Ostiense Vacations from $737

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,309, price is now $737 per person
$737
per person
Mar 11 - Mar 16
found 20 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Breakfast was fresh and healthy each morning. All of the staff were extremely nice and helpful. Loved my stay here, would stay here again and will recommend to friends.

Reviewed on Dec 28, 2025

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $1,738, price is now $952 per person
$952
per person
Mar 10 - Mar 16
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.6/10 Exceptional! (335 reviews)
Wonderful stay, would be back

Reviewed on Dec 16, 2025

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,833, price is now $1,079 per person
$1,079
per person
Mar 10 - Mar 16
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.2/10 Wonderful! (208 reviews)
The staff was so lovely and polite and really helpful, hotel was clean and everything you needed. Hotel was brilliant location, only thing I would say is taxis and Ubers are a lot cheaper than the transfer service to airport that the hotel offered, but would defo recommend

Reviewed on Dec 4, 2025

EXE Domus Aurea

EXE Domus Aurea

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,268, price is now $791 per person
$791
per person
Mar 10 - Mar 16
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Rome (FCO)
8/10 Very Good! (490 reviews)
Everything was great. The check in process was fast. Enjoyed breakfast specially it was located on the rooftop. The room was always clean. Friendly and helpful staffs.

Reviewed on Dec 31, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,439, price is now $817 per person
$817
per person
Mar 13 - Mar 16
found 17 hours ago
Roundtrip non-stop flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Clean room friendly staff

Reviewed on Dec 12, 2025

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

9 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Aparthotel Colombo Roma

Aparthotel Colombo Roma

4 out of 5
Via Cristoforo Colombo 112 Rome RM
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $83 total per night from Feb 1 to Feb 2
$83 total
Feb 1 - Feb 2
Total with taxes and fees
9/10 Wonderful! (352 reviews)
room was clean and cozy, staff was helpful and friendly. 10/10 recommend

Reviewed on Dec 15, 2025

Aparthotel Colombo Roma
Hotel Dei Mellini

Hotel Dei Mellini

4 out of 5
Via Muzio Clementi 81 Rome RM
Fully refundableReserve now, pay when you stay
$195 nightly
The price is $232 total per night from Feb 1 to Feb 2
$232 total
Feb 1 - Feb 2
Total with taxes and fees
9.2/10 Wonderful! (989 reviews)
Cute Hotel, Great staff. Great location. Will definitely stay here again when visiting Rome

Reviewed on Jan 1, 2026

Hotel Dei Mellini
Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $157 total per night from Jan 11 to Jan 12
$157 total
Jan 11 - Jan 12
Total with taxes and fees
8.6/10 Excellent! (1,923 reviews)
Beautiful historic hotel. Staff was fantastic!

Reviewed on Dec 30, 2025

Hotel Quirinale
See all 16,003 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$35
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$77
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.