Puxico Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by Mike McClain

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    Better together

    Save up to $1,045 when you book a flight and hotel together*
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Puxico Hotel Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $83 total per night from Aug 15 to Aug 16
$83 total
Aug 15 - Aug 16
Total includes taxes and fees
7.8/10 Good! (1,004 reviews)
"Everything"

Reviewed on Aug 9, 2025

Motel 6 Poplar Bluff, MO
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 out of 5
3109 Oak Grove, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $112 total per night from Aug 17 to Aug 18
$112 total
Aug 17 - Aug 18
Total includes taxes and fees
9.2/10 Wonderful! (789 reviews)
"good"

Reviewed on Aug 7, 2025

Fairfield Inn & Suites by Marriott Poplar Bluff
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd, Poplar Bluff, MO
Fully refundable
$105 nightly
The price is $119 total per night from Aug 17 to Aug 18
$119 total
Aug 17 - Aug 18
Total includes taxes and fees
8.6/10 Excellent! (668 reviews)
"Was there with my daughter and grandchildren was awesome will come back"

Reviewed on Aug 7, 2025

Holiday Inn Poplar Bluff by IHG
See all 52 properties in Puxico
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Puxico vacation package cost?
You can grab a vacation package to this top destination on Expedia. However, how much your vacation to Puxico costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Puxico?
February, April and August are the best times to look for cheap Puxico vacation packages. Opting to travel in less busy months means you can usually find reduced prices on accommodations and flights.
How many days is enough for Puxico?
Typically, a handful of days is enough to explore the major attractions during your Puxico vacation. However, if you prefer to have more time to chill out or go on day trips, think about extending your itinerary.
How to find the best Puxico package deals?
Use Expedia's handy filters to help you find some unbeatable Puxico package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your adventure for midweek, or look for Puxico package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package well in advance.
Is it cheaper to book a Puxico vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll typically score a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Puxico vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Puxico?
If you're planning a spur-of-the-moment Puxico adventure, check out our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can find incredible deals on your flights and hotels by booking ahead.
Does Expedia offer Book Now, Pay Later Puxico vacation packages?
If you're anything like us, you love discovering new places but are not a fan of the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Puxico trip over 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.