Mesopotamia Vacations from $463

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Your Mesopotamia Vacation

Our vacation packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia vacation is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.
Capsis Bristol Boutique Hotel

Capsis Bristol Boutique Hotel

5 out of 5
Thessaloniki City Centre
Price was $680, price is now $463 per person
$463
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip flight included
Athens (ATH) to Thessaloniki (SKG)
9/10 Wonderful! (153 reviews)
Staff at front desk excellent! Convenient location.Grocery store across street and laundry next door! Nice clean room. If you get a room with courtyard view instead of street view prepare to see miscellaneous roofing, wood, and other people's balcony close by as your view. Aside from that. Excellent!

Reviewed on Aug 9, 2026

The Met Hotel, a member of Design Hotels

The Met Hotel, a member of Design Hotels

5 out of 5
Price was $772, price is now $532 per person
$532
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip flight included
Athens (ATH) to Thessaloniki (SKG)
9.2/10 Wonderful! (928 reviews)
When we got off the uber, the driver said this is one of the very nice hotels in town. It is true evertthing about this hotel is perfect. Very nice hotel, rooms are very modern. Our room, the toilet and shower has separate compartments ( with doors). The spa is great, breakfast has a good selection of food. All the staff from front desk, breakfast and the spa are very friendly. It also has shuttle that takes you to city centre and back. It runs every hour, but it’s not all day long, you need to check the schedule at the front desk every day. The negative thing I need to say is the location is a bit out off the way. It is a 18-20 mins walk to the metro. Or you can take the bus #31 across the street into city. The neighborhood is not very nice it is next to some auto repair shops and some abandoned buildings.

Reviewed on Oct 29, 2026

ON Residence

ON Residence

5 out of 5
Thessaloniki City Centre
Price was $853, price is now $591 per person
$591
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip flight included
Athens (ATH) to Thessaloniki (SKG)
9.8/10 Exceptional! (222 reviews)

City Hotel Thessaloniki

City Hotel Thessaloniki

4 out of 5
Thessaloniki City Centre
Price was $912, price is now $634 per person
$634
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip flight included
Athens (ATH) to Thessaloniki (SKG)
8.6/10 Excellent! (689 reviews)

ONOMA Hotel

ONOMA Hotel

5 out of 5
Vardaris
Price was $718, price is now $503 per person
$503
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip flight included
Athens (ATH) to Thessaloniki (SKG)
9.2/10 Wonderful! (207 reviews)
It was an excellent stay, all around!

Reviewed on Oct 13, 2026

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What to do in Mesopotamia

Archery Odyssey Traditional Archery Experience

Archery Odyssey Traditional Archery Experience

$67
per adult
Archery Odyssey Traditional Archery Experience
See all activities in Mesopotamia

Mesopotamia Hotel Deals

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Dec 6 to Dec 7
$72 total
Dec 6 - Dec 7
Total with taxes and fees
10/10 Exceptional! (2 reviews)
"Very nice and warm welcome from the owner. Quiet atmosphere. Great breakfast with a huge variety of different things. We definitely recommend for a stay."

Reviewed on Sep 22, 2026

To Spiti tis Sofias
Limneon Resort & Spa

Limneon Resort & Spa

5 out of 5
4th km National Road Kastoria Athens Kastoria
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $110 total per night from Nov 8 to Nov 9
$110 total
Nov 8 - Nov 9
Total with taxes and fees
9.2/10 Wonderful! (211 reviews)
"We loved our stay very much and will definitely be returning from the staff to the location and simply beautiful views we couldn’t ask for anything better the only suggestion is that they add dresser’s with draws so you can putt your cloths out instead of having to use your suit cases."

Reviewed on Aug 10, 2026

Limneon Resort & Spa
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens Kastoria Western Macedonia
$45 nightly
The price is $51 total per night from Nov 8 to Nov 9
$51 total
Nov 8 - Nov 9
Total with taxes and fees
Hotel Anastassiou
See all 48 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mesopotamia Vacation Packages

Mesopotamia Essential Information

Language
Greek
Currency
Euros
Local Welcome
Ya su
Local Goodbye
Yiá sou
Closest Airport
Kastoria (KSO-Aristoteles)
Population
2,100
Max Temp Winter
40ºF
Max Temp Summer
80ºF
Top Sights
Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria

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Frequently asked questions

Do you need to rent a car in Mesopotamia, or is public transport enough?
For a Mesopotamia vacation package, a rental car is generally recommended to fully explore this outdoor and nature destination. While your package includes flights, many of the scenic views and outdoor activities are spread out, such as Kastoria Lake, which is about 10 miles from central Mesopotamia. Having a car provides the flexibility to visit these attractions at your own pace. Travelers typically arrive via airports like Ioannina National (IOA) or Kastoria Aristoteles (KSO), and a car allows for convenient travel from these arrival points to your accommodation and around the region. This helps you make the most of your Mesopotamia vacation packages with flights.
Can I change or cancel my Mesopotamia vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Mesopotamia vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Mesopotamia vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Mesopotamia vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How can I save money on a Mesopotamia vacation package?
When you bundle, you can save up to 30%*. To save money on a Mesopotamia package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
How do I find last-minute vacation packages to Mesopotamia?
To find last-minute vacation packages to Mesopotamia, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Mesopotamia vacation packages?
Free cancellation on a Mesopotamia vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Mesopotamia vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Mesopotamia getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Mesopotamia vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.