Panama Vacations from $243

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The Latest Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
White House at Grand Central

White House at Grand Central

3.5 out of 5
Grand Center
Save 100% on your flight
Price was $339, price is now $243 per person
$243
per person
Sep 11 - Sep 13
found 10 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.4/10 Very Good! (144 reviews)
We liked the location of this hotel—it's right on campus or just across the street, making it feel safe and convenient. You’re only a couple of blocks away from fast food, Walgreens, and the bus, which was so convenient. The area feels regal and historic with beautifully manicured lawns, and everything was just as pictured. The air conditioning worked well, all the amenities were in place, and we really enjoyed the old-timey charm. The only minor suggestion I have is about the check-in process. Instead of having to haul luggage to a sister hotel to provide a credit card, it would be great to handle that by phone. It would save that extra trip, especially in the heat. Otherwise, it was a wonderful stay!

Reviewed on Jun 29, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $558, price is now $278 per person
$278
per person
Aug 21 - Aug 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,661 reviews)
We enjoyed our stay. Very helpful staff. Clean all the way around. Nice sized room and bathroom. Nice surrounding area. Convenient parking in the attached ramp (forget the on street parking.)

Reviewed on Jul 14, 2026

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV

2 out of 5
Save 100% on your flight
Price was $571, price is now $316 per person
$316
per person
Aug 21 - Aug 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
10/10 Exceptional! (1 review)
The property was excellent, and the home was very warm and welcoming.

Reviewed on Jun 25, 2026

The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
Price was $499, price is now $346 per person
$346
per person
Sep 17 - Sep 20
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,001 reviews)
A majority of the staff was friendly and helpful. Love the literary themes. Had a great stay and would definitely visit again.

Reviewed on Jul 12, 2026

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
Save 100% on your flight
Price was $452, price is now $329 per person
$329
per person
Aug 21 - Aug 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (1,984 reviews)
.

Reviewed on Jul 10, 2026

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Panama Hotel Deals

Baymont by Wyndham Litchfield

Baymont by Wyndham Litchfield

2.5 out of 5
1405 W Hudson Dr Litchfield IL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Jul 16 to Jul 17
$109 total
Jul 16 - Jul 17
Total with taxes and fees
8.2/10 Very Good! (1,008 reviews)
"Staff was so nice and place was clean love the place will definitely stay again"

Reviewed on Jul 12, 2026

Baymont by Wyndham Litchfield
Holiday Inn Express & Suites Litchfield West by IHG

Holiday Inn Express & Suites Litchfield West by IHG

2.5 out of 5
4 Thunderbird Circle Litchfield IL
Fully refundable
$114 nightly
The price is $125 total per night from Jul 21 to Jul 22
$125 total
Jul 21 - Jul 22
Total with taxes and fees
9.4/10 Exceptional! (638 reviews)
"Great room"

Reviewed on Jul 11, 2026

Holiday Inn Express & Suites Litchfield West by IHG
Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

2.5 out of 5
2265 S. State Route 127 Greenville IL
Fully refundable
$106 nightly
The price is $117 total per night from Aug 2 to Aug 3
$117 total
Aug 2 - Aug 3
Total with taxes and fees
8.4/10 Very Good! (451 reviews)
"Breakfast was good. Well stocked and appetizing."

Reviewed on Jul 2, 2026

Comfort Inn & Suites Greenville I-70
See all 47 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panama Vacation Packages

Panama Essential Information

Language
English
Currency
U.S dollars

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Frequently asked questions

How much does a Panama vacation package cost?
Offering great value package deals from $243 on Expedia, you'll be pleasantly surprised at how much a vacation to Panama costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Panama?
You can generally find reduced prices and better availability in November, December and January. Check out our cheap Panama vacation packages and you could score some great off-season deals.
How many days is enough for Panama?
Usually, a handful of days is enough to check out the major attractions during your Panama vacation. However, if you prefer to have some time to kick back or go on day trips, think about extending your trip.
How to find the best Panama package deals?
Use Expedia's filter tool to find some of the best Panama package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your escape for midweek, or search for Panama package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Panama vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to arranging accommodations and flights individually. Better still, you can customize your Panama getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Panama?
If you have your Panama travel dates locked in, book as soon as you can to bag some unbeatable deals. With Expedia, you can typically reserve some flights up to a year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are great for setting off on a whim.
Does Expedia offer Book Now, Pay Later Panama vacation packages?
Jet off on your dream getaway to Panama with help from our Book Now, Pay Later vacations. There's no need to save up or wait for payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans allow you to spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snag great deals while they last.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.