Ostiense Vacations from $1,595

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Tree Charme Augusto Boutique Hotel

Tree Charme Augusto Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,326, price is now $1,595 per person
$1,595
per person
Apr 14 - Apr 20
found 15 hours ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.6/10 Exceptional! (26 reviews)
Beautiful room, helpful staff and great location

Reviewed on Jan 7, 2026

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,726, price is now $2,010 per person
$2,010
per person
May 16 - May 22
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (208 reviews)
Very clean, very helpful staff

Reviewed on Jan 27, 2026

DOM Hotel

DOM Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,465, price is now $2,714 per person
$2,714
per person
May 17 - May 22
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (391 reviews)
Everything was superior!..Staff went above and beyond for my stay.

Reviewed on Jan 26, 2026

U-Visionary Roma Hotel

U-Visionary Roma Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,408, price is now $2,095 per person
$2,095
per person
May 17 - May 22
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.6/10 Exceptional! (411 reviews)
I was so disappointed with this hotel. It purports to be a 5 star hotel and I was certainly paying a rate commensurate with that but it simply isn’t of a high enough standard to deserve a 5 star rating. From staff arguing with each other in front of us to being denied entry to the bar because it was too busy; there simply isn’t enough room for me to list their faults here, which essentially come down to a lack of attention to detail and care but if the management want to write to me I will give them the full list.

Reviewed on Jan 3, 2026

TB Place Roma

TB Place Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,704, price is now $2,474 per person
$2,474
per person
Apr 14 - Apr 20
found 15 hours ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.2/10 Wonderful! (46 reviews)
Fantastic hotel, nice rooms, very helpful staff and a central but quiet location.

Reviewed on Feb 22, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $200 total per night from Mar 4 to Mar 5
$200 total
Mar 4 - Mar 5
Total with taxes and fees
8.6/10 Excellent! (1,945 reviews)
Nice hotel, good breakfast, good location, lots of shops and restaurants nearby.

Reviewed on Mar 2, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$223 nightly
The price is $264 total per night from Mar 12 to Mar 13
$264 total
Mar 12 - Mar 13
Total with taxes and fees
9.6/10 Exceptional! (1,008 reviews)
Very clean room and very friendly and helpful staff.

Reviewed on Feb 24, 2026

Hotel Nazionale
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$217 nightly
The price is $257 total per night from Mar 11 to Mar 12
$257 total
Mar 11 - Mar 12
Total with taxes and fees
9.4/10 Exceptional! (1,225 reviews)
Clean - spacious - professional staff- perfect location

Reviewed on Mar 1, 2026

Trastevere Roma | UNA Esperienze
See all 16,211 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.