San Francisco Vacations from $252

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Your San Francisco Vacation

With plenty of highlights as well as hidden gems, this city is best experienced with a San Francisco vacation package. Check out places to stay in Downtown Guayaquil, which is good for views, culture and history. Make your trip to San Francisco even more exciting by including some sightseeing. Malecon 2000, Banco Pichincha Monumental Stadium and Mall del Sol Commercial Center are among the leading attractions worth exploring. A couple of clicks is all it takes to put together a customized San Francisco vacation on Expedia.

The Latest San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Mansión Alcázar Boutique Hotel

Mansión Alcázar Boutique Hotel

4 out of 5
Downtown Cuenca
Save 100% on your flight
Price was $397, price is now $252 per person
$252
per person
Dec 11 - Dec 14
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.6/10 Exceptional! (308 reviews)
I had an amazing stay. This hotel is gorgeous

Reviewed on Sep 22, 2025

Sanchez hotel Spa by Chat Noir

Sanchez hotel Spa by Chat Noir

3 out of 5
San Sebastián
Save 100% on your flight
Price was $1,083, price is now $569 per person
$569
per person
Dec 21 - Dec 23
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
7.8/10 Good! (6 reviews)
Awesome people and space.

Reviewed on Sep 15, 2025

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador

2.5 out of 5
Las Peñas
Save 100% on your flight
Price was $2,861, price is now $1,704 per person
$1,704
per person
Nov 14 - Nov 20
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guayaquil (GYE)
10/10 Exceptional! (1 review)
I absolutely loved my stay at Hotel Rio Guayas! The staff was incredibly kind, attentive, and made me feel truly welcome. One of the highlights was the stunning river view from the restaurant absolutely unforgettable. The hotel feels luxurious, with beautiful artwork and elegant decor throughout. Everything was spotless and comfortable. I highly recommend this place and would love to stay again! For Sureeee

Reviewed on Jul 30, 2025

Hotel Boutique Santa Lucia

Hotel Boutique Santa Lucia

4 out of 5
Downtown Cuenca
Save 100% on your flight
Price was $428, price is now $286 per person
$286
per person
Dec 11 - Dec 14
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (353 reviews)
I suggest rooms need to be update like floors, bathroom, walls, furniture.

Reviewed on Sep 21, 2025

Hotel Cruz del Vado by Art Hotels Ecuador

Hotel Cruz del Vado by Art Hotels Ecuador

4.5 out of 5
Save 100% on your flight
Price was $542, price is now $365 per person
$365
per person
Dec 21 - Dec 23
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.4/10 Exceptional! (38 reviews)
Excellent service. I was pregnant and the wokers were very attentive. If you want to have a beautiful experience, It’s worth staying here.

Reviewed on Sep 26, 2025

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
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Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town.

Find hotels in Downtown Guayaquil

San Francisco Hotel Deals

Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Oct 5 to Oct 6
$100 total
Oct 5 - Oct 6
9.4/10 Exceptional! (1,020 reviews)
"The hotel was everything offered and more, the staff is extraordinary, from the outside security, front desk receptionists, servers throughout all the restaurants, housekeepers and more, these people know what it is to host. I’m planing my next trip to Ecuador and be certain that I won’t need to ..."

Reviewed on Sep 26, 2025

Oro Verde Guayaquil
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

3.5 out of 5
Juan Tanca Marengo Ave, Abel Romero St. Plaza Del Sol, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $95 total per night from Oct 12 to Oct 13
$95 total
Oct 12 - Oct 13
9/10 Wonderful! (1,001 reviews)
"Great service! Highly recommend"

Reviewed on Sep 22, 2025

Wyndham Garden Guayaquil
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto, Intl. Jose Joaquin de Olmedo, Guayaquil, Guayas
Fully refundable
$98 nightly
The price is $110 total per night from Oct 13 to Oct 14
$110 total
Oct 13 - Oct 14
9.2/10 Wonderful! (1,013 reviews)
"Excellent hotel with superb food and service. Shuttle service to and from airport a big plus."

Reviewed on Sep 29, 2025

Holiday Inn Guayaquil Airport by IHG
See all 389 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in San Francisco

By the riverside

Malecon 2000

4.5/5(180 reviews)

Malecon 2000 is just one of the places to see in Guayaquil, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

Malecon 2000
Santa Ana Hill

Santa Ana Hill

4.5/5(14 reviews)

Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Santa Ana Hill

U.S. Consulate General

4/5(22 reviews)

U.S. Consulate General is just one of the places to see in San Eduardo, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

U.S. Consulate General

Things to do

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

$59
per adult
Wine Tasting Experience with Tasting Menu
Ecuador Paragliding Guayaquil

Ecuador Paragliding Guayaquil

$75
per adult
Ecuador Paragliding Guayaquil
Making hot Chocolate!

Cocoa farm and Chocolate making!

$155
per adult
Cocoa farm and Chocolate making!
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.