Panama Vacations from $405

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The Latest Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
Central West End
Save 100% on your flight
Price was $575, price is now $405 per person
$405
per person
Jul 8 - Jul 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.2/10 Very Good! (1,008 reviews)
Broken drywall on bathroom floor, old candy bar wrapper in nightstand drawer. Left an item behind and no one would call back. Asked for a cab was told it takes 5 minutes, oh no I was late for an extremely important appointment.

Reviewed on May 2, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $957, price is now $425 per person
$425
per person
Jul 8 - Jul 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,639 reviews)
The entire stay was incredible

Reviewed on May 7, 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Save 100% on your flight
Price was $721, price is now $496 per person
$496
per person
Jul 8 - Jul 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (534 reviews)
The stay here was lovely! Very clean, recently renovated, and safe. The only bummer was that breakfast ended at 9am (this is advertised in multiple places, but we missed it). We would definitely stay here again and recommend to family and friends.

Reviewed on May 6, 2026

The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
Price was $674, price is now $465 per person
$465
per person
Jul 8 - Jul 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,006 reviews)
It has a very quaintly English theme. Very unique and fun.

Reviewed on May 8, 2026

Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

2.5 out of 5
Downtown West
Save 100% on your flight
Price was $634, price is now $448 per person
$448
per person
Jul 8 - Jul 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.6/10 Good! (723 reviews)
Everything was clean and staff was very friendly. Breakfast was meh, but sufficient to start the day.

Reviewed on May 8, 2026

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Panama Hotel Deals

Baymont by Wyndham Litchfield

Baymont by Wyndham Litchfield

2.5 out of 5
1405 W Hudson Dr Litchfield IL
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from May 14 to May 15
$99 total
May 14 - May 15
Total with taxes and fees
8.4/10 Very Good! (1,003 reviews)
.

Reviewed on May 6, 2026

Baymont by Wyndham Litchfield
Holiday Inn Express & Suites Litchfield West by IHG

Holiday Inn Express & Suites Litchfield West by IHG

2.5 out of 5
4 Thunderbird Circle Litchfield IL
Fully refundable
$121 nightly
The price is $133 total per night from May 20 to May 21
$133 total
May 20 - May 21
Total with taxes and fees
9.6/10 Exceptional! (617 reviews)
A great place to stay. The rooms were clean. Staff was welcoming. Nice and quiet place.

Reviewed on May 8, 2026

Holiday Inn Express & Suites Litchfield West by IHG
Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville

2 out of 5
1700 State Route 127 Greenville IL
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $78 total per night from May 24 to May 25
$78 total
May 24 - May 25
Total with taxes and fees
8/10 Very Good! (797 reviews)
Heating and air conditioning works. Staff is good. Parking is fine. Room is clean.

Reviewed on May 5, 2026

Super 8 by Wyndham Greenville
See all 45 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panama Vacation Packages

Panama Essential Information

Language
English
Currency
U.S dollars

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Frequently asked questions

How much does a Panama vacation package cost?
Offering great value package deals from $405 on Expedia, you'll be pleasantly surprised at how much a vacation to Panama costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Panama?
You can generally find reduced prices and better availability in November, December and January. Check out our cheap Panama vacation packages and you could score some great off-season deals.
How many days is enough for Panama?
Usually, a handful of days is enough to check out the major attractions during your Panama vacation. However, if you prefer to have some time to kick back or go on day trips, think about extending your trip.
How to find the best Panama package deals?
Use Expedia's filter tool to find some of the best Panama package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your escape for midweek, or search for Panama package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Panama vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to arranging accommodations and flights individually. Better still, you can customize your Panama getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Panama?
If you have your Panama travel dates locked in, book as soon as you can to bag some unbeatable deals. With Expedia, you can typically reserve some flights up to a year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are great for setting off on a whim.
Does Expedia offer Book Now, Pay Later Panama vacation packages?
Jet off on your dream getaway to Panama with help from our Book Now, Pay Later vacations. There's no need to save up or wait for payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans allow you to spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snag great deals while they last.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.