Title: TOP 10 Hotels in Mesopotamia (from $64) - COMPETITIVE PRICES | Expedia.com [Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6335336)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6335336.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6335336.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6335336.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.com/Mesopotamia.d6335336.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Mesopotamia Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Kastoria%2C+Western+Macedonia%2C+Greece®ionId=6335336&latLong=40.50174%2C21.165957&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=PETS) ## Check prices for these dates Tonight [Mar 25 - Mar 26](https://www.expedia.com/Hotel-Search?regionId=6335336&startDate=2026-03-25&endDate=2026-03-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 26 - Mar 27](https://www.expedia.com/Hotel-Search?regionId=6335336&startDate=2026-03-26&endDate=2026-03-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6335336&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6335336&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mesopotamia hotels ![Interior](https://images.trvl-media.com/lodging/101000000/100780000/100775800/100775775/68e1bf42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/101000000/100780000/100775800/100775775/5765e6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/101000000/100780000/100775800/100775775/293745cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/101000000/100780000/100775800/100775775/d97c5d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### To Spiti tis Sofias [](https://www.expedia.com/Kastoria-Hotels-To-Spiti-Tis-Sofias.h100775775.Hotel-Information) Kastoria 10/10 Exceptional (1 review) "Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin. " ![France](https://a.travel-assets.com/egds/marks/flags/fr.svg) Anonymous traveler $65 nightly $77 total Apr 14 - Apr 15 Total with taxes and fees [](https://www.expedia.com/Kastoria-Hotels-To-Spiti-Tis-Sofias.h100775775.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/20000000/19520000/19518600/19518575/154a1dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/20000000/19520000/19518600/19518575/6e5f574e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/20000000/19520000/19518600/19518575/e21f5828.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/20000000/19520000/19518600/19518575/b7911c36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Guest House Ilektra [](https://www.expedia.com/Voio-Hotels-Guest-House-Ilektra.h19518575.Hotel-Information) Voio 9.8/10 Exceptional (11 reviews) "Friendly and courteous hosts, great food and excellent service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pantelia $61 nightly $70 total Mar 26 - Mar 27 Total with taxes and fees [](https://www.expedia.com/Voio-Hotels-Guest-House-Ilektra.h19518575.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/127000000/126560000/126554100/126554079/d99163c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Double Room | In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126560000/126554100/126554079/3318cc24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126560000/126554100/126554079/2edaf936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/127000000/126560000/126554100/126554079/6b58ef61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Le Marron [](https://www.expedia.com/Voio-Hotels-Le-Marron.h126554079.Hotel-Information) Voio $99 nightly $116 total Mar 26 - Mar 27 Total with taxes and fees [](https://www.expedia.com/Voio-Hotels-Le-Marron.h126554079.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/19000000/18340000/18331700/18331611/4efcf6fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18340000/18331700/18331611/a9a22dd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/19000000/18340000/18331700/18331611/61d57c32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, Lake View | Individually decorated, soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/19000000/18340000/18331700/18331611/1df39c06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Guesthouse Vissinokipos [](https://www.expedia.com/Kastoria-Hotels-Guesthouse-Vissinokipos.h18331611.Hotel-Information) Kastoria 9.4/10 Exceptional (10 reviews) "Wonderfull view and very friendly people.the place is avery dpecial artistic decorated.wonderfull weather.nice varieties for breakfast.price was ver good.i recommend it!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carmen [](https://www.expedia.com/Kastoria-Hotels-Guesthouse-Vissinokipos.h18331611.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/5000000/4970000/4967200/4967133/bf0edcd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4970000/4967200/4967133/82f1b7b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/5000000/4970000/4967200/4967133/7b18d73a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4970000/4967200/4967133/29cb6748.