Title: Ostiense Vacation Packages 2026 from $1,991 | Expedia.com

[Ostiense Travel Guide](https://expedia.com/Rome-Ostiense.dx6227596)[Hotels in Ostiense](https://expedia.com/Ostiense-Rome-Hotels.0-n6227596-0.Travel-Guide-Filter-Hotels)[Flights to Rome](https://expedia.com/Cheap-Flights-To-Rome.d179899.Travel-Guide-Flights)[Things to do in Rome](https://expedia.com/Things-To-Do-In-Rome.d179899.Travel-Guide-Activities)[Car Rentals in Ostiense](https://expedia.com/Car-Rentals-In-Ostiense.d6227596.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6227596/f90e20ba-84aa-4ecb-a9fe-91e4de42a4b7.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Ostiense Vacations from $1,991

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as [Roman Forum](https://www.expedia.com/Roman-Forum-Rome-City-Centre.d502481.Vacation-Attraction), [Pantheon](https://www.expedia.com/Pantheon-Rome-City-Centre.d502483.Vacation-Attraction) and [Piazza Navona](https://www.expedia.com/Piazza-Navona-Rome-City-Centre.d508631.Vacation-Attraction). Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

## The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Charme Spagna Boutique Hotel](https://images.trvl-media.com/lodging/19000000/18300000/18294700/18294667/78fddb84_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Charme Spagna Boutique Hotel

Rome City Centre

Save 100% on your flight

$1,991

per person

May 16 - May 22

found 1 day ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.2/10 Wonderful! (220 reviews)

Very clean, very helpful staff

Reviewed on Jan 27, 2026

![U-Visionary Roma Hotel](https://images.trvl-media.com/lodging/46000000/45170000/45167200/45167180/d2a3197d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### U-Visionary Roma Hotel

Rome City Centre

Save 100% on your flight

$2,345

per person

May 10 - May 16

found 6 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.6/10 Exceptional! (411 reviews)

I was so disappointed with this hotel. It purports to be a 5 star hotel and I was certainly paying a rate commensurate with that but it simply isn’t of a high enough standard to deserve a 5 star rating. From staff arguing with each other in front of us to being denied entry to the bar because it was too busy; there simply isn’t enough room for me to list their faults here, which essentially come down to a lack of attention to detail and care but if the management want to write to me I will give them the full list.

Reviewed on Jan 3, 2026

![Palazzo Dama](https://images.trvl-media.com/lodging/14000000/13190000/13187600/13187549/f5a50c03_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Palazzo Dama

Rome City Centre

Save 100% on your flight

$2,639

per person

May 10 - May 16

found 6 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

8.8/10 Excellent! (171 reviews)

Wonderful stay at the Palazzo Dama for my husband’s 40th. We had a junior suite which was a good size, very comfortable and immaculate. Great location and friendly, professional staff. Lovely to stay in a boutique hotel with such unique features. Felt very luxe!

Reviewed on Feb 15, 2026

![DOM Hotel](https://images.trvl-media.com/lodging/8000000/7110000/7106300/7106251/59e09d18_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### DOM Hotel

Rome City Centre

Save 100% on your flight

$2,792

per person

May 17 - May 22

found 12 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.2/10 Wonderful! (391 reviews)

Everything was superior!..Staff went above and beyond for my stay.

Reviewed on Jan 26, 2026

![Palazzo Nainer](https://images.trvl-media.com/lodging/2000000/1040000/1037900/1037845/w3000h1997x0y0-eca3d01e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Palazzo Nainer

Rome City Centre

Save 100% on your flight

$2,059

per person

May 17 - May 22

found 12 hours ago

Roundtrip flight included

New York (JFK) to Rome (FCO)

9.4/10 Exceptional! (186 reviews)

Staff were wonderful! Breakfast was great. Very good location, too!

Reviewed on Feb 22, 2026

## Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. [Learn more about Ostiense](https://expedia.com/Rome-Ostiense.dx6227596)

![Via del Corso which includes heritage architecture, heritage elements and street scenes](https://images.trvl-media.com/place/6147046/23c2bc21-bb33-4778-b64d-bbfa58503b1c.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Rome City Centre

8 out of top 10 points of interest in this area

4.5/5(3,994 area reviews)

 Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago. 

[Find hotel + flight trips in Rome City Centre](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Rome%20City%20Centre&DestID=553248633938945217&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Rome Historic Centre showing a statue or sculpture, a fountain and a square or plaza](https://images.trvl-media.com/place/6200441/57c34773-acbf-4b05-b5e7-9b3e692babe1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Rome Historic Centre

5/5(1 area review)

 Enclosed by Aurelian Walls, this UNESCO-listed historic district boasts numerous museums, including the Capitoline Museums and Scuderie del Quirinale. Well-connected by public transport including the Roma Termini and Roma Ostiense stations which are nearby. 

