Historic Southwest Vacations from $565

Book a Hotel + Flight or Car together to unlock savings

Photo by Sara Crotts

Your Historic Southwest Vacation

Book a Historic Southwest vacation package and immerse yourself in the rhythm and vibe of this interesting neighborhood. With all your travel plans taken care of, the only thing you need to worry about here is having a great time. When it's time to head out and explore, you'll find lots of big-name attractions nearby including Mayo Civic Center, Apache Mall and Rochester Recreation Center. Visit one, two or all during your trip to Historic Southwest. Stop dreaming and start doing. When it's time to book your next vacation to Historic Southwest, Expedia is here to help.

The Latest Historic Southwest Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Aspen Select
Comfort Inn & Suites West - Medical Center
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
Broadway Plaza, Trademark Collection by Wyndham

Where to stay in Historic Southwest

Find the best Historic Southwest areas and neighborhoods for the activities you enjoy most. Learn more about Historic Southwest

Historic Southwest Hotel Deals

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway, Rochester, MN
Fully refundable
$80 nightly
The price is $92 total per night from Sep 12 to Sep 13
$92 total
Sep 12 - Sep 13
Total with taxes and fees
8.8/10 Excellent! (814 reviews)
"Generally, we found the staff at Mayo Clinic and others met in Rochester very friendly and helpful. The Indigo hotel staff not so much."

Reviewed on Aug 18, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $142 total per night from Aug 30 to Aug 31
$142 total
Aug 30 - Aug 31
Total with taxes and fees
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

3 out of 5
225 S Broadway, Rochester, MN
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $136 total per night from Sep 5 to Sep 6
$136 total
Sep 5 - Sep 6
Total with taxes and fees
Hilton Garden Inn Rochester Downtown, MN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Historic Southwest

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.