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Esperos Palace Luxury & Spa Hotel [](https://www.expedia.com/Kastoria-Hotels-Esperos-Palace-Luxury-Spa-Hotel.h4967133.Hotel-Information) Kastoria 9.0/10 Wonderful (84 reviews) "The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michal [](https://www.expedia.com/Kastoria-Hotels-Esperos-Palace-Luxury-Spa-Hotel.h4967133.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/14000000/13380000/13370900/13370805/aba1ef30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13380000/13370900/13370805/e63d45bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/14000000/13380000/13370900/13370805/7b4f5682.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom | Living area | LED TV](https://images.trvl-media.com/lodging/14000000/13380000/13370900/13370805/54f88421.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Orologopoulos Mansion [](https://www.expedia.com/Kastoria-Hotels-Orologopoulos-Mansion.h13370805.Hotel-Information) Kastoria 9.6/10 Exceptional (36 reviews) "Ideal accommodation in a tranquil area of the town, surrounded by character buildings. Several quality eating locations near by." ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Mark $101 nightly $120 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Kastoria-Hotels-Orologopoulos-Mansion.h13370805.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320031/1a61bc01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320031/777f6cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320031/9ba64b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320031/cb9be105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Anesis Hotel [](https://www.expedia.com/Kastoria-Hotels-Anesis-Hotel.h12320031.Hotel-Information) Kastoria 9.0/10 Wonderful (9 reviews) "Fantastic hotel in the heart of Kastoria. The owners are lovely people, very helpful and made me feel right at home. Will definitely stay there again!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Adam $55 nightly $64 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Kastoria-Hotels-Anesis-Hotel.h12320031.Hotel-Information) ![Lunch and dinner served](https://images.trvl-media.com/lodging/75000000/74430000/74421200/74421141/bf296f09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74430000/74421200/74421141/d1622ff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served](https://images.trvl-media.com/lodging/75000000/74430000/74421200/74421141/a33f09b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/75000000/74430000/74421200/74421141/9efd4fc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Guesthouse Monopati [](https://www.expedia.com/Amyntaio-Hotels-Guesthouse-Monopati.h74421141.Hotel-Information) Amyntaio 10/10 Exceptional (3 reviews) [](https://www.expedia.com/Amyntaio-Hotels-Guesthouse-Monopati.h74421141.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320036/w6487h5400x7y9-009caa8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320036/18af8a49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double or Twin Room | Premium bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320036/d5c55cab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320036/5972a4f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Calma Hotel & Spa [](https://www.expedia.com/Kastoria-Hotels-Calma-Hotel-Spa.h12320036.Hotel-Information) Kastoria 9.6/10 Exceptional (35 reviews) "Pleasant stay. Good amenities. Great staff. " ![New Zealand](https://a.travel-assets.com/egds/marks/flags/nz.svg) Robert [](https://www.expedia.com/Kastoria-Hotels-Calma-Hotel-Spa.h12320036.Hotel-Information) ![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/5000000/4800000/4791800/4791757/24141309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with satellite channels, TV](https://images.trvl-media.com/lodging/5000000/4800000/4791800/4791757/90243f5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4800000/4791800/4791757/3ebef3e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4800000/4791800/4791757/6e4b8b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kyknos De Luxe Hotel [](https://www.expedia.com/Kastoria-Hotels-Kyknos-De-Luxe-Hotel.h4791757.Hotel-Information) Kastoria 10/10 Exceptional (43 reviews) "Very nice clean, very polite staff and great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vasilios $87 nightly $105 total Apr 7 - Apr 8 Total with taxes and fees [](https://www.expedia.com/Kastoria-Hotels-Kyknos-De-Luxe-Hotel.h4791757.Hotel-Information) ![House | 2 bedrooms](https://images.trvl-media.com/lodging/124000000/123540000/123533000/123532946/19dc8c61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 2 bedrooms](https://images.trvl-media.com/lodging/124000000/123540000/123533000/123532946/d3390b94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 2 bedrooms](https://images.trvl-media.com/lodging/124000000/123540000/123533000/123532946/c7834e8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 2 bedrooms](https://images.trvl-media.com/lodging/124000000/123540000/123533000/123532946/eba32f9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Anastasia s Kastoria Cozy Modern Garden Retreat [](https://www.expedia.com/Kastoria-Hotels-Anastasia-S-Kastoria-Cozy-Modern-Garden-Retreat.h123532946.Hotel-Information) Kastoria [](https://www.expedia.com/Kastoria-Hotels-Anastasia-S-Kastoria-Cozy-Modern-Garden-Retreat.h123532946.