San Antonio Vacations from $546

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your San Antonio Vacation

Experience the best that San Antonio offers with a San Antonio vacation package. From its cafes to every other thing that makes it so special, this neighborhood will delight you from start to finish. When it's time to take in the sights, you'll find loads of awesome attractions nearby including Chipichape Shopping Center, Olympic Stadium Pascual Guerrero and Cali Zoo. Visit one, two or all during your trip to San Antonio. Stop daydreaming and start doing. When you're ready to book your next vacation to San Antonio, Expedia is here to help.

The Latest San Antonio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Torre De Cali Plaza Hotel
Casa San Carlos Lodge
Hotel MS Ciudad Jardín Plus
MS Pacífico Chipichape Plus
Hotel Avenida 3 Real

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio

San Antonio Hotel Deals

Alko Hotel Casa Nispero

Alko Hotel Casa Nispero

4 out of 5
Cra. 10 #3-28. B/ San Antonio Cali Valle del Cauca
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $116 total per night from Dec 1 to Dec 2
$116 total
Dec 1 - Dec 2
9.4/10 Exceptional! (254 reviews)
"Todo excelente y todo mundo demasiado amable. El desayuno aquí es espectacular."

Reviewed on Nov 10, 2026

Alko Hotel Casa Nispero
Viajero Cali Hostel & Salsa School

Viajero Cali Hostel & Salsa School

2 out of 5
Carrera 5 No. 4 - 56 Cali
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $48 total per night from Nov 16 to Nov 17
$48 total
Nov 16 - Nov 17
9/10 Wonderful! (70 reviews)
"Great exsperience i go there every time then in cali.It's one of the best places i highly recomend"

Reviewed on Oct 15, 2026

Viajero Cali Hostel & Salsa School
San Antonio Hotel Boutique

San Antonio Hotel Boutique

3 out of 5
Carrera 6 #2-51 Cali Valle del Cauca
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $76 total per night from Nov 14 to Nov 15
$76 total
Nov 14 - Nov 15
San Antonio Hotel Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.