Title: Orangeburg County Vacation Packages 2026 from $522 | Expedia.com [Orangeburg County Travel Guide](https://expedia.com/Orangeburg-County.dx553248635996998003)[Orangeburg County Hotels](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Hotel-Destinations)[Vacation Rentals in Orangeburg County](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Vacation-Rental-Destinations)[Orangeburg County Flights](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Flight-Destinations)[Car Rentals in Orangeburg County](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/9953/a26d5a16-8cd2-405d-94ab-122a2f63e661.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Orangeburg County Vacations & Trips from $522 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Orangeburg County Vacation Reserve a vacation package to Orangeburg County and make planning your getaway quick and easy. With all the logistics organized before you leave, you can focus on enjoying every second in this interesting destination. With so much to do and see on a trip to Orangeburg County, it can be difficult to know where to start. Kick off your journey in [Santee](https://www.expedia.com/Santee.d9953.Destination-Travel-Guides) at Santee State Park and Santee Cooper Country Club — two much-loved attractions here. Another great city worth adding to your itinerary is [Orangeburg](https://www.expedia.com/Orangeburg.d6058108.Destination-Travel-Guides). Be sure not to miss Edisto Memorial Gardens and Smith-Hammond-Middleton Memorial Center. Whether you plan to travel for a couple of days or a couple of weeks, Expedia are here to help you customize your next Orangeburg County vacation. ## Top destinations in Orangeburg County ![Santee River Dam on Lake Marion, South Carolina, Aerial drone view of electric power lines](https://images.trvl-media.com/place/9953/712fb946-715a-4a74-8bf7-2c2bbd891023.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santee [](https://expedia.com/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/6058108/7d590932-d0d2-48e4-90bf-23f9acc0734e.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Orangeburg [](https://expedia.com/Orangeburg.d6058108.Destination-Travel-Guides) ![Eutawville, South Carolina sunset near Lake Marion with empty hammock on pine trees overlooking water landscape view at Fountain lake in spring evening with nobody](https://images.trvl-media.com/place/3000455924/dc128f90-2885-4acb-80b5-581201528ba2.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Eutawville [](https://expedia.com/Eutawville.d3000455924.Destination-Travel-Guides) ## The Latest Orangeburg County Vacation Packages Price found within the past 48 hours. Click for updated prices. ![The Francis Marion Hotel](https://images.trvl-media.com/lodging/1000000/50000/41300/41204/3ad3c4ea_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Francis Marion Hotel Charleston Historic District Save 100% on your flight $522 per person May 2 - May 5 found 1 day ago Roundtrip flight included Boston (BOS) to Charleston (CHS) 9/10 Wonderful! (1,942 reviews) Beautiful room but bathroom is small Reviewed on Feb 25, 2026 ![Emeline](https://images.trvl-media.com/lodging/1000000/10000/8900/8890/d17025e1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Emeline Charleston Historic District Save 100% on your flight $981 per person May 3 - May 7 found 1 day ago Roundtrip flight included Boston (BOS) to Charleston (CHS) 9.4/10 Exceptional! (1,661 reviews) We checked in late the front desk agent couldn't be bothered. We had a loft suite The room had stained on the carpet in the stairs. The cost was not worth the experience we received. Reviewed on Feb 22, 2026 ![The Ryder Hotel](https://images.trvl-media.com/lodging/1000000/10000/4600/4544/722c7929_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Ryder Hotel Charleston Historic District Save 100% on your flight $736 per person May 2 - May 5 found 1 day ago Roundtrip flight included Boston (BOS) to Charleston (CHS) 8.6/10 Excellent! (1,002 reviews) Staff was wonderful. Hotel is in a great location. Reviewed on Feb 25, 2026 ![The Nicholas](https://images.trvl-media.com/lodging/109000000/108630000/108620900/108620832/cfdf2587_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Nicholas Downtown Charleston Save 100% on your flight $886 per person May 17 - May 21 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Charleston (CHS) 9.6/10 Exceptional! (30 reviews) Mattress firm to the extreme and not level. No on-site baggage storage. No on-site management (which meant management was not aware the smoke detectors were wired in and were being tested by a technician on on property rather than ringing due to batteries needing to be replaced). Not a true b&b in that there were only boxed meals to go. Reviewed on Dec 13, 2025 ![Andrew Pinckney Inn](https://images.trvl-media.com/lodging/1000000/110000/106200/106130/77985f82_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Andrew Pinckney Inn Charleston Historic District Save 100% on your flight $678 per person May 2 - May 5 found 1 day ago Roundtrip flight included Boston (BOS) to Charleston (CHS) 9.6/10 Exceptional! (1,413 reviews) Nice size rooms. Staff friendly. And very nice wine happy hour. Reviewed on Feb 25, 2026 ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_553248635996998003) ## Find the Best Orangeburg County Vacation Packages ## Orangeburg County Essential Information | Language | English | | --------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | U.S dollars | | Closest Airport | Columbia Metropolitan Airport (CAE) | | Top Sights | [Santee State Park](https://www.expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction), [Edisto Memorial Gardens](https://www.expedia.com/Edisto-Memorial-Gardens-Orangeburg.d553248621532654892.Vacation-Attraction) and [Santee State Park](https://www.expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction) | ## Orangeburg County Hotel Deals ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tru By Hilton Santee 263 Britain St. and 273 Britain St. Santee SC Fully refundableReserve now, pay when you stay $102 nightly $113 total Mar 4 - Mar 5 Total with taxes and fees 9.2/10 Wonderful! (735 reviews) Yes Reviewed on Feb 25, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&selected=92600969&PinnedHotelID=92600969&HadPinnedHotel=true®ionId=553248635996998003) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont by Wyndham Santee 249 Britain Street Santee SC Fully refundableReserve now, pay when you stay $80 nightly $89 total Mar 1 - Mar 2 Total with taxes and fees 8/10 Very Good! (1,425 reviews) Room clean. Convenient location. Quick check in. Reviewed on Feb 25, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=15379&PinnedHotelID=15379&HadPinnedHotel=true®ionId=553248635996998003) ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Santee 9074 Old Number Six Hwy Santee SC Fully refundableReserve now, pay when you stay $125 nightly $139 total Mar 8 - Mar 9 Total with taxes and fees 9.8/10 Exceptional! (1,003 reviews) This will definitely be our new place to stay on our way back-and-forth to North Carolina from Florida! Reviewed on Feb 25, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=26116&PinnedHotelID=26116&HadPinnedHotel=true®ionId=553248635996998003) [See all 648 properties in Orangeburg County](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026®ionId=553248635996998003) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf 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[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) Explore a world of travel with Expedia ## Other vacations you might like - Top cities in Orangeburg County - Vacations and getaways similar to Orangeburg County - Best vacation destinations by month - [Santee Vacations ](https://expedia.com/Santee.d9953.Destination-Travel-Guides) - [Orangeburg Vacations ](https://expedia.com/Orangeburg.d6058108.Destination-Travel-Guides) - [Eutawville Vacations ](https://expedia.com/Eutawville.d3000455924.Destination-Travel-Guides) - [Neeses Vacations ](https://expedia.com/Neeses.d3000456036.Destination-Travel-Guides) - [Cope Vacations ](https://expedia.com/Cope.d3000455896.Destination-Travel-Guides) - [Rowesville Vacations 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](https://www.expedia.com/lp/b/where-to-go/vacations-september) - [October Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-october) - [November Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-november) - [December Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-december) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app