Title: $26 Cheap Flights & Airfare to Madre de Dios Region - Expedia.com ![Paddling in the Peruvian Amazon #parks ](https://images.trvl-media.com/place/553248622106908538/a213e130-aa02-4189-958a-22853c352eba.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by nevin xavier ![](https://images.trvl-media.com/place/553248622106908538/a213e130-aa02-4189-958a-22853c352eba.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights to Madre de Dios Region from $26 [View $26 flight on Thu, Jun 25, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:CUZ,to:PEM,departure:6/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:26.00&airProductToken=AQowCi4IyGQSBDU3MjEYgs0BII9hKOXTkAMwodSQAzhYQABYAWoCWk9yCFhaTzAwMDAwEgoIARABGAEqAkgyGAEiBAgBEAEoAigDKAQwAQ) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travelers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only [Madre de Dios Region Hotels](https://expedia.com/Destinations-In-Madre-De-Dios-Region.d6235175.Hotel-Destinations)[Vacation Rentals in Madre de Dios Region](https://expedia.com/Destinations-In-Madre-De-Dios-Region.d6235175.Vacation-Rental-Destinations)[Car Rentals in Madre de Dios Region](https://expedia.com/Destinations-In-Madre-De-Dios-Region.d6235175.Car-Rental-Destinations)[Madre de Dios Region Vacations](https://expedia.com/Madre-De-Dios-Region.d6235175.Destination-Travel-Guides) ## Popular airlines to Madre de Dios Region - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_H2.svg) Sky Airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_IB.svg) Iberia - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AR.svg) Aerolineas Argentinas - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to Madre de Dios Region? Prices were available within the past 7 days and start at $26 for one-way flights and $60 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Wed, Jul 8 - Sun, Jul 12 CUZ Cusco PEM Puerto Maldonado $60 Roundtrip found 5 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:7/8/2026TANYT&leg2=from:PEM,to:CUZ,departure:7/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:59.15&airProductToken=AQowCi4IyGQSBDU3MjEYgs0BII9hKIXmkQMwweaRAzhBQABYAWoCWk9yCEFaTzAwMDAwCjAKLgjIZBIENTcyMhiPYSCCzQEo6ZOSAzCblJIDOEFAAFgBagJaT3IIQVpPMDAwMDASDAgBEAEYASoCSDIyABgBIgQIARABKAIoAygEMAE) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Fri, Jul 10 - Mon, Jul 13 CUZ Cusco PEM Puerto Maldonado $62 Roundtrip found 7 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:7/10/2026TANYT&leg2=from:PEM,to:CUZ,departure:7/13/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:61.55&airProductToken=AQoiCiAIyGQSBDU3MjEYgs0BII9hKMX8kQMwgf2RAzhYQABYAQoiCiAIyGQSBDU3MjIYj2Eggs0BKImfkgMwu5-SAzhBQABYARIKCAEQARgBKgJIMhgBIgQIARABKAQwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Tue, Aug 11 - Thu, Aug 13 CUZ Cusco PEM Puerto Maldonado $64 Roundtrip found 2 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:8/11/2026TANYT&leg2=from:PEM,to:CUZ,departure:8/13/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:63.85&airProductToken=AQowCi4IyGQSBDU3MjEYgs0BII9hKMXklAMwgeWUAzhaQABYAWoCWk9yCFpaTzAwMDAwCjAKLgjIZBIENTcyMhiPYSCCzQEo6fuUAzCb_JQDOEFAAFgBagJaT3IIQVpPMDAwMDASCggBEAEYASoCSDIYASIECAEQASgCKAMoBDAB) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Wed, Jul 