Ostiense Vacations from $1,118

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $2,102, price is now $1,118 per person
$1,118
per person
Apr 30 - May 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Courteous and helpful staff. Clean, great amenities

Reviewed on Feb 8, 2026

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Price was $2,707, price is now $1,334 per person
$1,334
per person
Apr 1 - Apr 7
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Very pleasant staff. Room clean and spacious. Nice and central for shopping, restaurants, sightseeing etc.

Reviewed on Feb 10, 2026

ROMEO Roma

ROMEO Roma

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $8,217, price is now $4,893 per person
$4,893
per person
May 4 - May 10
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
No reviews
U-Visionary Roma Hotel

U-Visionary Roma Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,033, price is now $1,810 per person
$1,810
per person
Apr 24 - Apr 29
found 4 hours ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (411 reviews)
I was so disappointed with this hotel. It purports to be a 5 star hotel and I was certainly paying a rate commensurate with that but it simply isn’t of a high enough standard to deserve a 5 star rating. From staff arguing with each other in front of us to being denied entry to the bar because it was too busy; there simply isn’t enough room for me to list their faults here, which essentially come down to a lack of attention to detail and care but if the management want to write to me I will give them the full list.

Reviewed on Jan 3, 2026

Elizabeth Unique Hotel

Elizabeth Unique Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,216, price is now $2,008 per person
$2,008
per person
Apr 1 - Apr 7
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (243 reviews)
Completely magical experience staying here. The superlative staff, stunning design and perfect location couldn’t have been better. This is my new home in Roma!

Reviewed on Jan 28, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $201 total per night from Mar 4 to Mar 5
$201 total
Mar 4 - Mar 5
Total with taxes and fees
8.6/10 Excellent! (1,938 reviews)
Room was elegant and comfortable. Staff was helpful and courteous. Nice stay!

Reviewed on Feb 11, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$188 nightly
The price is $225 total per night from Feb 15 to Feb 16
$225 total
Feb 15 - Feb 16
Total with taxes and fees
9.6/10 Exceptional! (1,002 reviews)
The location is amazing, the building is fascinating and the staff are incredibly helpful and friendly.

Reviewed on Feb 9, 2026

Hotel Nazionale
Hotel Dei Mellini

Hotel Dei Mellini

4 out of 5
Via Muzio Clementi 81 Rome RM
Fully refundableReserve now, pay when you stay
$258 nightly
The price is $301 total per night from Feb 15 to Feb 16
$301 total
Feb 15 - Feb 16
Total with taxes and fees
9.2/10 Wonderful! (1,007 reviews)
The room was of excellent standard and the staff were courteous.

Reviewed on Feb 11, 2026

Hotel Dei Mellini
See all 16,129 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64
per adult
94% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.