Río Sereno Vacations from $783
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The Latest Río Sereno vacation packages
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
$1,360
per person
Dec 10 - Dec 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,006 reviews)
Excelente servicio y ubicación. Buen desayuno y restaurantes.
Reviewed on Oct 19, 2026
Río Sereno Hotel Deals
Hotel Finca Lerida
Alto Quiel Los Naranjos Chiriqui
$168 nightly
$184 total
Oct 22 - Oct 23
Total with taxes and fees
9/10 Wonderful! (212 reviews)
"Todo muy rico y el lugar encantador"
Reviewed on Sep 28, 2026
Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals
Volcan, Via Cerro Punta Volcan Chiriqui
Fully refundableReserve now, pay when you stay
$120 nightly
$132 total
Nov 15 - Nov 16
Total with taxes and fees
8.2/10 Very Good! (271 reviews)
"Absolutely beautiful ground! Wonderful staff and a great breakfast! 100% will return!"
Reviewed on Oct 17, 2026
Hotel Dos Rios
43, Nueva California Nueva California
$86 nightly
$94 total
Oct 20 - Oct 21
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Río Sereno Vacation Packages
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Frequently asked questions
How to find the best Río Sereno package deals?
Use Expedia's filter tool to help you find some fabulous Río Sereno package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Río Sereno package deals in the low season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
When to book a vacation package to Río Sereno?
If you're planning a spontaneous Río Sereno trip, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score terrific deals on your hotels and flights by booking well in advance.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
