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Our top choices for Mesopotamia hotels

To Spiti tis Sofias

To Spiti tis Sofias
Kastoria
10.0 out of 10, Exceptional, (1)
"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin. "
France
Anonymous traveler
$67 nightly
The price is $77
Jan 20 - Jan 21, 2026
Total with taxes and fees
To Spiti tis Sofias

Guesthouse Monopati

Guesthouse Monopati
Amyntaio
10.0 out of 10, Exceptional, (3)
Guesthouse Monopati

Limneon Resort & Spa

Limneon Resort & Spa
4.0 star property
Kastoria
9.2 out of 10, Wonderful, (197)
"Wonderful stay. "
Canada
Konstantinos
$100 nightly
The price is $118
Jan 11 - Jan 12, 2026
Total with taxes and fees
Limneon Resort & Spa

Kyknos De Luxe Hotel

Kyknos De Luxe Hotel
Kastoria
10.0 out of 10, Exceptional, (43)
"Very nice clean, very polite staff and great breakfast!"
United States
Vasilios
$91 nightly
The price is $105
Jan 11 - Jan 12, 2026
Total with taxes and fees
Kyknos De Luxe Hotel

Guest House Ilektra

Guest House Ilektra
Voio
9.6 out of 10, Exceptional, (9)
"Wonderful views, easy to find, spacious rooms, and great hospitality."
United Kingdom
Maria
$61 nightly
The price is $70
Dec 29 - Dec 30
Total with taxes and fees
Guest House Ilektra

Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel
4.0 star property
Kastoria
9.0 out of 10, Wonderful, (84)
"The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing. "
United States
Michal
Esperos Palace Luxury & Spa Hotel

Chloe Hotel

Chloe Hotel
3.0 star property
Kastoria
10.0 out of 10, Exceptional, (86)
"We enjoyed the stay, friendly staff and nice breakfast "
Australia
Fani
$102 nightly
The price is $118
Jan 9 - Jan 10, 2026
Total with taxes and fees
Chloe Hotel

Calma Hotel & Spa

Calma Hotel & Spa
4.0 star property
Kastoria
9.6 out of 10, Exceptional, (35)
"Pleasant stay. Good amenities. Great staff. "
New Zealand
Robert
Calma Hotel & Spa

Guesthouse Vissinokipos

Guesthouse Vissinokipos
Kastoria
9.4 out of 10, Exceptional, (10)
"Wonderfull view and very friendly people.the place is avery dpecial artistic decorated.wonderfull weather.nice varieties for breakfast.price was ver good.i recommend it!"
United States
Carmen
Guesthouse Vissinokipos

Anesis Hotel

Anesis Hotel
2.0 star property
Kastoria
9.0 out of 10, Wonderful, (9)
"Fantastic hotel in the heart of Kastoria. The owners are lovely people, very helpful and made me feel right at home. Will definitely stay there again!"
Canada
Adam
$54 nightly
The price is $62
Jan 12 - Jan 13, 2026
Total with taxes and fees
Anesis Hotel

Andromeda Boutique hotel

Andromeda Boutique hotel
4.0 star property
Kastoria
8.8 out of 10, Excellent, (3)
Andromeda Boutique hotel

The Sunset Haven Kastoria Modern Lake Elegance

The Sunset Haven Kastoria Modern Lake Elegance
Kastoria
$173 nightly
The price is $197
Dec 30 - Dec 31
Total with taxes and fees
The Sunset Haven Kastoria Modern Lake Elegance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mesopotamia Hotel Reviews

More cheap stays in Mesopotamia

Hotels in Mesopotamia with star-rating

Find out more about Mesopotamia

Top reasons to visit Mesopotamia

  • Outdoor Adventures: Mesopotamia offers stunning landscapes and opportunities for hiking and exploring nature.
  • Rich Cultural Experiences: Discover fascinating history museums and local traditions that showcase the village's heritage.
  • Romantic Settings: Enjoy picturesque views and cozy spots perfect for couples looking to unwind.
  • Family-Friendly Atmosphere: The welcoming community and diverse activities make it ideal for travelers of all ages.
  • Relaxing Accommodations: Stay in inviting hotels with spa-themed experiences for a rejuvenating getaway.

Find great hotels near Mesopotamia

Discover a range of inviting hotels in Mesopotamia, Western Macedonia, perfect for business travelers and adventure seekers alike. With a focus on spa-themed experiences, these accommodations offer a blend of comfort and modern amenities. Whether you're searching for the best hotels or competitive room rates, you'll find options that cater to your every need, ensuring a memorable stay in this charming region of Greece.