8 - Sun, Jul 12 CUZ Cusco PEM Puerto Maldonado $66 Roundtrip found 5 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:7/8/2026TANYT&leg2=from:PEM,to:CUZ,departure:7/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:65.05&airProductToken=AQoxCi8IzIIBEgQyMTMzGILNASCPYSj36JEDMK7pkQM4R0AAWAFqAlFQcghHMjBRUDVaVhIMCAEQARgBKgJMQTIAGAEiBAgBEAEoAigEKAYwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Tue, May 26 - Wed, Jun 10 CUZ Cusco PEM Puerto Maldonado $67 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:5/26/2026TANYT&leg2=from:PEM,to:CUZ,departure:6/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:66.25&airProductToken=AQowCi4IyGQSBDU3MjEYgs0BII9hKKWCjgMw4YKOAzhYQABYAWoCWk9yCFhaTzAwMDAwCjAKLgjIZBIENTcyMhiPYSCCzQEo6auPAzCbrI8DOFpAAFgBagJaT3IIWlpPMDAwMDASCggBEAEYASoCSDIYASIECAEQASgCKAMoBDAB) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Fri, Mar 20 - Tue, Mar 24 CUZ Cusco PEM Puerto Maldonado $68 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:3/20/2026TANYT&leg2=from:PEM,to:CUZ,departure:3/24/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:67.01&airProductToken=AQowCi4IyGQSBDU3MjEYgs0BII9hKLGQiAMw95CIAzhaQABYAWoCWk9yCFpaTzAwMDAwEgoIARABGAEqAkgyGAEiBAgBEAEoAigDKAQwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Thu, May 21 - Wed, Jun 10 CUZ Cusco PEM Puerto Maldonado $69 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUZ,to:PEM,departure:5/21/2026TANYT&leg2=from:PEM,to:CUZ,departure:6/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:68.55&airProductToken=AQoiCiAIyGQSBDU3MjEYgs0BII9hKIXKjQMwwcqNAzhaQABYAQoiCiAIyGQSBDU3MjIYj2Eggs0BKOmrjwMwm6yPAzhaQABYARIKCAEQARgBKgJIMhgBIgQIARABKAQwAQ) ![Sky Airline Peru](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H8.gif) Mon, Apr 20 - Wed, May 13 MIA Miami PEM Puerto Maldonado $536 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:PEM,departure:4/20/2026TANYT&leg2=from:PEM,to:MIA,departure:5/13/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:535.11&airProductToken=AQpeCi0IyHASBDU1OTMYjAIgi2IowfGKAzCa9IoDOFVAAFgBagJaT3IIVVpPMDAwMDAKLQjIZBIENTcyMRiLYiCPYSjD94oDMIH5igM4WkABWAFqAlpPcghaWk8wMDAwMApeCi0IyGQSBDU3MjIYj2Egi2Io6fCMAzCs8owDOFRAAFgBagJaT3IIVFpPMDAwMDAKLQjIcBIENTU5MhiLYiCMAiiJ_IwDMPH-jAM4VUABWAFqAlpPcghVWk8wMDAwMBIKCAEQARgBKgJIMhgBIgQIARABKAIoAygEMAE) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Sun, Apr 19 - Tue, May 5 TPA Tampa PEM Puerto Maldonado $554 Roundtrip found 6 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:TPA,to:PEM,departure:4/19/2026TANYT&leg2=from:PEM,to:TPA,departure:5/5/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:553.71&airProductToken=AQqxAQo1CMSYARIEMTU5NBjzAyDgXCj75ooDMOPnigM4RUAAWAFqCU1BSU5CQVNJQ3IIWExOSjBOQlAKQQjEmAESBDYwNzgY4Fwgi2Iow-iKAzDY64oDOEVAAVgBaglNQUlOQkFTSUNyCFhMTkowTkJQegoIzIIBEgQyNDgzCjUIzIIBEgQyMDIzGItiII9hKOrvigMw0_CKAzhRQAFYAWoJTUFJTkJBU0lDcghYTE5KME5CUAqxAQo1CMyCARIEMjE5MxiPYSCLYiiZlowDMPiWjAM4UUAAWAFqCU1BSU5CQVNJQ3IIWExOSjBOQlAKQQjEmAESBDYwNzcYi2Ig4Fwo3JeMAzCem4wDOEVAAVgBaglNQUlOQkFTSUNyCFhMTkowTkJQegoIzIIBEgQyNDgyCjUIxJgBEgQxNTYwGOBcIPMDKLGcjAMwiJ2MAzhFQAFYAWoJTUFJTkJBU0lDcghYTE5KME5CUBIKCAEQARgBKgJETBgBIgQIARABKAIoAygEMAE) ![Aeromexico](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/am.gif) Thu, Sep 