Find Vacation Homes in Des Moines County, IA from $163

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Top Cities in Des Moines County

Vacation Homes in Des Moines County

Our top choices for Des Moines County vacation homes

Charming Cottage, close to all the sights.

10.0 out of 10, Exceptional, (23)
"This is a beautiful house! We had a wonderful time staying here; it is close to historic Nauvoo and had enough of space for our family of 8. It was nice to have a well equipped kitchen to use during our stay. "
Charming Cottage, close to all the sights.

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

9.6 out of 10, Exceptional, (13)
"A wonderful respite near to Macomb and all you would need. Cozy bed… Good coffee… Super quite…"
$154 nightly
The price is $163
Aug 31 - Sep 1
Total with taxes and fees
Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

10.0 out of 10, Exceptional, (13)
"Comfortable small town house in nice location. Perfect for our visit with family that lives in Montrose. All the comforts of home. Will be staying here again in future visits. Highly recommend this place for anyone looking to visit the area."
Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

Historic 1840s Lamoreaux House / Modern Addition

9.8 out of 10, Exceptional, (16)
"Had a wonderful time at the Vrbo and enjoyed the towns of Ft. Madison and Nauvoo. "
$372 nightly
The price is $394
Aug 27 - Aug 28
Total with taxes and fees
Historic 1840s Lamoreaux House / Modern Addition

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

$355 nightly
The price is $376
Aug 27 - Aug 28
Total with taxes and fees
PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

Cozy House

10.0 out of 10, Exceptional, (3)
"I loved it! We were greeted by the host and their dog (who’s friendly as ever!) upon arrival and everything went perfectly smooth from there. The blankets were honestly the best part, LOL! We were all obsessed! Perfect little spot to stay right off the highway in a quiet neighborhood. Will definitely consider it again in the future if I need somewhere to stay near here again! "
$167 nightly
The price is $176
Aug 27 - Aug 28
Total with taxes and fees
Cozy House

Nauvoo Windmill Farmhouse 10-12 people

10.0 out of 10, Exceptional, (8)
"Our family had a wonderful weekend at the Windmill Farmhouse! "
$198 nightly
The price is $209
Aug 27 - Aug 28
Total with taxes and fees
Nauvoo Windmill Farmhouse 10-12 people

Oquawka Cottage With River View

9.6 out of 10, Exceptional, (7)
"Visiting family nearby for Mother’s Day. Cute, cozy, clean little house with a big deck and view of the river from the master bedroom. Quiet neighborhood. Mindi responds quickly if you have questions or need anything. Really enjoyed our stay. "
$181 nightly
The price is $191
Aug 27 - Aug 28
Total with taxes and fees
Oquawka Cottage With River View

Riverside Waterfront on the Mississippi River

9.6 out of 10, Exceptional, (16)
"I would stay again for sure. Very nice place in a great location. "
$270 nightly
The price is $286
Sep 2 - Sep 3
Total with taxes and fees
Riverside Waterfront on the Mississippi River

Sauna & Private Hot Tub: Kirkwood Farmhouse!

Sauna & Private Hot Tub: Kirkwood Farmhouse!

Experience Beautiful Pioneer Home In Nauvoo!

10.0 out of 10, Exceptional, (74)
"We had a wonderful anniversary trip to Nauvoo. The historic and quaint Mix House added some period charm to our stay. While the house retains much of its 19th century charm, it has the modern conveniences needed for a relaxing stay. It may have been the off season, but food and meal choices were limited in Nauvoo itself. We were grateful for the items we ordered from The Apron Bake Shoppe."
$360 nightly
The price is $382
Sep 2 - Sep 3
Total with taxes and fees
Experience Beautiful Pioneer Home In Nauvoo!

Historic Gem 1840's newly furnished brick house.

10.0 out of 10, Exceptional, (79)
"Wonderful stay in a clean and comfortable historic home. "
Historic Gem 1840's newly furnished brick house.

Charming Modern 1950s Mid-Century Ranch.

9.8 out of 10, Exceptional, (11)
"Just me and just right. The location was awesome and the decor was also. Had a great stay and will again."
Charming Modern 1950s Mid-Century Ranch.

