Downtown Clayton Vacations from $267

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Your Downtown Clayton Vacation

Your next great adventure beckons with a vacation package to Downtown Clayton. Fun, food and great times — you're sure to find it in this neighborhood. Kick start your trip to Downtown Clayton by heading to nearby attractions such as St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis. Whatever your ideal Downtown Clayton vacation may look like, you can turn it into reality with Expedia.

The Latest Downtown Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
8.2/10 Very Good! (756 reviews)
The stay was too short

Reviewed on Jul 2, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (1,547 reviews)
The room was ok, tired decor (a mix between The Sopranos and Hobby Lobby), slightly dirty furniture (sofa and arm chair). Bathroom was clean, fan didn’t pull all the moisture out. We traveled for a medical appointment in Saint Louis and I barely got any rest on the cheap springy mattress (we are 40, and in healthy shape). Breakfast was horrible: three waffle makers(why?!), some cereal, microwaveable Jimmy Dean sandwiches instead of ANY hot dishes, Great Valley granola bars, a thermos of coffee, decaf, and coffee-flavored hot water for Lipton tea. Lovely staff, but not enough for us to come back again.

Reviewed on Jul 13, 2025

Ballpark Apartments by Barsala

Ballpark Apartments by Barsala

4 out of 5
Downtown St. Louis
Save 100% on your flight
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
7.4/10 Good! (9 reviews)
It's a great location, right across from the Ballpark. It is a fairly spartan apartment set-up, with concrete floors.. a little surprising? Parking is on the street or in a pay lot.

Reviewed on Jun 8, 2025

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
It was a great stay. The suggestions are rooms should have microwave and better internet

Reviewed on Jul 16, 2025

The Principal Hotel

The Principal Hotel

3.5 out of 5
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9.8/10 Exceptional! (88 reviews)
Very clean and quiet property. We loved that it was repurposed from an old Catholic school and the theme was really cool

Reviewed on Jul 11, 2025

Where to stay in Downtown Clayton

Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Clayton
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

3 out of top 10 points of interest in this area
4/5(4,004 area reviews)

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis

Downtown Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $118 total per night from Aug 3 to Aug 4
$118 total
Aug 3 - Aug 4
Total includes taxes and fees
8.8/10 Excellent! (2,904 reviews)
"Nice and clean."

Reviewed on Jul 15, 2025

Clayton Plaza Hotel & Extended Stay
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $167 total per night from Jul 24 to Jul 25
$167 total
Jul 24 - Jul 25
Total includes taxes and fees
9/10 Wonderful! (101 reviews)
Not for quick overnight stays...but beautiful.
"Quick overnight stop on a road trip. Hotel was very modern, with excellent facilities, but the parking is almost non-existent. Valet only. If you have a vehicle larger than an SUV, there may be an issue. Breakfast looked gourmet, and was expensive."

Reviewed on Jul 9, 2025

AC Hotel St. Louis Clayton
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza, St. Louis, MO
Fully refundableReserve now, pay when you stay
$579 nightly
The price is $674 total per night from Jul 20 to Jul 21
$674 total
Jul 20 - Jul 21
Total includes taxes and fees
9.2/10 Wonderful! (538 reviews)
"Wish they still had a pool"

Reviewed on Jul 12, 2025

The Ritz-Carlton, St. Louis
See all 1,771 properties in Downtown Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Downtown Clayton

Busch Stadium

Busch Stadium

4.5/5(1,469 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

Busch Stadium
St. Louis Union Station

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's acclaimed art scene or attend a baseball game.

St. Louis Union Station
Gateway Arch showing a city, a skyscraper and skyline

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch

Things to do

St Louis: City Museum General Admission Ticket

St Louis: City Museum General Admission Ticket

$22
per adult
94% of travellers recommend
St Louis: City Museum General Admission Ticket
St. Louis Arch Walking Tour and Entrance Ticket

St. Louis Arch Walking Tour and Entrance Ticket

$50
per adult
St. Louis Arch Walking Tour and Entrance Ticket
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

$32
per adult
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.