Ostiense Vacations from $834

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
P88Guesthouse

P88Guesthouse

3 out of 5
Rome City Centre
Price was $2,339, price is now $834 per person
$834
per person
Apr 1 - Apr 2
found 21 hours ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
7/10 Good! (4 reviews)
This was an okay place to stay. Some strange off-putting things made our experience somewhat negative. There was weird satanic art on the walls and a robot that looked like a surveillance device which we made sure to unplug. Other than that, the bathroom, bed, and temperature were nice. You definitely get what you pay for. Located conveniently next to the train station and we had a great day walking to and from.

Reviewed on Jul 25, 2025

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,712, price is now $1,996 per person
$1,996
per person
May 16 - May 22
found 1 hour ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (208 reviews)
Very clean, very helpful staff

Reviewed on Jan 27, 2026

Tree Charme Parliament Boutique Hotel

Tree Charme Parliament Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,363, price is now $2,060 per person
$2,060
per person
May 10 - May 16
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8.8/10 Excellent! (28 reviews)
One of the best hotels I’ve ever stayed at. It’s a newer hotel in Rome. The room was clean, the staff were very helpful, and the cleaning lady was very thorough. I’d definitely stay here again when I return to Rome. Also, the breakfast and service were great!

Reviewed on Dec 3, 2025

Hotel Mirti

Hotel Mirti

1 out of 5
Prenestino-Centocelle
Price was $2,374, price is now $854 per person
$854
per person
Apr 1 - Apr 2
found 21 hours ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
7.6/10 Good! (18 reviews)
Accessible to subway, mcdonalds and other local shops.

Reviewed on Jun 20, 2019

HOTEL XX SETTEMBRE

HOTEL XX SETTEMBRE

3 out of 5
Rome City Centre
Price was $2,393, price is now $883 per person
$883
per person
Apr 1 - Apr 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
8.6/10 Excellent! (82 reviews)
Staff was amazing. Although the neighborhood looks sketchy, specially at night, it is an amazing place to stay, never felt unsafe. Very close to train terminal which gives you easy access to move around. Room was clean and comfortable.

Reviewed on Feb 22, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
$160 nightly
The price is $194 total per night from Mar 1 to Mar 2
$194 total
Mar 1 - Mar 2
Total with taxes and fees
8.6/10 Excellent! (1,940 reviews)
The room is clean, staff is friendly, breakfast is good, the location is great. One negative is that We felt tramor occasionally from subway or bus.

Reviewed on Feb 25, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$224 nightly
The price is $264 total per night from Mar 5 to Mar 6
$264 total
Mar 5 - Mar 6
Total with taxes and fees
9.6/10 Exceptional! (1,006 reviews)
Very clean room and very friendly and helpful staff.

Reviewed on Feb 24, 2026

Hotel Nazionale
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$223 nightly
The price is $264 total per night from Mar 15 to Mar 16
$264 total
Mar 15 - Mar 16
Total with taxes and fees
9.4/10 Exceptional! (1,217 reviews)
Great staff, impeccable cleanliness, lovely scent ( yes the place smelt great) and awesome location

Reviewed on Feb 25, 2026

Trastevere Roma | UNA Esperienze
See all 16,211 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

4.5/5(352 reviews)

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64
per adult
94% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.