Find hotels near Mayo Clinic Florida, Jacksonville from $103

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Compare 1,854 hotels close to Mayo Clinic Florida with room rates, reviews, and availability. Most hotels are fully refundable.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
0.7 mi from Mayo Clinic Florida
9.4 out of 10, Exceptional, (445)
"Great facility to stay."
United States
Gary
$149 nightly
The price is $169
Dec 19 - Dec 20
Total with taxes and fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

TownePlace Suites by Marriott Jacksonville East

3.0 star property
Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida
9.2 out of 10, Wonderful, (545)
"Very good hotel"
United States
Careli
$114 nightly
The price is $129
Dec 18 - Dec 19
Total with taxes and fees
TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

2.5 star property
Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1001)
"Staff was super friendly and professional...rooms super clean and comfy"
United States
Brian
$103 nightly
The price is $117
Dec 13 - Dec 14
Total with taxes and fees
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.5 star property
1.7 mi from Mayo Clinic Florida
8.6 out of 10, Excellent, (1000)
"Good location for a family vacation "
United States
Angel
$105 nightly
The price is $119
Dec 19 - Dec 20
Total with taxes and fees
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

3.0 star property
0.2 mi from Mayo Clinic Florida
8.4 out of 10, Very Good, (751)
"Nice hotel, close to shops and mayo clinic."
United States
Judy
$161 nightly
The price is $183
Dec 13 - Dec 14
Total with taxes and fees
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Hilton Jacksonville At Mayo Clinic

4.5 star property
0.5 mi from Mayo Clinic Florida
9.4 out of 10, Exceptional, (47)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
$122 nightly
The price is $139
Dec 20 - Dec 21
Total with taxes and fees
Hilton Jacksonville At Mayo Clinic

Salt Air Inn & Suites

2.5 star property
4.8 mi from Mayo Clinic Florida
9.8 out of 10, Exceptional, (403)
"A cute little gem with some of the best hospitality in the area. "
United States
Windy
$127 nightly
The price is $145
Dec 7 - Dec 8
Total with taxes and fees
Salt Air Inn & Suites

TownePlace Suites by Marriott® Jacksonville Mayport

3.0 star property
6.7 mi from Mayo Clinic Florida
9.8 out of 10, Exceptional, (61)
"This was an awesome place to stay."
United States
Christine
$116 nightly
The price is $132
Dec 23 - Dec 24
Total with taxes and fees
TownePlace Suites by Marriott® Jacksonville Mayport

Element Jacksonville Beach

3.0 star property
3.4 mi from Mayo Clinic Florida
9.6 out of 10, Exceptional, (517)
"Clean room and friendly staff."
United States
Lucia
$127 nightly
The price is $144
Dec 21 - Dec 22
Total with taxes and fees
Element Jacksonville Beach

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

2.5 star property
Southside, 4.8 mi from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1004)
"East check in, clean room and very comfortable. Very convenient and comfortable for an overnight stop. Near shops and restaurant. "
United States
Cristina
$133 nightly
The price is $151
Dec 24 - Dec 25
Total with taxes and fees
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

The Hotel Palms

3.5 star property
4.8 mi from Mayo Clinic Florida
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
$169 nightly
The price is $192
Jan 1 - Jan 2, 2026
Total with taxes and fees
The Hotel Palms

Ponte Vedra Inn & Club

5.0 star property
3.9 mi from Mayo Clinic Florida
9.4 out of 10, Exceptional, (812)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
$428 nightly
The price is $474
Jan 4 - Jan 5, 2026
Total with taxes and fees
Ponte Vedra Inn & Club

The Lodge and Club at Ponte Vedra Beach

5.0 star property
3.9 mi from Mayo Clinic Florida
9.4 out of 10, Exceptional, (686)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
$380 nightly
The price is $421
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Lodge and Club at Ponte Vedra Beach

AC Hotel Jacksonville St Johns Town Center

2.5 star property
Southside, 5 mi from Mayo Clinic Florida
9.4 out of 10, Exceptional, (161)
"Staff was excellent...highly recommend this Hotel"
Canada
Robert
$164 nightly
The price is $186
Dec 19 - Dec 20
Total with taxes and fees
AC Hotel Jacksonville St Johns Town Center

Hampton Inn & Suites Jacksonville Deerwood Park

2.5 star property
Southside, 6.9 mi from Mayo Clinic Florida
9.4 out of 10, Exceptional, (1004)
"Great stay"
United States
Mary Jean
$90 nightly
The price is $103
Dec 28 - Dec 29
Total with taxes and fees
Hampton Inn & Suites Jacksonville Deerwood Park

Hyatt Place Jacksonville / St. Johns Town Center

3.0 star property
Southside, 5.4 mi from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1001)
"Good location, friendly staff, clean "
United States
john
$119 nightly
The price is $135
Dec 12 - Dec 13
Total with taxes and fees
Hyatt Place Jacksonville / St. Johns Town Center

Sheraton Jacksonville Hotel

4.0 star property
Deerwood, 5.9 mi from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1003)
"The Sheraton is a very nice hotel!"
United States
Grace
$104 nightly
The price is $118
Dec 21 - Dec 22
Total with taxes and fees
Sheraton Jacksonville Hotel

