Ostiense Vacations from $775

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Your Ostiense Vacation

Book a customized vacation package to Ostiense and get ready to experience its nightlife, bars and pubs and culture. However you want to spend your getaway in this food-lovers neighborhood, there are plenty of opportunities to mix relaxation and fun. Your trip to Ostiense wouldn't be complete without a visit to top attractions nearby such as Roman Forum, Pantheon and Piazza Navona. Whatever your travel plans or the size of your budget, booking your dream Ostiense vacation has never been easier with Expedia.

The Latest Ostiense Vacation Packages

Price found within the past 48 hours. Click for updated prices.
JC Hotel

JC Hotel

4 out of 5
Fonte Ostiense
Save 100% on your flight
Price was $1,370, price is now $775 per person
$775
per person
Mar 24 - Mar 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
8/10 Very Good! (133 reviews)
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Save 100% on your flight
Price was $1,844, price is now $1,023 per person
$1,023
per person
Apr 5 - Apr 10
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
Breakfast was fresh and healthy each morning. All of the staff were extremely nice and helpful. Loved my stay here, would stay here again and will recommend to friends.

Reviewed on Dec 28, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,808, price is now $1,012 per person
$1,012
per person
Apr 8 - Apr 12
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Heating is not good enough

Reviewed on Jan 8, 2026

Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,304, price is now $793 per person
$793
per person
Mar 26 - Mar 31
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
7.4/10 Good! (1,026 reviews)
Breakfast was great. English speaking staff were so helpful and friendly. Rooms just need more storage. Overall all I loved it.

Reviewed on Jan 12, 2026

Where to stay in Ostiense

Find the best Ostiense areas and neighborhoods for the activities you enjoy most. Learn more about Ostiense
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Ostiense Hotel Deals

Aparthotel Colombo Roma

Aparthotel Colombo Roma

4 out of 5
Via Cristoforo Colombo 112 Rome RM
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $80 total per night from Feb 1 to Feb 2
$80 total
Feb 1 - Feb 2
Total with taxes and fees
9/10 Wonderful! (357 reviews)
Nice welcome, good location, clean hotel

Reviewed on Jan 6, 2026

Aparthotel Colombo Roma
Hotel Dei Mellini

Hotel Dei Mellini

4 out of 5
Via Muzio Clementi 81 Rome RM
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $277 total per night from Jan 29 to Jan 30
$277 total
Jan 29 - Jan 30
Total with taxes and fees
9.2/10 Wonderful! (986 reviews)
Delightful return to the hotel - very friendly and helpful staff. Excellent breakfast selection.

Reviewed on Jan 11, 2026

Hotel Dei Mellini
Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $158 total per night from Jan 25 to Jan 26
$158 total
Jan 25 - Jan 26
Total with taxes and fees
8.6/10 Excellent! (1,926 reviews)
Great location. Hospitality was outstanding very accommodating snacks available and the breakfast was great. Highly recommended certainly will return.

Reviewed on Jan 10, 2026

Hotel Quirinale
See all 15,154 properties in Ostiense
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ostiense

Basilica of St. Paul Outside the Walls

Basilica of St. Paul Outside the Walls

You can learn about the history of Rome with a visit to Basilica of St. Paul Outside the Walls. Visit the churches and notable monuments in this vibrant area.

Basilica of St. Paul Outside the Walls
#GoodEats “Bucatini all’Amatriciana” 😋🤤 Taste of home ❤️

Eataly Roma

You can find the perfect gifts to bring home at Eataly Roma during your trip to Rome. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Eataly Roma

Roma Tre University

Walk around the campus at Roma Tre University during your stay in Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Roma Tre University

Things to do

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$35
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
3 in 1 Cooking Class near Navona: Fettuccine, Ravioli & Tiramisu

3 in 1 Cooking Class near Navona: Fettuccine, Ravioli & Tiramisu

$69
per adult
96% of travellers recommend
3 in 1 Cooking Class near Navona: Fettuccine, Ravioli & Tiramisu
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.