Title: Esquilino Vacation Packages 2026 from $841 | Expedia.com

[Esquilino Travel Guide](https://expedia.com/Rome-Esquilino.dx6170957)[Hotels in Esquilino](https://expedia.com/Esquilino-Rome-Hotels.0-n6170957-0.Travel-Guide-Filter-Hotels)[Flights to Rome](https://expedia.com/Cheap-Flights-To-Rome.d179899.Travel-Guide-Flights)[Things to do in Rome](https://expedia.com/Things-To-Do-In-Rome.d179899.Travel-Guide-Activities)[Car Rentals in Esquilino](https://expedia.com/Car-Rentals-In-Esquilino.d6170957.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6170957/e1d2a6c7-ecc0-4ef3-98b4-d776a206e284.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Esquilino Vacations from $841

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like [St. Peters Basilica](https://www.expedia.com/St-Peters-Basilica-Vatican.d6074144.Vacation-Attraction), [Roman Forum](https://www.expedia.com/Roman-Forum-Rome-City-Centre.d502481.Vacation-Attraction) and [Pantheon](https://www.expedia.com/Pantheon-Rome-City-Centre.d502483.Vacation-Attraction) are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

## The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Hotel Best Roma](https://images.trvl-media.com/lodging/2000000/1920000/1910100/1910044/aed1ffe1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Best Roma

Rome Historic Centre

$841

per person

Apr 1 - Apr 2

found 1 day ago

Roundtrip flight included

Miami (MIA) to Rome (FCO)

7.6/10 Good! (455 reviews)

Hotel was clean and breakfast ok. Very poor customer service on arrival. Ignored at check in and unwelcoming. Delay on room being ready. First impressions count!

Reviewed on Sep 22, 2025

![Charme Spagna Boutique Hotel](https://images.trvl-media.com/lodging/19000000/18300000/18294700/18294667/57c4458b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Charme Spagna Boutique Hotel

Rome City Centre

Save 100% on your flight

$1,996

per person

May 16 - May 22

found 23 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.2/10 Wonderful! (208 reviews)

Very clean, very helpful staff

Reviewed on Jan 27, 2026

![DOM Hotel](https://images.trvl-media.com/lodging/8000000/7110000/7106300/7106251/59e09d18_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### DOM Hotel

Rome City Centre

Save 100% on your flight

$2,642

per person

May 17 - May 22

found 17 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.2/10 Wonderful! (391 reviews)

Everything was superior!..Staff went above and beyond for my stay.

Reviewed on Jan 26, 2026

![U-Visionary Roma Hotel](https://images.trvl-media.com/lodging/46000000/45170000/45167200/45167180/d2a3197d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### U-Visionary Roma Hotel

Rome City Centre

Save 100% on your flight

$2,024

per person

May 17 - May 22

found 17 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.6/10 Exceptional! (411 reviews)

I was so disappointed with this hotel. It purports to be a 5 star hotel and I was certainly paying a rate commensurate with that but it simply isn’t of a high enough standard to deserve a 5 star rating. From staff arguing with each other in front of us to being denied entry to the bar because it was too busy; there simply isn’t enough room for me to list their faults here, which essentially come down to a lack of attention to detail and care but if the management want to write to me I will give them the full list.

Reviewed on Jan 3, 2026

![Tree Charme Parliament Boutique Hotel](https://images.trvl-media.com/lodging/46000000/45970000/45964700/45964652/16b7a559_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Tree Charme Parliament Boutique Hotel

Rome City Centre

Save 100% on your flight

$2,064

per person

May 10 - May 16

found 1 day ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

8.8/10 Excellent! (28 reviews)

One of the best hotels I’ve ever stayed at. It’s a newer hotel in Rome. The room was clean, the staff were very helpful, and the cleaning lady was very thorough. I’d definitely stay here again when I return to Rome. Also, the breakfast and service were great!

Reviewed on Dec 3, 2025

## Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. [Learn more about Esquilino](https://expedia.com/Rome-Esquilino.dx6170957)

![Via del Corso which includes heritage architecture, heritage elements and street scenes](https://images.trvl-media.com/place/6147046/23c2bc21-bb33-4778-b64d-bbfa58503b1c.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Rome City Centre

8 out of top 10 points of interest in this area

4.5/5(3,994 area reviews)

 Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago. 

[Find hotel + flight trips in Rome City Centre](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Rome%20City%20Centre&DestID=553248633938945217&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Rome Historic Centre showing a statue or sculpture, a fountain and a square or plaza](https://images.trvl-media.com/place/6200441/57c34773-acbf-4b05-b5e7-9b3e692babe1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Rome Historic Centre

5/5(1 area review)

 Enclosed by Aurelian Walls, this UNESCO-listed historic district boasts numerous museums, including the Capitoline Museums and Scuderie del Quirinale. Well-connected by public transport including the Roma Termini and Roma Ostiense stations which are nearby. 

