Name: Drury Inn & Suites Sikeston, MO
Price range: $125 total
Rating: 9.6

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Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

Top destinations in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.

A tree-lined landscape with a river and fields.

Find the Best Mississippi County Vacation Packages

Mississippi County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Nashville Intl. Airport (BNA)

Mississippi County Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

Fully refundableReserve now, pay when you stay

$60 nightly

$66 total

Jul 19 - Jul 20

Total with taxes and fees

6.6/10 (648 reviews)

"Bed bugs. Woke up itching. Stayed here 3 years ago and some things were updated, but didn’t get bug bites that stay. 1) helpful and kind staff 2) exterior is half way repainted, doors and trim in a state of patching. 3) room air was swampy, even with the ac on. 4) desk, tv stand, vanity, mirror, ..."

Reviewed on Jul 13, 2026

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO

Fully refundable

$70 nightly

$78 total

Jul 17 - Jul 18

Total with taxes and fees

6.8/10 (420 reviews)

"Staff was excellent. It was fine for what it was — a cheap place near the highway"

Reviewed on Jul 10, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$109 nightly

$125 total

Jul 27 - Jul 28

Total with taxes and fees

9.6/10 Exceptional! (1,017 reviews)

"Oh my! The food was delicious, the bed is completely comfy, the room was clean and very nice, the drinks were perfect, all of the crowd that was there were all happy and pleased, I just can’t express how nice our stay was. In fact we’re staying again in the same place! ❤️"

Reviewed on Jul 13, 2026

See all 112 properties in Mississippi County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.