17 - Thu, Sep 24 RDU Raleigh PEM Puerto Maldonado $944 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:RDU,to:PEM,departure:9/17/2026TANYT&leg2=from:PEM,to:RDU,departure:9/24/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:943.17&airProductToken=AQqfAQo0CMGaARIDNDMxGPGgASCMuQEonYiYAzCripgDOExAAFgBagdDTEFTSUNBcghMTFhNVjVDQgoyCMGaARICNDYYjLkBIItiKMiRmAMwupSYAzhMQAFYAWoHQ0xBU0lDQXIITExYTVY1Q0IKMwjBmgESBDg2NDgYi2Igj2EoqJqYAzCMm5gDOExAAVgBagdDTEFTSUNBcghMTFhNVjVDQgqrAQo_CMGaARIEODg4NBiPYSCLYijc15gDMLvYmAM4SEAAWAFqB0NMQVNJQ0FyCEhMWE1RNUNCegoIzIIBEgQ4ODg0CjIIwZoBEgIxORiLYiCMuQEosNqYAzCd3ZgDOEhAAVgBagdDTEFTSUNBcghITFhNUTVDQgo0CMGaARIDNDMwGIy5ASDxoAEoyd-YAzDF4ZgDOEhAAVgBagdDTEFTSUNBcghITFhNUTVDQhIKCAEQARgBKgJBTRgBIgQIARABKAIoAygEMAE) ## About Flying to Madre de Dios Region Fill your carry-on, arrange your Madre de Dios Region flights, and get ready for an unparalleled adventure. We know that most of the fun is in the preparation when the time comes to consider your next adventure. Discovering your region, unearthing the greatest entertainment, and investigating plane tickets are all a part of creating memories that will last a lifetime. And whether you're on the hunt for a thrilling getaway with the family or a soulful retreat in solitude, when you use Expedia to arrange your trip to Madre de Dios Region, you'll find innumerable ways to personalize your adventure with our awesome deals and straightforward confirmation process. ### The Best Madre de Dios Region Flight Awaits We're devoted to assisting you hunt for cheap flights to this region that won't break the bank. We get that you want to devote more of your hard-earned money toward exploring the sights and less on the price of your airfare to this one-of-a-kind region. And that's the reason we provide you with a sprawling selection of affordable airline tickets, including both return flights and single-way reservations, to ensure your Madre de Dios Region travel plans stay within your budget. On your vacation in Madre de Dios Region, surround yourself in the local scene by sampling regional dishes and enjoying the after-hours scene. And if you'd like to explore even more of this region, pay a visit to Puerto Maldonadoor Tambopata. Regardless of where in this region you choose to go, swing by the iconic landmarks on your vacation, and enjoy panoramas of the most picturesque areas. It's easy to see why so many adventurers, amateur historians, and travel bugs from all walks of life are attracted to this incredible destination. ### Book Your Madre de Dios Region Vacation Right Away Expedia aims to save you time and money when securing your tickets to the Madre de Dios Region, so you can spend your days making the most of your stay and not worrying about emptying your wallet. We offer a variety of airlines, airports, and departure times, making it even easier for you to reserve your airfare whether you're searching for an overnight flight or a direct flight to a particular terminal. We even have a hassle-free smartphone booking app, which invites you to arrange your trip from wherever it's easiest for you. If you have some time to off from