COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

St. Louis, MO Vacation Packages

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St. Louis Vacation: Coronavirus Information

Most St. Louis hotels offer free cancellation. Consider booking refundable hotels rather than non-refundable ones. Just look for the ‘free cancellation’ message during your hotel search. Prices can vary, but right now we believe that flexibility matters.

For more information about the impact of COVID-19 on your St. Louis trip, please visit our Coronavirus Information page (opens in new window).

What are the advantages of a road trip to St. Louis?

There’s nothing quite like a St. Louis road trip. And Expedia makes it easy for you to turn all those road trip ideas into reality. You can find cheap deals on hotels in St. Louis or bundle your hotels with car rentals to save even more. With our St. Louis packages, you’ll find hitting the highway for that road trip adventure is more affordable than ever.  

How to plan a road trip to St. Louis?

Planning a road trip can feel daunting, especially when you’ll be making multiple bookings for your itinerary. But you can find car rentals in St. Louis and low rates on hotels all in one place— Expedia. How you plan your road trip depends on what’s important to you. People love to take road trips to experience the great outdoors, bond with friends or family and see more of the world. When planning, bundle your car rental and hotel into one discounted package to maximize savings on both. Or, leave room for spontaneity, booking what you need when you need it with our last-minute deals.  

What to do on a road trip to St. Louis?

When taking a road trip adventure, it’s best to plan how you want to spend your time on your road trip itinerary. We don’t want you to miss out on any of the best things to do in St. Louis. You can book all the road trip activities on your St. Louis wishlist, and even plan activities along your route as well.  

How to rent a car for a road trip?

For an epic road trip, you'll need the perfect car. Renting a car for a road trip is the best option that doesn’t put miles or strain on your vehicle, and especially when it's also so affordable. Because when you book on Expedia, it doesn't need to be expensive. You can pick up a cheap car rental and head out to one of these incredible vacation rentals in St. Louis. And when you bundle car rentals with hotel stays, you'll save even more on each part of your journey.

Top St. Louis Flight + Hotel Deals

The Ritz-Carlton, St. Louis
The Chase Park Plaza Royal Sonesta St. Louis
Kennedys Red Barn Inn
The Westin St. Louis
Stoney Creek Hotel & Conference Center Columbia

Where to stay in St. Louis

Find the best St. Louis areas and neighborhoods for the activities you enjoy most. Learn more about St. Louis

Top Hotels in St. Louis

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Free Cancellation
The price is $139 per night from May 16 to May 16
4.3/5Excellent! (3,365 reviews)

Reviewed on May 10, 2021

Hyatt Regency St. Louis at The Arch
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Free CancellationReserve now, pay when you stay
The price is $135 per night from Jun 1 to Jun 1
4.6/5Exceptional! (1,830 reviews)
"The hotel itself is very nice. The parking garage had a low clearance (6’8”) so I had to remove my roof-top cargo box."

Reviewed on May 14, 2021

Drury Plaza Hotel St. Louis at the Arch
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Free CancellationReserve now, pay when you stay
The price is $105 per night from May 16 to May 16
4.3/5Excellent! (1,135 reviews)
"My family loved the free game room."

Reviewed on May 14, 2021

Clayton Plaza Hotel & Extended Stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top things to do in St. Louis

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