  • Esperos Palace Luxury & Spa Hotel: Nestled 5 miles from Mesopotamia, the Esperos Palace Luxury & Spa Hotel is a 4-star oasis ideal for business travelers seeking a touch of relaxation. This property boasts a sophisticated business environment with amenities like a Conference Center and multiple Meeting Rooms. Guests can unwind in the full-service spa, which offers soothing massages, a steam room, and a traditional Turkish bath, alongside an indoor pool. Luxurious and serene, this hotel perfectly blends work and leisure, making it a top choice for those looking to rejuvenate after a busy day.
  • Hotel Anastassiou: Located 5 miles away from Mesopotamia, Hotel Anastassiou is the perfect getaway for adventure and business enthusiasts alike. With immediate access to ski lifts and shuttles, guests can easily enjoy exhilarating activities such as skiing, snowboarding, and kayaking nearby. The hotel caters to business needs with a dedicated Business Center and Meeting Rooms. Whether you’re carving down snowy slopes or conducting meetings, this hotel offers a unique blend of excitement and efficiency, ensuring an unforgettable stay for every traveler.
  • Kyknos De Luxe Hotel: A stylish 3.5-star accommodation situated 5 miles from Mesopotamia, the Kyknos De Luxe Hotel caters to travelers seeking luxury and a business-friendly atmosphere. With well-appointed rooms and essential business amenities, including meeting facilities, this hotel ensures comfort and convenience. Its upscale design and inviting ambiance make it an appealing choice for those looking to combine a high-quality stay with the necessities of a productive trip. Guests can expect attentive service and a relaxing environment, perfect for unwinding after a busy day.

Where to stay in Mesopotamia

Mesopotamia, a charming village in Western Macedonia, Greece, offers a delightful blend of outdoor adventures, romantic getaways, and rich cultural experiences. Nearby cities and neighborhoods provide a family-friendly atmosphere with options for every budget. Enjoy stunning city views and explore the scenic area around Mesopotamia, where friendly locals and trendy spots await. Whether you're seeking relaxation or excitement, this region has something special for every traveler.

  • Kastoria: Nestled in the heart of Western Macedonia, Kastoria is a picturesque city surrounded by stunning landscapes and the serene Lake Orestiada. Known for its outdoor adventures and scenic beauty, visitors flock here to enjoy activities like skiing in the nearby mountains and relaxing in local spas. The city boasts a rich history, with captivating historic sites and monasteries that reflect its cultural heritage. A stroll through its charming streets offers a glimpse into traditional life, while the breathtaking views of the lake and mountains provide a perfect backdrop for memorable photographs.
  • Árgos Orestikón: Just a short drive from Mesopotamia, Árgos Orestikón is a vibrant city rich in cultural experiences. With a focus on history and heritage, visitors can explore fascinating museums and archaeological sites that showcase the region's storied past. The city is a cultural hub where travelers can immerse themselves in local traditions and craftsmanship. The inviting atmosphere, paired with seasonal festivities peaking in the fall and winter, makes Árgos Orestikón a delightful stop on your journey.
  • Dispilio: Located near the shores of Lake Orestiada, Dispilio is a charming village perfect for those seeking adventure and outdoor sports. The area is popular for skiing, with easy access to ski resorts and fields, making it a winter wonderland for snow enthusiasts. In addition to its thrilling activities, Dispilio offers beautiful lakeside views and cultural experiences, including local museums that delve into the region’s heritage. With its moderate tourist season peaking in the summer, this village is an ideal retreat for nature lovers and adventure seekers alike.

Things to do in Mesopotamia

Mesopotamia, nestled in the picturesque region of Kastoria, offers a delightful mix of outdoor adventures, romantic settings, and rich cultural experiences. Visitors can enjoy visits to local attractions, indulge in the beautiful scenery, and embark on available trips that highlight the area's charm. While there may not be an amusement park directly in Mesopotamia, the surrounding natural beauty and cultural activities provide plenty of entertainment for a memorable vacation.

Shopping

In Mesopotamia, visit local shops for unique souvenirs and gifts. If you're up for a drive, check out the nearby Kozani Mall, offering a range of retail options, from fashion to home goods. Enjoy the vibrant atmosphere and local craftsmanship in the area.

Recreation

Experience the tranquility of the Mesopotamia Wellness Center, where you can indulge in rejuvenating spa treatments and yoga sessions amidst serene natural surroundings. Afterward, explore the beautiful nearby hiking trails, offering stunning views of the landscape, perfect for relaxation and reflection.

Adventure

In Mesopotamia, explore the beautiful Lake Orestiada for kayaking and fishing adventures. Nearby, the stunning Vitsi Mountain offers hiking trails with breathtaking views, perfect for outdoor enthusiasts. Engage with local culture through traditional cuisine and festivals that showcase the rich heritage of Western Macedonia.

