Puxico Vacations from $348

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The Latest Puxico vacation packages

Price found within the past 48 hours. Click for updated prices.
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
Price was $383, price is now $348 per person
$348
per person
Dec 3 - Dec 6
found 13 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
6.8/10 (143 reviews)
Clean Room

Reviewed on Oct 26, 2026

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
Price was $1,070, price is now $1,017 per person
$1,017
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Manhattan (MHK) to Cape Girardeau (CGI)
8/10 Very Good! (1,003 reviews)
The hallways reeked of marijuana smoke. Changed hotels the second night.

Reviewed on Nov 2, 2026

Perryville RV Resort

Perryville RV Resort

2 out of 5
Price was $373, price is now $355 per person
$355
per person
Dec 3 - Dec 6
found 13 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
8.8/10 Excellent! (8 reviews)

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
Price was $424, price is now $405 per person
$405
per person
Dec 3 - Dec 6
found 13 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
9.2/10 Wonderful! (638 reviews)

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
Price was $1,133, price is now $1,087 per person
$1,087
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Manhattan (MHK) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,003 reviews)
Was really impressed, I don’t normally write reviews. Free drinks and food in the evening, lovely staff. clean room. Was really a cut above.

Reviewed on Nov 1, 2026

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Puxico Hotel Deals

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $102 total per night from Nov 15 to Nov 16
$102 total
Nov 15 - Nov 16
Total with taxes and fees
9.4/10 Exceptional! (1,003 reviews)
"The hotel and our room was very nice. Their location is very convenient. It was very quiet and the breakfast was great. Parking was close and everyone was friendly and helpful."

Reviewed on Nov 2, 2026

Hampton Inn Poplar Bluff
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $88 total per night from Nov 12 to Nov 13
$88 total
Nov 12 - Nov 13
Total with taxes and fees
8/10 Very Good! (1,004 reviews)
"The hallways reeked of marijuana smoke. Changed hotels the second night."

Reviewed on Nov 2, 2026

Motel 6 Poplar Bluff, MO
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
$100 nightly
The price is $105 total per night from Nov 4 to Nov 5
$105 total
Nov 4 - Nov 5
Total with taxes and fees
Lake Wappapello
See all 52 properties in Puxico
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Puxico Vacation Packages

Puxico Essential Information

Language
English
Currency
U.S dollars
Population
870

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Frequently asked questions

How much does a Puxico vacation package cost?
You can grab a vacation package to this top destination from $348 on Expedia. However, how much your vacation to Puxico costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Puxico?
February, April and August are the best times to look for cheap Puxico vacation packages. Opting to travel in less busy months means you can usually find reduced prices on accommodations and flights.
How many days is enough for Puxico?
Typically, a handful of days is enough to explore the major attractions during your Puxico vacation. However, if you prefer to have more time to chill out or go on day trips, think about extending your itinerary.
How to find the best Puxico package deals?
Use Expedia's handy filters to help you find some unbeatable Puxico package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your adventure for midweek, or look for Puxico package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package well in advance.
Is it cheaper to book a Puxico vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll typically score a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Puxico vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Puxico?
If you're planning a spur-of-the-moment Puxico adventure, check out our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can find incredible deals on your flights and hotels by booking ahead.
Does Expedia offer Book Now, Pay Later Puxico vacation packages?
If you're anything like us, you love discovering new places but are not a fan of the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Puxico trip over 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.