Ostiense Vacations from $1,059

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Smart Guesthouse

Smart Guesthouse

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,709, price is now $1,059 per person
$1,059
per person
Apr 12 - Apr 18
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (76 reviews)
Great location because of how close it is to the train station, stay was very pleasant. The hotel was super communicative. Would recommend!

Reviewed on Nov 19, 2025

Elizabeth Unique Hotel

Elizabeth Unique Hotel

5 out of 5
Rome City Centre
Price was $2,645, price is now $2,061 per person
$2,061
per person
Mar 17 - Mar 21
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.6/10 Exceptional! (243 reviews)
Completely magical experience staying here. The superlative staff, stunning design and perfect location couldn’t have been better. This is my new home in Roma!

Reviewed on Jan 28, 2026

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Price was $1,892, price is now $1,190 per person
$1,190
per person
Apr 13 - Apr 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Courteous and helpful staff. Clean, great amenities

Reviewed on Feb 8, 2026

Terrace Pantheon Relais

Terrace Pantheon Relais

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,625, price is now $1,662 per person
$1,662
per person
Apr 12 - Apr 18
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.2/10 Wonderful! (863 reviews)
Such an elegant design to make for a hotel. Top notch staff and Marco and his team are amazing with help for anything from dinner to tours. Highly recommend this hotel for your stay in Rome

Reviewed on Jan 13, 2026

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,539, price is now $1,630 per person
$1,630
per person
Apr 4 - Apr 9
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (208 reviews)
Very clean, very helpful staff

Reviewed on Jan 27, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $206 total per night from Feb 10 to Feb 11
$206 total
Feb 10 - Feb 11
Total with taxes and fees
8.6/10 Excellent! (1,941 reviews)
The hotel was great ! Spotlessly clean , lovely large room and bathroom . The breakfast was plentiful with a large selection of choice both hot and cold. We loved the location - just a stroll to the sights of the Coliseum and Trevi Fountain. A lovely stay in Rome!

Reviewed on Feb 8, 2026

Hotel Quirinale
Hotel Nazionale

Hotel Nazionale

4 out of 5
Piazza Montecitorio, 131 Rome RM
$187 nightly
The price is $224 total per night from Feb 11 to Feb 12
$224 total
Feb 11 - Feb 12
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Everything was high standard

Reviewed on Jan 19, 2026

Hotel Nazionale
Hilton Garden Inn Rome Airport

Hilton Garden Inn Rome Airport

4 out of 5
Via Vittorio Bragadin 2 Fiumicino RM
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $187 total per night from Feb 16 to Feb 17
$187 total
Feb 16 - Feb 17
Total with taxes and fees
8/10 Very Good! (3,675 reviews)
The room was clean, the staff was courteous, and the shuttle service to the airport was great, but the mattress in my room was very uncomfortable and needs to get replaced. Thank you

Reviewed on Feb 3, 2026

Hilton Garden Inn Rome Airport
See all 16,132 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Light in the Basilica of St Paul

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64
per adult
94% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.