[Find hotel + flight trips in Rome Historic Centre](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Rome%20Historic%20Centre&DestID=6200441&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Trastevere showing street scenes as well as a couple](https://images.trvl-media.com/place/6046256/44314ce1-293d-46c2-8929-fc821edf8fc1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Trastevere

4.5/5(411 area reviews)

 Narrow cobbled streets lined by ancient houses give this area a charming character. Enjoy lively pubs and restaurants at night, while being close to international academic institutions and the River Tiber. 

[Find hotel + flight trips in Trastevere](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Trastevere&DestID=6046256&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Monti which includes heritage elements, heritage architecture and a ruin](https://images.trvl-media.com/place/6185346/01855336-589e-456f-975e-2734b7e91944.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Monti

4.5/5(1,380 area reviews)

 Relax in wine bars and restaurants, take a walking tour and discover the famous Colosseum and other historic sites in one of Rome’s prominent districts. 

[Find hotel + flight trips in Monti](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Monti&DestID=6185346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Trevi which includes food and markets](https://images.trvl-media.com/place/553248634717495100/5af85b66-a718-45b6-9792-c4ffe84ee4d6.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Trevi

 Art galleries, churches, and museums are just a few things travelers like about Trevi. Sights like Trevi Fountain and Piazza di Trevi are spots to explore, and you can get around the greater Rome area at Barberini Station. 

[Find hotel + flight trips in Trevi](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Trevi&DestID=553248634717495100&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Esquilino Hotel Deals

![Napoleon Hotel](https://images.trvl-media.com/lodging/1000000/10000/6600/6548/9e2b5c71_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Napoleon Hotel

Piazza Vittorio Emanuele II 105 Rome RM

Fully refundableReserve now, pay when you stay

$111 nightly

$139 total

Mar 16 - Mar 17

Total with taxes and fees

8.4/10 Very Good! (1,003 reviews)

Staff was courteous and friendly. Very helpful! The room was very clean and comfortable.

Reviewed on Feb 26, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F16%2F2026&endDate=3%2F17%2F2026&selected=6548&PinnedHotelID=6548&HadPinnedHotel=true&regionId=6170957)

![Hotel Aphrodite](https://images.trvl-media.com/lodging/1000000/990000/982500/982481/d6f00bdd_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Aphrodite

Via Marsala 90 Rome RM

Fully refundableReserve now, pay when you stay

$193 nightly

$231 total

Mar 13 - Mar 14

Total with taxes and fees

7.8/10 Good! (1,002 reviews)

Room was clean and the staff was very nice!

Reviewed on Feb 15, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F13%2F2026&endDate=3%2F14%2F2026&selected=982481&PinnedHotelID=982481&HadPinnedHotel=true&regionId=6170957)

![NH Collection Roma Palazzo Cinquecento](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/e4a6fedb_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

NH Collection Roma Palazzo Cinquecento

Piazza Dei Cinquecento, 90 Rome RM

Fully refundableReserve now, pay when you stay

$241 nightly

$289 total

Mar 1 - Mar 2

Total with taxes and fees

9/10 Wonderful! (1,001 reviews)

Excelent….

Reviewed on Feb 27, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=12741260&PinnedHotelID=12741260&HadPinnedHotel=true&regionId=6170957)

[See all 708 properties in Esquilino](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F28%2F2026&endDate=3%2F1%2F2026&regionId=6170957)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Esquilino

![Piazza Santa Maria in Trastevere in Rome, Italy](https://images.trvl-media.com/place/6158757/6a9a67b6-ee19-42e4-920e-9802d2659cd2.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the fascinating museums and acclaimed theater scene in this vibrant area. 

[](https://expedia.com/Piazza-Santa-Maria-Maggiore-Rome-City-Centre.d6158757.Vacation-Attraction)

#### Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the fascinating museums and acclaimed theater scene in this vibrant area. 

[](https://expedia.com/Piazza-Vittorio-Emanuele-II-Rome-City-Centre.d6193783.Vacation-Attraction)

#### Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the acclaimed theater scene and notable monuments in this vibrant area. 

[](https://expedia.com/Basilica-Di-Santa-Croce-In-Gerusalemme-Rome-Historic-Centre.d6124499.Vacation-Attraction)

### Things to do

![Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour](https://mediaim.expedia.com/localexpert/3138351/99f75742-d99d-48ce-8246-922f96cce825.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55

per adult

**84%** of travellers recommend

[](https://expedia.com/things-to-do/rome-colosseum-with-arena.a3138351.activity-details)

![Underground Rome Catacombs Tour with Aqueducts & Appian Way](https://mediaim.expedia.com/localexpert/291957/243c9d6c-4638-44ba-a057-8874feadf6f4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64

per adult

**94%** of travellers recommend

[](https://expedia.com/things-to-do/underground-rome-catacombs-tour-with-aqueducts-appian-way.a291957.activity-details)

![Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica](https://mediaim.expedia.com/localexpert/1008396/d1b7fce5-e5c4-48ff-9148-df750d6ee6ce.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89

per adult

**90%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-group-tour-of-the-vatican.a1008396.activity-details)

[See all activities in Rome](https://expedia.com/things-to-do/search?rid=6170957)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.