Title: Río Sereno Vacation Packages 2026 from $656 | Expedia.com

[Río Sereno Travel Guide](https://expedia.com/Rio-Sereno.dx829296881617084416)[Hotels in Río Sereno](https://expedia.com/Rio-Sereno-Hotels.d829296881617084416.Travel-Guide-Hotels)[Vacation Rentals in Río Sereno](https://expedia.com/Rio-Sereno-Vacation-Rentals.d829296881617084416.Travel-Guide-VacationRentals)[Flights to Río Sereno](https://expedia.com/Cheap-Flights-To-Rio-Sereno.d829296881617084416.Travel-Guide-Flights)[Car Rentals in Río Sereno](https://expedia.com/Car-Rentals-In-Rio-Sereno.d829296881617084416.Car-Rental-Guide)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium)

# Río Sereno Vacations from $656

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## The Latest Río Sereno vacation packages

Price found within the past 48 hours. Click for updated prices.

![Villa Botero By Casa Mojito B&B](https://images.trvl-media.com/lodging/12000000/11930000/11927200/11927153/393d35f8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Villa Botero By Casa Mojito B&B

Save 100% on your flight

$656

per person

May 4 - May 11

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.8/10 Exceptional! (60 reviews)

We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Mahogany Suites

$711

per person

Apr 8 - Apr 12

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

10/10 Exceptional! (1 review)

Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

![Yoo by Wynwood House](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f526e4da_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Yoo by Wynwood House

Calidonia

$779

per person

May 4 - May 11

found 24 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.2/10 Wonderful! (5 reviews)

Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025

![Playa Caracol Residences Vacation Rental](https://images.trvl-media.com/lodging/40000000/39140000/39130700/39130628/d7354164_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Playa Caracol Residences Vacation Rental

$894

per person

May 10 - May 17

found 10 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

7.2/10 Good! (26 reviews)

Great, clean condo overlooking the pool and ocean. We didn't cook our meals, but used the restaurant on site. Staff was friendly and professional.

Reviewed on Dec 7, 2025

![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Central Hotel Panama Casco Viejo

Casco Viejo

$1,136

per person

May 15 - May 19

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,002 reviews)

Room was amazing, beautiful hotel in the center of town. Service also very good and attentive. Amazing breakfast.

Reviewed on Feb 24, 2026

Don't see what you're looking for?

See all available trips from Columbus to Río Sereno

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-27/2026-04-03/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_829296881617084416)

## Río Sereno Hotel Deals

![Glamping on a coffee plantation on the Panama Costa Rica broder.](https://images.trvl-media.com/lodging/91000000/90330000/90329000/90328937/b7bbacf5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Glamping on a coffee plantation on the Panama Costa Rica broder.

 Rio Sereno Chiriquí Province

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F13%2F2026&endDate=3%2F14%2F2026&selected=90328937&PinnedHotelID=90328937&HadPinnedHotel=true&regionId=829296881617084416)

[](https://expedia.com/Hotel-Search?startDate=3%2F13%2F2026&endDate=3%2F14%2F2026&selected=90328937&PinnedHotelID=90328937&HadPinnedHotel=true&regionId=829296881617084416)

![Hotel Bambito By Faranda Boutique, a member of Radisson Individuals](https://images.trvl-media.com/lodging/2000000/1700000/1691400/1691326/e018a7d8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Bambito By Faranda Boutique, a member of Radisson Individuals

Volcan, Via Cerro Punta Volcan Chiriqui

Fully refundableReserve now, pay when you stay

$108 nightly

$119 total

Mar 1 - Mar 2

Total with taxes and fees

8.2/10 Very Good! (246 reviews)

Everything very good, Great staff! Beautiful and relaxing place

Reviewed on Feb 6, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=1691326&PinnedHotelID=1691326&HadPinnedHotel=true&regionId=829296881617084416)

![Los Brezos Boutique Hotel](https://images.trvl-media.com/lodging/70000000/69410000/69404700/69404636/0830ff2c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Los Brezos Boutique Hotel

Calle Tercera Norte Volcan Chiriquí

Fully refundableReserve now, pay when you stay

9.4/10 Exceptional! (29 reviews)

Excellent choice for your stay in Volcan. I stayed for 2 nights as solo traveler. Great staff and management. Everyone was helpful and friendly. Volcan is a great base for exploring Cerro Punto region for a day or 2\. I highly recommend this hotel.

Reviewed on Feb 11, 2026

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F13%2F2026&endDate=3%2F14%2F2026&selected=69404636&PinnedHotelID=69404636&HadPinnedHotel=true&regionId=829296881617084416)

[](https://expedia.com/Hotel-Search?startDate=3%2F13%2F2026&endDate=3%2F14%2F2026&selected=69404636&PinnedHotelID=69404636&HadPinnedHotel=true&regionId=829296881617084416)

[See all 42 properties in Río Sereno](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F28%2F2026&endDate=3%2F1%2F2026&regionId=829296881617084416)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Río Sereno Vacation Packages

## More vacations you might like

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

## Frequently asked questions

### How to find the best Río Sereno package deals?

### When to book a vacation package to Río Sereno?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app