Esquilino Vacations from $751

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Smart Guesthouse

Smart Guesthouse

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 11 - Sep 15
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (44 reviews)
The room is in excellent condition, clean and a very comfortable bed. Super convenient since it’s 2 blocks away from the Termini. Plus, the owner answers your questions very quickly and all these details make your visit a very enjoyable experience.

Reviewed on Jun 28, 2025

Eurostars Roma Aeterna

Eurostars Roma Aeterna

4 out of 5
Municipio VII
Save 100% on your flight
per person
Sep 5 - Sep 12
found 21 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8.2/10 Very Good! (1,000 reviews)
All personnel were very respectful, helpful, always with a smile and willing to help. I will recommend this hotel 300% . Excellent!

Reviewed on Jun 19, 2025

Tree Charme Parliament Boutique Hotel

Tree Charme Parliament Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 5 - Sep 12
just found
Roundtrip flight included
New York (JFK) to Rome (FCO)
9/10 Wonderful! (6 reviews)
Property was lovely, very clean, and safe. It was walking distance to the Pantheon, Spanish Steps, and Trevi Fountain. Rooms were very clean, well kept, and staff was fantastic. Highly recommend!

Reviewed on Jul 5, 2025

Hotel Piazza Di Spagna

Hotel Piazza Di Spagna

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 5 - Sep 12
just found
Roundtrip flight included
New York (JFK) to Rome (FCO)
9/10 Wonderful! (442 reviews)
The place was clean, the staff was nice, the check-in process was easy. I would stay here again for sure!

Reviewed on Jul 3, 2025

LH Hotel Andreotti

LH Hotel Andreotti

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 5 - Sep 12
just found
Roundtrip flight included
New York (JFK) to Rome (FCO)
7.8/10 Good! (291 reviews)
The hotel is ideally located close to the main train station and within walking distance of the main attractions. There are numerous restaurants close by. The check in process was smooth, the only disappointment was that I had booked two rooms but we were placed on different floors. The room was a good size, the tv did not work properly and one plug socket did not work but these were not huge issues for us and I imagine if we had reported them they would have been investigated. The bathroom was great, loved the shower! The biggest bonus was the breakfast (which was included). There was a big selection (toast, pancakes, cereal, some hot meat & eggs and more plus hot and cold drinks). I would not hesitate to stay at the hotel again.

Reviewed on May 25, 2025

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel
Napoleon Hotel
4 out of 5
Piazza Vittorio Emanuele II 105, Rome, RM
$153 nightly
The price is $186 total per night from Jul 13 to Jul 14
$186 total
Jul 13 - Jul 14
Total includes taxes and fees
8.4/10 Very Good! (1,001 reviews)
"Great location in Rome, Underground station is right there so its very convenient to get around. Nice rooms and the breakfast is excellent, great choices."

Reviewed on Jul 3, 2025

Napoleon Hotel
Hotel Morgana
Hotel Morgana
4 out of 5
Via Filippo Turati 31 33 35, Rome, RM
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $188 total per night from Jul 7 to Jul 8
$188 total
Jul 7 - Jul 8
Total includes taxes and fees
8/10 Very Good! (1,000 reviews)
"Great location"

Reviewed on Jun 24, 2025

Hotel Morgana
NH Collection Roma Palazzo Cinquecento
NH Collection Roma Palazzo Cinquecento
5 out of 5
Piazza Dei Cinquecento, 90, Rome, RM
$328 nightly
The price is $384 total per night from Aug 5 to Aug 6
$384 total
Aug 5 - Aug 6
Total includes taxes and fees
9/10 Wonderful! (999 reviews)
"Our rooms were great - comfortable and extremely clean. Service was excellent. The breakfast buffet was delicious and had the best variety."

Reviewed on Jun 17, 2025

NH Collection Roma Palazzo Cinquecento
See all 674 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Palm Trees in the Evening Light

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Piazza Vittorio Emanuele II
Piazza Santa Maria Maggiore

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Pompeii, Amalfi Coast and Sorrento Day Trip from Rome

From Rome: Sorrento & Amalfi Coast with Pompeii or Positano Option

$103
per adult
92% of travellers recommend
From Rome: Sorrento & Amalfi Coast with Pompeii or Positano Option
Rome Hop-On Hop-Off Big Bus Tour

Rome Hop-On Hop-Off Big Bus Tour

$20
per adult
82% of travellers recommend
Rome Hop-On Hop-Off Big Bus Tour
Having fun while tasting Chianti

Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence

$93
per adult
100% of travellers recommend
Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.