Ostiense Vacations from $1,000

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
EXE Domus Aurea

EXE Domus Aurea

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 3 - Sep 10
found 16 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (476 reviews)
Good location and friendly staff. Although this didn’t bother me, it could be a bit noisy at night due to some night walkers on the street.

Reviewed on Nov 19, 2024

Smart Guesthouse

Smart Guesthouse

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 6 - Sep 13
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (44 reviews)
The room is in excellent condition, clean and a very comfortable bed. Super convenient since it’s 2 blocks away from the Termini. Plus, the owner answers your questions very quickly and all these details make your visit a very enjoyable experience.

Reviewed on Jun 28, 2025

Piazza di Spagna Suite de Charme

Piazza di Spagna Suite de Charme

1 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 3 - Sep 10
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (212 reviews)
Already recommended this place to friends. As close to the Spanish steps for the price as one can get!

Reviewed on Jun 27, 2025

Rhinoceros

Rhinoceros

5 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 15 - Sep 20
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.4/10 Exceptional! (18 reviews)
Hotel Vite - By Naman Hotellerie

Hotel Vite - By Naman Hotellerie

3 out of 5
Rome City Centre
per person
Aug 24 - Aug 30
found 15 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9/10 Wonderful! (831 reviews)
We’ve stated here two times and we love it! The staff is especially great and accommodating.

Reviewed on Jun 24, 2025

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Cardo Roma, Autograph Hotel
Cardo Roma, Autograph Hotel
4 out of 5
Viale Del Pattinaggio 100, Rome, RM
Fully refundableReserve now, pay when you stay
$180 nightly
The price is $216 total per night from Jul 24 to Jul 25
$216 total
Jul 24 - Jul 25
Total includes taxes and fees
8.8/10 Excellent! (47 reviews)
"We enjoyed our one night stay at Carco Romo. We were heading out on a cruise the next morning. They were very helpful in arranging transportation to our Colosseum tour into the city. The next morning breakfast was available and with great variety at the restaurant downstairs. We would recommend this ..."

Reviewed on Jun 19, 2025

Cardo Roma, Autograph Hotel
Hotel Quirinale
Hotel Quirinale
4 out of 5
Via Nazionale 7, Rome, RM
Fully refundableReserve now, pay when you stay
$242 nightly
The price is $284 total per night from Jul 20 to Jul 21
$284 total
Jul 20 - Jul 21
Total includes taxes and fees
8.4/10 Very Good! (1,823 reviews)
"Beautiful hotel and the staff were so accommodating and friendly! The courtyard is picturesque and the breakfast buffet exceeded our expectations!!!"

Reviewed on Jun 28, 2025

Hotel Quirinale
Hilton Garden Inn Rome Airport
Hilton Garden Inn Rome Airport
4 out of 5
Via Vittorio Bragadin 2, Fiumicino, RM
Fully refundableReserve now, pay when you stay
$208 nightly
The price is $243 total per night from Jul 4 to Jul 5
$243 total
Jul 4 - Jul 5
Total includes taxes and fees
8/10 Very Good! (2,829 reviews)
"Great just to stay one night in order to get to the airport early in the morning"

Reviewed on Jun 30, 2025

Hilton Garden Inn Rome Airport
See all 15,473 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

4.5/5(352 reviews)

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the stunning cathedral and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the churches and notable monuments in this vibrant area.

Roma Tre University

Things to do

Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$68
per adult
92% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
Ancient Ostia Antica Semi-Private Day Trip from Rome by Train with Guide

Ancient Ostia Antica Semi-Private Day Trip from Rome by Train with Guide

$68
per adult
96% of travellers recommend
Ancient Ostia Antica Semi-Private Day Trip from Rome by Train with Guide
3-Day Southern Italy Tour: Naples, Pompeii, Sorrento & Capri from Rome

3-Day Sorrento, Capri & Pompeii Mini Tour

$1,305
per traveler
80% of travellers recommend
3-Day Sorrento, Capri & Pompeii Mini Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.