Madre de Dios Region Vacations & Trips

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Your Madre de Dios Region Vacation

Choose one of our vacation packages to Madre de Dios Region and wander wherever your adventurous soul takes you. Hiking and nature are just a couple of the things you can look forward to in this wonderful destination. Start your trip to Madre de Dios Region by spending a few nights in Tambopata, one of the top cities here. Expedia has hotels, flights and all your other travel needs to help you curate your very own customized Madre de Dios Region vacation today.

Top destinations in Madre de Dios Region

A river winding through a dense forest under a cloudy sky.

Tambopata

Tambopata
A close-up of a pink hibiscus flower with prominent stamens.

Las Piedras

Las Piedras
A calm river with wooden docks and lush greenery in the background.

Manu

Manu

Where to stay in Madre de Dios Region

Find the best Madre de Dios Region areas and neighborhoods for the activities you enjoy most.Learn more about Madre de Dios Region
Learn more about Madre de Dios Region

Chapajal

While Chapajal might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Puerto Maldonado Plaza de Armas and Puerto Maldonado Obelisk.

Best Places to Vacation in Madre de Dios Region

1. Escape to Tambopata with a vacation package

Tambopata in the Madre de Dios Region of Peru offers a unique outdoor vacation experience. With its lush jungle and rainforest, it provides the perfect setting for adventure and exploration. Visitors can enjoy activities such as hiking, wildlife spotting, and exploring natural parks. The region is known for its diverse wildlife and stunning natural beauty. Families will find plenty of family-friendly activities to enjoy, and there are also dining options available to satisfy any palate. Whether it's destination activities, tours, or sightseeing, Tambopata offers a memorable outdoor vacation for all.

  • The peak season is from July to September
  • The off-peak season is from November to January
  • Travelers tend to stay 3 days in Tambopata

2. Create memories in Puerto Maldonado with a vacation package

Puerto Maldonado, located in the Madre de Dios Region of Peru, offers a unique outdoor vacation experience. With its lush jungles, majestic rivers, and picturesque lakes, this destination is perfect for nature enthusiasts. Visitors can enjoy boating tours, birdwatching, and exploring the vast rainforests. For those seeking a touch of luxury, there are upscale accommodations available. Puerto Maldonado is a haven for adventure seekers, offering activities such as hunting and sightseeing tours. Immerse yourself in the local atmosphere and experience the beauty of this vibrant city.

  • The peak season is from January to March
  • The off-peak season is from October to December
  • Travelers tend to stay 2 days in Puerto Maldonado

3. Experience Las Piedras with a travel package

Las Piedras in the Madre de Dios Region of Peru offers a stunning atmosphere for outdoor vacations. Immerse yourself in the lush rainforests and explore the vast biodiversity of the Amazon. Go on thrilling adventures like jungle hikes, wildlife spotting, and canoeing along the rivers. Experience the local culture by visiting nearby indigenous communities and learning about their traditions. Stay in eco-lodges and enjoy the tranquility of the surroundings. Whether you're a nature enthusiast or an adventure seeker, Las Piedras offers an unforgettable outdoor vacation experience.

  • Travelers tend to stay 3 days in Las Piedras

4. Find your perfect Manu vacation

Manu, located in the Madre de Dios Region of Peru, offers a unique outdoor vacation experience. The region's geographic affinities make it perfect for natural parks and wildlife conservation. Visitors to Manu can immerse themselves in destination activities, such as guided tours and sightseeing, that allow them to explore the stunning natural beauty of the area. Whether it's trekking through the lush rainforests, spotting exotic wildlife, or visiting indigenous communities, Manu provides an authentic and unforgettable outdoor adventure for travelers from the United States and beyond.

