New Madrid, MO
Travel Guide
Visit New Madrid
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid MO
$343 nightly
The price is $369 total per night from Jun 29 to Jun 30
$369 total
Jun 29 - Jun 30
Total with taxes and fees
Stay at this vacation home in New Madrid. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions New Madrid Historical Museum and River Ridge ...
10/10 Exceptional! (1 review)
"The host was very quick to respond and so great to work with for on our stay."
Reviewed on Nov 11, 2025
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
$102 nightly
The price is $115 total per night from Jul 12 to Jul 13
$115 total
Jul 12 - Jul 13
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (580 reviews)
"Enjoyed my stay very clean and comfortable"
Reviewed on Jun 23, 2026
Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $114 total per night from Jul 5 to Jul 6
$114 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (95 reviews)
"It was absolutely wonderful! The staff was helpful, and I loved how clean everything was!"
Reviewed on Jun 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid MO
Stay at this vacation home in New Madrid. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions New Madrid Historical Museum and River Ridge ...
10/10 Exceptional! (1 review)
"The host was very quick to respond and so great to work with for on our stay."
Reviewed on Nov 11, 2025
Duck Hunting, Fishing or Relaxing Family Vacation
Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy a garden, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ...
10/10 Exceptional! (233 reviews)
"Everything was wonderful and very peaceful, fishing was a little off. But we had a great time."
Reviewed on Jun 22, 2026
Buddy's Reel' Em Inn 2 Bd 1 Bath home on Reelfoot Lake. Sleeps 6.
Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Willow Towhead and Rat Island are located ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
New Madrid Historical Museum
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
Hunter-Dawson State Historic Site
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.
River Ridge Winery
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
Explore a world of travel with Expedia
- Hotels near New Madrid Historical Museum
- Hotels near River Ridge Winery
- Hotels near Hunter-Dawson State Historic Site
- Lilbourn Hotels
- Marston Hotels
- Hotels near Marston Community Center
- Rv Parks in Marston
- Hotels with Free Breakfast in Marston
- 5 Star Hotels in Marston
- Pet-Friendly Hotels in Marston
- Houseboats in Marston
- Catron Hotels
- 5 Star Hotels in Catron
- 4 Star Hotels in Catron
- Motels in Catron
- Matthews Hotels
- Hotels near Big Oak Tree State Park
- Portageville Hotels
- Canalou Hotels
- Motels in Portageville
- East Prairie Hotels
- Lodges in East Prairie
- Motels in East Prairie
- Vacation Homes in East Prairie
- Parma Hotels
- Risco Hotels
- 3 Star Hotels in Risco
- Sikeston Hotels
- Hotels near Central Park
- Hotels near Sikeston Depot Museum
- Cheap Hotels in Sikeston
- Pet-Friendly Hotels in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Cabin Rentals in Sikeston
- Hotels with Hot Tubs in Sikeston
- Casino Hotels in Sikeston
- B&B in Sikeston
- Hotels with Restaurants in Sikeston
- Hotels with Kitchenettes in Sikeston
- Romantic Hotels in Sikeston
- 5 Star Hotels in Sikeston
- Luxury Hotels in Sikeston
- Hotels with Bars in Sikeston
- Resorts & Hotels with Spas in Sikeston
- Motels in Sikeston
- Hotels with Connecting Rooms in Sikeston
- Wyndham Hotels in Sikeston
- Hotels with Laundry Facilities in Sikeston
- Hotel Wedding Venues Hotels in Sikeston
- Historic Hotels in Sikeston
- Family Hotels in Sikeston
- Gay friendly Hotels in Sikeston
- Hotels with Suites in Sikeston
- Hotels & Resorts for Couples in Sikeston
- Hotels with an Outdoor Pool in Sikeston
- Hotels with Free Breakfast in Sikeston
- 4 Star Hotels in Sikeston
- Car rentals near Howardville
- Car rentals near Marston
- Car rentals near Catron
- Convertible Car Rentals in Catron
- Standard Car Rentals in Catron
- Suv Car Rentals in Catron
- Car rentals near Canalou
- Car rentals near Portageville
- Car rentals near East Prairie
- Car rentals near Risco
- Car rentals near Baker
- Enterprise Rental Cars in Sikeston
- Hertz Rental Cars in Sikeston
- Car rentals near Sikeston
- Van Car Rentals in Sikeston
- Budget Rental Cars in Sikeston
- Avis Rental Cars in Sikeston
