and diverse countries in the world, with destinations that include Brazil, Argentina, Chile, and Peru. A cruise to South America takes you to many different sights and cultures in a single trip, from the natural wonders of the Amazon rainforest to the historic cities of Buenos Aires and Santiago. You can also find cruises to South America from Florida, allowing you to start your journey close to home.

How can I find cheap cruises to South America?

Cheap cruises, such as a 7-day cruise to South America, can be found by booking as far in advance as possible and sorting your search results by price. If you can book a South America cruise in 2026, you will be more likely to find the least expensive South America cruise prices. That being said, you can usually find great South America cruise deals simply by entering your desired features, date, and time of departure, and filtering your results by price to find 7-day cruise deals, for example.

What are the best cruise lines to South America?

MSC Cruises to South America are some of the most popular that Expedia has to offer. Celebrity cruises, Norwegian Cruise Line, Costa cruises, and Seabourn Cruise Line are also some of the best cruise lines to South America and will allow you to visit stunning destinations such as Chile, Peru, Argentina, Brazil, and others on a 7-day cruise from Florida.

How can I find good South America cruise deals?

Be sure to check your search results for the green text that indicates discounted cruises to South America. Expedia offers a wealth of tools to help you find great deals on some of the best South America cruises around, including viewing the itinerary of every trip so you can be sure you get to see Mayan ruins or the Andes Mountains, or enjoy the fantastic nightlife on your 7-day cruise in 2025. You can also look at some of our preselected 7-day cruise deals to Brazil, Argentina, and other countries in South America and view the green box that shows you the savings you get for each one.

What to look out for when you book your South America cruise?

Decide which experiences you want and check to see which cruises offer those experiences by looking at the itinerary for each cruise that interests you. You can find this by clicking on a search result and then "Itinerary". Your South America cruise can allow you to see a dramatic variety of locales from mountains to rainforests, thriving cities to small villages, and ancient ruins and beyond, so plan your travels carefully. Consider looking at cruises to specific countries like an Argentina cruise for nightlife or a Beagle Channel cruise to see penguin colonies and sea lions. A 3-day cruise from San Diego or California does not allow you enough travel time, but you still have plenty of options for a 7-day or 5-day cruise from another departure point, such as a 3-day, 4-day, 5-day, or 7-day cruise from Florida in 2025.

Where are the best places to go on a cruise to South America?

A cruise trip to South America offers the chance to see some of the most iconic places on Earth, from the vibrant nightclubs in Rio de Janeiro to the amazing food culture and historic Plaza de Mayo in Buenos Aires, the wildlife in the Galapagos Islands, and beyond. A South America river cruise might take you up the Amazon River or to explore the delta of the Rio de la Plata. Book your 5-day cruise or your 7-day cruise in 2025 and get ready to make memories that'll last a lifetime.

When is the best time to go on a cruise to South America?

The best time for cruises that go to South America depends on where you wish to travel, but wildlife enthusiasts may want to book an October cruise to catch the whale and Magellan penguin migration, or a January or February cruise to see the penguin chicks hatch. Whales are also active in January and February. Most cruises run between October and May when the weather is warm and dry. Generally, it's advisable to book your 7-day cruise to South America for 2026.

How long does it take to go to South America by cruise ship?

Because it takes a long time to travel to South America by cruise ship, a boat cruise to South America from the United States will take a long time, though cruises to South America from Florida or cities like Miami, Los Angeles, and Fort Lauderdale may occasionally be available. This means that a 3-day cruise from California or a 5-day cruise from Florida does not allow you enough travel time. However, many 7-day cruises depart from South America and end there. If you depart from a port in South America like Santos, Brazil, you can find everything from a 2-day or 3-day cruise in South America to a 7-day cruise to South America or even full 2-week long excursions.

What are some great luxury cruises to South America?

Norwegian and Celebrity offer some of the best South America cruises and can include luxurious amenities such as elegant sit-down dining with live musical entertainment and Broadway shows, room service, spa treatments, and full fitness facilities. Viking South America cruises are also a popular option for 3-day or 4-day cruises. You can even book a 5-day cruise in 2025 to South America on a ship with full suites that allow you to have several rooms of luxurious living space.

