Ostiense Vacations from $703

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Exe International Palace

Exe International Palace

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,124, price is now $703 per person
$703
per person
Feb 22 - Feb 28
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
7.8/10 Good! (1,002 reviews)
Rooms are tight, old building has not been upgraded. No AC.

Reviewed on Dec 7, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,670, price is now $860 per person
$860
per person
Feb 22 - Feb 28
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Clean room friendly staff

Reviewed on Dec 12, 2025

Nobu Hotel Roma

Nobu Hotel Roma

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,177, price is now $2,097 per person
$2,097
per person
Feb 1 - Feb 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
No reviews
Six Senses Rome

Six Senses Rome

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,823, price is now $3,291 per person
$3,291
per person
Feb 22 - Feb 28
found 15 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.6/10 Exceptional! (56 reviews)
Amazing staff, beautifully decorated hotel, super amenities. Truly wonderful find in the heart of Rome.

Reviewed on Nov 17, 2025

Hotel Delle Nazioni

Hotel Delle Nazioni

4 out of 5
Rome City Centre
Price was $1,392, price is now $998 per person
$998
per person
Feb 22 - Feb 28
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9/10 Wonderful! (1,002 reviews)
It was a nice place to stay and breakfast was amazing. Rooms were clean and quiet. Close to most of attractions and there was a Taxi station next to the hotel.

Reviewed on Dec 13, 2025

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Dei Mellini

Hotel Dei Mellini

4 out of 5
Via Muzio Clementi 81 Rome RM
$269 nightly
The price is $313 total per night from Jan 7 to Jan 8
$313 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
9.2/10 Wonderful! (981 reviews)
Clean, great staff, great location

Reviewed on Dec 9, 2025

Hotel Dei Mellini
The Hive Hotel

The Hive Hotel

4 out of 5
Via Torino 6 Rome RM
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $135 total per night from Jan 7 to Jan 8
$135 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
9/10 Wonderful! (1,715 reviews)
Lovely hotel. Very clean, lovely room and fantastic staff who couldn’t do enough for you. Would definitely return in a heartbeat

Reviewed on Dec 11, 2025

The Hive Hotel
Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $159 total per night from Jan 11 to Jan 12
$159 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
8.6/10 Excellent! (1,917 reviews)
This hotel was amazing! The location is incredible- just 2 min. walk to the metro station and the street has lots of restaurants and shopping of every kind- from high end stores like Max Mara to kitchy souvenir stores. It has so much history and character! The front desk was very helpful, always ...

Reviewed on Dec 14, 2025

Hotel Quirinale
See all 16,067 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

4.5/5(352 reviews)

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$31
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$36
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.