Ruta Independencia Vacations from $680

Book a Hotel + Flight or Car together to unlock savings

Photo by Marina Alcantara

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Ruta Independencia Vacation

Our Ruta Independencia vacation packages are a simple and practical way to arrange and book your next retreat. Uncover the true character of this unique neighborhood without the bother of having to plan everything yourself. Some top nearby attractions to visit during your trip to Ruta Independencia include Zocalo Square, Church of Santo Domingo de Guzman and Auditorio Guelaguetza. Stop daydreaming and start doing. When it's time to lock in your next vacation to Ruta Independencia, Expedia is here to help.

The Latest Ruta Independencia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Boutique Naura Centro

Hotel Boutique Naura Centro

3.5 out of 5
Oaxaca Centro
Save 100% on your flight
Price was $1,184, price is now $680 per person
$680
per person
Apr 11 - Apr 16
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Oaxaca Intl. (OAX)
9.2/10 Wonderful! (952 reviews)
We had an interior King room. It was small, but nicely

Reviewed on Feb 8, 2026

Casa De Sierra Azul

Casa De Sierra Azul

3.5 out of 5
Oaxaca Centro
Save 100% on your flight
Price was $1,281, price is now $751 per person
$751
per person
Apr 11 - Apr 16
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Oaxaca Intl. (OAX)
9.2/10 Wonderful! (888 reviews)
Clean room and staff.

Reviewed on Feb 7, 2026

Hotel Los Amantes

Hotel Los Amantes

3 out of 5
Oaxaca Centro
Save 100% on your flight
Price was $1,343, price is now $799 per person
$799
per person
Apr 11 - Apr 16
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Oaxaca Intl. (OAX)
8.4/10 Very Good! (224 reviews)
Overall a great experience

Reviewed on Nov 29, 2025

Capital O Parador Crespo Hotel, Oaxaca

Capital O Parador Crespo Hotel, Oaxaca

3 out of 5
Oaxaca Centro
Price was $1,216, price is now $765 per person
$765
per person
Mar 30 - Apr 3
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Oaxaca Intl. (OAX)
7.8/10 Good! (247 reviews)
We didn’t have free breakfast, but for the price was aceptable

Reviewed on Oct 19, 2025

Grand Fiesta Americana Oaxaca

Grand Fiesta Americana Oaxaca

5 out of 5
Oaxaca Centro
Price was $2,859, price is now $1,813 per person
$1,813
per person
Apr 11 - Apr 18
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Oaxaca Intl. (OAX)
9.6/10 Exceptional! (655 reviews)
Excelwnte! Increible arquitectura y staff muy amable

Reviewed on Jan 30, 2026

Where to stay in Ruta Independencia

Find the best Ruta Independencia areas and neighborhoods for the activities you enjoy most. Learn more about Ruta Independencia
#lifeatexpedia #lovemyjob #weloveourmarkets #latam #oaxaca #mexico #green Hundreds of plant species, all of them native to Oaxaca. A magical place!!!

Oaxaca Centro

7 out of top 10 points of interest in this area
4.5/5(695 area reviews)

Discover colonial-era structures and immerse in native Zapotec and Mixtec cultures in this UNESCO World Heritage Site. Explore the archeological marvel of Monte Albán and admire the unique green stone architecture.

Find hotels in Oaxaca Centro

Ruta Independencia Hotel Deals

One Oaxaca Centro Hotel

One Oaxaca Centro Hotel

3 out of 5
Calzada de la Republica #205 Oaxaca OAX
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $100 total per night from Feb 21 to Feb 22
$100 total
Feb 21 - Feb 22
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
The room if clean and all basic amenities supplied. It is a small room, but it met our needs. Staff is courteous. Breakfast is a hot breakfast buffet with regional cuisine.

Reviewed on Jan 25, 2026

One Oaxaca Centro Hotel
Hotel Casa del Sótano

Hotel Casa del Sótano

3.5 out of 5
Tinoco y Palacios 414, Col. Centro Oaxaca OAX
$101 nightly
The price is $120 total per night from Mar 1 to Mar 2
$120 total
Mar 1 - Mar 2
Total with taxes and fees
9/10 Wonderful! (1,010 reviews)
Great place to stay!

Reviewed on Feb 5, 2026

Hotel Casa del Sótano
Grand Fiesta Americana Oaxaca

Grand Fiesta Americana Oaxaca

5 out of 5
Jose Maria Pino Suarez 702 Oaxaca OAX
$284 nightly
The price is $337 total per night from Mar 1 to Mar 2
$337 total
Mar 1 - Mar 2
Total with taxes and fees
9.6/10 Exceptional! (695 reviews)
Lovely hotel. Beautiful space and kind staff.

Reviewed on Feb 4, 2026

Grand Fiesta Americana Oaxaca
See all 860 properties in Ruta Independencia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Ruta Independencia

Église Santo Domingo de Guzmán, Oaxaca

Church of Santo Domingo de Guzmán

5/5(286 reviews)

Church of Santo Domingo de Guzmán is just one of the places to see in Oaxaca, so why not enjoy the other things to explore during your travels? While in this culturally rich area, find time to visit its shops.

Church of Santo Domingo de Guzmán
Aerial views of the Ex-convent of Santo Domingo in the City of Oaxaca, Mexico, the roofs are reddish and there is an ethnobotanical garden

Oaxaca Ethnobotanical Garden

4.5/5(184 reviews)

Explore the great outdoors at Oaxaca Ethnobotanical Garden, a lovely green space in Oaxaca. While in this culturally rich area, find time to visit its shops.

Oaxaca Ethnobotanical Garden
Oaxaca is a beautiful city!

Santo Domingo Square

4.5/5(121 reviews)

During your trip to Oaxaca, you can find the perfect gifts to bring home at Santo Domingo Square. Discover the art scene and cathedral in this culturally rich area.

Santo Domingo Square

Things to do

Bike tour to the Tule Tree and the Gastronomic Market

Bike tour to the Tule Tree and the Gastronomic Market

$30
per adult
Bike tour to the Tule Tree and the Gastronomic Market
Oaxaca de Juarez: Monte Alban Half-Day Tour

Oaxaca de Juarez: Monte Alban Half-Day Tour

$30
per adult
94% of travellers recommend
Oaxaca de Juarez: Monte Alban Half-Day Tour
Monte Alban, Alebrijes & Black Pottery: Oaxaca Essential Day Tour

Monte Alban, Alebrijes & Black Pottery: Oaxaca Essential Day Tour

$42
per adult
Monte Alban, Alebrijes & Black Pottery: Oaxaca Essential Day Tour
See all activities in Oaxaca
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.