Esquilino Vacations from $1,446

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Paolo II

Hotel Paolo II

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,193, price is now $1,446 per person
$1,446
per person
Apr 28 - May 5
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9/10 Wonderful! (334 reviews)
Friendly staff, nice room

Reviewed on Mar 3, 2026

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $3,440, price is now $2,035 per person
$2,035
per person
May 23 - May 30
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.6/10 Exceptional! (353 reviews)
Wonderful bijou oasis! Exceptionally friendly and helpful staff made for a memorable and relaxing stay.

Reviewed on Mar 11, 2026

Terrace Pantheon Relais

Terrace Pantheon Relais

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,282, price is now $2,795 per person
$2,795
per person
May 23 - May 30
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.2/10 Wonderful! (887 reviews)
Very friendly staff with the hotel situated in a very convenient location close to great places to eat.

Reviewed on Mar 15, 2026

Hotel Splendide Royal - The Leading Hotels of the World

Hotel Splendide Royal - The Leading Hotels of the World

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $5,877, price is now $3,853 per person
$3,853
per person
May 23 - May 30
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (1,002 reviews)
Fantastic, beautiful .

Reviewed on Feb 28, 2026

Palazzo Nainer

Palazzo Nainer

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,224, price is now $2,818 per person
$2,818
per person
May 23 - May 30
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (199 reviews)
Staff were wonderful! Breakfast was great. Very good location, too!

Reviewed on Feb 22, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $166 total per night from Mar 16 to Mar 17
$166 total
Mar 16 - Mar 17
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
My room had very tired furniture and an extremely small shower cubicle. Cleaners came in every day with clean towels and sheets. Bed okay as was rest of bathroom space

Reviewed on Mar 11, 2026

Napoleon Hotel
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
Fully refundableReserve now, pay when you stay
$359 nightly
The price is $418 total per night from Apr 2 to Apr 3
$418 total
Apr 2 - Apr 3
Total with taxes and fees
9/10 Wonderful! (1,004 reviews)
Very close to Termini railway station. So easy to go to the airport. Very nice breakfast.

Reviewed on Mar 9, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$231 nightly
The price is $272 total per night from Apr 7 to Apr 8
$272 total
Apr 7 - Apr 8
Total with taxes and fees
7.6/10 Good! (1,000 reviews)
I have very bad allergies when staying in this hotel. Not sure what exactly am I allergic to in the room. Other than that, hotel is okay.

Reviewed on Mar 2, 2026

Hotel Aphrodite
See all 711 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.