Esquilino Vacations from $784

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Euro House Inn Airport

Euro House Inn Airport

4 out of 5
Isola Sacra
Price was $1,191, price is now $784 per person
$784
per person
Feb 7 - Feb 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
15.6/10 Exceptional! (914 reviews)
Everything was perfect

Reviewed on Nov 6, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,345, price is now $799 per person
$799
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
18.4/10 Exceptional! (612 reviews)
Staff were nice and this place was close to everything! Loved it!

Reviewed on Nov 6, 2025

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,351, price is now $816 per person
$816
per person
Jan 14 - Jan 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
19.2/10 Exceptional! (267 reviews)
We just left Rome and our Hotel was in very nice neighborhood close to Metro line B Bologna which is 9 min walk from hotel to connect us to city center. Beds were very comfortable we had 3 twin bed room with 2 long closets for all three of our clothes nice medium size bathroom and staff at front desk GREAT CREW

Reviewed on Nov 7, 2025

HT6 Boutique Hotel

HT6 Boutique Hotel

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,226, price is now $788 per person
$788
per person
Feb 11 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Rome (FCO)
18.8/10 Exceptional! (392 reviews)
Lots of restaurants, easy walking, felt very safe

Reviewed on Sep 18, 2025

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Price was $1,269, price is now $828 per person
$828
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
19.2/10 Exceptional! (335 reviews)
Chambre très bien équipée et petit déjeuner parfait. Calme et propreté

Reviewed on Nov 14, 2025

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

9 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $158 total per night from Dec 10 to Dec 11
$158 total
Dec 10 - Dec 11
Total with taxes and fees
8.4/10 Very Good! (1,004 reviews)
Lovely stay ay th Napoleon hotel. All staff were very welcoming, room was a very good size, breakfast had a great choice and it was an all round great stay. Would definitely stay again.

Reviewed on Nov 18, 2025

Napoleon Hotel
Hotel Terminal

Hotel Terminal

3 out of 5
Via Principe Amedeo 103 Rome RM
Fully refundableReserve now, pay when you stay
$49 nightly
The price is $68 total per night from Dec 2 to Dec 3
$68 total
Dec 2 - Dec 3
Total with taxes and fees
7.4/10 Good! (323 reviews)
Great location & staff!

Reviewed on Nov 12, 2025

Hotel Terminal
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
Fully refundableReserve now, pay when you stay
$250 nightly
The price is $298 total per night from Dec 1 to Dec 2
$298 total
Dec 1 - Dec 2
Total with taxes and fees
9/10 Wonderful! (999 reviews)
Nice hotel, great location.

Reviewed on Nov 11, 2025

NH Collection Roma Palazzo Cinquecento
See all 689 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Palm Trees in the Evening Light

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II
Piazza Santa Maria Maggiore

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Piazza Santa Maria Maggiore

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the acclaimed art scene and stunning cathedral in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$51
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
82% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$40
per adult
88% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.