Greenville Vacations from $506

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Greenville vacation packages

Price found within the past 48 hours. Click for updated prices.
The West End

The West End

2 out of 5
Central West End
Price was $626, price is now $506 per person
$506
per person
Mar 27 - Mar 30
found 19 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.4/10 Very Good! (389 reviews)
Great staff and management. Very helpful and fully responsive

Reviewed on Dec 25, 2025

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Price was $1,207, price is now $937 per person
$937
per person
Mar 27 - Mar 30
found 19 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.6/10 Excellent! (10 reviews)
Overall, we loved the apartment. It was cute, beds were very comfortable.

Reviewed on May 8, 2025

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

4 out of 5
Downtown St. Louis
Price was $969, price is now $753 per person
$753
per person
Mar 26 - Mar 29
found 4 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.8/10 Excellent! (458 reviews)
Property and room was really nice. I will be staying here in the future

Reviewed on Nov 25, 2025

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was $765, price is now $619 per person
$619
per person
Feb 20 - Feb 23
found 19 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.4/10 Very Good! (1,006 reviews)
Was an amazing hotel to stay at!! Clean spacious and very nice!!! Will stay here again!!

Reviewed on Dec 31, 2025

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

2.5 out of 5
Price was $628, price is now $509 per person
$509
per person
Mar 26 - Mar 29
found 4 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (988 reviews)
This location was very nice. Right by everything. The staff was excellent/ friendly/ helpful. The rooms were nice and clean. I will stay here again.

Reviewed on Dec 20, 2025

Don't see what you're looking for?
See all available trips from Columbus to Greenville
View all trips

Discover the most popular places to visit in Greenville

Greenville Country Club

4/5(4 reviews)

Enjoy a round of golf in Greenville at Greenville Country Club. You'll find more to see and do in this family-friendly area.

Greenville Country Club

Patriot's Park

4/5(7 reviews)

You can take time to visit Patriot's Park during your travels to Greenville. Wander the parks in this family-friendly area.

Patriot's Park

Greenville Hotel Deals

Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

2.5 out of 5
2265 S. State Route 127 Greenville IL
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $100 total per night from Jan 18 to Jan 19
$100 total
Jan 18 - Jan 19
Total with taxes and fees
8.4/10 Very Good! (417 reviews)
Good

Reviewed on Nov 29, 2025

Comfort Inn & Suites Greenville I-70
Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville

2 out of 5
1700 State Route 127 Greenville IL
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $74 total per night from Jan 11 to Jan 12
$74 total
Jan 11 - Jan 12
Total with taxes and fees
7.8/10 Good! (762 reviews)
The room was super clean and the staff was nice

Reviewed on Dec 23, 2025

Super 8 by Wyndham Greenville
SureStay Hotel by Best Western Greenville

SureStay Hotel by Best Western Greenville

2.5 out of 5
1731 S State Route 127 Greenville IL
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $70 total per night from Jan 18 to Jan 19
$70 total
Jan 18 - Jan 19
Total with taxes and fees
7.4/10 Good! (562 reviews)
Clean room, a little outdated but the comfortable bed more than makes up for that. Heard a few loud vehicles early in the evening next door but by 10 pm it was quiet. Room was spacious and easy to get to.

Reviewed on Dec 24, 2025

SureStay Hotel by Best Western Greenville
See all 61 properties in Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Greenville Vacation Packages

Greenville Essential Information

Language
English
Currency
U.S dollars
Population
6,700
Max Temp Winter
40ºF
Max Temp Summer
80ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Greenville vacation package cost?
Offering great value package deals from $506 on Expedia, you'll be pleasantly surprised at how much a vacation to Greenville costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Greenville?
If you're looking to score a cheap Greenville vacation package, consider visiting in January, March and December. You'll typically find lower prices on hotels and airfares during these months — perfect for travelers wishing to save money.
How many days is enough for Greenville?
Generally, a handful of days is enough to visit the major attractions during your Greenville vacation. However, if you want to have some time to unwind or take day tours, consider extending your itinerary.
How to find the best Greenville package deals?
Use Expedia's handy filters to find some great Greenville package deals. When you start your search, simply set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your escape for midweek, or search for Greenville package deals in the off-season. Play around with your travel dates and you may score even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package as soon as possible.
Is it cheaper to book a Greenville vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll usually get a better deal than booking each component individually. And you'll still enjoy the flexibility to create a personalized Greenville vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Greenville?
Enjoy incredible discounts by booking your flights in advance with Expedia. If being spontaneous is more your thing, snap up one of our last-minute deals for an impromptu Greenville escape.
Does Expedia offer Book Now, Pay Later Greenville vacation packages?
If you're like us, you love exploring new places but don't love the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the overall cost of your Greenville vacation over 3, 6 or 12 months. There are also no hidden costs or late payment fees, so you can snap up great vacation packages with payment plans as soon as you spot them.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.