Downtown Clayton Vacations from $361
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Your Downtown Clayton Vacation
Your next great adventure beckons with a vacation package to Downtown Clayton. Fun, food and great times — you're sure to find it in this neighborhood. Kick start your trip to Downtown Clayton by heading to nearby attractions such as St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis. Whatever your ideal Downtown Clayton vacation may look like, you can turn it into reality with Expedia.
The Latest Downtown Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hampton Inn By Hilton St Louis Airport
Woodson Terrace
Price was $482, price is now $361 per person
$361
per person
Feb 28 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
8.8/10 Excellent! (96 reviews)
Booked this hotel to catch a flight the next day. The hotel was clean and the breakfast was decent. The long term parking was confusing to find when I pulled in and cost more than was noted on Expedia. The shuttle driver was very nice and prompt and the shuttle was easy to find.
Reviewed on Dec 10, 2025
The Wildwood Hotel
Save 100% on your flight
Price was $1,300, price is now $654 per person
$654
per person
Feb 13 - Feb 19
found 5 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
I will definitely be staying there again next time we travel through St. Louis. I enjoyed the stay it was clean quiet and the surrounding area was nice. Wonderful hotel.
Reviewed on Dec 12, 2025
White House at Grand Central
Grand Center
Price was $724, price is now $524 per person
$524
per person
Feb 13 - Feb 19
found 5 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
8.6/10 Excellent! (123 reviews)
Very clean and very friendly people
Reviewed on Nov 11, 2025
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $579, price is now $432 per person
$432
per person
Feb 28 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
Fun staff and a very cool hotel. Great room, too!
Reviewed on Dec 11, 2025
Marriott St. Louis West
Price was $502, price is now $378 per person
$378
per person
Feb 28 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
8.6/10 Excellent! (1,000 reviews)
They did not clean my room. Despite a 6 night stay, I got my towels refreshed on day 5, bed was made but surfaces were not cleaned.
Also restaurant closed at 1pm - so lunch had to be early.
Reviewed on Dec 9, 2025
Where to stay in Downtown Clayton
Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Downtown Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $106 total per night from Dec 14 to Dec 15
$106 total
Dec 14 - Dec 15
Total with taxes and fees
8.8/10 Excellent! (3,028 reviews)
Clean room, good breakfast and good location
Reviewed on Dec 9, 2025
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $142 total per night from Dec 21 to Dec 22
$142 total
Dec 21 - Dec 22
Total with taxes and fees
9/10 Wonderful! (222 reviews)
The staff were very helpful while there! I recommend doing valet instead of self parking so you wouldn’t have to go through any hassle with finding a parking space but overall my stay was great. The bed was really comfy. I would definitely stay there again when visiting St Louis.
Reviewed on Nov 25, 2025
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Dec 19 to Dec 20
$140 total
Dec 19 - Dec 20
Total with taxes and fees
8.8/10 Excellent! (675 reviews)
Small rooms but beautiful lobby.
Reviewed on Oct 27, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Downtown Clayton
St. Louis Union Station
4/5(615 reviews)
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Gateway Arch
4.5/5(2,511 reviews)
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
St. Louis Zoo
4.5/5(1,212 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$32
per adult
Best of St. Louis Small Group Tour w/ Arch & River Cruise
$169
per adult
84% of travellers recommend
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
$30
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.