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A calm lake reflecting autumn trees with vibrant orange and yellow foliage.

Greenville Vacations from $280

Book a Hotel + Flight or Car together to unlock savings

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  • Better together

    Save up to $2,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

The Latest Greenville Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Property entrance
    Aug 21 - Aug 24

    The Wildwood Hotel + Flight

    Wildwood
    3 nights
    3.5 star property
    9.2/10 - Wonderful (1,661 reviews)
    "Very nice place, with elegant decoration, a generous “continental “ breakfast, very quiet and comfortable room, nearby park, and nice pool and hot tub."
    Reviewed July 21, 2026
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    $567
    $280
    per traveler
    found 1 day ago
    The Wildwood Hotel
  • House | Private kitchen
    Aug 21 - Aug 24

    Remodeled and Inviting Free EV + Flight

    Fenton
    3 nights
    2.0 star property
    10/10 - Exceptional (1 review)
    "The property was excellent, and the home was very warm and welcoming."
    Reviewed June 25, 2026
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    Save 100% on your flight
    $566
    $338
    per traveler
    found 11 hours ago
    Remodeled and Inviting Free EV
  • Gastropub
    Sep 23 - Sep 26

    The Cheshire + Flight

    Richmond Heights
    3 nights
    4.0 star property
    8.8/10 - Excellent (1,009 reviews)
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    Save 100% on your flight
    $460
    $300
    per traveler
    found 1 day ago
    The Cheshire
  • Lobby lounge
    Sep 6 - Sep 12

    Residence Inn by Marriott St. Louis West County + Flight

    Town and Country
    6 nights
    3.0 star property
    9.2/10 - Wonderful (261 reviews)
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    Save 100% on your flight
    $779
    $529
    per traveler
    found 13 hours ago
    Residence Inn by Marriott St. Louis West County
  • Courtyard
    Sep 23 - Sep 26

    The Knight Center at Washington University + Flight

    St. Louis
    3 nights
    2.5 star property
    9.4/10 - Exceptional (631 reviews)
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    Save 100% on your flight
    $422
    $305
    per traveler
    found 1 day ago
    The Knight Center at Washington University

Greenville Hotel Deals

Lobby

Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70
2.5 star property
2.4 mi from Greenville
8.4 out of 10, Very Good, (455 reviews)
"Breakfast was adequate. Air worked we, and we experienced a quiet peaceful night."
$98 nightly
The price is $109
Aug 2 - Aug 3
Total with taxes and fees
Comfort Inn & Suites Greenville I-70
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Greenville

Frequently Asked Questions

How much does a Greenville vacation package cost?

Offering great value package deals from $280 on Expedia, you'll be pleasantly surprised at how much a vacation to Greenville costs! Our packages make travel planning easier and your savings go further.

What are the cheapest months to go to Greenville?

If you're looking to score a cheap Greenville vacation package, consider visiting in January, March and December. You'll typically find lower prices on hotels and airfares during these months — perfect for travelers wishing to save money.

How many days is enough for Greenville?

Generally, a handful of days is enough to visit the major attractions during your Greenville vacation. However, if you want to have some time to unwind or take day tours, consider extending your itinerary.

How to find the best Greenville package deals?

Use Expedia's handy filters to find some great Greenville package deals. When you start your search, simply set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your escape for midweek, or search for Greenville package deals in the off-season. Play around with your travel dates and you may score even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package as soon as possible.

Is it cheaper to book a Greenville vacation as a package?

Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll usually get a better deal than booking each component individually. And you'll still enjoy the flexibility to create a personalized Greenville vacation by choosing your preferred type of stay, airline and car class.

When to book a vacation package to Greenville?

Enjoy incredible discounts by booking your flights in advance with Expedia. If being spontaneous is more your thing, snap up one of our last-minute deals for an impromptu Greenville escape.

Does Expedia offer Book Now, Pay Later Greenville vacation packages?

If you're like us, you love exploring new places but don't love the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the overall cost of your Greenville vacation over 3, 6 or 12 months. There are also no hidden costs or late payment fees, so you can snap up great vacation packages with payment plans as soon as you spot them.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.