6. Book your ideal Alerta with a vacation package

Inca, Tambopata, in the Madre de Dios Region of Peru, offers a unique and inexpensive vacation experience. Immerse yourself in the lush Amazon rainforest, where you can explore the vibrant biodiversity, encounter exotic wildlife, and witness breathtaking landscapes. Engage in thrilling activities like jungle treks, riverboat tours, and birdwatching. Experience the local culture by visiting indigenous communities, learning about their traditions, and trying traditional cuisine. For an affordable vacation, there are budget-friendly accommodations and local markets to explore. Inca provides an authentic and unforgettable adventure in the heart of the Peruvian Amazon.

5. Enjoy Sandoval with a travel package

Sandoval in Tambopata, Madre de Dios Region, Peru offers a unique and immersive outdoor vacation experience. Nestled within the Amazon rainforest, this region is a haven for nature lovers. Explore the pristine Sandoval Lake, surrounded by lush greenery and home to diverse wildlife such as macaws, monkeys, and giant river otters. Embark on guided jungle treks to discover the rich biodiversity of the area, including vibrant bird species, towering trees, and exotic plants. Immerse yourself in the local culture by visiting nearby indigenous communities and learning about their traditional way of life. Sandoval promises an unforgettable adventure in the heart of the Peruvian Amazon.

Find the Best Madre de Dios Region Vacation Packages

Madre de Dios Region Essential Information

Language
Spanish
Currency
Peruvian sols
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Padre Aldamiz Intl. Airport (PEM)
Top Sights
Tambopata National Reserve, Sandoval Lake and Manu National Park

Madre de Dios Region Hotel Deals

IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

Tambopata KM. 7 Otr. Carretera Bajo Tambopata Madre de Dios
$174 nightly
$174 total
Nov 8 - Nov 9
9.2/10 Wonderful! (25 reviews)
"We had the best stay! We booked the airport transfers, tours, and all meals, and everything exceeded our expectations. The food was incredible, and the rooms were comfortable, clean, and had wonderful AC—a true relief after a day of exploring! All of the staff were so helpful, welcoming, and courteous. ..."

Reviewed on Oct 13, 2026

IKAM Riverview Amazon Lodge - Asociado Casa Andina
Inkaterra Reserva Amazonica

Inkaterra Reserva Amazonica

Madre De Dios River Km. 15 Las Piedras Madre de Dios
9.4/10 Exceptional! (54 reviews)
"Only remark is to enable electricity in the rooms during the day without interruption for fan and charging phones (solar panel with batteries for example). It was very hot and hard to rest in the room"

Reviewed on Jul 19, 2026

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Inkaterra Reserva Amazonica
Tambopata Edosikiana Ecolodge

Tambopata Edosikiana Ecolodge

Av. Aeropuerto S/N Comunidad Infierno Tambopata Tambopata Madre de Dios
2/10 (1 review)
"Staff was helpful Otherwise nothing was amazing. Room was not too clean, food was okayish, no choice was given."