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/89000000/88290000/88283900/88283893/2c3bb5a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room | In-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/89000000/88290000/88283900/88283893/b1efecbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/89000000/88290000/88283900/88283893/faf466e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/89000000/88290000/88283900/88283893/45db7f2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Andromeda Boutique hotel [](https://www.expedia.com/Kastoria-Hotels-Andromeda-Boutique-Hotel.h88283893.Hotel-Information) Kastoria 8.8/10 Excellent (3 reviews) [](https://www.expedia.com/Kastoria-Hotels-Andromeda-Boutique-Hotel.h88283893.Hotel-Information) ![2 bars/lounges](https://images.trvl-media.com/lodging/14000000/13240000/13236700/13236658/8b1d5aa1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/14000000/13240000/13236700/13236658/1725b636.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, Lake View | Minibar, in-room safe, desk, soundproofing](https://images.trvl-media.com/lodging/14000000/13240000/13236700/13236658/c6af0d88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/14000000/13240000/13236700/13236658/69491c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Limneon Resort & Spa [](https://www.expedia.com/Kastoria-Hotels-Limneon-Resort-Spa.h13236658.Hotel-Information) Kastoria 9.2/10 Wonderful (199 reviews) "Wonderful stay. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Konstantinos $93 nightly $118 total Apr 22 - Apr 23 Total with taxes and fees [](https://www.expedia.com/Kastoria-Hotels-Limneon-Resort-Spa.h13236658.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3590000/3580400/3580393/5a9847cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, Lake View | View from room](https://images.trvl-media.com/lodging/4000000/3590000/3580400/3580393/f5d3f1dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/4000000/3590000/3580400/3580393/37147189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/4000000/3590000/3580400/3580393/61858d6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Chloe Hotel [](https://www.expedia.com/Kastoria-Hotels-Chloe-Hotel.h3580393.Hotel-Information) Kastoria 10/10 Exceptional (87 reviews) "We enjoyed the stay, friendly staff and nice breakfast " ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Fani $121 nightly $144 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/Kastoria-Hotels-Chloe-Hotel.h3580393.Hotel-Information) ![Apartment | Interior](https://images.trvl-media.com/lodging/127000000/126450000/126447800/126447709/w1600h836x0y0-c68609e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | Interior](https://images.trvl-media.com/lodging/127000000/126450000/126447800/126447709/w1600h835x0y0-004cee4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/127000000/126450000/126447800/126447709/cdac8d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | Jetted tub](https://images.trvl-media.com/lodging/127000000/126450000/126447800/126447709/4055bf7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lūma Retreat [](https://www.expedia.com/Kastoria-Hotels-Luma-Retreat.h126447709.Hotel-Information) Kastoria [](https://www.expedia.com/Kastoria-Hotels-Luma-Retreat.h126447709.Hotel-Information) ![Apartment | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/123000000/122570000/122560500/122560404/da27481d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/123000000/122570000/122560500/122560404/43f9dc33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/123000000/122570000/122560500/122560404/a411bbb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/123000000/122570000/122560500/122560404/c8716788.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Sunset Haven Kastoria Modern Lake Elegance [](https://www.expedia.com/Kastoria-Hotels-The-Sunset-Haven-Kastoria-Modern-Lake-Elegance.h122560404.Hotel-Information) Kastoria [](https://www.expedia.com/Kastoria-Hotels-The-Sunset-Haven-Kastoria-Modern-Lake-Elegance.h122560404.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-08&endDate=2026-04-09®ionId=6335336&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Hotels.d6335336.