Mesopotamia Vacations from $491

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Your Mesopotamia Vacation

Our vacation packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia vacation is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.
Sandy Seaside Suites

Sandy Seaside Suites

4 out of 5
Save 100% on your flight
per person
Sep 11 - Sep 16
found 19 hours ago
Roundtrip flight included
Belgrade (BEG) to Thessaloniki (SKG)
10/10 Exceptional! (1 review)
This hotel exceeded every expectation that I had! There are lots I could talk about; the cleanliness, the beautiful rooms, the superb breakfast but what really makes this hotel is the amazing staff who all go over and above to help and genuinely invest in making your stay as positive as possible.

Reviewed on Jul 30, 2025

Domes Noruz Kassandra - Adults Only, Halkidiki

Domes Noruz Kassandra - Adults Only, Halkidiki

5 out of 5
Save 100% on your flight
per person
Sep 16 - Sep 23
found 1 day ago
Roundtrip non-stop flight included
Belgrade (BEG) to Thessaloniki (SKG)
9.4/10 Exceptional! (110 reviews)
Everything about this property from the moment you get to the gate is excellent. Checkin was smooth, property is beautiful! Extended my stay twice

Reviewed on Jul 1, 2025

Porto Carras Meliton

Porto Carras Meliton

5 out of 5
Save 100% on your flight
per person
Sep 11 - Sep 16
found 19 hours ago
Roundtrip flight included
Belgrade (BEG) to Thessaloniki (SKG)
8.4/10 Very Good! (102 reviews)
Very helpful stuff , great location , great amenities . Would love to see continuing investments towards this property as its history is long and it deserves to be on the top list every time.

Reviewed on Jul 28, 2025

Ajul Luxury Hotel & Spa Resort, a Registry Collection Hotel

Ajul Luxury Hotel & Spa Resort, a Registry Collection Hotel

5 out of 5
Save 100% on your flight
per person
Sep 16 - Sep 23
found 1 day ago
Roundtrip non-stop flight included
Belgrade (BEG) to Thessaloniki (SKG)
8/10 Very Good! (8 reviews)
Mirabilia Boutique Hotel

Mirabilia Boutique Hotel

3 out of 5
Save 100% on your flight
per person
Sep 16 - Sep 23
found 1 day ago
Roundtrip non-stop flight included
Belgrade (BEG) to Thessaloniki (SKG)
9.6/10 Exceptional! (50 reviews)
Wow !! This place is just amazing… everything (staff-room-location-service-breakfast was 5star ) we highly recommend and we will be back for sure !! Thank you guys for everything!

Reviewed on Aug 17, 2024

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Discover the most popular places to visit in Mesopotamia

Kastoria Lake

5/5(2 reviews)

Commune with nature and explore the great outdoors at Kastoria Lake during your travels in Kastoria. While you're in the area, stroll along the lakeside.

Kastoria Lake

Holy Monastery of Panagias Mauriotissas

Learn about the local history of Kastoria when you take a trip to Holy Monastery of Panagias Mauriotissas. While you're in the area, stroll along the lakeside.

Holy Monastery of Panagias Mauriotissas

Dragon's Lair

Explore the great outdoors at Dragon's Lair, a lovely green space in Kastoria. While you're in the area, stroll along the lakeside.

Dragon's Lair

What to do in Mesopotamia

Archery Odyssey Traditional Archery Experience

Archery Odyssey Traditional Archery Experience

$70
per adult
Archery Odyssey Traditional Archery Experience
See all activities in Mesopotamia

Mesopotamia Hotel Deals

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia, Kastoria, Western Macedonia
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $77 total per night from Aug 12 to Aug 13
$77 total
Aug 12 - Aug 13
Total includes taxes and fees
To Spiti tis Sofias
Limneon Resort & Spa

Limneon Resort & Spa

4 out of 5
4th km National Road Kastoria Athens, Kastoria
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $120 total per night from Jul 31 to Aug 1
$120 total
Jul 31 - Aug 1
Total includes taxes and fees
9.2/10 Wonderful! (182 reviews)
"Beautiful property"

Reviewed on Jul 22, 2025

Limneon Resort & Spa
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens, Kastoria, Western Macedonia
Fully refundableReserve now, pay when you stay
$47 nightly
The price is $56 total per night from Aug 27 to Aug 28
$56 total
Aug 27 - Aug 28
Total includes taxes and fees
7.8/10 Good! (65 reviews)
"Nice simple stay."

Reviewed on Mar 13, 2025

Hotel Anastassiou
See all 43 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mesopotamia Vacation Packages

Mesopotamia Essential Information

Language
Greek
Currency
Euros
Local Welcome
Ya su
Local Goodbye
Yiá sou
Closest Airport
Kastoria (KSO-Aristoteles)
Population
2,100
Max Temp Winter
40ºF
Max Temp Summer
80ºF
Top Sights
Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria

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Frequently asked questions

How much does a Mesopotamia vacation package cost?
Offering excellent value package deals from $491 on Expedia, you'll be surprised at how little a vacation to Mesopotamia costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Mesopotamia?
You can typically find reduced prices and greater availability in November, December and January. Check out our cheap Mesopotamia vacation packages and you could score some great off-season deals.
How many days is enough for Mesopotamia?
The ideal duration of your Mesopotamia vacation depends on what you'd like to do. Typically, a handful of days to a week will give you plenty of time to visit all the leading attractions and discover some hidden treasures along the way.
How to find the best Mesopotamia package deals?
Begin your search for a Mesopotamia package deal by entering your preferred trip dates and destination under our "Packages" tab. Then apply a few filters, like "Popular locations" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the ideal Mesopotamia package deal straight away, just change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Mesopotamia adventure underway.
Is it cheaper to book a Mesopotamia vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll generally snag a better deal than booking each component separately. And you'll still get the freedom to create a personalized Mesopotamia vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Mesopotamia?
Secure incredible discounts by booking your flights early with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mesopotamia vacation.
Does Expedia offer Book Now, Pay Later Mesopotamia vacation packages?
If you're anything like us, you love traveling the world but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the total cost of your Mesopotamia vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up great vacation packages with payment plans as soon as you see them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.