Río Grande Vacations from $776

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Río Grande vacation packages

Price found within the past 48 hours. Click for updated prices.
Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was $1,008, price is now $776 per person
$776
per person
May 19 - May 24
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.4/10 Exceptional! (182 reviews)
Amazing staff, so helpful and welcoming! Great size room, Perfectly situated in old town

Reviewed on Feb 7, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,003, price is now $1,326 per person
$1,326
per person
Apr 9 - Apr 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,008 reviews)
The staff was great an the hotel

Reviewed on Mar 2, 2026

Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3.5 out of 5
Casco Viejo
Price was $1,385, price is now $1,061 per person
$1,061
per person
May 24 - May 31
found 1 day ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
9.2/10 Wonderful! (7 reviews)
Staff was courteous, and the room was very beautiful. Would stay here again!

Reviewed on Dec 31, 2025

Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was $1,163, price is now $901 per person
$901
per person
Apr 9 - Apr 13
found 1 day ago
Roundtrip flight included
New York (JFK) to Panama City (PTY)
9/10 Wonderful! (143 reviews)
J’ai tout aimé de l’endroit qui était féerique, tranquille, directement sur le bord de la plage. Le personnel impeccable et la chambre parfaite et confortable 😊

Reviewed on Feb 23, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,075, price is now $842 per person
$842
per person
May 22 - May 25
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,437 reviews)
View of the city but you can ask prior arrival your prefernce. Shops are nearby

Reviewed on Mar 2, 2026

Don't see what you're looking for?
See all available trips from Columbus to Río Grande
View all trips

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.
Book now

Río Grande Hotel Deals

Charming 3-bedroom countryside Villa in Rio Grande with Pool, WiFi, AC

Charming 3-bedroom countryside Villa in Rio Grande with Pool, WiFi, AC

Rio Grande Coclé Province
Get rates
Charming 3-bedroom countryside Villa in Rio Grande with Pool, WiFi, AC
Hotel Coclé

Hotel Coclé

3.5 out of 5
Via Interamericana Penonome Cocle
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $74 total per night from Mar 8 to Mar 9
$74 total
Mar 8 - Mar 9
Total with taxes and fees
8.8/10 Excellent! (223 reviews)
Excellent customer service and my room was very nice

Reviewed on Feb 27, 2026

Hotel Coclé
Hostal Las Catalinas Ecológicas

Hostal Las Catalinas Ecológicas

2.5 out of 5
Los Álveos El Valle de Anton Coclé
Get rates
Hostal Las Catalinas Ecológicas
See all 48 properties in Río Grande
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Río Grande Vacation Packages

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How to find the best Río Grande package deals?
Begin your search for a Río Grande package deal by entering your travel dates and destination under our "Packages" tab. Then add some filters, like "Property type" and "Guest rating," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with unbeatable savings. If you don't find the perfect Río Grande package deal straight away, simply switch up your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Río Grande adventure underway.
When to book a vacation package to Río Grande?
If you've got your Río Grande travel dates finalized, book early to score some fantastic deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for traveling on a whim.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.