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Compare 1,869 hotels close to Mayo Clinic Florida with room rates, reviews, and availability. Most hotels are fully refundable.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Reception

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
9.4 out of 10, Exceptional, (406)
"The place was clean and staff was wonderful. Will be staying again!"
$158 nightly
The price is $179
Jul 27 - Jul 28
Total includes taxes and fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
TownePlace Suites by Marriott Jacksonville East
Terrace/patio

TownePlace Suites by Marriott Jacksonville East

3.0 star property
9.2 out of 10, Wonderful, (469)
"Nice and quiet hotel "
$121 nightly
The price is $137
Jul 17 - Jul 18
Total includes taxes and fees
TownePlace Suites by Marriott Jacksonville East
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Terrace/patio

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

2.5 star property
9.0 out of 10, Wonderful, (1000)
"I loved our stay"
$118 nightly
The price is $134
Jul 20 - Jul 21
Total includes taxes and fees
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Terrace/patio

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

3.0 star property
8.4 out of 10, Very Good, (724)
"Close to mayo"
$161 nightly
The price is $183
Jul 19 - Jul 20
Total includes taxes and fees
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Suite, 1 King Bed (Additional Living Area) | Golf view

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.5 star property
8.4 out of 10, Very Good, (1001)
"Perfect location "
$111 nightly
The price is $126
Jul 20 - Jul 21
Total includes taxes and fees
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
TownePlace Suites by Marriott® Jacksonville Mayport
Front of property - evening/night

TownePlace Suites by Marriott® Jacksonville Mayport

3.0 star property
10.0 out of 10, Exceptional, (5)
"New hotel in the area with friendly staff and a clean and convenient place to stay - the room had a kitchenette and a spacious shower. "
$118 nightly
The price is $134
Jul 27 - Jul 28
Total includes taxes and fees
TownePlace Suites by Marriott® Jacksonville Mayport
Salt Air Inn & Suites
BBQ/picnic area

Salt Air Inn & Suites

2.5 star property
9.8 out of 10, Exceptional, (339)
"Great place to stay"
$152 nightly
The price is $173
Jul 13 - Jul 14
Total includes taxes and fees
Salt Air Inn & Suites
Element Jacksonville Beach
Lobby

Element Jacksonville Beach

3.0 star property
9.6 out of 10, Exceptional, (482)
"It was a clean hotel with fairly comfortable beds. "
$135 nightly
The price is $153
Jul 27 - Jul 28
Total includes taxes and fees
Element Jacksonville Beach
The Hotel Palms
Standard Room, 2 Queen Beds, Non Smoking | 1 bedroom, down comforters, minibar, iron/ironing board

The Hotel Palms

3.5 star property
9.6 out of 10, Exceptional, (287)
"Easy comfy convenient. "
$189 nightly
The price is $215
Aug 3 - Aug 4
Total includes taxes and fees
The Hotel Palms
Ponte Vedra Inn & Club
Reception

Ponte Vedra Inn & Club

5.0 star property
9.4 out of 10, Exceptional, (801)
"We enjoyed our stay Friendly Professional Staff "
$478 nightly
The price is $530
Aug 1 - Aug 2
Total includes taxes and fees
Ponte Vedra Inn & Club
The Lodge and Club at Ponte Vedra Beach
Beach/ocean view

The Lodge and Club at Ponte Vedra Beach

5.0 star property
9.4 out of 10, Exceptional, (669)
"Loved our stay, my sixth at this property. JR the waiter at breakfast at the Inn, was delightful!Cant wait to come back!"
$628 nightly
The price is $697
Jul 13 - Jul 14
Total includes taxes and fees
The Lodge and Club at Ponte Vedra Beach
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Exterior

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Clean hotel, would stay here again"
$115 nightly
The price is $131
Jul 13 - Jul 14
Total includes taxes and fees
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
AC Hotel Jacksonville St Johns Town Center
Lounge

AC Hotel Jacksonville St Johns Town Center

2.5 star property
9.4 out of 10, Exceptional, (117)
"Great place to stay, easy in/out, nice facilities and plenty to do in the area. "
$169 nightly
The price is $192
Jul 11 - Jul 12
Total includes taxes and fees
AC Hotel Jacksonville St Johns Town Center
Holiday Inn Express Jacksonville Beach by IHG
Standard Room, 2 Queen Beds, Accessible (Accessible Tub) | 1 bedroom, in-room safe, desk, laptop workspace

Holiday Inn Express Jacksonville Beach by IHG

2.5 star property
9.2 out of 10, Wonderful, (1001)
"Clean convenient and close to dining "
$111 nightly
The price is $126
Jul 13 - Jul 14
Total includes taxes and fees
Holiday Inn Express Jacksonville Beach by IHG
Four Points by Sheraton Jacksonville Beachfront
Exterior

Four Points by Sheraton Jacksonville Beachfront

3.0 star property
9.2 out of 10, Wonderful, (1003)
"Very nice for a quick get away"
$186 nightly
The price is $211
Jul 27 - Jul 28
Total includes taxes and fees
Four Points by Sheraton Jacksonville Beachfront
Hampton Inn Jacksonville Beach/Oceanfront
2 outdoor pools, pool umbrellas, sun loungers

Hampton Inn Jacksonville Beach/Oceanfront

3.0 star property
9.2 out of 10, Wonderful, (2306)
"Great hotel for the price and ocean view room."
$175 nightly
The price is $199
Jul 27 - Jul 28
Total includes taxes and fees
Hampton Inn Jacksonville Beach/Oceanfront
Hyatt Place Jacksonville / St. Johns Town Center
Sports facility

Hyatt Place Jacksonville / St. Johns Town Center

3.0 star property
9.2 out of 10, Wonderful, (1000)
"Very happy with our stay."
$189 nightly
The price is $215
Jul 13 - Jul 14
Total includes taxes and fees
Hyatt Place Jacksonville / St. Johns Town Center
Sheraton Jacksonville Hotel
Property amenity

Sheraton Jacksonville Hotel

4.0 star property
9.2 out of 10, Wonderful, (1001)
"Very friendly staff and property is nice and well maintained. Close to mall and nice food options"
$134 nightly
The price is $152
Aug 1 - Aug 2
Total includes taxes and fees
Sheraton Jacksonville Hotel
Best Western Oceanfront
On the beach

Best Western Oceanfront

2.5 star property
9.0 out of 10, Wonderful, (1003)
"Enjoyed our stay. Great location. "
$141 nightly
The price is $160
Aug 3 - Aug 4
Total includes taxes and fees
Best Western Oceanfront
Springhill Suites By Marriott Jacksonville Beach Oceanfront
On the beach, windsurfing

Springhill Suites By Marriott Jacksonville Beach Oceanfront

4.0 star property
9.0 out of 10, Wonderful, (521)
"It was nice, very clean and the staff was great"
$167 nightly
The price is $190
Aug 3 - Aug 4
Total includes taxes and fees
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 34 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Another good choice is Residence Inn By Marriott Jacksonville - Mayo Clinic Area, located just 0.7 mi (1.1 km) away.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 34 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can enjoy live performances at Wilson Center For the Arts and Players by the Sea. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Gonzales Park. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.