Nightlife

The nightlife in Mesopotamia is vibrant and welcoming. Enjoy a lively evening at the local tavern, where you can savor traditional Greek meze while sipping ouzo. For a more energetic vibe, check out the nearby bar featuring live music that keeps the atmosphere buzzing until late.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Mesopotamia

To save money on your trip to Mesopotamia, consider visiting in March or October to November when prices are lower. Book your hotel about a month in advance or check for last-minute deals on Expedia, especially on Saturdays for the best rates. Utilize Expedia's search tool to find budget-friendly accommodations by filtering prices from lowest to highest. Take advantage of package deals by combining hotels with flights and activities for extra savings. Joining Expedia's One Key membership can provide exclusive discounts and help you earn rewards for future stays.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Mesopotamia are March and October to November, where the prices are slightly lower. This is in comparison to April and July to August, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel in Mesopotamia is usually 1 month out from when you are planning to stay. If you're a little more spontaneous, you could also peruse Expedia's last minute deals which could secure you a cheaper stay. Look out for the green banner below the price to spot the deals.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Mesopotamia is Saturday. The most expensive day to stay in Mesopotamia is Thursday.
  • Find cheap hotels on Expedia: Try utilizing Expedia's search tool to refine your choices based on your budget, desired location, and the type of hotel you're looking for. To find the best prices and deals available, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Mesopotamia with your flights and activities through an Expedia package.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Mesopotamia

Mesopotamia in Kastoria, Western Macedonia, Greece, is perfect for outdoor, romantic, and culture-themed vacations. Visitors can explore beautiful lakes, fascinating history museums, and notable landmarks. The area's points of interest offer a blend of cultural experiences, scenic views, and opportunities to enjoy the beach, making it an ideal destination for travelers seeking a rich and diverse getaway.

  • Kastoria Lake: Nestled 5 miles from Mesopotamia, Kastoria Lake is a serene escape with picturesque scenery, perfect for romantic walks or outdoor activities. Enjoy the tranquil vibe while taking in the stunning natural beauty.
  • Taxiarhia of the Metropolis: Located 5 miles away, this landmark offers a blend of trendy and luxurious experiences while remaining budget-friendly. It's an ideal spot to appreciate local culture and architecture.
  • Byzantine Museum of Kastoria: Just 6 miles from Mesopotamia, this museum immerses you in the rich history and culture of the Byzantine era, showcasing remarkable artifacts that tell a story of the past.

Best time to go to Mesopotamia

The best time to visit Mesopotamia can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Mesopotamia falls in August, when visitor numbers are moderately high and weather is sunny with no rain. The coolest average temperature in Mesopotamia falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January32.5°F (0.3°C)Light RainMostly SunnyModerately LowAverage
February36.1°F (2.3°C)Light RainMostly SunnyModerately LowAverage
March41.7°F (5.4°C)Light RainMostly SunnyAverageSlightly Low
April50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly High
May57.9°F (14.4°C)Light RainMostly SunnyAverageAverage
June66.0°F (18.9°C)No RainMostly SunnyAverageAverage
July72.3°F (22.4°C)No RainSunnyModerately HighSlightly High
August72.5°F (22.5°C)No RainSunnyModerately HighSlightly High
September64.2°F (17.9°C)No RainMostly SunnyModerately HighAverage
October54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
November45.1°F (7.3°C)Light RainMostly SunnyModerately LowSlightly Low
December36.3°F (2.4°C)Light RainMostly SunnyAverageAverage

The nearest major airports for your trip to Mesopotamia

Traveling to Mesopotamia, Greece, can be conveniently done via two major airports. Kozani Airport (KZI-Filippos) is located 38 miles away, with nearby hotel options including Elimeia 3, a 3-star hotel 9 miles from the airport, and Anesis Hotel, just 2 miles away. Kastoria Airport (KSO-Aristoteles) is closer at 7 miles from Mesopotamia, offering luxurious stays like Limneon Resort & Spa, a 5-star hotel 3 miles away, and Orologopoulos Mansion, also 5-star and 5 miles away. Hotels near Kastoria provide various transportation services, including free airport shuttles and on-request transfers, ensuring a smooth travel experience.

Frequently asked questions

What is the best area to stay in Mesopotamia?
The best area to stay in Mesopotamia, Western Macedonia, Greece, is within the town center itself, particularly along the main thoroughfare of Eparchiaki Odos Kastorias-Mesopotamias.

This central area is where you'll find most of the town's amenities, including local shops, bakeries, and traditional tavernas. It's a convenient base for exploring the surrounding region, with easy access to roads leading to nearby attractions. Families appreciate this area for its practicality and the ease of finding essentials close by.

For those seeking a more tranquil experience, the residential streets just off the main road offer a quieter alternative. These areas provide a peaceful setting while still being within a short walk of the town center's conveniences.
When is the best time to go to Mesopotamia?
The best time to visit Mesopotamia, Western Macedonia, Greece, is during the late spring (May to early June) and early autumn (September to early October) when the weather is pleasant and comfortable for exploring.

During these months, you'll experience mild temperatures, typically ranging from the mid-60s to high 70s Fahrenheit (18-26°C), with less humidity and fewer crowds than the peak summer months. This makes it ideal for outdoor activities like hiking in the surrounding mountains or visiting local historical sites without the intense heat. Travelers looking for a relaxing trip with comfortable weather will find these periods particularly appealing.

For those interested in cultural events and local festivals, early autumn often features grape harvests and traditional celebrations, offering a unique insight into the region's heritage.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Mesopotamia.
How can I save on a Mesopotamia hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Mesopotamia hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Mesopotamia hotel?
Prices for hotels in Mesopotamia often vary, but you can find a great deal from $62 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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