Esquilino Vacations from $1,698

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,070, price is now $1,698 per person
$1,698
per person
Apr 30 - May 5
found 8 hours ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.2/10 Wonderful! (641 reviews)
Great location in the heart of Rome. Most major attractions are within walking distance — about 25 minutes to the Vatican, Trevi Fountain, and Pantheon, 10 minutes to the Spanish Steps, and around 35 minutes to the Colosseum (or 15 minutes by metro). The staff were very friendly and welcoming, and our room was cleaned and the bed made every day. The hotel is clean, well presented, and located on the second floor. The shower was spacious and we appreciated the free water dispenser with reusable bottles provided. Breakfast is simple but enough to start the day. The only minor issues were that the ground floor buzzer didn’t seem to work on arrival, and the underside of the decorative bed runner had a stain. Overall, a comfortable stay in a very convenient location.

Reviewed on Mar 12, 2026

TB Place Roma

TB Place Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $5,526, price is now $3,515 per person
$3,515
per person
May 23 - May 30
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (53 reviews)
Fantastic hotel, nice rooms, very helpful staff and a central but quiet location.

Reviewed on Feb 22, 2026

Residenza Piranesi Boutique Hotel

Residenza Piranesi Boutique Hotel

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,256, price is now $2,928 per person
$2,928
per person
May 23 - May 30
found 1 hour ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (86 reviews)
Room was lovely and the staff was super helpful . The restaurant next door is great and the location of the hotel is great just down the block from the Spanish Steps!

Reviewed on Mar 18, 2026

LH Hotel Lloyd Rome

LH Hotel Lloyd Rome

3 out of 5
Salario
Price was $2,495, price is now $1,782 per person
$1,782
per person
May 23 - May 30
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
8/10 Very Good! (671 reviews)
Nice spacious room and the location of the hotel is very central. Breakfast was mediocre and needs a general upgrade (even for a 3 star hotel)

Reviewed on Feb 8, 2026

Palazzo Caruso

Palazzo Caruso

4 out of 5
Rome City Centre
Price was $3,482, price is now $2,535 per person
$2,535
per person
May 23 - May 30
found 1 hour ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.2/10 Wonderful! (401 reviews)
Clean room, staff was very friendly close to shops, the fountain and restaurants

Reviewed on Mar 16, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(4,006 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $198 total per night from Mar 29 to Mar 30
$198 total
Mar 29 - Mar 30
Total with taxes and fees
8.4/10 Very Good! (1,001 reviews)
Comfortable stay. Really enjoyed it

Reviewed on Mar 22, 2026

Napoleon Hotel
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
Fully refundableReserve now, pay when you stay
$364 nightly
The price is $424 total per night from Apr 2 to Apr 3
$424 total
Apr 2 - Apr 3
Total with taxes and fees
9/10 Wonderful! (1,002 reviews)
Great hotel

Reviewed on Mar 17, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$192 nightly
The price is $229 total per night from Apr 21 to Apr 22
$229 total
Apr 21 - Apr 22
Total with taxes and fees
7.6/10 Good! (1,000 reviews)
I have very bad allergies when staying in this hotel. Not sure what exactly am I allergic to in the room. Other than that, hotel is okay.

Reviewed on Mar 2, 2026

Hotel Aphrodite
See all 707 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.