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Hotels.d6335336.Travel-Guide-Hotels) ## Top Mesopotamia Hotel Reviews ![Limneon Resort & Spa](https://images.trvl-media.com/lodging/14000000/13240000/13236700/13236658/8b1d5aa1_y.jpg) ### Limneon Resort & Spa 10/10 Excellent "This is an incredible hotel for families - child friendly, clean, and wonderful facilities. There is a small indoor play zone with someone who looks after the kids. The breakfast buffet is fantastic. The indoor pool is lovely. Everyone that works here is the kindest! My family and I had a wonderful stay " [](https://expedia.com/Kastoria-Hotels-Limneon-Resort-Spa.h13236658.Hotel-Information) ![Guest House Ilektra](https://images.trvl-media.com/lodging/20000000/19520000/19518600/19518575/154a1dd3_y.jpg) ### Guest House Ilektra 10/10 Excellent "Friendly and courteous hosts, great food and excellent service " [](https://expedia.com/Voio-Hotels-Guest-House-Ilektra.h19518575.Hotel-Information) ![Kyknos De Luxe Hotel](https://images.trvl-media.com/lodging/5000000/4800000/4791800/4791757/24141309_y.jpg) ### Kyknos De Luxe Hotel 10/10 Excellent "The staff was warm and welcoming. The rooms were amazing and the breakfast was fantastic. Lots of ethnic Greek foods" [](https://expedia.com/Kastoria-Hotels-Kyknos-De-Luxe-Hotel.h4791757.Hotel-Information) ![Calma Hotel & Spa](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320036/w6487h5400x7y9-009caa8e_y.jpg) ### Calma Hotel & Spa 8/10 Good "We arrived off season , We felt like the hotel was in a sleepy mood, we arrived late and although the reception was working all the lights at the loby where shut. In general it felt like the hotel has great potential, but even the pool was drained. The breakfast was served in a very small portions and didn't felt fresh. May be on season this hotel will be a better choice The room was clean and comfortable Friendly reception staff Specus parking Please help the sweet gray cat he got some trouble with his eye 🙏" [](https://expedia.com/Kastoria-Hotels-Calma-Hotel-Spa.h12320036.Hotel-Information) ![Orologopoulos Mansion](https://images.trvl-media.com/lodging/14000000/13380000/13370900/13370805/aba1ef30_y.jpg) ### Orologopoulos Mansion 8/10 Good "Ideal accommodation in a tranquil area of the town, surrounded by character buildings. Several quality eating locations near by." [](https://expedia.com/Kastoria-Hotels-Orologopoulos-Mansion.h13370805.Hotel-Information) ![Esperos Palace Luxury & Spa Hotel](https://images.trvl-media.com/lodging/5000000/4970000/4967200/4967133/bf0edcd5_y.jpg) ### Esperos Palace Luxury & Spa Hotel 10/10 Excellent "The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing. " [](https://expedia.com/Kastoria-Hotels-Esperos-Palace-Luxury-Spa-Hotel.h4967133.Hotel-Information) ![Chloe Hotel](https://images.trvl-media.com/lodging/4000000/3590000/3580400/3580393/5a9847cb_y.jpg) ### Chloe Hotel 10/10 Excellent "Romantic and special. Highly recommend. Kastoria is a rare find. This hotel is a great getaway. " [](https://expedia.com/Kastoria-Hotels-Chloe-Hotel.h3580393.Hotel-Information) ## More cheap stays in Mesopotamia ![Anesis Hotel](https://images.trvl-media.com/lodging/13000000/12330000/12320100/12320031/1a61bc01_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Anesis Hotel Grammou 10 Kastoria $55 nightly $64 total Mar 31 - Apr 1 Total with taxes and fees 9/10 Wonderful! (9 reviews) [](https://expedia.com/Kastoria-Hotels-Anesis-Hotel.h12320031.Hotel-Information) ![Hotel Anastassiou](https://images.trvl-media.com/lodging/7000000/6140000/6136500/6136437/92fd8775_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Anastassiou 1st km Highway Kastoria-Athens Kastoria Western Macedonia [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&selected=6136437&PinnedHotelID=6136437&HadPinnedHotel=true®ionId=6335336) [](https://expedia.com/Kastoria-Hotels-Hotel-Anastassiou.h6136437.Hotel-Information) ![Arhontiko Christodoulou](https://images.trvl-media.com/lodging/37000000/36790000/36784300/36784216/99031f32_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Arhontiko Christodoulou vrontero Prespes [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&selected=36784216&PinnedHotelID=36784216&HadPinnedHotel=true®ionId=6335336) [](https://expedia.com/Prespes-Hotels-Arhontiko-Christodoulou.h36784216.Hotel-Information) ## Hotels in Mesopotamia with star-rating ![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg) 5 Star Hotels 1 properties [](https://expedia.com/5Star-Mesopotamia-Hotels.s50-0-d6335336.Travel-Guide-Filter-Hotels) ## Find out more about Mesopotamia ### Top reasons to visit Mesopotamia - **Scenic Beauty:** Mesopotamia is known for its stunning landscapes, including picturesque lakes and charming villages, perfect for outdoor adventures. - **Cultural Experiences:** Engage in local culture through museums, landmarks, and