Isolotto Vacations from $1,292

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Florence Boutique

Eurostars Florence Boutique

Historic Centre of Florence
$1,292
per person
Nov 21 - Nov 28
found 2 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
8.6/10 Excellent! (503 reviews)
The bed was comfortable but low to the floor. The shower was very slippery and could have used a shower mat. The breakfast was great. The staff were very nice and helpful.

Reviewed on Oct 10, 2026

Hotel Villa Liana

Hotel Villa Liana

Historic Centre of Florence
$1,387
per person
Nov 21 - Nov 28
found 2 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
8.8/10 Excellent! (369 reviews)
Hotel Eliana is a Gem! It’s a 20 minute walk from the center but I like it that way because it is quiet also after eating so much food from Central market I need to walk it down all the staff are very attentive, friendly and helpful. I will definitely go back in this hotel again. I have in fact, suggested this to my close friends who are coming to Italy next year 10 members of the family.

Reviewed on Oct 7, 2026

Relais Uffizi, Tailor made Hotel

Relais Uffizi, Tailor made Hotel

Historic Centre of Florence
$1,601
per person
Nov 21 - Nov 28
found 2 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
9.2/10 Wonderful! (169 reviews)
The room was very clean. The staff was awesome. Special thanks goes to Francesca that took care of us in the dining room. She was awesome. The room stated that every room had a hairdryer but that was incorrect at least for our room. The room also didn’t have many flat tables to set things down on this includes the bathroom. More tables should be included in the room. The hotel location was near the main tourist attractions which made finding things easier. Overall we would stay there again.

Reviewed on Oct 6, 2026

Hotel Annabella Roof Terrace

Hotel Annabella Roof Terrace

Historic Centre of Florence
$1,547
per person
Nov 21 - Nov 28
found 2 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
8.8/10 Excellent! (181 reviews)
the room was so clean and staff are accommodating

Reviewed on Sep 28, 2026

Park Palace

Park Palace

Oltrarno
$1,338
per person
Nov 21 - Nov 28
found 2 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
9/10 Wonderful! (361 reviews)
"I recently stayed at your hotel and, unfortunately, my experience with the customer service was extremely disappointing. Despite the hotel's beautiful atmosphere, the staff were unfriendly, nasty, and even racist. They were not welcoming or kind, which made our stay unpleasant. If you're looking for a place with good customer service, I wouldn't recommend this hotel."

Reviewed on Dec 12, 2025

Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. Learn more about Isolotto
A river with buildings on the right bank.

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty.

A historic building with ornate carvings and statues, featuring large wooden doors and steps leading up to it.

Duomo

Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence.

A stone bridge with green shutters over a river.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A bustling European square with historic buildings, shops, and a prominent clock tower.

Santa Croce

One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants.

Isolotto Hotel Deals

Plus Florence - Hostel

Plus Florence - Hostel

Via Santa Caterina D'Alessandria, 15 Florence FI
Fully refundableReserve now, pay when you stay
$54 nightly
$77 total
Nov 10 - Nov 11
Total with taxes and fees
Plus Florence - Hostel
Hotel Paris

Hotel Paris

Via Banchi 2 Florence FI
Fully refundableReserve now, pay when you stay
$142 nightly
$169 total
Nov 10 - Nov 11
Total with taxes and fees
Hotel Paris
The Social Hub Florence Belfiore

The Social Hub Florence Belfiore

Viale Belfiore, 55 Florence FI
Fully refundableReserve now, pay when you stay
$72 nightly
$95 total
Nov 8 - Nov 9
Total with taxes and fees
9.4/10 Exceptional! (779 reviews)
"If you expect Hilton or Marriott level of service, stay elsewhere. This was a chic trendy hotel catering to the younger clients. Check in is self serve, though a staff member immediately came over to help when they saw our confusion with no front desk. We were in another building which requires going ..."

Reviewed on Oct 11, 2026

The Social Hub Florence Belfiore
See all 11,906 properties in Isolotto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

$21
per adult
94% of travellers recommend
Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$21
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Michaelangelo's David

Accademia timed-entry Ticket with App Guide

$45
per adult
90% of travellers recommend
Accademia timed-entry Ticket with App Guide
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.