Title: Mesotopos Vacation Rentals from $104: Search Short-Term Rentals | Expedia.com

[Mesotopos Travel Guide](https://expedia.com/Mesotopos.dx3000377841)[Hotels in Mesotopos](https://expedia.com/Mesotopos-Hotels.d3000377841.Travel-Guide-Hotels)[Car Rentals in Mesotopos](https://expedia.com/Car-Rentals-In-Mesotopos.d3000377841.Car-Rental-Guide)[Mesotopos Vacation Packages](https://expedia.com/Mesotopos.d3000377841.Destination-Travel-Guides)

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## Check prices for these dates

In two weeks

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=3000377841&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=3000377841&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=3000377841&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=3000377841&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Mesotopos vacation rentals

![Comfort House, Non Smoking, Sea View | Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/116000000/115810000/115809500/115809456/fea8a5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Full-size fridge, oven, electric kettle, cookware/dishes/utensils](https://images.trvl-media.com/lodging/116000000/115810000/115809500/115809456/09395b00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort House, Mobility Accessible, Sea View | Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/116000000/115810000/115809500/115809456/00ec1d97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort House, Mobility Accessible, Sea View | Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/116000000/115810000/115809500/115809456/859cf12b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Lesvos

[](https://www.expedia.com/Lesvos-Hotels-Apolithon-Premium-Houses.h115809456.Hotel-Information)

$94 nightly

$104 total

Mar 13 - Mar 14

Total with taxes and fees

[](https://www.expedia.com/Lesvos-Hotels-Apolithon-Premium-Houses.h115809456.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-16&endDate=2026-03-17&regionId=3000377841&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_3000377841)

## Find vacation rentals that suit your style

Villas

[](https://www.expedia.com/Hotel-Search?destination=Mesotopos%2C+Lesvos%2C+North+Aegean+Islands%2C+Greece&regionId=3000377841&latLong=39.132097%2C26.002914&adults=2&startDate=2026-05-31&d1=2026-05-31&endDate=2026-06-03&d2=2026-06-03&lodging=VILLA)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Mesotopos%2C+Lesvos%2C+North+Aegean+Islands%2C+Greece&regionId=3000377841&latLong=39.132097%2C26.002914&adults=2&startDate=2026-05-31&d1=2026-05-31&endDate=2026-06-03&d2=2026-06-03&lodging=APART_HOTEL)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Mesotopos%2C+Lesvos%2C+North+Aegean+Islands%2C+Greece&regionId=3000377841&latLong=39.132097%2C26.002914&adults=2&startDate=2026-05-31&d1=2026-05-31&endDate=2026-06-03&d2=2026-06-03&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Mesotopos%2C+Lesvos%2C+North+Aegean+Islands%2C+Greece&regionId=3000377841&latLong=39.132097%2C26.002914&adults=2&startDate=2026-05-31&d1=2026-05-31&endDate=2026-06-03&d2=2026-06-03&lodging=VACATION_HOME)

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## Top Mesotopos Hotel Reviews

![Kaloni village apartments](https://images.trvl-media.com/lodging/19000000/18340000/18331700/18331638/125d0edf_y.jpg)

### Kaloni village apartments

10/10 Excellent

"Too Y and clean"

[](https://expedia.com/Lesvos-Hotels-Kaloni-Village-Apartments.h18331638.Hotel-Information)

![Delfinia Hotel & Bungalows](https://images.trvl-media.com/lodging/19000000/18110000/18107000/18106998/23b8b3b1_y.jpg)

### Delfinia Hotel & Bungalows

8/10 Good

"Clean rooms. Nice property right on the beach. Only downside was the pool closed too early."

[](https://expedia.com/Lesvos-Hotels-Delfinia-Hotel-Bungalows.h18106998.Hotel-Information)

![Aeolian Village Beach Resort](https://images.trvl-media.com/lodging/73000000/72650000/72649600/72649521/58a5d2d3_y.jpg)

### Aeolian Village Beach Resort

6/10 Okay

"Hotel has the Best sea/beach in the area. Turnover doesnt meet the expectation. Dinner was good, breakfast product quality was poor. 1.5 hour drive from the ferry. But overall it was a nice stay for us"

[](https://expedia.com/Lesvos-Hotels-Aeolian-Village-Beach-Resort.h72649521.Hotel-Information)

![Sappho Hotel](https://images.trvl-media.com/lodging/20000000/19860000/19852300/19852289/6c42b713_y.jpg)

### Sappho Hotel

10/10 Excellent

"I had a great stay at the hotel, it’s an amazing location right on the seafront, a few minutes walk to shops, restaurants and local amenities. The village is very small and easy to get around with the bus station and taxi office nearby. The staff were friendly and helpful and the front desk is open fairly late. My the room was very spacious and comfortable and was cleaned daily and towels, shampoos were topped up. I felt very safe staying there as a solo traveller and would definitely stay there again, as it was reasonably priced. The breakfast was not included in my booking but there is an option to pay on the day for Greek / Continental breakfast. Efxaristo bola! "

[](https://expedia.com/Lesvos-Hotels-Sappho-Hotel.h19852289.Hotel-Information)

![Eleia Seafront Rooms & Villas](https://images.trvl-media.com/lodging/14000000/13240000/13234200/13234115/c6043278_y.jpg)

### Eleia Seafront Rooms & Villas

10/10 Excellent

"Beautiful location very near Petra, rooms and facilities wonderful."

[](https://expedia.com/Lesvos-Hotels-Eleia-Seafront-Villas.h13234115.Hotel-Information)

## Find out more about Mesotopos

**Everything you need to know about Mesotopos vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mesotopos vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mesotopos vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Mesotopos vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Mesotopos. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Mesotopos in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $104 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Mesotopos rentals**

At Expedia, we put the best Mesotopos vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Mesotopos rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mesotopos vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mesotopos. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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## Frequently asked questions

### Are there vacation rentals in Mesotopos?

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