Ostiense Vacations from $696

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,186, price is now $696 per person
$696
per person
Jan 18 - Jan 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Yes..very clean..staff extra helpful for first time tourists...wonderful experience

Reviewed on Dec 8, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,728, price is now $1,007 per person
$1,007
per person
Jan 10 - Jan 16
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Location is absolutely perfect - great spot for walking everywhere, no need for Taxis at all. Staff incredibly friendly and helpful. Would stay again.

Reviewed on Nov 24, 2025

Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,157, price is now $722 per person
$722
per person
Jan 18 - Jan 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
7.4/10 Good! (1,026 reviews)
… everything correct, clean room, generous breakfast, air conditioning, hot water, elevator, location, location, location …

Reviewed on Dec 7, 2025

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Price was $1,762, price is now $1,144 per person
$1,144
per person
Feb 16 - Feb 21
found 11 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (335 reviews)
Great place to stay

Reviewed on Dec 1, 2025

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,265, price is now $835 per person
$835
per person
Feb 28 - Mar 3
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (208 reviews)
The staff was so lovely and polite and really helpful, hotel was clean and everything you needed. Hotel was brilliant location, only thing I would say is taxis and Ubers are a lot cheaper than the transfer service to airport that the hotel offered, but would defo recommend

Reviewed on Dec 4, 2025

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

9 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $171 total per night from Dec 14 to Dec 15
$171 total
Dec 14 - Dec 15
Total with taxes and fees
8.6/10 Excellent! (1,919 reviews)
The staff was nice, the room was ample and clean. It was perfectly located near the train station and walk about from all main attractions.

Reviewed on Dec 4, 2025

Hotel Quirinale
The Hive Hotel

The Hive Hotel

4 out of 5
Via Torino 6 Rome RM
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $127 total per night from Dec 14 to Dec 15
$127 total
Dec 14 - Dec 15
Total with taxes and fees
9/10 Wonderful! (1,699 reviews)
Quiet comfortable and great location

Reviewed on Dec 4, 2025

The Hive Hotel
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$222 nightly
The price is $262 total per night from Jan 6 to Jan 7
$262 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
9.2/10 Wonderful! (1,160 reviews)
The hotel facilities are new and the staff are very kind

Reviewed on Dec 1, 2025

Trastevere Roma | UNA Esperienze
See all 16,023 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$39
per adult
88% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$53
per adult
82% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
T

Colosseum Underground & Ancient Rome Guided Tour

$72
per adult
92% of travellers recommend
Colosseum Underground & Ancient Rome Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.