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A serene lake with trees reflecting in the water, surrounded by a forest of tall, slender trees with autumn foliage.

Orangeburg County Vacations & Trips from $784

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Top destinations in Orangeburg County

A tree with Spanish moss and autumn leaves in a body of water.
FlightsHotels

Santee

Santee

The Latest Orangeburg County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Restaurant
    Oct 12 - Oct 16

    The Ryder Hotel + Flight

    Charleston Historic District
    4 nights
    3.5 star property
    8.8/10 - Excellent (1,112 reviews)
    Roundtrip • Boston (BOS) - Charleston (CHS)
    BOS - CHS • Nonstop CHS - BOS • 1 stop
    Save 100% on your flight
    $1,272
    $784
    per traveler
    found 1 day ago
    The Ryder Hotel
  • House (5 Bedrooms) | Interior
    Sep 16 - Sep 22

    Summerset by Avantstay Resort Pool + Outdoor Lounge + Firepit + Movie Room IOP Beach Retreat + Flight

    Isle of Palms
    6 nights
    3.0 star property
    Roundtrip • New York (EWR) - Charleston (CHS)
    EWR - CHS • Nonstop CHS - EWR • Nonstop
    Save 100% on your flight
    $6,201
    $4,360
    per traveler
    found 1 day ago
    Summerset by Avantstay Resort Pool + Outdoor Lounge + Firepit + Movie Room IOP Beach Retreat
  • Reception
    Sep 7 - Sep 12

    The Pinch Hotel + Flight

    Charleston Historic District
    5 nights
    4.0 star property
    9.8/10 - Exceptional (203 reviews)
    Roundtrip • Boston (BOS) - Charleston (CHS)
    BOS - CHS • Nonstop CHS - BOS • 1 stop
    Save 100% on your flight
    $1,508
    $1,076
    per traveler
    found 1 day ago
    The Pinch Hotel
  • Lobby
    Oct 8 - Oct 11

    The Charleston Place + Flight

    Charleston Historic District
    3 nights
    5.0 star property
    9.6/10 - Exceptional (1,004 reviews)
    "We got married at the Charleston Place 22 years ago! We have been back there about 17+ times since. The hotel, staff and amenities only get better each year; from personal, hand-written notes, to room service (breakfast) by to pool, to champagne waiting in our room at night!!! It is wonderful to see many of the same beautiful, cheerful faces year after year. The staff is AMAZING. I would definitely recommend making The Charleston Place a tradition for any couple ❤️"
    Reviewed August 1, 2026
    Roundtrip • Boston (BOS) - Charleston (CHS)
    BOS - CHS • Nonstop CHS - BOS • 2 stops
    Save 100% on your flight
    $2,509
    $1,800
    per traveler
    found 1 day ago
    The Charleston Place
  • Aerial view
    Oct 8 - Oct 11

    Planters Inn + Flight

    Charleston Historic District
    3 nights
    4.5 star property
    9.6/10 - Exceptional (1,000 reviews)
    "Great central location. Very charming property. Nice room. Clean bathroom. Friendly and helpful staff. We will definitely stay again when we return to Charleston."
    Reviewed July 30, 2026
    Roundtrip • Boston (BOS) - Charleston (CHS)
    BOS - CHS • Nonstop CHS - BOS • 2 stops
    Save 100% on your flight
    $2,333
    $1,686
    per traveler
    found 1 day ago
    Planters Inn

Discover the most popular places to visit in Orangeburg County

Santee Cooper Country Club

7.8/10 (94 reviews)
Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savor the top-notch restaurants.

Orangeburg County Hotel Deals

Property amenity

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
22.4 mi from Orangeburg County
9.8 out of 10, Exceptional, (1,001 reviews)
"Clean, amazing staff, beautiful amenities! Loved every second of our stay!!!!"
$134 nightly
The price is $149
Aug 9 - Aug 10
Total with taxes and fees
Fairfield Inn & Suites by Marriott Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Orangeburg County
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.