traditional activities that showcase the area's rich heritage. - **Romantic Getaway:** The enchanting atmosphere, especially in early fall, makes it an ideal destination for couples seeking a romantic retreat. - **Family-Friendly Activities:** Mesopotamia offers a variety of activities suitable for families, ensuring fun for all ages. - **Diverse Accommodations:** Enjoy a range of lodging options, from luxurious hotels to cozy stays, catering to different traveler needs. ### Find great hotels near Mesopotamia Discover a range of hotel accommodations in Mesopotamia, Kastoria, Western Macedonia, Greece, perfect for both business travelers and adventure seekers. From luxurious options to cozy stays, you'll find the best hotels that cater to your needs, including spa services and unique vacation experiences. Explore the local culture while enjoying top-notch amenities that ensure a memorable visit to this enchanting region. - **[Esperos Palace Luxury & Spa Hotel: ](https://www.expedia.com/Kastoria-Hotels-Esperos-Palace-Luxury-Spa-Hotel.h4967133.Hotel-Information)** Esperos Palace Luxury & Spa Hotel is a 4-star retreat, boasting an impressive guest rating of 9.0\. Situated 5 miles from Mesopotamia, this hotel is perfect for travelers seeking a spa-themed and business-friendly experience. The hotel features a full-service spa that includes a steam room, accessible spa facilities, and treatment rooms for massages, ensuring relaxation and rejuvenation. Guests can also enjoy the inviting pool service, making it an ideal choice for those looking to unwind after a day of exploring. - **[Hotel Anastassiou: ](https://www.expedia.com/Kastoria-Hotels-Hotel-Anastassiou.h6136437.Hotel-Information)** Hotel Anastassiou is a budget-friendly option with a guest rating of 8.0, also located 5 miles from Mesopotamia. This hotel caters to adventure seekers and business travelers alike, offering easy access to ski shuttles and lifts. With a variety of adventure sports available nearby, including hiking, biking, fishing, and kayaking, this hotel is perfect for those looking to explore the great outdoors. Its combination of practicality and access to recreational activities makes it an appealing choice for an active vacation. - **[Kyknos De Luxe Hotel: ](https://www.expedia.com/Kastoria-Hotels-Kyknos-De-Luxe-Hotel.h4791757.Hotel-Information)** Kyknos De Luxe Hotel is a 3.5-star property that has earned a perfect guest rating of 10.0\. Located just 5 miles from Mesopotamia, this hotel is ideal for travelers seeking luxury and business amenities. The elegant accommodations provide a sophisticated atmosphere complemented by high-end services. With an emphasis on comfort and style, Kyknos De Luxe Hotel promises a memorable stay for those looking to indulge in a luxurious vacation experience. ### Where to stay in Mesopotamia Mesopotamia, nestled in the picturesque region of Kastoria, Greece, offers a perfect blend of scenic beauty and outdoor adventures. Explore charming villages, indulge in local culture, and enjoy family-friendly activities. Stroll through trendy shopping spots and savor the romantic atmosphere in early fall, when the landscape is adorned in vibrant colors. Discover the warmth of friendly locals and immerse yourself in the unique experiences that make Mesopotamia a delightful vacation destination. - **[Kastoria: ](https://www.expedia.com/Kastoria-Hotels.d1928.Travel-Guide-Hotels)** Nestled in the heart of Western Macedonia, Kastoria is a picturesque city surrounded by stunning natural landscapes and serene lakes. As the central hub of Mesopotamia, it offers a unique blend of outdoor adventures and cultural experiences. Visitors flock to Kastoria for activities such as skiing in the nearby mountains and relaxing in local spas. The city is also renowned for its historic landmarks, including ancient monasteries and charming old town streets. With its vibrant autumn colors and cozy ambiance, Kastoria is especially inviting in September and November to December, making it an ideal destination year-round. - **[Árgos Orestikón: ](https://www.expedia.com/Argos-Orestikon-Hotels.d3000031412.Travel-Guide-Hotels)** Just 6 miles from Mesopotamia, Árgos Orestikón is a charming city that captivates visitors with its lush valleys and outdoor recreational opportunities. Known for its adventure-filled atmosphere, this city attracts travelers throughout the year, particularly in September and December to January. Whether you're hiking through scenic landscapes or exploring local eateries, Árgos Orestikón provides a taste of authentic Greek culture. Its proximity to natural beauty makes it a perfect base for day trips and outdoor excursions. - **[Dispilio: ](https://www.expedia.com/Dispilio-Hotels.d6335332.Travel-Guide-Hotels)** Located 7 miles from Mesopotamia, Dispilio is a quaint village that offers a unique