Historic Southwest Vacations from $690

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Your Historic Southwest Vacation

Book a Historic Southwest vacation package and immerse yourself in the rhythm and vibe of this interesting neighborhood. With all your travel plans taken care of, the only thing you need to worry about here is having a great time. When it's time to head out and explore, you'll find lots of big-name attractions nearby including Mayo Civic Center, Apache Mall and Rochester Recreation Center. Visit one, two or all during your trip to Historic Southwest. Stop dreaming and start doing. When it's time to book your next vacation to Historic Southwest, Expedia is here to help.

The Latest Historic Southwest Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express Rochester South - Mayo Area by IHG
The Berkman
Hyatt House Rochester/Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Where to stay in Historic Southwest

Find the best Historic Southwest areas and neighborhoods for the activities you enjoy most. Learn more about Historic Southwest

Historic Southwest Hotel Deals

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Nov 14 to Nov 15
$131 total
Nov 14 - Nov 15
Total with taxes and fees
8.6/10 Excellent! (1,018 reviews)
"Needs renovation"

Reviewed on Nov 9, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

3 out of 5
225 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $136 total per night from Dec 11 to Dec 12
$136 total
Dec 11 - Dec 12
Total with taxes and fees
8.8/10 Excellent! (969 reviews)
"The staff were helpful. Our room was super uncomfortable the first night. We didn't get much sleep. The thermostat didn't want to cooperate. But the staff promptly got that fixed the second night. Better sleep. The hot tub was wonderful after a long day on our feet. Would recommend."

Reviewed on Nov 9, 2026

Hilton Garden Inn Rochester Downtown, MN
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $86 total per night from Dec 11 to Dec 12
$86 total
Dec 11 - Dec 12
Total with taxes and fees
Med City Inn & Suites - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Historic Southwest attractions

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.