Name: Hyatt Regency San Francisco
Price range: $258 total

Your Downtown South San Francisco Vacation

Culture, dining, adventure, food — you'll find it all in Downtown South San Francisco. Experience the very best of this neighborhood with a customized Downtown South San Francisco vacation package. Be sure to include some sightseeing during your trip to Downtown South San Francisco. Nearby Sees Candies and K1 Speed San Francisco are on the must-see lists of most travelers. Expedia is here to help put your travel plans into action. Book your ultimate Downtown South San Francisco vacation now.

The Latest Downtown South San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Bay Landing San Francisco Airport Hotel

Save 100% on your flight

$377

per person

Oct 16 - Oct 19

found 1 day ago

Roundtrip non-stop flight included

Dallas (DFW) to San Francisco (SFO)

9/10 Wonderful! (4,506 reviews)

The hotel is dated but the service was excellent. Friendly and helpful

Reviewed on Sep 6, 2025

Nob Hill Hotel

Downtown San Francisco

Save 100% on your flight

$503

per person

Oct 23 - Oct 28

found 1 day ago

Roundtrip non-stop flight included

Dallas (DFW) to San Francisco (SFO)

7.8/10 Good! (1,003 reviews)

Older hotel that had history and color. It was great stay, everything was neat and people working there were super clean

Reviewed on Aug 27, 2025

Hotel Riu Plaza Fisherman's Wharf

Fisherman's Wharf

Save 100% on your flight

$556

per person

Oct 16 - Oct 19

found 1 day ago

Roundtrip non-stop flight included

Dallas (DFW) to San Francisco (SFO)

9/10 Wonderful! (6,758 reviews)

It was clean, good place to walk around. Good breakfast!

Reviewed on Sep 4, 2025

Fitzgerald Hotel

Union Square

Save 100% on your flight

$402

per person

Oct 16 - Oct 19

found 1 day ago

Roundtrip non-stop flight included

Dallas (DFW) to San Francisco (SFO)

7.8/10 Good! (440 reviews)

Staff is so polite and very helpful. The beds were firm-great for anyone who has a challenged back. Elevator is vintage and really neat but, not made for modern luggage and wheelchairs. Super clean-I always check! Lovely, convenient stay.

Reviewed on Aug 4, 2025

Bay Bridge Inn

Downtown San Francisco

Save 100% on your flight

$483

per person

Oct 23 - Oct 28

found 1 day ago

Roundtrip non-stop flight included

Dallas (DFW) to San Francisco (SFO)

7.6/10 Good! (1,008 reviews)

The Bay Bridge Inn is close to Powell Street BART station and the ball park. Very walkable. The bottom sheet on the bed pops off without a lot to f movement. That is not comfortable.

Reviewed on Sep 2, 2025

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown South San Francisco

Fisherman's Wharf

1 out of top 10 points of interest in this area

4/5(38 area reviews)

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

Union Square

4/5(5,164 area reviews)

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco

3 out of top 10 points of interest in this area

3/5(1,084 area reviews)

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

Downtown South San Francisco Hotel Deals

Holiday Inn Golden Gateway by IHG

1500 Van Ness Ave, San Francisco, CA

$119 nightly

$140 total

Sep 7 - Sep 8

Total with taxes and fees

Hotel Riu Plaza Fisherman's Wharf

2500 Mason St, San Francisco, CA

$167 nightly

$197 total

Sep 7 - Sep 8

Total with taxes and fees

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco, CA

$219 nightly

$258 total

Sep 7 - Sep 8

Total with taxes and fees

See all 4,599 properties in Downtown South San Francisco

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.