Photo by Amber Palmer
Find Hotels near Mayo Clinic Florida, Jacksonville from $62
Search over 1 million properties and 550 airlines worldwide.
Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.
Most hotels are fully refundable. Because flexibility matters.
Check prices on hotels close to Mayo Clinic Florida
Top Hotels Close to Mayo Clinic Florida
1.4 mi from Mayo Clinic Florida
4.3/5Excellent! (42 reviews)
We had fun; pool needed care
"We came to this property with multiple families and children ranging 6-13. There was plenty of space for everyone. My only real complaint is the pool. It was green and cloudy when we got there and only continued to get worse. By the last day I would not allow the kids to get into it because of the ..."
Reviewed on Aug 13, 2021
Get rates
0.2 mi from Mayo Clinic Florida
Fully refundableReserve now, pay when you stay
4.1/5Very Good! (573 reviews)
"Have stayed here many times. Always excellent."
Reviewed on Sep 7, 2021
0.6 mi from Mayo Clinic Florida
Fully refundableReserve now, pay when you stay
4.8/5Exceptional! (12 reviews)
"The receptionist was very professional, and friendly. I liked everything about the room, except the walls are a bit thin, and you can hear the people in the room next door like they are sitting next to you. Luckily they didn't stay up all night. Other than that, we enjoyed our stay, and they room ..."
Reviewed on Sep 7, 2021
You could be seeing lower prices
With member prices, you could save 10% or more right now on thousands of properties.
0.1 mi from Mayo Clinic Florida
4.7/5Exceptional! (3 reviews)
Great location, especially to Mayo Clinic!
"This home was clean and located in a safe, quiet neighborhood. The host was very attentive to our needs and very polite. We would definitely stay at The Retreat again!"
Reviewed on May 28, 2021
Get rates
0.8 mi from Mayo Clinic Florida
4.8/5Exceptional! (15 reviews)
Vacation Stay
"The house was very nice. It has everything we needed and was in a very convenient location. It was an enjoyable stay."
Reviewed on Aug 17, 2021
Get rates
1.2 mi from Mayo Clinic Florida
4.5/5Wonderful! (13 reviews)
Thumbs Up
"Very nice! has a great beach vibe. Quiet, friendly neighborhood. Great host."
Reviewed on Sep 6, 2021
Get rates
0.9 mi from Mayo Clinic Florida
5/5Exceptional! (3 reviews)
Lovely stay
"House was very clean! Pool was so relaxing and loved being 5 minutes from the beach. Would definitely stay here again! The hosts were very nice and had great communication!"
Reviewed on Sep 7, 2021
Get rates
0.8 mi from Mayo Clinic Florida
4.7/5Exceptional! (3 reviews)
Labor Day vacation
"The overall stay was great just had trouble getting inside when we arrived. The previous renters locked the door handle but Mike was there quick and fixed the situation."
Reviewed on Sep 8, 2021
Get rates
1.7 mi from Mayo Clinic Florida
Fully refundableReserve now, pay when you stay
4.3/5Excellent! (63 reviews)
"Near Mayo Clinic"
Reviewed on Aug 16, 2021
0.7 mi from Mayo Clinic Florida
0.7 mi from Mayo Clinic Florida
1.7 mi from Mayo Clinic Florida
1.7 mi from Mayo Clinic Florida
Fully refundableReserve now, pay when you stay
4.4/5Wonderful! (978 reviews)
"Staff was very kind."
Reviewed on Sep 15, 2021
1.1 mi from Mayo Clinic Florida
5/5Exceptional! (4 reviews)
Something for everyone in the family!
"Our family (ages 1 and up) had a fabulous time! One of our sons had planned a surprise proposal for his girlfriend and we were just a short distance from the event at Brew Hound. Afterwards, most of the adults celebrated with stops along the beach bars on 1st Street. The grand kids loved the beach ..."
