Esquilino Vacations from $1,010

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Price was $1,395, price is now $1,010 per person
$1,010
per person
Apr 21 - Apr 24
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.6/10 Exceptional! (357 reviews)
Wonderful bijou oasis! Exceptionally friendly and helpful staff made for a memorable and relaxing stay.

Reviewed on Mar 11, 2026

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,154, price is now $2,456 per person
$2,456
per person
May 25 - Jun 1
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.2/10 Wonderful! (221 reviews)
Very clean, very helpful staff

Reviewed on Jan 27, 2026

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Price was $1,720, price is now $1,118 per person
$1,118
per person
Apr 21 - Apr 24
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.2/10 Wonderful! (641 reviews)
Great location in the heart of Rome. Most major attractions are within walking distance — about 25 minutes to the Vatican, Trevi Fountain, and Pantheon, 10 minutes to the Spanish Steps, and around 35 minutes to the Colosseum (or 15 minutes by metro). The staff were very friendly and welcoming, and our room was cleaned and the bed made every day. The hotel is clean, well presented, and located on the second floor. The shower was spacious and we appreciated the free water dispenser with reusable bottles provided. Breakfast is simple but enough to start the day. The only minor issues were that the ground floor buzzer didn’t seem to work on arrival, and the underside of the decorative bed runner had a stain. Overall, a comfortable stay in a very convenient location.

Reviewed on Mar 12, 2026

Palazzo Nainer

Palazzo Nainer

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,772, price is now $2,491 per person
$2,491
per person
May 25 - Jun 1
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.4/10 Exceptional! (199 reviews)
Staff were wonderful! Breakfast was great. Very good location, too!

Reviewed on Feb 22, 2026

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $3,079, price is now $1,702 per person
$1,702
per person
Jun 1 - Jun 7
found 22 hours ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Rome (FCO)
9.6/10 Exceptional! (288 reviews)
Courteous and helpful staff. Clean, great amenities

Reviewed on Feb 8, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(4,006 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $196 total per night from Mar 29 to Mar 30
$196 total
Mar 29 - Mar 30
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
Very nice and close to the train station

Reviewed on Mar 17, 2026

Napoleon Hotel
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
Fully refundableReserve now, pay when you stay
$360 nightly
The price is $419 total per night from Apr 2 to Apr 3
$419 total
Apr 2 - Apr 3
Total with taxes and fees
9/10 Wonderful! (1,002 reviews)
Great hotel

Reviewed on Mar 17, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $151 total per night from Mar 22 to Mar 23
$151 total
Mar 22 - Mar 23
Total with taxes and fees
7.6/10 Good! (1,000 reviews)
I have very bad allergies when staying in this hotel. Not sure what exactly am I allergic to in the room. Other than that, hotel is okay.

Reviewed on Mar 2, 2026

Hotel Aphrodite
See all 707 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.