Find luxury hotels in Greenville, MO

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Frequently asked questions

Are you looking for a luxury hotel for your stay in Greenville?
Amenities are an important consideration when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want a posh hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Greenville has to offer. Greenville has some interesting things to see and do including Mark Twain National Forest, so you might want to take in the local sights during your visit.
When can I expect good weather in Greenville?
Planning for the weather is a good way to make your trip to Greenville relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Greenville is 59 inches.
What's there to see and do in Greenville?
Experience Greenville with a stop at Mark Twain National Forest, Lake Wappapello, and Lake Wappapello State Park. If you have a bit of extra time while you're in the area, you might want to check out Sam A. Baker State Park.