blend of history and adventure. Popular for skiing and outdoor sports, this village sees a surge of visitors from July to September, drawn by its ski resorts and breathtaking scenery. The area is rich in archaeological significance, featuring sites that showcase its historical past. Whether you’re exploring the archaeological site or enjoying winter sports, Dispilio promises an enriching experience for those seeking both adventure and cultural insights. ### Things to do in Mesopotamia Mesopotamia offers a perfect blend of scenic beauty and outdoor adventures, making it an ideal destination for a romantic getaway. Visitors can enjoy cultural activities, private tours, and explore the region's picturesque landscapes. With opportunities for both relaxation and adventure, Mesopotamia is perfect for those seeking a charming retreat or an engaging weekend escape filled with unique experiences. **Shopping** In Mesopotamia, you can visit local shops for unique gifts and souvenirs. If you're up for a drive, check out the nearby Kastoria Shopping Mall, about 12 miles away, offering a mix of shops and boutiques perfect for finding special treasures from your trip. **Recreation** Experience rejuvenation at the Mesopotamia Wellness Center, where you can indulge in soothing spa treatments and holistic therapies. Enjoy outdoor yoga sessions amidst nature, followed by a refreshing hike in the nearby hills, offering serene views and a chance to connect with the tranquil environment. **Adventure** Experience the stunning beauty of Mesopotamia through hiking the scenic trails that weave through lush landscapes. Engage in thrilling water sports on nearby lakes, or explore local culture by visiting traditional villages. Don't miss the chance to taste authentic Greek cuisine at charming tavernas along the way. **Nightlife** In Mesopotamia, you can enjoy a lively nightlife scene with local taverns featuring traditional Greek music and dance. The vibrant atmosphere is complemented by cozy cafes and bars where you can unwind and socialize with locals, creating an unforgettable experience in this charming town. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Mesopotamia - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Mesopotamia are March and October to November, where the prices are slightly lower. This is in comparison to April and July to August, where prices are slightly higher. - **The best time to book a hotel:** The cheapest time to book a hotel in Mesopotamia is usually 1 month out from when you are planning to stay. If you're a little more spontaneous, you could also peruse Expedia's last minute deals which could secure you a cheaper stay. Look out for the green banner below the price to spot the deals. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Mesopotamia is Saturday. The most expensive day to stay in Mesopotamia is Thursday. - **Find cheap hotels on Expedia:** Expedia’s search tool enables you to set your budget, choose your desired location, and customize your preferences. You can organize the results to display prices from lowest to highest, making it easy to find the most affordable hotels. Additionally, you have the option to narrow down your choices by hotel type; for instance, selecting the Eco-certified filter will showcase hotels that are sustainable and environmentally friendly. - **Consider bundling your trip:** You can save money by combining your hotel stay in Mesopotamia with your flights and activities through an Expedia package. ### Find the best attractions near Mesopotamia Mesopotamia offers a perfect blend of scenic beauty and cultural experiences, ideal for outdoor and romantic getaways. Visitors can explore picturesque lakes, delve into local history at museums, and admire notable landmarks. The area caters to travelers seeking a mix of culture, outdoor adventures, and beach experiences, making it a delightful destination for all types of vacationers. - **[Kastoria Lake: ](https://www.expedia.com/Kastoria-Lake-Hotels.0-l553248621532501791-0.Travel-Guide-Filter-Hotels)** This picturesque lake, located 5 miles from Mesopotamia, offers stunning views and a perfect setting for outdoor activities. Enjoy romantic walks along the shoreline or relax on the beach while taking in the serene scenery. - **[Taxiarhia of the Metropolis: ](https://www.expedia.com/Taxiarhia-Of-The-Metropolis-Hotels.0-l553248621533101283-0.Travel-Guide-Filter-Hotels)** A luxurious landmark also situated 5 miles from Mesopotamia, this site blends trendy architecture with budget-friendly experiences. Explore its beautiful design and the vibrant atmosphere that attracts both locals and tourists alike. - **[Byzantine Museum of Kastoria: ](https://www.expedia.com/Byzantine-Museum-Of-Kastoria-Hotels.0-l6263517-0.Travel-Guide-Filter-Hotels)** Located 6 miles away, this museum immerses you in the rich