the office that has almost arrived, it's an excellent chance to reserve a flight to Madre de Dios Region. Prepare your new smartphone for gorgeous vistas and your tummy for delectable eats - it's vacation time! Arrange your adventure to Madre de Dios Region today, and get ready to take off on an unbelievable experience tomorrow. When it's time to finding flights to Madre de Dios Region that align your price range and agenda, there's no reason to look further than our extensive selection right here. Just designate your desired travel dates now to find the best specials on flights in Madre de Dios Region. Here at Expedia, we’re committed to helping you find cheap flights to Madre de Dios Region that won’t break the bank. We know you want to put more of your hard-earned cash toward exploring the sites and less on the price of your airfare. That’s why we provide you with a vast selection of affordable plane tickets, including roundtrip and one-way reservations, to ensure your Peru travel plans remain within your budget. Take advantage of our lowest rates on airfare and have leftover money to spare on your travel adventures. When it comes to finding flights to Madre de Dios Region that match your price range and itinerary, look no further than our options right here. We offer a variety of airlines, airports, and flight times making it easier for you to book your airfare. Whether you’re looking for a redeye ticket or a flight to a specific terminal, you’ll find exactly what you need. We also provide a hassle-free mobile booking app, which lets you reserve wherever and whenever is most convenient for you. Book your airfare to Madre de Dios Region today and get ready to embark on an unforgettable getaway tomorrow. \*Flight schedules are subject to change. \*Flight schedules are subject to change. - Top Flights Destinations - Top Madre de Dios Region Hotels - Airlines Operating - Expedia's Latest Trends ### Top Flight Destinations In Madre de Dios Region - [Flights to Tambopata ](https://expedia.com/Cheap-Flights-To-Tambopata.d6141821.Travel-Guide-Flights) - [Flights to Puerto Maldonado ](https://expedia.com/Cheap-Flights-To-Puerto-Maldonado.d2765.Travel-Guide-Flights) - [Flights to Las Piedras ](https://expedia.com/Cheap-Flights-To-Las-Piedras.d6353421.Travel-Guide-Flights) - [Flights to Barcelona ](https://expedia.com/Cheap-Flights-To-Barcelona.d553248635975856761.Travel-Guide-Flights) - [Flights to Jungle Region ](https://expedia.com/Cheap-Flights-To-Jungle-Region.d6140812.Travel-Guide-Flights) - [Flights to Manu ](https://expedia.com/Cheap-Flights-To-Manu.d6353333.Travel-Guide-Flights) - [Flights to Peruvian Highlands ](https://expedia.com/Cheap-Flights-To-Peruvian-Highlands.d6140813.Travel-Guide-Flights) - [Flights to Sepahua ](https://expedia.com/Cheap-Flights-To-Sepahua.d3000423119.Travel-Guide-Flights) - [Flights to Sandoval ](https://expedia.com/Cheap-Flights-To-Sandoval.d3000005825.Travel-Guide-Flights) - [Flights to Iberia ](https://expedia.com/Cheap-Flights-To-Iberia.d553248635973465267.Travel-Guide-Flights) - [Flights to Inca ](https://expedia.com/Cheap-Flights-To-Inca.d3000005881.Travel-Guide-Flights) - [Flights to Alerta ](https://expedia.com/Cheap-Flights-To-Alerta.d6307719.Travel-Guide-Flights) ### Top Flight Destinations In the World - [Flights to France ](https://expedia.com/Destinations-In-France.d59.Flight-Destinations) - [Flights to United States of America ](https://expedia.com/Destinations-In-United-States-Of-America.d201.Flight-Destinations) - [Flights to Germany ](https://expedia.com/Destinations-In-Germany.d64.Flight-Destinations) - [Flights to China ](https://expedia.com/Destinations-In-China.d37.Flight-Destinations) - [Flights to India ](https://expedia.com/Destinations-In-India.d80.Flight-Destinations) - [Flights to Greece ](https://expedia.com/Destinations-In-Greece.d67.Flight-Destinations) - [Flights to Indonesia ](https://expedia.com/Destinations-In-Indonesia.d81.Flight-Destinations) - [Flights to United Kingdom ](https://expedia.com/Destinations-In-United-Kingdom.d190.Flight-Destinations) - [Flights to Mexico ](https://expedia.com/Destinations-In-Mexico.d117.Flight-Destinations) - [Flights to South Korea ](https://expedia.com/Destinations-In-South-Korea.d94.Flight-Destinations) - [Flights to Norway ](https://expedia.com/Destinations-In-Norway.d138.Flight-Destinations) - [Flights to Australia ](https://expedia.com/Destinations-In-Australia.d10.Flight-Destinations) - [Flights to Sweden ](https://expedia.com/Destinations-In-Sweden.d173.Flight-Destinations) - [Flights to Switzerland ](https://expedia.com/Destinations-In-Switzerland.d174.Flight-Destinations) - [Flights to Brazil ](https://expedia.com/Destinations-In-Brazil.d23.Flight-Destinations) - [Flights to Colombia ](https://expedia.com/Destinations-In-Colombia.d38.Flight-Destinations) - [Flights to Japan ](https://expedia.com/Destinations-In-Japan.d89.Flight-Destinations) - [Flights to Canada ](https://expedia.com/Destinations-In-Canada.d31.Flight-Destinations) - [Flights to Philippines ](https://expedia.com/Destinations-In-Philippines.d145.Flight-Destinations) - [Flights to Spain ](https://expedia.com/Destinations-In-Spain.d166.Flight-Destinations) ### Top Madre de Dios Region Hotels - [IKAM Riverview Amazon Lodge - Asociado Casa Andina ](https://expedia.com/Tambopata-Hotels-IKAM-Riverview.h102656968.Hotel-Information) - [Inkaterra Reserva Amazonica ](https://expedia.com/Las-Piedras-Hotels-Inkaterra-Reserva-Amazonica.h894833.Hotel-Information) - [Hacienda Herrera Tambopata ](https://expedia.com/Tambopata-Hotels-Hacienda-Herrera-Tambopata.h29871476.Hotel-Information) - [Tambopata Research Center ](https://expedia.com/Inambari-Hotels-Tambopata-Research-Center.h4208480.Hotel-Information) - [Libelula Hotel ](https://expedia.com/Tambopata-Hotels-Hospedaje-Libelula.h91391298.Hotel-Information) - [Tambopata River ](https://expedia.com/Tambopata-Hotels-Tambopata-River.h18832869.Hotel-Information) - [Inkaterra Hacienda Concepcion ](https://expedia.com/Tambopata-Hotels-Inkaterra-Hacienda-Concepcion.h15470957.Hotel-Information) - [La Fauna Hotel ](https://expedia.com/Tambopata-Hotels-El-Fauno-Hostel.h46499505.Hotel-Information) - [Posada Amazonas ](https://expedia.com/Tambopata-Hotels-Posada-Amazonas.h4208434.Hotel-Information) - [Monte Amazonico Lodge ](https://expedia.com/Tambopata-Hotels-Monte-Amazonico-Lodge.h15894630.Hotel-Information) - [Tronco