Esquilino Vacations from $1,351

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Price was $2,153, price is now $1,351 per person
$1,351
per person
May 27 - Jun 2
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
7.6/10 Good! (1,097 reviews)
The room was spacious, bigger than others i have stayed in, in Italy. I love the location, and it’s convenient proximity to Ottaviano Metro Station. The breakfast area was large and fit a lot of people, which was nice because I don’t like to be crammed in a tight spot.

Reviewed on Mar 26, 2026

DOM Hotel

DOM Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,023, price is now $2,656 per person
$2,656
per person
Jun 10 - Jun 15
found 4 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.2/10 Wonderful! (403 reviews)
The staff make this property special. They truly treat you like family!! This place is the best!! My new favorite spot lace in Rome!!

Reviewed on Mar 17, 2026

Terrace Pantheon Relais

Terrace Pantheon Relais

4 out of 5
Rome City Centre
Price was $3,082, price is now $2,131 per person
$2,131
per person
Jun 10 - Jun 15
found 4 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.2/10 Wonderful! (887 reviews)
The staff were the best. Very helpful, honest, and friendly. Will definitely come back here again next time I am in Rome.

Reviewed on Mar 22, 2026

Palazzo Nainer

Palazzo Nainer

4 out of 5
Rome City Centre
Price was $2,883, price is now $2,045 per person
$2,045
per person
Jun 10 - Jun 15
found 4 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (199 reviews)
All good Just located in a very touristy area of Rome Rooftop bar is nice !

Reviewed on Mar 21, 2026

Monastero dei Santi

Monastero dei Santi

5 out of 5
Municipio I
Save 100% on your flight
Price was $3,549, price is now $2,564 per person
$2,564
per person
Jun 10 - Jun 15
found 4 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
10/10 Exceptional! (27 reviews)
This hotel is far from being a 5 star. Is the most tacky place I ever been. The food of their restaurant is terrible, the rooms are outdated

Reviewed on Mar 13, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Rome City Centre

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(4,037 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $185 total per night from Mar 29 to Mar 30
$185 total
Mar 29 - Mar 30
Total with taxes and fees
8.4/10 Very Good! (1,004 reviews)
Great location just steps from the nearest metro stop. Plenty of restaurants nearby. Although no kettle automatically in the room, I asked on my way out of the hotel, and a kettle, cups and tea and coffee were in the room when I got back. Great choice for breakfast each day too,

Reviewed on Mar 24, 2026

Napoleon Hotel
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
$375 nightly
The price is $436 total per night from Apr 2 to Apr 3
$436 total
Apr 2 - Apr 3
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)
We stayed 7 nights at NH Collection Roma Palazzo Cinquecento and had a great experience. Staff was very friendly, welcoming and helpful throughout. We did have a small issue with the AC, as we prefer a cooler room, but the staff was very accommodating and promptly moved us to a room better suited ...

Reviewed on Mar 26, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $152 total per night from Mar 27 to Mar 28
$152 total
Mar 27 - Mar 28
Total with taxes and fees
7.8/10 Good! (1,001 reviews)
The staff were very helpful and nice. The room was always nice and cleaned when we back in our room from Rome exploring. The breakfast buffet was so convenient.

Reviewed on Mar 25, 2026

Hotel Aphrodite
See all 715 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.