Ostiense Vacations from $754

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Kent

Hotel Kent

3 out of 5
Salario
Price was $1,086, price is now $754 per person
$754
per person
Jan 1 - Jan 8
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
7.6/10 Good! (143 reviews)
it was a good experience, very nice staff, so convenient, easy transportation. Highly recommend!

Reviewed on Oct 21, 2025

JC Hotel

JC Hotel

4 out of 5
Fonte Ostiense
Save 100% on your flight
Price was $1,715, price is now $883 per person
$883
per person
Jan 1 - Jan 8
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (133 reviews)
Monastero dei Santi

Monastero dei Santi

5 out of 5
Municipio I
Save 100% on your flight
Price was $4,650, price is now $2,918 per person
$2,918
per person
Dec 27 - Jan 3
found 15 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
10/10 Exceptional! (24 reviews)
Amazing time. A great 8 days! Thank you! A rare view of Rome!!

Reviewed on Oct 8, 2025

EXE Domus Aurea

EXE Domus Aurea

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,231, price is now $779 per person
$779
per person
Jan 1 - Jan 8
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (483 reviews)
Good location and friendly staff. Although this didn’t bother me, it could be a bit noisy at night due to some night walkers on the street.

Reviewed on Nov 19, 2024

TB Place Roma

TB Place Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,685, price is now $1,155 per person
$1,155
per person
Dec 7 - Dec 12
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (43 reviews)
We pretty much likes everything about the property. My wife and I travel a lot and normally go to very good hotels which are bigger, but we wanted to try a boutique hotel this time and it did not disappoint. We stayed for 6 nights. For starters, their people are wonderful, with a special shout out to Martina at the front desk and the young lady that runs the breakfast (we should know her name). The location is great, the hotel is in great condition. We stayed in a junior suite and it was a really good size. We tend to be on the picky side, and honestly we can’t find anything bad to say. Keep it up!

Reviewed on Jun 1, 2025

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7, Rome, RM
$157 nightly
The price is $191 total per night from Nov 18 to Nov 19
$191 total
Nov 18 - Nov 19
Total with taxes and fees
8.6/10 Excellent! (1,892 reviews)
"Have stayed in this hotel many times over the last 15 years. Disappointing the very slow draining shower which wasn’t fixed despite requesting it to be. Will still stay again in future as it is such a good location / classic Rome."

Reviewed on Oct 18, 2025

Hotel Quirinale
The Social Hub Rome

The Social Hub Rome

Viale Scalo San Lorenzo 10, Rome, RM
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $116 total per night from Nov 2 to Nov 3
$116 total
Nov 2 - Nov 3
Total with taxes and fees
9/10 Wonderful! (455 reviews)
"The whole set up is a modern feel with a bit of its own personality. Great amenities (24/7 gym/laundry), large lounge space for fun and work. Friendly staff"

Reviewed on Oct 21, 2025

The Social Hub Rome
Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105, Rome, RM
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $195 total per night from Nov 20 to Nov 21
$195 total
Nov 20 - Nov 21
Total with taxes and fees
8.2/10 Very Good! (1,019 reviews)
"Joel was amazing . Warm welcome at front desk, attentive. Easy access to metro station. Comfortable."

Reviewed on Oct 19, 2025

Napoleon Hotel
See all 15,642 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the churches and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
82% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$35
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Picture 1 for Activity Rome: Vatican Museums, Sistine Chapel, and Basilica Tour

Vatican Museums, Sistine Chapel & St. Peter's Square Tour

$92
per adult
86% of travellers recommend
Vatican Museums, Sistine Chapel & St. Peter's Square Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.