Matthews Vacations from $348

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The Latest Matthews vacation packages

Price found within the past 48 hours. Click for updated prices.
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
Price was $383, price is now $348 per person
$348
per person
Dec 3 - Dec 6
found 16 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
6.8/10 (143 reviews)
Clean Room

Reviewed on Oct 26, 2026

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
Price was $1,070, price is now $1,017 per person
$1,017
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Manhattan (MHK) to Cape Girardeau (CGI)
8/10 Very Good! (1,003 reviews)
The hallways reeked of marijuana smoke. Changed hotels the second night.

Reviewed on Nov 2, 2026

Perryville RV Resort

Perryville RV Resort

2 out of 5
Price was $373, price is now $355 per person
$355
per person
Dec 3 - Dec 6
found 16 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
8.8/10 Excellent! (8 reviews)

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
Price was $424, price is now $405 per person
$405
per person
Dec 3 - Dec 6
found 16 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
9.2/10 Wonderful! (638 reviews)

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
Price was $1,133, price is now $1,087 per person
$1,087
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Manhattan (MHK) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,003 reviews)
Was really impressed, I don’t normally write reviews. Free drinks and food in the evening, lovely staff. clean room. Was really a cut above.

Reviewed on Nov 1, 2026

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Matthews Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Nov 8 to Nov 9
$108 total
Nov 8 - Nov 9
Total with taxes and fees
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $76 total per night from Nov 8 to Nov 9
$76 total
Nov 8 - Nov 9
Total with taxes and fees
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $109 total per night from Nov 22 to Nov 23
$109 total
Nov 22 - Nov 23
Total with taxes and fees
Hampton Inn Sikeston
See all 41 properties in Matthews
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Matthews Vacation Packages

Matthews Essential Information

Language
English
Currency
U.S dollars
Population
630

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Frequently asked questions

How much does a Matthews vacation package cost?
You'll find cheap prices from $348 on Expedia for your Matthews escape. However, a range of factors like the length of stay, hotel choice and season will determine how much your vacation to Matthews costs.
What are the cheapest months to go to Matthews?
If you're hoping to score a cheap Matthews vacation package, consider traveling in January, September and November. You're likely to find better prices on flights and accommodations during these months — perfect for travelers wishing to save money.
How many days is enough for Matthews?
Usually, a handful of days is enough to visit the major attractions during your Matthews vacation. But if you want to have time to chill out or take day tours, think about extending your trip.
How to find the best Matthews package deals?
Begin your search for a Matthews package deal by entering your travel dates and destination under our "Packages" tab. Then apply some filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with unbeatable savings. If you don't find the ideal Matthews package deal right away, just change your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Matthews escape off to a flying start.
Is it cheaper to book a Matthews vacation as a package?
An Expedia vacation package could score you significant savings when compared to arranging accommodations and flights separately. Better still, you can customize your Matthews trip to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Matthews?
If you've got your Matthews travel dates locked in, book as early as you can to bag some unbeatable deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are ideal for traveling on a whim.
Does Expedia offer Book Now, Pay Later Matthews vacation packages?
Your Matthews getaway should be a relaxing escape from your busy life, not a reason for money worries. So to allow you that extra flexibility, we've joined up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and spread the cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.