Ostiense Vacations from $1,127

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,870, price is now $1,127 per person
$1,127
per person
Apr 4 - Apr 9
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Excelente lugar en una area muy tranquila y cerca de lugares para ir a comer o cenar, su personal muy amable elvis, Diego todo si personal .🙏🙏🙏

Reviewed on Jan 17, 2026

Hotel Varese Roma

Hotel Varese Roma

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,087, price is now $1,371 per person
$1,371
per person
May 2 - May 9
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8.6/10 Excellent! (342 reviews)
Room clean with complete amenities. Close to Termini. Breakfast was great. Nice staff.

Reviewed on Jan 4, 2026

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,846, price is now $1,635 per person
$1,635
per person
Apr 2 - Apr 7
found 20 hours ago
Roundtrip flight included
Los Angeles (LAX) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Amazing location, very clean and staff were delightful!! Will definitely come back next time in Rome!

Reviewed on Feb 1, 2026

ROMEO Roma

ROMEO Roma

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $6,702, price is now $3,961 per person
$3,961
per person
Apr 16 - Apr 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
No reviews
Elizabeth Unique Hotel

Elizabeth Unique Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,578, price is now $1,628 per person
$1,628
per person
Apr 16 - Apr 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (243 reviews)
Completely magical experience staying here. The superlative staff, stunning design and perfect location couldn’t have been better. This is my new home in Roma!

Reviewed on Jan 28, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $182 total per night from Feb 9 to Feb 10
$182 total
Feb 9 - Feb 10
Total with taxes and fees
8.6/10 Excellent! (1,939 reviews)
Location is very good and close to the station. Nice old building rooms very clean and smelt lovely!

Reviewed on Feb 4, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$187 nightly
The price is $224 total per night from Feb 11 to Feb 12
$224 total
Feb 11 - Feb 12
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Everything was high standard

Reviewed on Jan 19, 2026

Hotel Nazionale
Hilton Garden Inn Rome Airport

Hilton Garden Inn Rome Airport

4 out of 5
Via Vittorio Bragadin 2 Fiumicino RM
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $187 total per night from Feb 15 to Feb 16
$187 total
Feb 15 - Feb 16
Total with taxes and fees
8/10 Very Good! (3,675 reviews)
The room was clean, the staff was courteous, and the shuttle service to the airport was great, but the mattress in my room was very uncomfortable and needs to get replaced. Thank you

Reviewed on Feb 3, 2026

Hilton Garden Inn Rome Airport
See all 16,132 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$30
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.