cultural history of the region. Discover fascinating exhibits that showcase Byzantine art and artifacts, making it a must-visit for history enthusiasts. ### Best time to go to Mesopotamia The best time to visit Mesopotamia is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are moderately high and weather is sunny with no rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 32.5°F (0.3°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | February | 36.1°F (2.3°C) | Light Rain | Mostly Sunny | Average | Average | | March | 41.7°F (5.4°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | | April | 50.2°F (10.1°C) | Light Rain | Mostly Sunny | Average | Slightly High | | May | 57.9°F (14.4°C) | Light Rain | Mostly Sunny | Average | Average | | June | 66.0°F (18.9°C) | No Rain | Mostly Sunny | Average | Average | | July | 72.3°F (22.4°C) | No Rain | Sunny | Moderately High | Slightly High | | August | 72.5°F (22.5°C) | No Rain | Sunny | Moderately High | Slightly High | | September | 64.2°F (17.9°C) | No Rain | Mostly Sunny | Moderately High | Average | | October | 54.1°F (12.3°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | November | 45.1°F (7.3°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | | December | 36.3°F (2.4°C) | Light Rain | Mostly Sunny | Average | Average | ### The nearest major airports for your trip to Mesopotamia To reach Mesopotamia, you can fly into several nearby airports. Corfu Airport ([CFU](https://www.expedia.com/Ioannis-Kapodistrias-Airport-Hotels.0-aCFU-0.Travel-Guide-Filter-Hotels)) is approximately 91 miles away, with excellent hotel options like the 5-star [Angsana Corfu Resort & Spa](https://www.expedia.com/Corfu-Hotels-Angsana-Corfu.h66197379.Hotel-Information), located 4 miles from the airport, offering transfers and shuttles. [IOA](https://www.expedia.com/Ioannina-National-Airport-Hotels.0-aIOA-0.Travel-Guide-Filter-Hotels)nnina Airport (IOA) is about 59 miles away; nearby, the 5-star [Hotel Du Lac Congress Center & Spa](https://www.expedia.com/Ioannina-Hotels-Hotel-Du-Lac-Congress-Center-Spa.h9741033.Hotel-Information) is just 3 miles from the airport. Kozani Airport ([KZI](https://www.expedia.com/Filippos-Airport-Hotels.0-aKZI-0.Travel-Guide-Filter-Hotels)) is 38 miles from Mesopotamia, with accommodations like [Anesis Hotel](https://www.expedia.com/Kozani-Hotels-Anesis-Hotel.h1516031.Hotel-Information), only 2 miles away. Each of these airports provides convenient access to your destination, ensuring a smooth travel experience. ## Frequently asked questions ### What is the best area to stay in Mesopotamia? > This central area is where you'll find most of the town's amenities, including local shops, bakeries, and traditional tavernas. It's a convenient base for exploring the surrounding region, with easy access to roads leading to nearby attractions. Families appreciate this area for its practicality and the ease of finding essentials close by. > > > For those seeking a more tranquil experience, the residential streets just off the main road offer a quieter alternative. These areas provide a peaceful setting while still being within a short walk of the town center's conveniences. ### When is the best time to go to Mesopotamia? > During these months, you'll experience mild temperatures, typically ranging from the mid-60s to high 70s Fahrenheit (18-26°C), with less humidity and fewer crowds than the peak summer months. This makes it ideal for outdoor activities like hiking in the surrounding mountains or visiting local historical sites without the intense heat. Travelers looking for a relaxing trip with comfortable weather will find these periods particularly appealing. > > > For those interested in cultural events and local festivals, early autumn often features grape harvests and traditional celebrations, offering a unique insight into the region's heritage. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Mesopotamia hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Mesopotamia hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Poria Hotels ](https://www.expedia.com/Poria-Hotels.d6335337.Travel-Guide-Hotels) - [Non-Smoking Hotels in Maniakoi ](https://www.expedia.com/Maniakoi-Hotels-Smoke-Free-Hotels.0-0-d3000702866-tSmokeFreeHotels.Travel-Guide-Filter-Hotels) - [Hotels near Kastoria Lake ](https://www.expedia.com/Kastoria-Lake-Hotels.0-l553248621532501791-0.Travel-Guide-Filter-Hotels) - [Kastoria Hotels ](https://www.expedia.com/Kastoria-Hotels.d1928.Travel-Guide-Hotels) - [Hotel Wedding Venues Hotels in Kastoria ](https://www.expedia.com/Kastoria-Hotels-Wedding-Hotels.0-0-d1928-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Kastoria ](https://www.expedia.com/Kastoria-Hotels-Hotels-With-Indoor-Pool.0-0-d1928-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - 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