Santee Vacations from $365

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Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

The Latest Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
Seven Oaks
Price was $503, price is now $365 per person
$365
per person
Sep 22 - Sep 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Columbia (CAE)
8.2/10 Very Good! (1,111 reviews)
Great stay

Reviewed on Jul 11, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

3 out of 5
Price was $612, price is now $454 per person
$454
per person
Sep 22 - Sep 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Columbia (CAE)
8.2/10 Very Good! (1,011 reviews)
Everyone that we came in contact with was awesome. Our room , the pool and the breafast was great. The location is five min. To our family so we will definitely be making this our go to when we are in columbia ,south carolina.

Reviewed on Jul 12, 2026

Tru By Hilton Columbia Greystone

Tru By Hilton Columbia Greystone

2.5 out of 5
Price was $740, price is now $578 per person
$578
per person
Aug 28 - Sep 3
found 1 day ago
Roundtrip flight included
Boston (BOS) to Columbia (CAE)
9.2/10 Wonderful! (1,009 reviews)
Avoid them at all cost!!!! Floors in my room were filthy. And to top it all off when I took the first bite of my scrambled eggs there was a hair it. Never going to another Hilton again. I will get my money refunded through my cc

Reviewed on Jul 11, 2026

Holiday Inn Express & Suites Columbia-Fort Jackson by IHG

Holiday Inn Express & Suites Columbia-Fort Jackson by IHG

2.5 out of 5
Price was $695, price is now $559 per person
$559
per person
Sep 22 - Sep 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Columbia (CAE)
8.6/10 Excellent! (1,004 reviews)
Check in was really easy staff was so kind and helpful if I had a complaint it would probably be the high charge for canceling a day early . My fault but I thought it was excess .

Reviewed on Jul 10, 2026

Courtyard by Marriott Columbia Downtown at USC

Courtyard by Marriott Columbia Downtown at USC

3 out of 5
Downtown Columbia
Price was $904, price is now $733 per person
$733
per person
Aug 28 - Sep 3
found 1 day ago
Roundtrip flight included
Boston (BOS) to Columbia (CAE)
8.8/10 Excellent! (1,010 reviews)
Everything about my stay was excellent. Hotel had everything we needed. Staff were very friendly and helpful. Looking forward to several more stays as my granddaughter maneuvers herself through University of South Carolina.

Reviewed on Jul 11, 2026

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Stay near popular Santee attractions

Santee State Park

8.0/10 (219 reviews)
Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.
See properties

Santee Hotel Deals

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $108 total per night from Aug 2 to Aug 3
$108 total
Aug 2 - Aug 3
Total with taxes and fees
9.2/10 Wonderful! (877 reviews)
"The staff and breakfast and atmosphere was excellent and welcoming. The only down side is there weren’t any closets or dressers in the hotel room to fully settle in. Also the pool wasn’t completely clean and had some floating brown bubbles. Other than that the hotel and staff were amazing."

Reviewed on Jul 9, 2026

Tru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $87 total per night from Jul 26 to Jul 27
$87 total
Jul 26 - Jul 27
Total with taxes and fees
8/10 Very Good! (1,481 reviews)
"We just stopped for a night on the way back home from Florida. All staff were super friendly and kind! The room was clean and upgraded. Very close from I-95, surrounded by the restaurant and gas stations. Reasonable price with nice staff is all I needed!!"

Reviewed on Jul 12, 2026

Baymont by Wyndham Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $124 total per night from Jul 14 to Jul 15
$124 total
Jul 14 - Jul 15
Total with taxes and fees
8.8/10 Excellent! (1,007 reviews)
"Convenient location and a comfortable stay."

Reviewed on Jul 11, 2026

Best Western Plus Santee Inn
See all 313 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santee Vacation Packages

Santee Essential Information

Language
English
Currency
U.S dollars
Population
940
Max Temp Winter
55ºF
Max Temp Summer
90ºF
Top Sights
Santee State Park, Santee Cooper Country Club and Santee National Golf Club

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Frequently asked questions

How much does a Santee vacation package cost?
Offering excellent value package deals from $365 on Expedia, you'll be surprised at how little a vacation to Santee costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Santee?
If you're hoping to snag a cheap Santee vacation package, consider visiting in January, September and October. You're likely to find better prices on accommodations and flights during these quieter months — ideal for budget-conscious travelers.
How many days is enough for Santee?
The ideal length for your Santee vacation depends on what you'd like to see and do. Usually, a few days to a week will give you time to hit all the leading attractions and explore some hidden treasures along the way.
Is it worth booking a vacation package to Santee?
It's no wonder a Santee vacation is on the to-do list of many travelers. Major attractions like Santee State Park are just the beginning of things to see and do here.
How to find the best Santee package deals?
Use Expedia's handy filters to help you find some fabulous Santee package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or search for Santee package deals in the low season. Switch up your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Santee vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking stays and flights individually. Better still, you can customize your Santee trip to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Santee?
If you have your Santee vacation dates locked in, book as soon as you can to score some incredible deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
If you're anything like us, you love discovering new places but don't love the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the total cost of your Santee trip across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up cheap vacation packages with payment plans as soon as you spot them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.