Ostiense Vacations from $828

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,391, price is now $828 per person
$828
per person
Apr 25 - Apr 30
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
7.4/10 Good! (1,026 reviews)
Hotel is nice very close to St. Peter Basilica. Room is clean, breakfast is good.

Reviewed on Feb 1, 2026

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Price was $2,765, price is now $1,279 per person
$1,279
per person
Apr 16 - Apr 22
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Amazing location, very clean and staff were delightful!! Will definitely come back next time in Rome!

Reviewed on Feb 1, 2026

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,975, price is now $957 per person
$957
per person
Apr 16 - Apr 21
found 11 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Excelente lugar en una area muy tranquila y cerca de lugares para ir a comer o cenar, su personal muy amable elvis, Diego todo si personal .🙏🙏🙏

Reviewed on Jan 17, 2026

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $2,201, price is now $1,279 per person
$1,279
per person
Apr 17 - Apr 22
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (335 reviews)
Wonderful stay, would be back

Reviewed on Dec 16, 2025

Exe International Palace

Exe International Palace

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,118, price is now $1,294 per person
$1,294
per person
Apr 18 - Apr 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
7.8/10 Good! (1,002 reviews)
Very nice ,clean, and friendly hotel.

Reviewed on Feb 3, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Aparthotel Colombo Roma

Aparthotel Colombo Roma

4 out of 5
Via Cristoforo Colombo 112 Rome RM
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $108 total per night from Feb 23 to Feb 24
$108 total
Feb 23 - Feb 24
Total with taxes and fees
9/10 Wonderful! (365 reviews)
The staff were so kind and helpful. I loved the fact that tours were included in the stay. The hotel is near the major bus lines to get to tourist attractions.

Reviewed on Jan 15, 2026

Aparthotel Colombo Roma
Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $164 total per night from Feb 8 to Feb 9
$164 total
Feb 8 - Feb 9
Total with taxes and fees
8.6/10 Excellent! (1,932 reviews)
Great room,Great location in Rome.we stayed 6 nights.when i go back to Rome I would stay here again.

Reviewed on Feb 1, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$181 nightly
The price is $216 total per night from Feb 9 to Feb 10
$216 total
Feb 9 - Feb 10
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Everything was high standard

Reviewed on Jan 19, 2026

Hotel Nazionale
See all 16,123 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

4.5/5(352 reviews)

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$30
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.