Reviewed on Aug 9, 2021
Get rates
1.2 mi from Mayo Clinic Florida
4.1/5Very Good! (8 reviews)
Great
"Great cozy place!"
Reviewed on Sep 11, 2021
Get rates
1.3 mi from Mayo Clinic Florida
Fully refundableReserve now, pay when you stay
4.3/5Excellent! (971 reviews)
"The staff were very friendly and professional. They were able to assist me with all of my inquiries and needs. 10/10 would recommend and would likely stay again."
Reviewed on Sep 9, 2021
Don't see what you're looking for?
See all available properties in Mayo Clinic Florida
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find cheap hotels near Mayo Clinic Florida
Hometown Inn & Suites Jacksonville - Butler Blvd./Southpoint
4940 Mustang Road, Butler Blvd./Southpoint, Jacksonville, FL
2.5/5 (946 reviews)
Sonesta Simply Suites Jacksonville
4990 Belfort Rd, Jacksonville, FL
4.4/5Excellent! (756 reviews)
Margaritaville Jacksonville Beach
715 1st St N, Jacksonville Beach, FL
4.2/5Very Good! (273 reviews)
Quality Inn Atlantic Beach-Mayo Clinic Jax Area
2401 Mayport Rd, Atlantic Beach, FL
4.1/5Very Good! (550 reviews)
Red Roof Inn PLUS+ Jacksonville - Southpoint
6969 Lenoir Avenue E, Jacksonville, FL
3.9/5Very Good! (803 reviews)
SureStay Hotel by Best Western Jacksonville South
5018 University Boulevard West, Jacksonville, FL
3.6/5Good! (387 reviews)
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and popular theater scene. Jacksonville is home to 202 hotels and other accommodations, so you can find something that's perfect for your stay.
Staying Near Mayo Clinic Florida
Take your pick of these hotels and other accommodations, all within a mile of Mayo Clinic Florida:
- The Inn At Mayo Clinic: With a stay at this 3-star condo, guests can enjoy access to free breakfast and free parking, along with an in-room kitchen. Our customers like its beach locale and overall value.
- Courtyard by Marriott Jacksonville Mayo Clinic/Beaches: This 3-star hotel features a restaurant, an outdoor pool, and free WiFi. It's a favorite with Expedia travelers for its pool and clean, comfortable rooms.
- Water Front Home on the Intracoastal Minutes Mayo and the Beach Casa De La Costa: Amenities in this vacation home include a kitchen and a fireplace.
Things to See and Do Near Mayo Clinic Florida
While you're in town visiting Mayo Clinic Florida, you can discover everything there is to see and do within a few miles of the area.
Spend some time exploring the natural beauty of Cradle Creek Preserve, South Beach Park and Sunshine Playground, and Gonzales Park. Take in some of the local culture at Players by the Sea, Beaches Museum & History Park, and J. Johnson Gallery. A trip to Atlantic Village Shopping Center and Beaches Town Center might be just the ticket for souvenir shopping.
Adventure Landing and University of North Florida are both worth a visit while you're checking out the area. You might also stop by St. Johns Town Center, located 5.2 mi (8.4 km) from Mayo Clinic Florida, or TPC Sawgrass which is 5.8 mi (9.3 km) away.
Frequently asked questions
Recent reviews of Mayo Clinic Florida hotels
Expedia Verified Review
5 / 5 Excellent
New modern hotel right on the beach. Everything you need is within walking distance.
A verified traveler stayed at Margaritaville Jacksonville Beach
Posted 7 hours ago
Expedia Verified Review
5 / 5 Excellent
Perfect
A verified traveler from Osprey stayed at Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area, an IHG Hotel
Posted 4 days ago
Expedia Verified Review
5 / 5 Excellent
The staff were very friendly and professional. They were able to assist me with all of my inquiries and needs. 10/10 would recommend and would likely stay again.
