Ostiense Vacations from $815

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,464, price is now $815 per person
$815
per person
Apr 20 - Apr 23
found 10 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Very pleasant staff. Room clean and spacious. Nice and central for shopping, restaurants, sightseeing etc.

Reviewed on Feb 10, 2026

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $2,652, price is now $1,468 per person
$1,468
per person
Apr 18 - Apr 25
found 19 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Rome (FCO)
9.6/10 Exceptional! (335 reviews)
Lovely hotel with lovely, warm and welcoming staff. Nothing too much trouble. Conveniently located about 7 minutes walk from Piazza del Popolo and within easy reach of bus, tram and metro stops. Breakfasts offered a great variety of delicious options to suit all tastes and diets. We also enjoyed a lovely dinner one evening as well as a delicious cocktail. We will definitely return.

Reviewed on Feb 10, 2026

Palazzo Dama

Palazzo Dama

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,467, price is now $3,070 per person
$3,070
per person
Mar 20 - Mar 27
found 2 days ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
8.8/10 Excellent! (171 reviews)
We had a great time at the hotel. The staff were very friendly and helpful, the rooms were clean and comfortable, and the atmosphere was relaxing. The location was convenient, and we really enjoyed the facilities. Overall, it was a wonderful stay, and we would definitely come back.”

Reviewed on Aug 16, 2025

Palazzo Nainer

Palazzo Nainer

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,608, price is now $1,822 per person
$1,822
per person
Mar 20 - Mar 27
found 2 days ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.4/10 Exceptional! (186 reviews)
Perfect location, clean room, friendly staff, great vibe. Would recommend staying here for sure

Reviewed on Feb 15, 2026

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,549, price is now $898 per person
$898
per person
Apr 10 - Apr 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Courteous and helpful staff. Clean, great amenities

Reviewed on Feb 8, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $201 total per night from Feb 22 to Feb 23
$201 total
Feb 22 - Feb 23
Total with taxes and fees
8.6/10 Excellent! (1,940 reviews)
Room was elegant and comfortable. Staff was helpful and courteous. Nice stay!

Reviewed on Feb 11, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$195 nightly
The price is $232 total per night from Feb 26 to Feb 27
$232 total
Feb 26 - Feb 27
Total with taxes and fees
9.4/10 Exceptional! (1,004 reviews)
The location is amazing, the building is fascinating and the staff are incredibly helpful and friendly.

Reviewed on Feb 9, 2026

Hotel Nazionale
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $183 total per night from Feb 25 to Feb 26
$183 total
Feb 25 - Feb 26
Total with taxes and fees
9.4/10 Exceptional! (1,209 reviews)
Great experience and location

Reviewed on Feb 14, 2026

Trastevere Roma | UNA Esperienze
See all 16,129 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64
per adult
94% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.