Reviewed on Jun 15, 2026

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Tambopata Edosikiana Ecolodge
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What's included in a Madre de Dios Region vacation package?
A Madre de Dios Region vacation package in Tambopata lets you combine flights, hotel stays, and rental cars, with flights typically arriving at Puerto Maldonado (PEM-Padre Aldamiz Intl.) airport. Some hotels in Tambopata offer free breakfast, and a select few provide airport shuttle service.Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
How can I save money on a Madre de Dios Region vacation package?
When you bundle, you can save up to 30%*. To save money on a Madre de Dios Region package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What is the best time to visit Madre de Dios Region?
The best time for a Madre de Dios Region vacation is generally during the months of June through August, with July often being the peak month for visitors. This period typically sees higher demand for travel to the region. While these months are popular, conditions can vary across the different cities and areas within Madre de Dios Region.
Which destinations should I consider for a Madre de Dios Region vacation?
When planning a Madre de Dios Region vacation, choosing the right base depends on your travel style:
  • Tambopata: As the area with the most lodging choices, Tambopata is a strong base for travelers focused on outdoor activities, adventure, and eco-friendly travel, offering plenty of places to stay.
  • Puerto Maldonado: Ideal for those who prefer a mix of city attractions and outdoor adventures, Puerto Maldonado serves as a gateway to the region's natural beauty.
  • Las Piedras: This area is well-suited for romantic getaways, providing a more secluded setting for couples seeking adventure and scenic views in an eco-friendly environment.
Is Madre de Dios Region better suited for a beach vacation or a cultural trip?
Madre de Dios Region is primarily an outdoor and nature destination, known for adventure activities and its rich biodiversity. Travelers seeking a Madre de Dios Region vacation will find themselves immersed in the Amazon Basin's jungle, with opportunities to explore vast protected areas like the Tambopata National Reserve.The region also offers a unique cultural experience, home to ancient Inca ruins and several indigenous tribes, providing a glimpse into Peru's deep historical roots and vibrant local cultures. Your Madre de Dios Region vacation package can be customized around these natural and cultural explorations.
Which airport should I use for a Madre de Dios Region vacation?
For a Madre de Dios Region vacation, the primary airport within the region is Puerto Maldonado (PEM-Padre Aldamiz Intl.). This airport provides direct access to the heart of the Amazon. Many travelers also use Cusco (CUZ-Alejandro Velasco Astete Intl.) as a major gateway, connecting to the Madre de Dios Region via onward flights or ground transportation from the city of Cusco.
What are the top things to do in Madre de Dios Region?
A Madre de Dios Region vacation is best explored from a base like Tambopata, offering a mix of urban and natural attractions:Browse and book things to do in Madre de Dios Region on Expedia.
Can I change or cancel my Madre de Dios Region vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Madre de Dios Region vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Madre de Dios Region vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Madre de Dios Region vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Madre de Dios Region?
To find last-minute vacation packages to Madre de Dios Region, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Madre de Dios Region vacation packages?
Free cancellation on a Madre de Dios Region vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Madre de Dios Region vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Madre de Dios Region getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Madre de Dios Region vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

Stay near popular Madre de Dios Region attractions

Lac Sachavacayoc

6.0/10 (2 reviews)
Commune with nature and explore the great outdoors at Lac Sachavacayoc during your travels in Tambopata. While you're in the area, wander around the rainforest.
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Puerto Maldonado Plaza de Armas

8.2/10 (22 reviews)
You can find out about the history of Puerto Maldonado with a stop at Puerto Maldonado Plaza de Armas. Wander the riverfront and forest while you're in the area.
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Lake Sandoval

9.8/10 (31 reviews)
Commune with nature and explore the great outdoors at Lake Sandoval during your travels in Tambopata. Wander the riverfront and rainforest while you're in the area.
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Manu National Park

Explore the great outdoors at Manu National Park, a lovely green space in Manu.
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Puerto Maldonado Obelisk

8.4/10 (9 reviews)
Find out about the history of Puerto Maldonado when you spend time at Puerto Maldonado Obelisk. Wander the riverfront and forest while you're in the area.
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Reserva Nacional Tambopata

10.0/10 (4 reviews)
Explore the great outdoors at Reserva Nacional Tambopata, a lovely green space in Inambari.
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Collpa La Cachuela

8.4/10 (6 reviews)
You can take time to visit Collpa La Cachuela during your travels to Puerto Maldonado. Wander the riverfront and forest while you're in the area.
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What to do in Madre de Dios Region

Sandoval Lake Full Day Tour in Tambopata

Sandoval Lake Full Day Tour in Tambopata

$75
per adult
Sandoval Lake Full Day Tour in Tambopata
Puerto Maldonado: Kayak and Zip Line Adventure + Monkey Isla

Puerto Maldonado: Kayak and Zip Line Adventure + Monkey Isla

$65
per adult
Puerto Maldonado: Kayak and Zip Line Adventure + Monkey Isla
Puerto Maldonado: Sandoval Lake Full-Day Trip with Canoeing

Puerto Maldonado: Sandoval Lake Full-Day Trip with Canoeing

$95
per adult
100% of travellers recommend
Puerto Maldonado: Sandoval Lake Full-Day Trip with Canoeing
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.