Esquilino Vacations from $1,225

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,912, price is now $1,225 per person
$1,225
per person
Apr 20 - Apr 24
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.2/10 Wonderful! (220 reviews)
Very clean, very helpful staff

Reviewed on Jan 27, 2026

TB Place Roma

TB Place Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,813, price is now $3,074 per person
$3,074
per person
May 23 - May 30
found 22 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (53 reviews)
Fantastic hotel, nice rooms, very helpful staff and a central but quiet location.

Reviewed on Feb 22, 2026

Tree Charme Parliament Boutique Hotel

Tree Charme Parliament Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,687, price is now $2,382 per person
$2,382
per person
May 23 - May 30
found 22 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9/10 Wonderful! (34 reviews)
One of the best hotels I’ve ever stayed at. It’s a newer hotel in Rome. The room was clean, the staff were very helpful, and the cleaning lady was very thorough. I’d definitely stay here again when I return to Rome. Also, the breakfast and service were great!

Reviewed on Dec 3, 2025

Terrace Pantheon Relais

Terrace Pantheon Relais

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,200, price is now $2,717 per person
$2,717
per person
May 23 - May 30
found 22 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.2/10 Wonderful! (887 reviews)
clean and big room, great breakfest, good location

Reviewed on Feb 18, 2026

Palazzo Nainer

Palazzo Nainer

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,166, price is now $2,740 per person
$2,740
per person
May 23 - May 30
found 22 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.4/10 Exceptional! (199 reviews)
Staff were wonderful! Breakfast was great. Very good location, too!

Reviewed on Feb 22, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $119 total per night from Mar 15 to Mar 16
$119 total
Mar 15 - Mar 16
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
My room had very tired furniture and an extremely small shower cubicle. Cleaners came in every day with clean towels and sheets. Bed okay as was rest of bathroom space

Reviewed on Mar 11, 2026

Napoleon Hotel
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
Fully refundableReserve now, pay when you stay
$365 nightly
The price is $425 total per night from Apr 2 to Apr 3
$425 total
Apr 2 - Apr 3
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)
Very close to Termini railway station. So easy to go to the airport. Very nice breakfast.

Reviewed on Mar 9, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
$119 nightly
The price is $149 total per night from Mar 15 to Mar 16
$149 total
Mar 15 - Mar 16
Total with taxes and fees
7.6/10 Good! (1,000 reviews)
I have very bad allergies when staying in this hotel. Not sure what exactly am I allergic to in the room. Other than that, hotel is okay.

Reviewed on Mar 2, 2026

Hotel Aphrodite
See all 711 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Beach Vacations
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Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.