Ostiense Vacations from $768

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Roma Aurelia Antica

Hotel Roma Aurelia Antica

4 out of 5
Gianicolense Suburb
Price was $1,208, price is now $768 per person
$768
per person
Feb 24 - Feb 27
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Rome (FCO)
7/10 Good! (597 reviews)
It was an overnight comfortable stay. Enjoyed a good breakfast and staff was very helpful.

Reviewed on Oct 14, 2025

Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Price was $1,512, price is now $914 per person
$914
per person
Feb 16 - Feb 22
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
7.4/10 Good! (1,026 reviews)
Breakfast was fresh and plenty of choices or variety and staff are all very good.

Reviewed on Dec 11, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,523, price is now $942 per person
$942
per person
Jan 11 - Jan 16
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Location is absolutely perfect - great spot for walking everywhere, no need for Taxis at all. Staff incredibly friendly and helpful. Would stay again.

Reviewed on Nov 24, 2025

Hotel Giulietta e Romeo

Hotel Giulietta e Romeo

3 out of 5
Municipio X
Price was $1,232, price is now $777 per person
$777
per person
Feb 24 - Feb 27
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Rome (FCO)
7.2/10 Good! (110 reviews)
Beautiful ride and nice neighbourhood

Reviewed on Aug 5, 2025

Hotel Splendide Royal - The Leading Hotels of the World

Hotel Splendide Royal - The Leading Hotels of the World

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,420, price is now $1,545 per person
$1,545
per person
Feb 28 - Mar 5
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.4/10 Exceptional! (1,001 reviews)
The hotel is beautiful. The staff were wonderful and very helpful, pleasant and so accommodating. Everyone made us feel welcome and at home.

Reviewed on Nov 17, 2025

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $172 total per night from Dec 14 to Dec 15
$172 total
Dec 14 - Dec 15
Total with taxes and fees
8.6/10 Excellent! (1,912 reviews)
Fabio at the front desk was super helpful with dinner reservations. The breakfast was delicious. Great location.

Reviewed on Dec 10, 2025

Hotel Quirinale
The Hive Hotel

The Hive Hotel

4 out of 5
Via Torino 6 Rome RM
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $125 total per night from Dec 14 to Dec 15
$125 total
Dec 14 - Dec 15
Total with taxes and fees
9/10 Wonderful! (1,715 reviews)
Lovely hotel. Very clean, lovely room and fantastic staff who couldn’t do enough for you. Would definitely return in a heartbeat

Reviewed on Dec 11, 2025

The Hive Hotel
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $241 total per night from Jan 11 to Jan 12
$241 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
9.2/10 Wonderful! (1,160 reviews)
The hotel facilities are new and the staff are very kind

Reviewed on Dec 1, 2025

Trastevere Roma | UNA Esperienze
See all 16,021 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

4.5/5(352 reviews)

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$53
per adult
82% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$39
per adult
88% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$30
per adult
82% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.