Ostiense Vacations

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
$166 nightly
The price is $200 total per night from Mar 2 to Mar 3
$200 total
Mar 2 - Mar 3
Total with taxes and fees
8.6/10 Excellent! (1,936 reviews)
Good service, close to activities

Reviewed on Feb 22, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$194 nightly
The price is $231 total per night from Feb 26 to Feb 27
$231 total
Feb 26 - Feb 27
Total with taxes and fees
9.6/10 Exceptional! (1,009 reviews)
Very clean room and very friendly and helpful staff.

Reviewed on Feb 24, 2026

Hotel Nazionale
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $248 total per night from Mar 8 to Mar 9
$248 total
Mar 8 - Mar 9
Total with taxes and fees
9.4/10 Exceptional! (1,222 reviews)
Lovely hotel located in beautiful Trastevere.

Reviewed on Feb 25, 2026

Trastevere Roma | UNA Esperienze
See all 16,222 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

4.5/5(352 reviews)

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64
per adult
94% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.