Puxico Vacation Rentals from $95: Search Short-Term Rentals

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Our top choices for Puxico vacation rentals

1. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Wappapello

Shea E.

$218 nightly

Sep 16 - Sep 17

Total with taxes and fees

2. Lake Wappapello

Williamsville

Tonya

$90 nightly

Oct 10 - Oct 11

Total with taxes and fees

3. Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Greenville

Joshua H.

$222 nightly

Sep 16 - Sep 17

Total with taxes and fees

4. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter

Kathryn T.

$202 nightly

Sep 20 - Sep 21

Total with taxes and fees

5. Hunting / Fishing Cabin at Lake Wappapello

Williamsville

$234 nightly

Sep 16 - Sep 17

Total with taxes and fees

6. 40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

Anonymous traveler

$281 nightly

Oct 7 - Oct 8

Total with taxes and fees

7. 40-Acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

Elsie C.

$282 nightly

Oct 7 - Oct 8

Total with taxes and fees

8. Cozy 2-bedroom house in welcoming Poplar Bluff

Poplar Bluff

Carrie H.

$175 nightly

Sep 16 - Sep 17

Total with taxes and fees

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Top Puxico Hotel Reviews

Hampton Inn By Hilton Dexter

8/10 Good

"Very nice hotel - our favorite when we visit the grandkids! Our only issue this time was with housekeeping. We arrived Friday afternoon, asked that our room be serviced on Sunday, (they only do it every other day), and it was not done. Also, in the shower were the usual shampoo and shower gel, but instead of conditioner, the 3rd dispenser was body lotion! I asked if the lotion could be replaced with conditioner - didn’t happen. Disappointed!"

EC Reed's Mercantile and Hotel

10/10 Excellent

"This hotel is perfect!!! We loved the check in process which is the easiest i have ever encountered. The hotel is so cute and nostalgic. I fell in love with the room, the lobby and the restaurant. Very nice people here. The food was absolutely delicious. The music playing in the hotel lobby was lite and relaxing. The bed in room 6 was so comfortable like a big fluffy cloud. The mercantile has the most unique items. I wish i would have time to visit the old time soda shop. The coffee bar was awesome. I love the patriot coffee k cups . The honey for the coffee was top tier. There is nothing about this place that we did not love. Please do yourself a favor and stop by, i promise its worth the stop. There is also a small barber shop at the entrance of the hotel. Thank yall for the kindness shown to us and we cant wait to visit again"

Lake Wappapello

10/10 Excellent

"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from the park. We ordered deli sandwiches from here and picked up some icecream. The sandwiches were delicious and the store had pretty much whatever you might need. The checkin process was great with good communication about which cabin to go to, what the door code was etc... We plan to come back for a longer stay so we can have another evening around the firepit and see all of the stars. Great place to stay."

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

10/10 Excellent

"My wife and I stayed here for anniversary trip. The fox den is a perfect combination of 1970's vibes, while still having modern conveniences. We appreciated the fresh eggs provided and well stocked kitchen for making breakfast.The host put much effort in making sure it was great experience with great guidebook that provided information on everything in the fox den and recommended local places for dining and exploring. We also had the charcuterie add-on, which looked and tasted amazing and was perfect for snacking on during our stay.The location is very secluded as described. My only advice would be to plan your excursions from the fox den as it does take some extra travel time (especially if you normally live in more populated areas) than what you may be used to. That being said the natural beauty of the area, along with the peace and quiet was worth the extra distance. Overall, we had a great stay and would recommend the fox den to anyone looking for escape into both nature and the 1970's."

Private lake, beach & hot tub, romantic getaway or family vaca

8/10 Good

"Great location to access the lake close by. Very picturesque location.Pics are a lil deceiving in that things are actually on a smaller scale IRL but still good amenities.Be aware, the pond is not swimmable but paddle boat is fun."

Find out more about Puxico

Everything you need to know about Puxico vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Puxico vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Puxico vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Puxico vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Puxico. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Puxico in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $95 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Puxico rentals

At Expedia, we put the best Puxico vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Puxico rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Puxico vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Puxico. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Puxico?

Yes, we offer vacation rentals close to popular sights in Puxico, or you can go with a more remote option if you're looking for a relaxing stay.

What's the top vacation rental that Puxico has to offer?

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy: This vacation home rental near Puxico offers a fireplace, a balcony, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games.

What’s there to see and do in Puxico?

While exploring the area, visit family-friendly sights like Dexter Welcome Center Depot and Museum, or get outside and enjoy nature at Mark Twain National Forest. In the larger area, you’ll find Mingo Wilderness and Lake Wappapello.

What’s a vacation rental in Puxico like?

A vacation rental is a private property where you can stay for a couple of days or more in Puxico. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel right at home. If you're concerned about cleanliness, a vacation rental can provide a sense of privacy away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for a family getaway.

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Check prices for these dates

Our top choices for Puxico vacation rentals

1. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

2. Lake Wappapello

3. Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

4. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

5. Hunting / Fishing Cabin at Lake Wappapello

6. 40-acre Poplar Bluff Nature Lovers Paradise!

7. 40-Acre Poplar Bluff Nature Lovers Paradise!

8. Cozy 2-bedroom house in welcoming Poplar Bluff

9. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

10. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

11. Poplar Bluff pet friendly comfort and convenience

Find vacation rentals that suit your style

Top Puxico Hotel Reviews

Hampton Inn By Hilton Dexter

EC Reed's Mercantile and Hotel

Cozy hobby farm cabin under the stars!

Dexter Inn

Lake Wappapello

Motel 6 Poplar Bluff, MO

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Private lake, beach & hot tub, romantic getaway or family vaca

OYO Hickory House Inn

Find out more about Puxico

Frequently asked questions

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