Downtown Clayton Vacations from $381
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Your Downtown Clayton Vacation
Your next great adventure beckons with a vacation package to Downtown Clayton. Fun, food and great times — you're sure to find it in this neighborhood. Kick start your trip to Downtown Clayton by heading to nearby attractions such as St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis. Whatever your ideal Downtown Clayton vacation may look like, you can turn it into reality with Expedia.
The Latest Downtown Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
Price was $523, price is now $381 per person
$381
per person
Oct 31 - Nov 4
found 14 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
8.2/10 Very Good! (763 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.
Reviewed on Jul 26, 2025
The Wildwood Hotel
Save 100% on your flight
Price was $800, price is now $433 per person
$433
per person
Oct 31 - Nov 4
found 14 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.2/10 Wonderful! (1,571 reviews)
I felt very safe in this area; it was well maintained and lots to do within walking distance and close to the hotel. Parking and check-in were a little confusing as there was a car parked right at the front doors and driveway was intentionally blocked. After driving around the block a couple of times, I figured out that parking is actually on the street. I later figured out the parking lot down the road a bit, which was also little confusing because you couldn't tell if the parking was for the surrounding shopping areas or for the hotel. There weren't any visible signs to clarify.
Reviewed on Sep 3, 2025
The Knight Center at Washington University
Price was $653, price is now $464 per person
$464
per person
Oct 31 - Nov 4
found 14 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.4/10 Exceptional! (393 reviews)
Perfect if visiting your college student child , safe, very clean , spacious !
Reviewed on Sep 5, 2025
The Principal Hotel
Price was $955, price is now $737 per person
$737
per person
Nov 25 - Nov 30
found 24 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.8/10 Exceptional! (124 reviews)
staf went above and beyond to make sure our trip was the best
Reviewed on Sep 1, 2025
Staybridge Suites O'Fallon Chesterfield by IHG
Price was $597, price is now $466 per person
$466
per person
Oct 16 - Oct 20
found 5 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.4/10 Very Good! (375 reviews)
The room was clean and comfortable and spacious.
Reviewed on Sep 3, 2025
Where to stay in Downtown Clayton
Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Downtown Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $120 total per night from Sep 21 to Sep 22
$120 total
Sep 21 - Sep 22
Total with taxes and fees
AC Hotel St. Louis Clayton
227 South Central Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $151 total per night from Sep 28 to Sep 29
$151 total
Sep 28 - Sep 29
Total with taxes and fees
Le Méridien St. Louis Clayton
7730 Bonhomme Ave, St. Louis, MO
$165 nightly
The price is $193 total per night from Sep 28 to Sep 29
$193 total
Sep 28 - Sep 29
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Downtown Clayton
Busch Stadium
4.5/5(1,469 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
St. Louis Union Station
4/5(615 reviews)
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's acclaimed theater scene or attend a baseball game.
Gateway Arch
4.5/5(2,511 reviews)
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Things to do
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
$24
per adult
Best of St. Louis Small Group Tour w/ Arch & River Cruise
$169
per adult
84% of travellers recommend
St. Louis Ghosts: Gateway Ghouls and Hauntings
$26
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