“The Place” Blocks away from MOCO

10.0 out of 10, Exceptional, (1)
"A Very Clean and comfortable house. Definitely would stay again."
“The Place” Blocks away from MOCO

Countryside Biggsville Home w/ Yard, Dogs Welcome!

2.0 star property
10.0 out of 10, Exceptional, (1)
"Great location for our family. Very clean and loved that there is 2 1/2 bathrooms and sleeps 10 so everyone had a place to sleep. "
Countryside Biggsville Home w/ Yard, Dogs Welcome!

Home Away From Home

10.0 out of 10, Exceptional, (2)
"Our experience all around was good. Communication with host was easy and they worked with us great. House was clean, in a quite neighborhood and definitely better than a hotel."
$191 nightly
The price is $202
Aug 27 - Aug 28
Total with taxes and fees
Home Away From Home

Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

10.0 out of 10, Exceptional, (31)
"Awesome place to stay short drive from anything you want to do in the area. Highly recommended hands down one of the top places we’ve ever stayed."
Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

Idyllic Biggsville Vacation Rental: 10 Mi to River

$195 nightly
The price is $205
Sep 1 - Sep 2
Total with taxes and fees
Idyllic Biggsville Vacation Rental: 10 Mi to River

Downtown Columbus 2 bedroom unit with great views!

8.0 out of 10, Very Good, (2)
"Clean and comfortable. Host communicated well. Nothing to complain about. Would stay here again."
Downtown Columbus 2 bedroom unit with great views!

Grand Victorian on the Mississippi

9.6 out of 10, Exceptional, (19)
"Such a cool property in a quiet neighborhood. It offers plenty of space for a large family."
$372 nightly
The price is $417
Aug 28 - Aug 29
Total with taxes and fees
Grand Victorian on the Mississippi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Des Moines County Hotel Reviews

Find out more about Des Moines County

Find out more about Des Moines County

Booking Tips to Find the Best Des Moines County Vacation Homes


How much does it cost to rent a vacation home in Des Moines County?

You can find incredible Des Moines County vacation homes for all types of budgets: between $163 and $417 per night. The more amenities the rental has, and its proximity to popular places, the higher the price.


What is the best time to stay in a vacation home in Des Moines County?

If you are looking for a great deal on your vacation home in Des Moines County, consider visiting in , when prices are usually cheaper.


How many vacation homes are available for rent in Des Moines County?

There are 29 rental houses to choose from for your trip. You’ll find holiday homes located throughout the city, near sightseeing spots, and close to local nature areas.


How do I find the best deal for a vacation home in Des Moines County?

Begin by entering your trip dates to see what type of Des Moines County rental houses are available. Use the map to zoom closer into the areas or zoom out to include more locations. Use the filters on the left side of your search results to narrow down by star rating, price, number of bedrooms, amenities, and more—Expedia makes it easy to score the best deal for your budget.


Why should I rent a vacation home in Des Moines County?

Booking Des Moines County vacation home rentals is the perfect way to spend a vacation because of the privacy, variety of amenities, and comfort you’ll have in your own space.


What amenities are available in a private vacation home?

When thinking about what you want in your Des Moines County rental house, dream big! Depending on your budget and the area, you’ll find amenities like a private pool, hot tub, free parking, fully-equipped kitchen, in-home washer and dryer, Wi-Fi, and a beautiful view or easy access to local sightseeing spots. You can even filter your search results by accessibility to ensure that everyone in your party will be comfortable.


Why should I book a vacation home with Expedia?

Expedia has some of the best selection and deals on available vacation homes in the area—and all in one place. We reward you with members points back on every booking and ensure you get the right accommodation for the best price. And you’ll save big when you bundle your travel together, like booking a car rental in Des Moines County along with your vacation property, into a Des Moines County vacation package.


Can I cancel my vacation home with Expedia?

Some accommodations are free to cancel and refundable if done so by a specific date, while others may be non-refundable. To make sure that you can get your money back on cancellations, use the “free cancellation” filter during your search. Contact our customer service portal if you need help.

Des Moines County Vacation Homes information

Number of reviews
304
Accommodation
29 Vacation Homes
Lowest Price
$163
Highest Price
$417

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Explore a world of travel with Expedia