Esquilino Vacations from $1,160

Book a Hotel + Flight or Car together to unlock savings

Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Paolo II

Hotel Paolo II

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,806, price is now $1,160 per person
$1,160
per person
May 10 - May 16
found 11 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9/10 Wonderful! (333 reviews)
Friendly staff, nice room

Reviewed on Mar 3, 2026

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $2,787, price is now $1,471 per person
$1,471
per person
May 10 - May 16
found 9 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.6/10 Exceptional! (353 reviews)
The staff was so nice! The morning breakfast is amazing! This is a great North Rome spot, fairly close to several key areas to include the Spanish stairs. Lots of locals eat here and it's not as touristy as some of the spots in center square. We took the limo service back and forth to the airport, which was really nice.

Reviewed on Feb 21, 2026

Exe International Palace

Exe International Palace

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,440, price is now $1,449 per person
$1,449
per person
Apr 27 - May 4
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
7.8/10 Good! (1,002 reviews)
Very nice ,clean, and friendly hotel.

Reviewed on Feb 3, 2026

TB Place Roma

TB Place Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,930, price is now $2,416 per person
$2,416
per person
May 10 - May 16
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (53 reviews)
Fantastic hotel, nice rooms, very helpful staff and a central but quiet location.

Reviewed on Feb 22, 2026

Hotel Splendide Royal - The Leading Hotels of the World

Hotel Splendide Royal - The Leading Hotels of the World

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $5,519, price is now $3,532 per person
$3,532
per person
May 17 - May 22
found 12 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (1,000 reviews)
Fantastic, beautiful .

Reviewed on Feb 28, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
Fully refundableReserve now, pay when you stay
$340 nightly
The price is $397 total per night from Apr 6 to Apr 7
$397 total
Apr 6 - Apr 7
Total with taxes and fees
9/10 Wonderful! (1,003 reviews)
Staff at reception not particularly friendly or welcoming.

Reviewed on Mar 6, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $157 total per night from Mar 9 to Mar 10
$157 total
Mar 9 - Mar 10
Total with taxes and fees
7.6/10 Good! (1,001 reviews)
I have very bad allergies when staying in this hotel. Not sure what exactly am I allergic to in the room. Other than that, hotel is okay.

Reviewed on Mar 2, 2026

Hotel Aphrodite
Mecenate Palace

Mecenate Palace

4 out of 5
Via Carlo Alberto 3 Rome RM
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $190 total per night from Mar 9 to Mar 10
$190 total
Mar 9 - Mar 10
Total with taxes and fees
9/10 Wonderful! (1,007 reviews)
Very courteous and helpful staff. Great breakfast. Location very convenient to Roma Termini.

Reviewed on Mar 3, 2026

Mecenate Palace
See all 710 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the acclaimed theater scene and notable monuments in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.