Río Sereno Vacations from $931
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The Latest Río Sereno vacation packages
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
$1,115
per person
Nov 4 - Nov 11
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (1,010 reviews)
Nice hotel. Great location. Good breakfast. Our only complaint is about noise. The hotel has live music in the atrium from early in the morning until about 10 pm. Our room, along with many others, had windows facing into the atrium, and the noise from the music, and sometimes large tour groups at breakfast, may disturb your sleep.
Reviewed on Aug 10, 2026
Megapolis Hotel Panamá
San Francisco
$1,125
per person
Sep 25 - Oct 2
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,628 reviews)
Fabulous rooms friendly staff and great location.would do over again and again
Reviewed on Aug 14, 2026
Hyatt Regency Panama City
Bella Vista
$1,071
per person
Sep 25 - Oct 2
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.6/10 Exceptional! (398 reviews)
Excellent stay, The property was beautiful and the staff are very friendly and attentive.
Reviewed on Aug 14, 2026
Río Sereno Hotel Deals
Hotel Finca Lerida
Alto Quiel Los Naranjos Chiriqui
$168 nightly
$184 total
Aug 16 - Aug 17
Total with taxes and fees
Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals
Volcan, Via Cerro Punta Volcan Chiriqui
Fully refundableReserve now, pay when you stay
$112 nightly
$123 total
Aug 23 - Aug 24
Total with taxes and fees
Hotel Dos Rios
43, Nueva California Nueva California
$86 nightly
$94 total
Aug 15 - Aug 16
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Río Sereno Vacation Packages
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Frequently asked questions
How to find the best Río Sereno package deals?
Use Expedia's filter tool to help you find some fabulous Río Sereno package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Río Sereno package deals in the low season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
When to book a vacation package to Río Sereno?
If you're planning a spontaneous Río Sereno trip, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score terrific deals on your hotels and flights by booking well in advance.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