A verified traveler stayed at Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Posted 9 days ago
Lovely stay
5 / 5 Excellent
House was very clean! Pool was so relaxing and loved being 5 minutes from the beach. Would definitely stay here again! The hosts were very nice and had great communication!
A verified traveler stayed at The Lagoon Pool House - 1 mile from Mayo Clinic
Posted 10 days ago
Expedia Verified Review
5 / 5 Excellent
Have stayed here many times. Always excellent.
A verified traveler stayed at Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Posted 11 days ago
Expedia Verified Review
5 / 5 Excellent
stayed here from thursday 9/2 thru sunday 9/5. rooms were clean and staff friendly. free breakfast. not just a continental breakfast. they served a full breakfast. would defintintely sstay here again. close to the beach is a major plus. really enjoyed my stay here
A verified traveler stayed at Holiday Inn Express Jacksonville Beach, an IHG Hotel
Posted 11 days ago
Convenient for the Mayo.
5 / 5 Excellent
Very impressed. My wife was being seen at the Mayo Clinic the next, so this worked well for.
A verified traveler stayed at Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Posted 2 weeks ago
Expedia Verified Review
5 / 5 Excellent
Clean
A verified traveler stayed at Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Posted 1 month ago
Vacation Stay
5 / 5 Excellent
The house was very nice. It has everything we needed and was in a very convenient location. It was an enjoyable stay.
A verified traveler stayed at Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Posted 1 month ago
Expedia Verified Review
5 / 5 Excellent
Near Mayo Clinic
A verified traveler stayed at TownePlace Suites by Marriott Jacksonville East
Posted 1 month ago
More trip options
- Other Hotels near Mayo Clinic Florida, Southside
- Hotels near popular Jacksonville Attractions
- Hotels in top Southside neighborhoods
- More Hotel Options in Mayo Clinic Florida
- Expedia's Latest Trends
- Bright and Updated 2 BR Apt
- Entire home
- HCB 53 Suenos Luxury Yacht
- Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
- Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
- Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area
- Cute South Jax Beach House near Mayo
- Holiday Inn Express Jacksonville Beach
- Pablo Waterfront - Private Dock & Salt Water Pool
- Margaritaville Jacksonville Beach
- Frontdesk | Links at Windsor Parke Apts Jacksonville
- Beach Hotels (178)
- Business Hotels (149)
- Family Hotels (192)
- Golf Hotels (166)
- Hotels & Resorts for Couples (135)
- Hotels on the Lake (7)
- Hotels with Connecting Rooms (92)
- Hotels with Free Breakfast (131)
- Hotels with Free Parking (169)
- Hotels with Free Wifi (251)
- Hotels with Hot Tubs (69)
- Hotels with Laundry Facilities (237)
- Hotels with Restaurants (203)
- Hotels with Room Service (46)
- Hotels with a Pool (267)
- Hotels with an Indoor Pool (13)
- Hotels with an Outdoor Pool (266)
- Non-Smoking Hotels (144)
- Pet-friendly Hotels (101)
- Resorts & Hotels with Spas (65)
Hotels
Riverside HotelsWest Jacksonville HotelsHotels near Memorial Hospital JacksonvilleHotels near Jacksonville Cruise TerminalHotels near Ayala CenterHotels near Times-Union Center for the Performing ArtsHotels near Daily's PlaceLegacy Inn and Suites ArtesiaHotels near VyStar Veterans Memorial ArenaHotels near Jacksonville Zoo and GardensQuality Inn Windsor MillFive Points HotelsHotels near River City Market PlaceHotels near Jacksonville Naval Air StationTRU By Hilton WinchesterBeach Hotels in HomosassaHotels near University of North FloridaHotels near TIAA Bank FieldWaterfront Inn - Mackinaw CityHotels near Florida TheatreHotels near Regency SquareHotels near St. Johns Town CenterHotels near Prime F. Osborn Convention CenterHotels near Shands Jacksonville Medical CenterHotels near Jacksonville University