Title: Puxico Vacation Packages 2026 from $424 | Expedia.com

[Hotels in Puxico](https://expedia.com/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[Vacation Rentals in Puxico](https://expedia.com/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Car Rentals in Puxico](https://expedia.com/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide)

![](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Puxico Vacations from $424

## Book a Hotel + Flight or Car together to unlock savings

Photo by Mike McClain 

## The Latest Puxico vacation packages

Price found within the past 48 hours. Click for updated prices.

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Candlewood Suites Cape Girardeau by IHG

$424

per person

Apr 30 - May 7

found 1 day ago

Roundtrip flight included

Chicago (CHI) to Cape Girardeau (CGI)

8.2/10 Very Good! (901 reviews)

Excessive fee for dogs was $75.00\. No breakfast. Very loud room next to freeway. Old coil bed could feel every move my husband made. Will not be coming back.

Reviewed on Mar 2, 2026

![EC Reed's Mercantile and Hotel](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/a0829ae4_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### EC Reed's Mercantile and Hotel

Save 100% on your flight

$429

per person

Apr 30 - May 7

found 1 day ago

Roundtrip flight included

Chicago (CHI) to Cape Girardeau (CGI)

9.6/10 Exceptional! (84 reviews)

Clean rooms, great value.

Reviewed on Nov 28, 2025

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Drury Plaza Hotel Cape Girardeau Conference Center

$588

per person

Apr 30 - May 7

found 1 day ago

Roundtrip flight included

Chicago (CHI) to Cape Girardeau (CGI)

9.6/10 Exceptional! (1,001 reviews)

Great breakfast, location right off the freeway, pleasant staff

Reviewed on Mar 17, 2026

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

$570

per person

Apr 30 - May 7

found 1 day ago

Roundtrip flight included

Chicago (CHI) to Cape Girardeau (CGI)

9.4/10 Exceptional! (1,007 reviews)

I was amazed to find out this place is 20+ years old. It is in great shape. Room was wonderful. Breakfast was great; very lovely stay.

Reviewed on Mar 13, 2026

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Drury Inn & Suites Cape Girardeau

$520

per person

Apr 30 - May 7

found 1 day ago

Roundtrip flight included

Chicago (CHI) to Cape Girardeau (CGI)

9.4/10 Exceptional! (1,007 reviews)

Always the friendliest staff, like they love their job and feel respected. Always a clean room. Had a suite for this day, and ver spacious, felt like an apartment.

Reviewed on Mar 17, 2026

Don't see what you're looking for?

See all available trips from Columbus to Puxico

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-19/2026-04-26/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=CGI&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

## Puxico Hotel Deals

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$70 nightly

$74 total

Mar 28 - Mar 29

Total with taxes and fees

8/10 Very Good! (1,000 reviews)

Bed was worn out felt like I was sleeping on a pile of rocks. Had 2 towels when made a reservation for 5\. Glad I only made a 1 night reservation. This one ruined it for all the rest

Reviewed on Mar 17, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F28%2F2026&endDate=3%2F29%2F2026&selected=15689127&PinnedHotelID=15689127&HadPinnedHotel=true&regionId=553248634983343452)

![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Drury Inn & Suites Poplar Bluff

2220 N Westwood Blvd Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$94 nightly

$106 total

Apr 12 - Apr 13

Total with taxes and fees

9.2/10 Wonderful! (1,000 reviews)

They were great with my dog. And a very nice, clean room. And the food and drinks were a very nice addition!

Reviewed on Mar 19, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=41515&PinnedHotelID=41515&HadPinnedHotel=true&regionId=553248634983343452)

![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$110 nightly

$124 total

Apr 2 - Apr 3

Total with taxes and fees

9.4/10 Exceptional! (877 reviews)

Our stay was good and the room was clean. The only issue we ran into was that room was next to the water pumps and there was a good bit of background noise throughout the night. Other than that everything was great. The breakfast in the morning was good and there were enough choices for everyone ...

Reviewed on Mar 15, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F2%2F2026&endDate=4%2F3%2F2026&selected=28807257&PinnedHotelID=28807257&HadPinnedHotel=true&regionId=553248634983343452)

[See all 52 properties in Puxico](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026&regionId=553248634983343452)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Puxico Vacation Packages

## Puxico Essential Information

| Language   | English     |
| ---------- | ----------- |
| Currency   | U.S dollars |
| Population | 870         |

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## Frequently asked questions

### How much does a Puxico vacation package cost?

### What are the cheapest months to go to Puxico?

### How many days is enough for Puxico?

### How to find the best Puxico package deals?

### Is it cheaper to book a Puxico vacation as a package?

### When to book a vacation package to Puxico?

### Does Expedia offer Book Now, Pay Later Puxico vacation packages?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.