Tambopata Adventure ](https://expedia.com/Tambopata-Hotels-Tronco-Tambopata-Adventure.h89151158.Hotel-Information) - [Villa Hermosa de Tambopata ](https://expedia.com/Tambopata-Hotels-Villa-Hermosa-De-Tambopata.h26711015.Hotel-Information) - [Ecolucerna Lodge Tambopata ](https://expedia.com/Tambopata-Hotels-Ecolucerna-Lodge.h16754742.Hotel-Information) - [Plaza Jungle Hostel ](https://expedia.com/Tambopata-Hotels-Plaza-Jungle-Hostel.h116766592.Hotel-Information) - [Refugio Amazonas ](https://expedia.com/Tambopata-Hotels-Refugio-Amazonas.h4208497.Hotel-Information) - [ Andean Wings Sotupa Eco Lodge ](https://expedia.com/Tambopata-Hotels-Sotupa-Eco-House.h4846845.Hotel-Information) - [Amazon Planet ](https://expedia.com/Tambopata-Hotels-Amazon-Planet.h14862139.Hotel-Information) - [Paradise Amazon Lodge & Adventure ](https://expedia.com/Tambopata-Hotels-Paradise-Amazon-Lodge-Adventure.h29926865.Hotel-Information) - [Kapievi Ecovillage ](https://expedia.com/Tambopata-Hotels-Kapievi-Ecovillage.h42379887.Hotel-Information) - [Majachos House ](https://expedia.com/Tambopata-Hotels-Majachos-House.h115827164.Hotel-Information) ### Airlines Operating - [Amber Air ](https://expedia.com/Amber-Air-Flights.c0A.Travel-Guide-Airlines) - [BlueAir ](https://expedia.com/BlueAir-Flights.c0B.Travel-Guide-Airlines) - [Catovair ](https://expedia.com/Cobra-Aviation-Flights.c0C.Travel-Guide-Airlines) - [Darwin Airline SA Lugano ](https://expedia.com/Darwin-Airline-SA-Lugano-Flights.c0D.Travel-Guide-Airlines) - [Evergreen International ](https://expedia.com/Evergreen-International-Flights.c0E.Travel-Guide-Airlines) - [Ghadames Air Transport ](https://expedia.com/Ghadames-Air-Transport-Flights.c0G.Travel-Guide-Airlines) - [Aircompany Kokshetau ](https://expedia.com/AirCompany-Kokshetau-Flights.c0K.Travel-Guide-Airlines) - [Palau Asia ](https://expedia.com/Palau-Asia-Flights.c0P.Travel-Guide-Airlines) - [Royal Airways Limited ](https://expedia.com/Royal-Airways-Limited-Flights.c0S.Travel-Guide-Airlines) - [Vietnam Air Service Co. ](https://expedia.com/Vietnam-Air-Service-Co-Flights.c0V.Travel-Guide-Airlines) ### Expedia's Latest Trends Hotels - [Hotels with Restaurants in Huánuco Region](https://expedia.com/Destinations-In-Huanuco-Region-Hotels-With-Restaurants.0-0-d6235179-tHotelswithRestaurants.Hotel-Filter-Destinations) - [Romantic Hotels in Lima Region](https://expedia.com/Destinations-In-Lima-Region-Romantic-Hotel.0-0-d6235880-tRomanticHotel.Hotel-Filter-Destinations) - [Resorts & Hotels with Spas in Ayacucho Region](https://expedia.com/Destinations-In-Ayacucho-Region-Spa-Hotel.0-0-d6235222-tSpaHotel.Hotel-Filter-Destinations) - [Hotels in Huánuco Region](https://expedia.com/Destinations-In-Huanuco-Region.d6235179.Hotel-Destinations) - [Hotel Wedding Venues in Lima Region](https://expedia.com/Destinations-In-Lima-Region-Wedding-Hotels.0-0-d6235880-tWeddingHotels.Hotel-Filter-Destinations) - [All-inclusive Resorts in Cusco Region](https://expedia.com/Destinations-In-Cusco-Region-All-Inclusive-Hotel.0-0-d6235224-tAllinclusiveHotel.Hotel-Filter-Destinations) - [Hotels in Ucayali Region](https://expedia.com/Destinations-In-Ucayali-Region.d6235164.Hotel-Destinations) - [Resorts & Hotels with