A bridge over a muddy river with green trees and hills in the background.

Mississippi County Vacations & Trips from $644

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Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

Top destinations in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.
FlightsHotels

Charleston

Charleston

The Latest Mississippi County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A modern lobby with a reception desk, seating area, and large windows.
    Dec 22 - Dec 26

    La Quinta Inn & Suites by Wyndham Hopkinsville + Flight

    Hopkinsville
    4 nights
    3.0 star property
    7.6/10 - Good (1,002 reviews)
    Roundtrip • Denver (DEN) - Paducah (PAH)
    DEN - BNA • Nonstop BNA - DEN • 1 stop
    $672
    $644
    per traveler
    found 21 hours ago
    La Quinta Inn & Suites by Wyndham Hopkinsville
  • A dining area with yellow walls, wooden tables and chairs, potted plants, and a window with a view of a house.
    Dec 22 - Dec 26

    American Inn Princeton + Flight

    Princeton
    4 nights
    2.5 star property
    7.6/10 - Good (240 reviews)
    Roundtrip • Denver (DEN) - Paducah (PAH)
    DEN - PAH • 1 stop PAH - DEN • 1 stop
    $1,233
    $1,154
    per traveler
    found 21 hours ago
    American Inn Princeton
  • A motel with a covered entrance, a sign for Kentucky-Barkley Lakes Inn, and a clear blue sky.
    Dec 22 - Dec 26

    Motel 6 Grand Rivers, KY + Flight

    Grand Rivers
    4 nights
    2.0 star property
    7.2/10 - Good (728 reviews)
    "Because of no restraunts in the area we were able to call the front desk and order a pizza and they fixed it and brought it to our room."
    Reviewed November 8, 2026
    Roundtrip • Denver (DEN) - Paducah (PAH)
    DEN - PAH • 1 stop PAH - DEN • 1 stop
    $1,209
    $1,136
    per traveler
    found 21 hours ago
    Motel 6 Grand Rivers, KY
  • A hotel room with two beds, a desk, a chair, a TV, and a bathroom visible in the background.
    Dec 22 - Dec 26

    Relax Inn & Suites + Flight

    Kuttawa
    4 nights
    2.5 star property
    9.2/10 - Wonderful (1,001 reviews)
    Roundtrip • Denver (DEN) - Paducah (PAH)
    DEN - PAH • 1 stop PAH - DEN • 1 stop
    $1,241
    $1,187
    per traveler
    found 21 hours ago
    Relax Inn & Suites
  • A wooden porch with white rocking chairs, a covered seating area, and a sign for a tailor shop.
    Dec 22 - Dec 26

    The Outpost + Flight

    Grand Rivers
    4 nights
    2.0 star property
    9.2/10 - Wonderful (37 reviews)
    Roundtrip • Denver (DEN) - Paducah (PAH)
    DEN - BNA • Nonstop BNA - DEN • 1 stop
    $776
    $742
    per traveler
    found 21 hours ago
    The Outpost

Discover the most popular places to visit in Mississippi County

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Mississippi County Hotel Deals

A building with a fountain and flower beds in front.

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
6.4 mi from Mississippi County
6.8 out of 10, (443 reviews)
$66 nightly
The price is $74
Nov 10 - Nov 11
Total with taxes and fees
The Riverstone Hotel Charleston-Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mississippi County
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.