Situated in Jacksonville Coast, this health care institution is worth a visit. But you'll find loads more to explore in the area. St. Johns Town Center, University of North Florida, and TPC Sawgrass aren't too far from Mayo Clinic Florida.

Plan a trip to see Mayo Clinic Florida

Price found within the past 48 hours. Click for updated prices.

Comfort Inn & Suites Jacksonville - Orange Park Near Naval Air Station

Westside

Save 100% on your flight

$229

per person

Jan 17 - Jan 20

found 12 hours ago

Roundtrip flight included

Boston (BOS) to Jacksonville (JAX)

9.4/10 Exceptional! (1,005 reviews)

The only thing I didn't like, was whem my famly and I geather in the lobby common area to socialize the music was tasteless, and the front desk staff stated they were not allowed to access any functions on the lobby tv. So you are stuck listening to elavertor music and the weather station. But overall I had a great stay.

Reviewed on Nov 30, 2025

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Isle of Palms

Save 100% on your flight

$494

per person

Feb 19 - Feb 23

found 13 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)

9.4/10 Exceptional! (437 reviews)

Marriot… a room refresh does not include making the bed? WTAF?! Also, no smoking means no smoking. A man smoked a cigar in the court yard without any interference from the staff. It’s too bad, the room was spacious and clean but the follow through in non existent.

Reviewed on Nov 10, 2025

Comfort Suites Baymeadows Near Butler Blvd

Save 100% on your flight

$429

per person

Feb 19 - Feb 25

found 1 day ago

Roundtrip flight included

Boston (BOS) to Jacksonville (JAX)

8.2/10 Very Good! (1,004 reviews)

Staff were very nice and professional. Hotel was clean. The room was spacious….i would’ve given a 5 star but only thing I didn’t like was the bathroom; it was way too small.

Reviewed on Nov 28, 2025

Reviews of Mayo Clinic Florida

4.5

Top Destination

5 - Excellent

294

4 - Good

76

3 - Okay

46

2 - Disappointing

7

1 - Terrible

10

5/5 - Excellent

Verified traveler

This place is amazing it’s a little drive from the hotel which we didn’t know at first but it made having to stay an extra day for more texts bearable.

5/5 - Excellent

Verified traveler

The Mayo Clinic is SOO organized--your schedule is printed out, and every dept. knows where you should be and when! So impressed with this routine and with the doctors we had been scheduled to see. Also, the café has a great selection of foods for everyone and more than reasonably priced! We even decided to go to the café for lunch prior to my husband's appt. Everyone is so very helpful and understanding!

5/5 - Excellent

Verified traveler

Great location 7 minutes from Mayo

5/5 - Excellent

Verified traveler

The Red Roof Inn Plus is directly west of the Mayo Clinic if you stay on Rte 202. Once you get on the 202 at the San Pablo Rd exit by Mayo Clinic you don't have to get off of the 202 until you end up basically just blocks from the Red Roof Inn. It takes about 1/2 hour depending on traffic to make the trip but an easy route.

5/5 - Excellent

Verified traveler

Hotel is a great location for visiting Mayo Clinic.

5/5 - Excellent

Verified traveler

Very conveinient to Mayo and easy to find.

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