Mesopotamia Vacations from $1,823

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Your Mesopotamia Vacation

Our vacation packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia vacation is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.
The Met Hotel, a member of Design Hotels

The Met Hotel, a member of Design Hotels

5 out of 5
Price was $2,059, price is now $1,823 per person
$1,823
per person
Jun 9 - Jun 15
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Thessaloniki (SKG)
9.2/10 Wonderful! (871 reviews)
The staff was amazingly kind and accommodating. Hotel was clean and smelled amazing. Appreciate the shuttle into the square. I look forward to coming back again!

Reviewed on Oct 22, 2025

ON Residence

ON Residence

5 out of 5
Thessaloniki City Centre
Price was $2,411, price is now $1,999 per person
$1,999
per person
Jun 9 - Jun 15
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Thessaloniki (SKG)
9.8/10 Exceptional! (184 reviews)
Beautiful room. Modern and luxurious.

Reviewed on Dec 23, 2025

The Excelsior Small Luxury Hotels of the World

The Excelsior Small Luxury Hotels of the World

5 out of 5
Thessaloniki City Centre
Price was $2,460, price is now $2,088 per person
$2,088
per person
Jun 9 - Jun 15
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Thessaloniki (SKG)
9.6/10 Exceptional! (426 reviews)
The room was clean. The hotel is very central which is good for exploring, however there is a lot of noise, especially in the mornings.

Reviewed on Mar 12, 2026

ONOMA Hotel

ONOMA Hotel

5 out of 5
Vardaris
Price was $2,166, price is now $1,860 per person
$1,860
per person
Jun 9 - Jun 15
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Thessaloniki (SKG)
9.2/10 Wonderful! (154 reviews)
Everything! Staff excellent , rainforest showers and great breakfast. Highly recommended

Reviewed on Nov 5, 2025

Domes Noruz Kassandra - Adults Only, Halkidiki

Domes Noruz Kassandra - Adults Only, Halkidiki

5 out of 5
Price was $5,992, price is now $5,248 per person
$5,248
per person
Jun 19 - Jun 25
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Thessaloniki (SKG)
9.4/10 Exceptional! (129 reviews)
Difficult to get a lounger on the beach despite the hotels claimed policy to stop people reserving them with towels and leaving them empty

Reviewed on Oct 17, 2025

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Discover the most popular places to visit in Mesopotamia

Kastoria Lake

5/5(2 reviews)

Commune with nature and explore the great outdoors at Kastoria Lake during your travels in Kastoria. While you're in the area, stroll along the lakeside.

Kastoria Lake

Dragon's Lair

Explore the great outdoors at Dragon's Lair, a lovely green space in Kastoria. While you're in the area, stroll along the lakeside.

Dragon's Lair

Holy Monastery of Panagias Mauriotissas

After visiting Holy Monastery of Panagias Mauriotissas, make a plan to see the other sights and activities in Kastoria. While you're in the area, stroll along the lakeside.

Holy Monastery of Panagias Mauriotissas

What to do in Mesopotamia

Archery Odyssey Traditional Archery Experience

Archery Odyssey Traditional Archery Experience

$71
per adult
Archery Odyssey Traditional Archery Experience
See all activities in Mesopotamia

Mesopotamia Hotel Deals

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $72 total per night from May 25 to May 26
$72 total
May 25 - May 26
Total with taxes and fees
10/10 Exceptional! (1 review)
Le meilleur de notre séjour
Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin.

Reviewed on Aug 18, 2025

To Spiti tis Sofias
Limneon Resort & Spa

Limneon Resort & Spa

4 out of 5
4th km National Road Kastoria Athens Kastoria
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $130 total per night from May 13 to May 14
$130 total
May 13 - May 14
Total with taxes and fees
9.2/10 Wonderful! (202 reviews)
All staff superb both at reception and throughout the property. Rooms large and immaculate with all amenities. Property superb. Location peaceful and relaxing with balcony and view of the lake. Only 5 mins by car to Kastoria town. 8-10 Euros by taxi. Would have liked to stay longer if we had the ...

Reviewed on Apr 23, 2026

Limneon Resort & Spa
Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel

4 out of 5
Chloe Area Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $149 total per night from May 11 to May 12
$149 total
May 11 - May 12
Total with taxes and fees
9/10 Wonderful! (84 reviews)
The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing.

Reviewed on Sep 4, 2025

Esperos Palace Luxury & Spa Hotel
See all 49 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mesopotamia Vacation Packages

Mesopotamia Essential Information

Language
Greek
Currency
Euros
Local Welcome
Ya su
Local Goodbye
Yiá sou
Closest Airport
Kastoria (KSO-Aristoteles)
Population
2,100
Max Temp Winter
40ºF
Max Temp Summer
80ºF
Top Sights
Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria

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Frequently asked questions

How much does a Mesopotamia vacation package cost?
Offering excellent value package deals from $1,823 on Expedia, you'll be surprised at how little a vacation to Mesopotamia costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Mesopotamia?
You can typically find reduced prices and greater availability in November, December and January. Check out our cheap Mesopotamia vacation packages and you could score some great off-season deals.
How many days is enough for Mesopotamia?
The ideal duration of your Mesopotamia vacation depends on what you'd like to do. Typically, a handful of days to a week will give you plenty of time to visit all the leading attractions and discover some hidden treasures along the way.
How to find the best Mesopotamia package deals?
Begin your search for a Mesopotamia package deal by entering your preferred trip dates and destination under our "Packages" tab. Then apply a few filters, like "Popular locations" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the ideal Mesopotamia package deal straight away, just change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Mesopotamia adventure underway.
Is it cheaper to book a Mesopotamia vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll generally snag a better deal than booking each component separately. And you'll still get the freedom to create a personalized Mesopotamia vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Mesopotamia?
Secure incredible discounts by booking your flights early with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mesopotamia vacation.
Does Expedia offer Book Now, Pay Later Mesopotamia vacation packages?
If you're anything like us, you love traveling the world but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the total cost of your Mesopotamia vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up great vacation packages with payment plans as soon as you see them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.