Panama Vacations from $454

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The Latest Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
Price was $587, price is now $454 per person
$454
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
8/10 Very Good! (1,002 reviews)
Everything was amazing but parking was not enough. We had to park on ur median. Rooms are older but still nice. Good area. Friendly staff.

Reviewed on Feb 21, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $730, price is now $483 per person
$483
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Great place to stay! We arrived later at night around 11pm and the front desk gal working at that time was wonderful. Nice, quiet, clean and in a very nice area.

Reviewed on Feb 27, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $768, price is now $567 per person
$567
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
Great customer service. The locals there are friendly as well as the staff members

Reviewed on Feb 23, 2026

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
Central West End
Price was $827, price is now $633 per person
$633
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
8.2/10 Very Good! (1,003 reviews)
Room was nice. Staff was very friendly Warm cookies were good

Reviewed on Feb 26, 2026

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

4 out of 5
Downtown St. Louis
Price was $898, price is now $689 per person
$689
per person
Apr 9 - Apr 12
found 13 hours ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
8.8/10 Excellent! (458 reviews)
Not the best and not the

Reviewed on Feb 24, 2026

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Panama Hotel Deals

Baymont by Wyndham Litchfield

Baymont by Wyndham Litchfield

2.5 out of 5
1405 W Hudson Dr Litchfield IL
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $100 total per night from Feb 28 to Mar 1
$100 total
Feb 28 - Mar 1
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
Loved the breakfast

Reviewed on Feb 24, 2026

Baymont by Wyndham Litchfield
Holiday Inn Express & Suites Litchfield West by IHG

Holiday Inn Express & Suites Litchfield West by IHG

2.5 out of 5
4 Thunderbird Circle Litchfield IL
Fully refundable
$119 nightly
The price is $131 total per night from Mar 1 to Mar 2
$131 total
Mar 1 - Mar 2
Total with taxes and fees
9.6/10 Exceptional! (591 reviews)
All of sbovy

Reviewed on Feb 17, 2026

Holiday Inn Express & Suites Litchfield West by IHG
Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

2.5 out of 5
2265 S. State Route 127 Greenville IL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $103 total per night from Mar 15 to Mar 16
$103 total
Mar 15 - Mar 16
Total with taxes and fees
8.4/10 Very Good! (428 reviews)
The woman who checked us in is such a hard worker. The next morning she was running the desk and helping in the breakfast area as it was extremely busy. However…our room had just been cleaned and it had a weird smell. I always check for bedbugs at any place we stay. Bed sheets looked clean and fresh ...

Reviewed on Feb 15, 2026

Comfort Inn & Suites Greenville I-70
See all 38 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panama Vacation Packages

Panama Essential Information

Language
English
Currency
U.S dollars

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Frequently asked questions

How much does a Panama vacation package cost?
Offering great value package deals from $454 on Expedia, you'll be pleasantly surprised at how much a vacation to Panama costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Panama?
You can generally find reduced prices and better availability in November, December and January. Check out our cheap Panama vacation packages and you could score some great off-season deals.
How many days is enough for Panama?
Usually, a handful of days is enough to check out the major attractions during your Panama vacation. However, if you prefer to have some time to kick back or go on day trips, think about extending your trip.
How to find the best Panama package deals?
Use Expedia's filter tool to find some of the best Panama package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your escape for midweek, or search for Panama package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Panama vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to arranging accommodations and flights individually. Better still, you can customize your Panama getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Panama?
If you have your Panama travel dates locked in, book as soon as you can to bag some unbeatable deals. With Expedia, you can typically reserve some flights up to a year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are great for setting off on a whim.
Does Expedia offer Book Now, Pay Later Panama vacation packages?
Jet off on your dream getaway to Panama with help from our Book Now, Pay Later vacations. There's no need to save up or wait for payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans allow you to spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snag great deals while they last.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.