Hotel Indigo Jacksonville-Deerwood Park by IHG

3.5 star property
Southside, 6.7 mi from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1004)
"Very nice stay "
United States
Timmothy
$114 nightly
The price is $129
Dec 21 - Dec 22
Total with taxes and fees
Hotel Indigo Jacksonville-Deerwood Park by IHG

Best Western Oceanfront

3.0 star property
3.6 mi from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1007)
"The room was clean and the bed was very comfortable! The view was beautiful! I will definitely stay here again in the future "
United States
Tinya
$123 nightly
The price is $140
Dec 16 - Dec 17
Total with taxes and fees
Best Western Oceanfront

Holiday Inn Express Jacksonville Beach by IHG

3.0 star property
2.9 mi from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1001)
"The check in was simple and a room was ready for us before check out time. We were able to rest and sleep well during our stay in Jacksonville Beach."
United States
David
$111 nightly
The price is $126
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Express Jacksonville Beach by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Mayo Clinic Florida Hotel Reviews

Hotels near other Mayo Clinic Florida attractions

Frequently asked questions

What are the top-rated hotels near Mayo Clinic Florida?
Finding the perfect stay near Mayo Clinic Florida can enhance your visit, especially when exploring top-rated hotels that offer comfort and convenience.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is situated within an 18-minute walking distance from Mayo Clinic Florida and has a solid review rating of 9.4. This 3-star hotel provides travelers with a complimentary buffet breakfast each morning, alongside amenities such as an outdoor pool and a well-equipped fitness center available 24/7. The presence of a kitchen in every room, complete with a refrigerator and microwave, allows travelers to prepare meals at their convenience, enhancing their stay in Jacksonville.

Element Jacksonville Beach

Element Jacksonville Beach is a delightful 3-star hotel located just 5.0 miles from Mayo Clinic Florida, with an impressive review rating of 9.6. This hotel offers a variety of amenities including an outdoor pool, a fitness center, and free breakfast—ideal for travelers looking for a refreshing stay. Unique features like a hydromassage showerhead and a fully equipped kitchen with a dishwasher and stovetop elevate the experience, making it a great choice for travelers seeking both relaxation and functionality.

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG is just 4.3 miles from Mayo Clinic Florida, with an excellent review rating of 9.2. This inviting hotel features an outdoor pool and offers a daily buffet breakfast to start the day right. Guests will appreciate the free internet access and the relaxing terrace, while the nearby a nearby beach adds an enjoyable outdoor experience to their visit.
What hotels are within walking distance to Mayo Clinic Florida?
Discover the convenience of staying near Mayo Clinic Florida with these top-rated hotels that provide comfort and accessibility for your visit.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is a welcoming 3-star hotel just an 18-minute walk from Mayo Clinic Florida, rated 9.4 by travelers. Guests appreciate the spacious rooms featuring kitchen amenities such as a dishwasher and microwave, along with the convenience of free daily breakfast. The outdoor pool and 24-hour fitness center provide great options for relaxation and exercise, while the garden area enhances the overall ambiance.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches offers a prime location only 3 minutes from Mayo Clinic Florida, a review rating of 8.4. This 3-star hotel features an outdoor pool and a well-equipped fitness center, ensuring travelers have ample opportunities to unwind. With modern amenities like premium bedding and a snack bar, visitors can enjoy a comfortable stay close to their medical appointments.
How much is a hotel near Mayo Clinic Florida?
Staying near Mayo Clinic Florida is a treat, with plenty of hotels from $103 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, especially in peak season. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a vacation during weekends or around public holidays.
What are the most popular family-friendly hotels near Mayo Clinic Florida?
For families visiting Mayo Clinic Florida, these top-rated hotels offer a perfect blend of comfort and convenience during your stay in Jacksonville.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area, rated 9.4 by travelers, is only an 18-minute walk from Mayo Clinic Florida. This 3-star hotel is designed with families in mind, offering spacious suites with kitchen facilities and free rollaway beds. Guests can take advantage of the outdoor pool, 24-hour fitness center, and complimentary breakfast to start their day right.

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG offers a family-friendly experience just 4.3 miles from Mayo Clinic Florida, with a great traveler rating score of 9.2. Families will appreciate the free cribs, connecting rooms, and outdoor pool. Additional amenities include a complimentary breakfast served daily and easy access to the nearby beach, making it a great option for relaxation after a visit to the clinic.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG is a family-friendly hotel located just 3.0 miles from Mayo Clinic Florida. With a review rating of 8.4, this hotel features amenities such as free cribs, connecting rooms, and complimentary buffet breakfast, ensuring a comfortable stay for families. Guests can also enjoy an outdoor pool and easy access to nearby shopping and golf courses.
Which hotels near Mayo Clinic Florida offer the best views?
Discover top-rated hotels near Mayo Clinic Florida that not only provide comfort but also stunning views.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG is a welcoming 3-star hotel located just 3.0 miles from Mayo Clinic Florida, rated 8.4 by travelers. This hotel features an outdoor pool with golf course views, perfect for relaxation after a day of appointments. Guests can enjoy a complimentary buffet breakfast daily, along with access to fitness facilities and free self-parking. A nearby shopping center adds to the convenience, making it an ideal choice for those seeking both comfort and scenic views.
What are the best affordable hotels near Mayo Clinic Florida?
Finding affordable and comfortable accommodations near Mayo Clinic Florida is essential for travelers seeking a smooth experience. Here are some top-rated options that cater to both convenience and budget.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is a 3-star hotel situated a short 18-minute walk from Mayo Clinic Florida, with a great traveler rating score of 9.4. This hotel is perfect for families, offering free breakfast daily and a kitchen in each suite for convenient meal preparation. Additional amenities include an outdoor pool, 24-hour fitness facilities, and free self-parking, making it a practical choice for extended stays or quick visits alike.

