If you're a fan of live theater productions, make sure you spend an evening at Manos Hatzidakis Theatre. Make a reservation ahead of time to secure the best seats.
You'll be spoiled for sightseeing choice when staying in Heraklion. Manos Hatzidakis Theatre is an ideal place to begin here, but there are loads of other interesting spots to enjoy. Palace of Knossos, Heraklion Archaeological Museum, and Natural History Museum of Crete are not far from the arts and culture attraction and will round out your day nicely.