Santee Vacations from $354

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Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

The Latest Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
Price was $459, price is now $354 per person
$354
per person
Oct 16 - Oct 19
found 8 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Columbia (CAE)
8.2/10 Very Good! (1,002 reviews)
I like how clean and calm the place is. The staff was good, approachable and well-mannered.

Reviewed on Aug 24, 2025

Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

4 out of 5
Downtown Columbia
Save 100% on your flight
Price was $1,444, price is now $1,140 per person
$1,140
per person
Oct 16 - Oct 19
found 8 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Columbia (CAE)
9.4/10 Exceptional! (1,000 reviews)
Friendly and helpful staff! Would definitely stay again

Reviewed on Aug 21, 2025

Sleep Inn Airport

Sleep Inn Airport

2.5 out of 5
Price was $448, price is now $359 per person
$359
per person
Nov 5 - Nov 8
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Columbia (CAE)
7.8/10 Good! (789 reviews)
Area felt a bit sketchy but the employee I dealt with was awesome and the bed was super comfy. Worth the money, wish they had less scary looking folks walking around shirtless.

Reviewed on Aug 4, 2025

Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG

Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG

2.5 out of 5
Price was $587, price is now $474 per person
$474
per person
Oct 16 - Oct 19
found 8 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Columbia (CAE)
8.6/10 Excellent! (1,009 reviews)
The location was amazing.

Reviewed on Aug 21, 2025

Homewood Suites by Hilton Columbia

Homewood Suites by Hilton Columbia

3 out of 5
Price was $670, price is now $542 per person
$542
per person
Oct 16 - Oct 19
found 8 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Columbia (CAE)
8.2/10 Very Good! (864 reviews)
The stay was ok but needs better cleaners, bed sheets with stains, bathtub not cleaned, chairs in the breakfast area filthy, rust in the bthtub, peeling paint, dirty corners. This place needs a rehab. And make over. Its a shame too that many military families viait here for the graduations and this is the conditions.

Reviewed on Aug 16, 2025

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Discover the most popular places to visit in Santee

Santee State Park

You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savor the top-notch restaurants.

Santee State Park

Santee Cooper Country Club

Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savor the top-notch restaurants.

Santee Cooper Country Club

Santee National Golf Club

Enjoy a round of golf in Santee at Santee National Golf Club. While you're here, you can savor the top-notch restaurants.

Santee National Golf Club

Santee Hotel Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Aug 25 to Aug 26
$83 total
Aug 25 - Aug 26
Total with taxes and fees
7.8/10 Good! (1,329 reviews)
"The front desk lady was fantastic! So helpful when it came to finding a place to grab a quick bite to eat. The property itself was very lovely. It was clean and updated with a touch of old school motel feel."

Reviewed on Aug 19, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Sep 7 to Sep 8
$112 total
Sep 7 - Sep 8
Total with taxes and fees
9/10 Wonderful! (510 reviews)
"Everything was excellent but the bed was too hard."

Reviewed on Aug 23, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $144 total per night from Sep 1 to Sep 2
$144 total
Sep 1 - Sep 2
Total with taxes and fees
9.8/10 Exceptional! (1,001 reviews)
"Really amazing hotel for a quick stop. Beyond friendly staff. Great well lit parking with plenty of food options close bye. Bed and pillows were great l. We will be back. Even gave our dog some doggy biscuits. Great job"

Reviewed on Aug 21, 2025

Fairfield Inn & Suites by Marriott Santee
See all 292 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Santee vacation package cost?
Offering excellent value package deals from $354 on Expedia, you'll be surprised at how little a vacation to Santee costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Santee?
If you're hoping to snag a cheap Santee vacation package, consider visiting in January, September and October. You're likely to find better prices on accommodations and flights during these quieter months — ideal for budget-conscious travelers.
How many days is enough for Santee?
The ideal length for your Santee vacation depends on what you'd like to see and do. Usually, a few days to a week will give you time to hit all the leading attractions and explore some hidden treasures along the way.
Is it worth booking a vacation package to Santee?
It's no wonder a Santee vacation is on the to-do list of many travelers. Major attractions like Santee State Park are just the beginning of things to see and do here.
How to find the best Santee package deals?
Use Expedia's handy filters to help you find some fabulous Santee package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or search for Santee package deals in the low season. Switch up your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Santee vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking stays and flights individually. Better still, you can customize your Santee trip to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Santee?
If you have your Santee vacation dates locked in, book as soon as you can to score some incredible deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
If you're anything like us, you love discovering new places but don't love the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the total cost of your Santee trip across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.