San Francisco Vacations from $589
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Your San Francisco Vacation
When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.
The Latest San Francisco Vacation Packages
Mahogany Suites
Reviewed on Dec 21, 2025
Central Hotel Panama Casco Viejo
Reviewed on Dec 21, 2025
Megapolis Hotel Panamá
Reviewed on Dec 20, 2025
Hotel Riu Plaza Panama
Reviewed on Dec 21, 2025
Where to stay in San Francisco
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
San Francisco Hotel Deals
Megapolis Hotel Panamá
Big rooms, excellent food choices
Reviewed on Dec 20, 2025
Las Americas Golden Tower Panama
It was a very nice stay. The room is nice, organized and clean with a great view of the city. The blankets are a little too warm and we wished for a lighter blankets. Breakfast buffet was very good with many food choices and best custom eggs cooked tailored to our demands. Uber to Casco Viejo was ...
Reviewed on Dec 15, 2025
Plaza Paitilla Inn Hotel
Great location of the hotel with a lovely breakfast and friendly staff
Reviewed on Dec 19, 2025
Discover the most popular places to visit in San Francisco
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
ATLAPA Conventions Center
Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its lively bars.
Multicentro Panama
During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.
Things to do
Boat tour in the Panama Canal to Monkeys and sloths islands
Panama City: Poin Full Package Experience
