Puxico Vacations from $443
Book a Hotel + Flight or Car together to unlock savings
Photo by Mike McClain
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
The Latest Puxico vacation packages
Price found within the past 48 hours. Click for updated prices.
Comfort Suites Jackson-Cape Girardeau
Price was $708, price is now $685 per person
$685
per person
Mar 19 - Mar 21
found 23 hours ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Cape Girardeau (CGI)
8.2/10 Very Good! (738 reviews)
Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone.
Reviewed on Dec 19, 2025
Town House Inn
Price was $460, price is now $445 per person
$445
per person
Feb 23 - Feb 25
found 1 day ago
Roundtrip non-stop flight included
Denver (DEN) to Cape Girardeau (CGI)
7.6/10 Good! (422 reviews)
Upon arrival, the room I was given had problems: there were cockroaches scurrying about in the kitchenette area. Plus the room smelled like a smoker's room, even though the room sign stated it was smoke free. Not a good way to start! I went to the on-site manager and explained, and to his credit, he was very accommodating. He gave me another room, and it was better: no roaches, no smoke smell. The bed mattresses had zippered mattress protectors (good! bed bed prevention) and the shower was very good: ample hot water, good water pressure. For the budget price I paid (about $68), this hotel was acceptable.
Reviewed on Dec 24, 2025
Puxico Hotel Deals
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $60 total per night from Jan 16 to Jan 17
$60 total
Jan 16 - Jan 17
Total with taxes and fees
7.8/10 Good! (1,005 reviews)
Parking is easy and plentiful. Beds and pillows are always comfortable. Staff was friendly and helpful with my questions. Very much recommended.
Reviewed on Jan 7, 2026
Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $107 total per night from Jan 18 to Jan 19
$107 total
Jan 18 - Jan 19
Total with taxes and fees
9.2/10 Wonderful! (976 reviews)
We were greeted by a pleasant young clerk, with a smile, and very helpful. Our room was on the 2nd floor, our room was clean, with microwave n a mini fridge. The breakfast bar was good,and you get silverware and plates. No plastic utensils and no paperplates. It was a great stay. Thank you!
Reviewed on Jan 7, 2026
Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$110 nightly
The price is $124 total per night from Jan 18 to Jan 19
$124 total
Jan 18 - Jan 19
Total with taxes and fees
8.6/10 Excellent! (711 reviews)
The front desk woman was great
Reviewed on Dec 21, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Puxico Vacation Packages
Puxico Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 870 |
More vacations you might like
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
