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Puxico Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Puxico vacation rentals

A kitchen with wooden cabinets, a stainless steel refrigerator, a stove, and a window.

1. Hunting / Fishing Cabin at Lake Wappapello

Hunting / Fishing Cabin at Lake Wappapello
Williamsville
8.0 out of 10, Very good, (1 review)
"The coffee pot looked like it hadn't been used for a while. Bathrooms and beds were very nice."
United States
Donna M.
$223 nightly
The price is $237
Nov 5 - Nov 6
Total with taxes and fees
Hunting / Fishing Cabin at Lake Wappapello
A modern kitchen with stainless steel appliances, wooden cabinets, and a white countertop.

2. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Dexter
10.0 out of 10, Exceptional, (4 reviews)
"Perfect place for our stay on the way to North Carolina! Clean, cozy and convenient!"
United States
Robert G.
$152 nightly
The price is $164
Nov 5 - Nov 6
Total with taxes and fees
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
A hot tub with a wooden interior and a view of a forest through large windows.

3. Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Greenville
10.0 out of 10, Exceptional, (13 reviews)
"Cute, cozy, private getaway that you won't want to leave!"
United States
Jade G.
$258 nightly
The price is $272
Nov 9 - Nov 10
Total with taxes and fees
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.

4. Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
8.4 out of 10, Very good, (7 reviews)
"Pet friendly. Family-friendly "
United States
Tonya
$100 nightly
The price is $105
Nov 5 - Nov 6
Total with taxes and fees
Lake Wappapello
A two-story house with a front porch, a covered entryway, and a small garden with white flowers.

5. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
7.8 out of 10, Good, (39 reviews)
"Overall, it was a good experience. I would stay again."
United States
Tammy G.
$191 nightly
The price is $206
Nov 8 - Nov 9
Total with taxes and fees
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
A modern kitchen with wooden cabinets, a stainless steel refrigerator, an oven, and a dishwasher. There is a dining table with chairs and a small rug on the floor.

6. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Poplar Bluff
9.0 out of 10, Wonderful, (18 reviews)
"Very clean, well stocked kitchen with necessities. We enjoyed our stay!"
United States
Melissa W.
$259 nightly
The price is $272
Nov 5 - Nov 6
Total with taxes and fees
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Puxico Hotel Reviews

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"Met ll expectations for a clean and comfortable room. Breakfast was excellent, with cheese omelets, bacon, biscuits, and gravy. Staff was excellent."
Jim 1-night trip
Posted 7 hours ago
Hampton Inn Poplar Bluff

Find out more about Puxico

Everything you need to know about Puxico vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Puxico vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Puxico vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Puxico vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Puxico. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Puxico in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $105 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Puxico rentals

At Expedia, we put the best Puxico vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Puxico rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Puxico vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Puxico. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Puxico?

Yes, we offer vacation rentals close to popular sights in Puxico, or you can go with a more remote option if you're looking for a relaxing stay.

What's the top vacation rental that Puxico has to offer?

Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp: This vacation home rental near Puxico has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings.

What’s there to see and do in Puxico?

While exploring the area, visit family-friendly sights like Dexter Welcome Center Depot and Museum, or get outside and enjoy nature at Mark Twain National Forest. In the larger area, you’ll find Mingo Wilderness and Lake Wappapello.

What’s a vacation rental in Puxico like?

A vacation rental is a private property where you can stay for a couple of days or more in Puxico. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel right at home. If you're concerned about cleanliness, a vacation rental can provide a sense of privacy away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for a family getaway.