Element Jacksonville Beach

Element Jacksonville Beach is a 3-star hotel located just 5.0 miles from Mayo Clinic Florida, with an impressive review rating of 9.6. This family-friendly hotel offers complimentary breakfast options, including a cooked breakfast and free WiFi, ensuring a pleasant start to your day. Guests can enjoy amenities such as an outdoor pool, fitness center, and fully-equipped kitchens in select rooms, making it an ideal choice for those looking for a comfortable and affordable stay.

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG is located 4.3 miles from Mayo Clinic Florida and has a solid review rating of 9.2. This hotel provides a complimentary buffet breakfast and free WiFi, suiting families and budget-conscious travelers. Guests can also take advantage of the outdoor pool, free self-parking, and nearby beach access, ensuring a relaxing and enjoyable experience during their stay.
Are there any hotels with pools close to Mayo Clinic Florida?
For those seeking a refreshing dip during their stay near Mayo Clinic Florida, there are excellent hotels with pools in Jacksonville. Here are some top-rated options to consider.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Just an 18-minute walk from Mayo Clinic Florida, the 3-star Residence Inn By Marriott Jacksonville offers a fantastic outdoor pool equipped with sun loungers and a poolside bar, perfect for relaxation after a long day. Rated 9.4 by travelers, this hotel features free buffet breakfast, a fitness center available 24/7, and spacious rooms complete with kitchen facilities, making it ideal for both short and extended stays.

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Located 3.5 miles from Mayo Clinic Florida, the Hampton Inn features an inviting outdoor pool with accessible options and sun loungers, rated 8.8 by travelers. Guests can enjoy a complimentary breakfast daily and access to fitness facilities. With nearby beach access, this hotel offers a blend of relaxation and convenience, perfect for those needing nearby the clinic.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Situated 3 miles from Mayo Clinic Florida, the Holiday Inn Express boasts an outdoor pool surrounded by sun loungers and umbrellas, rated 8.4 by travelers. Guests can indulge in a free breakfast each morning and benefit from modern amenities including a fitness center. This hotel is a great choice for those looking for comfort and convenience close to medical facilities.
What are the best pet-friendly hotels near Mayo Clinic Florida?
Searching for the best pet-friendly hotels near Mayo Clinic Florida? Look no further, as these top-rated options ensure a comfortable stay for both you and your furry companions.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

The Residence Inn By Marriott Jacksonville - Mayo Clinic Area is just an 18-minute walk from Mayo Clinic Florida and boasts an impressive review rating of 9.4. This 3-star hotel welcomes pets with amenities such as in-room pet accommodations and service animals. Guests can enjoy a complimentary buffet breakfast, an outdoor pool, and a well-equipped fitness center, making it a great choice for travelers seeking comfort and convenience.

Holiday Inn Express Jacksonville Beach by IHG

Located 4.3 miles from Mayo Clinic Florida, the Holiday Inn Express Jacksonville Beach by IHG is a fantastic option for pet owners, rated 9.2 by travelers. This hotel allows pets and offers amenities like free breakfast and an outdoor pool. Guests will appreciate the nearby sandy beach, making it perfect for leisurely walks with their dogs after a day at the clinic.

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

The Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area is a pet-friendly haven situated just 3.5 miles from Mayo Clinic Florida, with a great traveler rating score of 8.8. This hotel features in-room pet accommodations and a complimentary breakfast. Guests can unwind at the outdoor pool or explore the nearby beach, ensuring a pleasant stay for both pets and their owners.
Can I book a fully refundable hotel close to Mayo Clinic Florida?
Most bookings on Expedia are refundable if canceled within 24-48 hours of arrival, though this depends on the hotel's individual cancellation policy, which you should check in your booking confirmation. If free cancellation is available, you can cancel directly through your Expedia account by going to "My Trips" and selecting your reservation. To find fully refundable hotel options, simply enter "Mayo Clinic Florida", set your travel dates, and use the "Fully refundable" filter under "Deals & Discounts" on the results page. Alternatively, explore deals with free cancellation options on Expedia.
Can I find Expedia discounts for hotels near Mayo Clinic Florida?
To look for discounts on hotels near Mayo Clinic Florida, join One Key™—our free travel rewards program. One Key members always get our best prices and earn OneKeyCash™* on eligible bookings for every dollar spent. Another way to save is by bundling your hotel and flights together on Expedia.

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