[Find hotel + flight trips in Rome Historic Centre](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Rome%20Historic%20Centre&DestID=6200441&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Trastevere showing street scenes as well as a couple](https://images.trvl-media.com/place/6046256/44314ce1-293d-46c2-8929-fc821edf8fc1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Trastevere

4.5/5(411 area reviews)

 Narrow cobbled streets lined by ancient houses give this area a charming character. Enjoy lively pubs and restaurants at night, while being close to international academic institutions and the River Tiber. 

[Find hotel + flight trips in Trastevere](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Trastevere&DestID=6046256&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Monti which includes heritage elements, heritage architecture and a ruin](https://images.trvl-media.com/place/6185346/01855336-589e-456f-975e-2734b7e91944.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Monti

4.5/5(1,380 area reviews)

 Relax in wine bars and restaurants, take a walking tour and discover the famous Colosseum and other historic sites in one of Rome’s prominent districts. 

[Find hotel + flight trips in Monti](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Monti&DestID=6185346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Trevi which includes food and markets](https://images.trvl-media.com/place/553248634717495100/5af85b66-a718-45b6-9792-c4ffe84ee4d6.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Trevi

 Art galleries, churches, and museums are just a few things travelers like about Trevi. Sights like Trevi Fountain and Piazza di Trevi are spots to explore, and you can get around the greater Rome area at Barberini Station. 

[Find hotel + flight trips in Trevi](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Trevi&DestID=553248634717495100&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Ostiense Hotel Deals

![Hotel Quirinale](https://images.trvl-media.com/lodging/1000000/10000/1100/1058/df3b5a06_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Quirinale

Via Nazionale 7 Rome RM

$172 nightly

$207 total

Mar 4 - Mar 5

Total with taxes and fees

8.6/10 Excellent! (1,945 reviews)

Nice hotel, good breakfast, good location, lots of shops and restaurants nearby.

Reviewed on Mar 2, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&selected=1058&PinnedHotelID=1058&HadPinnedHotel=true&regionId=6227596)

![Hotel Nazionale](https://images.trvl-media.com/lodging/1000000/30000/26800/26756/7b7166b0_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Nazionale

Piazza Montecitorio, 131 Rome RM

$223 nightly

$264 total

Mar 12 - Mar 13

Total with taxes and fees

9.6/10 Exceptional! (1,010 reviews)

My favorite hotel in Rome states

Reviewed on Mar 2, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F12%2F2026&endDate=3%2F13%2F2026&selected=26756&PinnedHotelID=26756&HadPinnedHotel=true&regionId=6227596)

![Trastevere Roma | UNA Esperienze](https://images.trvl-media.com/lodging/75000000/74060000/74055900/74055827/0d267171_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Trastevere Roma | UNA Esperienze

Via Emilio Morosini 27 Rome RM

Fully refundableReserve now, pay when you stay

$193 nightly

$230 total

Mar 4 - Mar 5

Total with taxes and fees

9.4/10 Exceptional! (1,225 reviews)

Clean - spacious - professional staff- perfect location

Reviewed on Mar 1, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&selected=74055827&PinnedHotelID=74055827&HadPinnedHotel=true&regionId=6227596)

[See all 16,211 properties in Ostiense](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&regionId=6227596)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Ostiense

![Light in the Basilica of St Paul](https://images.trvl-media.com/place/6074140/81bfbca8-0a41-458b-9fb8-ef83ef529db6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area. 

[](https://expedia.com/Basilica-Of-St-Paul-Outside-The-Walls-Ostiense.d6074140.Vacation-Attraction)

#### Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area. 

[](https://expedia.com/Eataly-Roma-Ostiense.d553248621563230352.Vacation-Attraction)

#### Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area. 

[](https://expedia.com/Roma-Tre-University-Ostiense.d6147114.Vacation-Attraction)

### Things to do

![Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour](https://mediaim.expedia.com/localexpert/3138351/00713dcf-a749-4990-815b-c1abc113d09f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$82

per adult

**84%** of travellers recommend

[](https://expedia.com/things-to-do/rome-colosseum-with-arena.a3138351.activity-details)

![Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica](https://mediaim.expedia.com/localexpert/1008396/d1b7fce5-e5c4-48ff-9148-df750d6ee6ce.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$29

per adult

**90%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-group-tour-of-the-vatican.a1008396.activity-details)

![Rome Hop-On Hop-Off Big Bus Tour](https://mediaim.expedia.com/localexpert/376190/27f7cb2b-8299-411e-bfc9-45c2f55e37d8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$36

per adult

**84%** of travellers recommend

[](https://expedia.com/things-to-do/rome-big-bus-hop-on.a376190.activity-details)

[See all activities in Rome](https://expedia.com/things-to-do/search?rid=6227596)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.