Title: Río Sereno Vacation Packages 2026 from $613 | Expedia.com

[Río Sereno Travel Guide](https://expedia.com/Rio-Sereno.dx829296881617084416)[Hotels in Río Sereno](https://expedia.com/Rio-Sereno-Hotels.d829296881617084416.Travel-Guide-Hotels)[Vacation Rentals in Río Sereno](https://expedia.com/Rio-Sereno-Vacation-Rentals.d829296881617084416.Travel-Guide-VacationRentals)[Flights to Río Sereno](https://expedia.com/Cheap-Flights-To-Rio-Sereno.d829296881617084416.Travel-Guide-Flights)[Car Rentals in Río Sereno](https://expedia.com/Car-Rentals-In-Rio-Sereno.d829296881617084416.Car-Rental-Guide)

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# Río Sereno Vacations from $613

## Book a Hotel + Flight or Car together to unlock savings

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## The Latest Río Sereno vacation packages

Price found within the past 48 hours. Click for updated prices.

![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Mahogany Suites

$613

per person

Apr 2 - Apr 6

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

10/10 Exceptional! (1 review)

Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

![Villa Botero By Casa Mojito B&B](https://images.trvl-media.com/lodging/12000000/11930000/11927200/11927153/393d35f8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Villa Botero By Casa Mojito B&B

Save 100% on your flight

$762

per person

Mar 13 - Mar 20

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Panama City (PTY)

9.8/10 Exceptional! (60 reviews)

We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Central Hotel Panama Casco Viejo

Casco Viejo

$1,017

per person

Apr 15 - Apr 19

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,002 reviews)

The room had no window to the outside it instead had a large window into an interior hall. Maid service was inconsistent. Breakfast was not a good value.

Reviewed on Feb 5, 2026

![Playa Caracol Residences Vacation Rental](https://images.trvl-media.com/lodging/40000000/39140000/39130700/39130628/d7354164_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Playa Caracol Residences Vacation Rental

$948

per person

Mar 12 - Mar 18

found 11 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

7.2/10 Good! (26 reviews)

Great, clean condo overlooking the pool and ocean. We didn't cook our meals, but used the restaurant on site. Staff was friendly and professional.

Reviewed on Dec 7, 2025

![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Dreams Playa Bonita Panama - All Inclusive

$1,334

per person

Mar 21 - Mar 25

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

7.4/10 Good! (1,002 reviews)

The rooms were clean, and the property was very nice and well kept up. The service was slower than I liked, but it’s Panamá time I guess. The food was ok, depending on what you like.

Reviewed on Feb 2, 2026

Don't see what you're looking for?

See all available trips from Columbus to Río Sereno

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-06/2026-03-13/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

## Río Sereno Hotel Deals

![Glamping on a coffee plantation on the Panama Costa Rica broder.](https://images.trvl-media.com/lodging/91000000/90330000/90329000/90328937/b7bbacf5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Glamping on a coffee plantation on the Panama Costa Rica broder.

 Rio Sereno Chiriquí Province

[Get rates](https://expedia.com/Hotel-Search?startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&selected=90328937&PinnedHotelID=90328937&HadPinnedHotel=true&regionId=829296881617084416)

[](https://expedia.com/Hotel-Search?startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&selected=90328937&PinnedHotelID=90328937&HadPinnedHotel=true&regionId=829296881617084416)

![Hotel Bambito By Faranda Boutique, a member of Radisson Individuals](https://images.trvl-media.com/lodging/2000000/1700000/1691400/1691326/e018a7d8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Bambito By Faranda Boutique, a member of Radisson Individuals

Volcan, Via Cerro Punta Volcan Chiriqui

$100 nightly

$110 total

Feb 18 - Feb 19

Total with taxes and fees

8/10 Very Good! (242 reviews)

Very clean room

Reviewed on Jan 9, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F18%2F2026&endDate=2%2F19%2F2026&selected=1691326&PinnedHotelID=1691326&HadPinnedHotel=true&regionId=829296881617084416)

![Hotel Finca Lerida](https://images.trvl-media.com/lodging/5000000/4600000/4598400/4598341/160dc75a_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Finca Lerida

Alto Quiel Los Naranjos Chiriqui

8.8/10 Excellent! (188 reviews)

Spotless room and bathroom, the amazing staff that treats you like family, coffee tour and tasting is a must, very good food.

Reviewed on Jan 13, 2026

[Get rates](https://expedia.com/Hotel-Search?startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&selected=4598341&PinnedHotelID=4598341&HadPinnedHotel=true&regionId=829296881617084416)

[](https://expedia.com/Hotel-Search?startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&selected=4598341&PinnedHotelID=4598341&HadPinnedHotel=true&regionId=829296881617084416)

[See all 41 properties in Río Sereno](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F7%2F2026&endDate=2%2F8%2F2026&regionId=829296881617084416)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Río Sereno Vacation Packages

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## Frequently asked questions

### How to find the best Río Sereno package deals?

### When to book a vacation package to Río Sereno?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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