Mesopotamia Vacations from $171
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Mesopotamia Vacation
Our vacation packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia vacation is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.
The Latest Mesopotamia vacation packages
Price found within the past 48 hours. Click for updated prices.
EONA BEACH RESORT by Greek Pride
$171
per person
Oct 27 - Oct 29
found 1 day ago
Roundtrip flight included
Rome (FCO) to Thessaloniki (SKG)
7.4/10 Good! (19 reviews)
Breakfast was excellent and the cleaning staff was amazing.
The hotel needs a bit of TLC otherwise i enjoyed my stay :)
Reviewed on Sep 20, 2026
Wellness Santa Hotel - Adults Only
$179
per person
Oct 27 - Oct 29
found 1 day ago
Roundtrip flight included
Rome (FCO) to Thessaloniki (SKG)
8.4/10 Very Good! (204 reviews)
Great interior design, wonderfully staff.
Spa was excelente. Breakfast is very very good. Beach excelente.
Whole hotel and service was great
Potential for improvement-more comfortable beach chairs
We will be back
Reviewed on Sep 17, 2026
Andromeda Hotel Thessaloniki
Thessaloniki City Centre
$187
per person
Oct 27 - Oct 29
found 1 day ago
Roundtrip flight included
Rome (FCO) to Thessaloniki (SKG)
8/10 Very Good! (394 reviews)
I didn’t realized they did not serve breakfast! That is on me. The AirCo was set on a temperature I could not adjust. I woke up ever night sweating. I opened the window but it was also hot outside. I barely slept in 2 days! That’s not cool!
Reviewed on Jun 24, 2026
Don't see what you're looking for?
See all available trips from Columbus to Mesopotamia
View all tripsWhat to do in Mesopotamia
Archery Odyssey Traditional Archery Experience
$70
per adult
Mesopotamia Hotel Deals
To Spiti tis Sofias
Mesopotamia Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$69 nightly
$80 total
Oct 4 - Oct 5
Total with taxes and fees
10/10 Exceptional! (1 review)
Le meilleur de notre séjour
"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin."
Reviewed on Aug 18, 2025
Limneon Resort & Spa
4th km National Road Kastoria Athens Kastoria
Fully refundableReserve now, pay when you stay
$96 nightly
$127 total
Sep 21 - Sep 22
Total with taxes and fees
9.2/10 Wonderful! (209 reviews)
"We loved our stay very much and will definitely be returning from the staff to the location and simply beautiful views we couldn’t ask for anything better the only suggestion is that they add dresser’s with draws so you can putt your cloths out instead of having to use your suit cases."
Reviewed on Aug 10, 2026
Hotel Anastassiou
1st km Highway Kastoria-Athens Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$42 nightly
$50 total
Sep 27 - Sep 28
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Mesopotamia Vacation Packages
Mesopotamia Essential Information
Language | Greek |
|---|---|
Currency | Euros |
Local Welcome | Ya su |
Local Goodbye | Yiá sou |
Closest Airport | Kastoria (KSO-Aristoteles) |
Population | 2,100 |
Max Temp Winter | 40ºF |
Max Temp Summer | 80ºF |
Top Sights | Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria |
More vacations you might like
Frequently asked questions
How much does a Mesopotamia vacation package cost?
Offering excellent value package deals from $171 on Expedia, you'll be surprised at how little a vacation to Mesopotamia costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Mesopotamia?
You can typically find reduced prices and greater availability in November, December and January. Check out our cheap Mesopotamia vacation packages and you could score some great off-season deals.
How many days is enough for Mesopotamia?
The ideal duration of your Mesopotamia vacation depends on what you'd like to do. Typically, a handful of days to a week will give you plenty of time to visit all the leading attractions and discover some hidden treasures along the way.
How to find the best Mesopotamia package deals?
Begin your search for a Mesopotamia package deal by entering your preferred trip dates and destination under our "Packages" tab. Then apply a few filters, like "Popular locations" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the ideal Mesopotamia package deal straight away, just change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Mesopotamia adventure underway.
Is it cheaper to book a Mesopotamia vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll generally snag a better deal than booking each component separately. And you'll still get the freedom to create a personalized Mesopotamia vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Mesopotamia?
Secure incredible discounts by booking your flights early with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mesopotamia vacation.
Does Expedia offer Book Now, Pay Later Mesopotamia vacation packages?
If you're anything like us, you love traveling the world but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the total cost of your Mesopotamia vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up great vacation packages with payment plans as soon as you see them.
Explore a world of travel with Expedia
- Hotels with Laundry Facilities in Kastoria
- Poria Hotels
- 4 Star Hotels in Kastoria
- Luxury Hotels in Kastoria
- Hotels near Kastoria Lake
- Hotels with a Gym in Kastoria
- Kastoria Hotels
- 5 Star Hotels in Kastoria
- Resorts & Hotels with Spas in Kastoria
- Apartments in Kastoria
- Boutique Hotels in Kastoria
- Hotels near Museum of the Macedonian Struggle
- Hotel Wedding Venues Hotels in Kastoria
- Aposkepos Hotels
- Pet-Friendly Hotels in Kastoria
- Family Hotels in Kastoria
- Villas in Kastoria
- Mesopotamia Hotels
- 5 Star Hotels in Mesopotamia
- Hotels with Tennis Courts in Kastoria
- Hotels with an Indoor Pool in Kastoria
- Flights from Tirana (TIA) to Kastoria (KSO)
- Flights from Los Angeles (LAX) to Kastoria (KSO)
- Flights from Skopje (SKP) to Kastoria (KSO)
- Flights from Atlanta (ATL) to Kastoria (KSO)
- Flights from Tel Aviv (TLV) to Kastoria (KSO)
- Flights from Detroit (DTW) to Kastoria (KSO)
- Flights from Munich (MUC) to Kastoria (KSO)
- Flights from Aristoteles
- Flights to Kastoria
- Flights from Athens (ATH) to Kastoria (KSO)
- Flights to Poria
- Flights from Kalamata (KLX) to Kastoria (KSO)
- Flights to Mesopotamia
- Flights from London (LHR) to Kastoria (KSO)
- Flights from Frankfurt (FRA) to Kastoria (KSO)
- Flights from Cincinnati (CVG) to Kastoria (KSO)
- Flights from Thessaloniki (SKG) to Kastoria (KSO)
- Flights from Boston (BOS) to Kastoria (KSO)
- Flights from Vienna (VIE) to Kastoria (KSO)
- Flights from New York (NYC) to Kastoria (KSO)
- Flights from Kozani (KZI) to Kastoria (KSO)
- Flights from New York (JFK) to Kastoria (KSO)
- Dragon's Lair
- Visit Mesopotamia
- Visit Poria
- Museum of the Macedonian Struggle
- Visit Sidirochori
- Folklore Museum of Kastoria
- Kastoria Lake
- Holy Prophet Elias Church
- Kastoria Aquarium
- Visit Kastoria
- Korisos Vacations
- Holy Monastery of Panagias Mauriotissas
- Kastoria Vacations
- Byzantine Museum of Kastoria
- Visit Maniakoi
- Visit Korisos
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