Spas in Cusco Region](https://expedia.com/Destinations-In-Cusco-Region-Spa-Hotel.0-0-d6235224-tSpaHotel.Hotel-Filter-Destinations) - [Hotels in Arequipa Region](https://expedia.com/Destinations-In-Arequipa-Region.d6235846.Hotel-Destinations) - [All-inclusive Resorts in Lima Region](https://expedia.com/Destinations-In-Lima-Region-All-Inclusive-Hotel.0-0-d6235880-tAllinclusiveHotel.Hotel-Filter-Destinations) - [Cheap Hotels in Lima Region](https://expedia.com/Destinations-In-Lima-Region-Cheap-Hotels.0-0-d6235880-tCheapHotels.Hotel-Filter-Destinations) - [Hotels in Puno Region](https://expedia.com/Destinations-In-Puno-Region.d6235225.Hotel-Destinations) Flights - [Cheap Flights to Cusco Region](https://expedia.com/Destinations-In-Cusco-Region.d6235224.Flight-Destinations) - [Cheap Flights to Apurímac Region](https://expedia.com/Destinations-In-Apurimac-Region.d6235223.Flight-Destinations) - [Cheap Flights to Junín Region](https://expedia.com/Destinations-In-Junin-Region.d6235183.Flight-Destinations) Cars - [Car rentals in Huánuco Region](https://expedia.com/Destinations-In-Huanuco-Region.d6235179.Car-Rental-Destinations) - [convertible Car Rentals in Lima Region](https://expedia.com/Convertible-Car-Rentals-In-Lima-Region.d6235880-tConvertible.Car-Rental-Destination-Class) Activities - [Things to do in Apurímac Region](https://expedia.com/Things-To-Do-In-Apurimac-Region.d6235223.Travel-Guide-Activities) - [Things to do in Cusco Region](https://expedia.com/Things-To-Do-In-Cusco-Region.d6235224.Travel-Guide-Activities) - [Things to do in Lima Region](https://expedia.com/Things-To-Do-In-Lima-Region.d6235880.Travel-Guide-Activities) - [Things to do in Huánuco Region](https://expedia.com/Things-To-Do-In-Huanuco-Region.d6235179.Travel-Guide-Activities) Packages - [Arequipa Region Vacation](https://expedia.com/Arequipa-Region.d6235846.Destination-Travel-Guides) General - [Visit Huánuco Region](https://expedia.com/Huanuco-Region.dx6235179) - [Visit Ancash Region](https://expedia.com/Ancash-Region.dx6235887) - [Visit Ayacucho Region](https://expedia.com/Ayacucho-Region.dx6235222) - [Visit Loreto Region](https://expedia.com/Loreto-Region.dx6235145) - [Visit La Libertad Region](https://expedia.com/La-Libertad-Region.dx6235892) - [Visit Tacna Region](https://expedia.com/Tacna-Region.dx6235228) - [Visit Lima Region](https://expedia.com/Lima-Region.dx6235880) - [Visit Cusco Region](https://expedia.com/Cusco-Region.dx6235224) ## Trending flights to Madre de Dios Region These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Sky Airline Peru](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H8.gif) Mon, Apr 20 - Wed, May 13 MIA Miami PEM Puerto Maldonado $536 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:PEM,departure:4/20/2026TANYT&leg2=from:PEM,to:MIA,departure:5/13/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:535.11&airProductToken=AQpeCi0IyHASBDU1OTMYjAIgi2IowfGKAzCa9IoDOFVAAFgBagJaT3IIVVpPMDAwMDAKLQjIZBIENTcyMRiLYiCPYSjD94oDMIH5igM4WkABWAFqAlpPcghaWk8wMDAwMApeCi0IyGQSBDU3MjIYj2Egi2Io6fCMAzCs8owDOFRAAFgBagJaT3IIVFpPMDAwMDAKLQjIcBIENTU5MhiLYiCMAiiJ_IwDMPH-jAM4VUABWAFqAlpPcghVWk8wMDAwMBIKCAEQARgBKgJIMhgBIgQIARABKAIoAygEMAE) \*Available to One Key members.