What are some good all-inclusive cruises to South America?

To find some of the best 3-day all-inclusive cruises or longer cruises to South America, all you need to do is enter some basic info, then click on the trips that interest you. Some of the best all-inclusive cruise lines include MSC and Princess. You can see everything about your trip and everything that is included. A Porto Belo cruise, for example, may spend 2 days at sea and offer main dining, buffets, room service, spa facilities, and fitness facilities.

How to book a cruise to South America on Expedia?

Simply enter your destination, departure dates, cruise duration, and number of travelers, and a full list of options will pop up, such as 3-day cruises or 7-day cruises. From there, you can filter by ports, departures, cabin experience, and amenities. Keep an eye out in the results for the green text that indicates discounted cruises. From 2- to 3-day cruises to South America through a 5-day cruise to South America and even trips that last several weeks, booking a cruise to South America on Expedia is as simple as entering some basic information.

Do you need a passport to cruise to South America?

You may need a passport to cruise to South America depending on where your ship departs and returns. For a closed-loop cruise to South America that begins and ends at the same US port, such as a cruise from Miami to South America, you may be able to get by with just a state-issued ID card and birth certificate for your 4-day cruise. It is always helpful, however, to have a passport when visiting a foreign country, so it should be considered best practice.

Can I cancel my cruise booking to South America?

Canceling your cruise to South America is fairly simple and just requires a visit to your My Trips page on Expedia or contacting our helpful customer support team. Before you cancel, however, always check the rules and regulations of the cruise line you booked. Many cruise lines do not offer full refunds or charge cancellation fees, so it's best to stay informed to avoid unpleasant surprises before canceling.

Why should I book a cruise to South America with Expedia?

Expedia is your one-stop shop for South American cruise vacation trips, with an easy process that lets you control every aspect of your cruise. You can filter your selections by price, amenities, and even the point of departure. Plus, One Key members may even be able to earn points on eligible bookings that can be used for future discounts, so join up for free today.

About South America Cruises

Set sail to a world of color, music and beauty on a cruise around this dazzling and diverse continent.

Combine wildlife, ancient historical sights, city excitement and adventure sports all in the same trip with a South America cruise. Luxuriate in lengthy journeys that could take you to spectacular Inca ruins, lively capital cities and mountain-lined rivers in one action-packed vacation. 

A cruise around South America could take you to the majority of the continent’s 12 countries. Only Bolivia and Paraguay don’t have coastlines. Pull into port in many different nations, each with its own unique culture and atmosphere. Alternatively, select an all-Brazil trip to experience the continent’s largest country.

South America cruise ports vary between exhilarating city centers and untamed wildernesses. Those wanting to experience a South American city can choose between places such as the exciting carnival capital of Rio de Janeiro, the cultural center of Buenos Aires or Chile’s colorfully painted Valparaiso.

Nature-lovers and adventure-seekers have myriad choices for South America cruise expeditions. Look for penguins in Puerto Madryn or land in Punta Arenas to hike through the dramatic landscapes of Patagonia. From here, Antarctica is reachable as an epic, but expensive daytrip. 

A cruise in South America isn’t always ocean-bound. Fly into Manaus and drift serenely along the Amazon River through the heart of the continent. Typical itineraries on the river take you through dense jungles and sleepy village. Disembark on a canoe or take an excursion to get within a few feet of local wildlife.

Many South America cruise operators embrace the culture of the destination and give their ships a unique South American atmosphere. Feast on empanadas and churrasco (grilled meat) in the onboard restaurants or take lessons in tango dancing for energetic evenings on the ocean. 

The continent is so large that it is impossible to see it all in one trip. Most South America cruises last longer than 7 days. Cruise season here is primarily between November and early May. Choose to start your expedition in the U.S. or in South America itself. Many cruises to South America are not round-trips, especially round-the-horn cruises that circle Cape Horn, so you may need to book your return flight from a different destination.


Get expert advice iconGet expert advice icon

Get expert advice

If you have a question, or would like personalized assistance booking your cruise, contact an Expedia Cruises™ travel agent today.