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San Ignacio has only one Expedia-listed hotel option within 6 miles, so if you are looking to stay nearby, it is best to make your reservations early.
If you'd like to stay as close to downtown as you can, the Hotel Club y Centro Ecoturistico San Martin is where you should stay.
Tegucigalpa is another place where you could stay. It is where you'll find the National Autonomous University of Honduras and the Cristo Picacho Statue, and is 40 miles to the south of the midddle of San Ignacio. Hotel options in Tegucigalpa include the Real InterContinental Tegucigalpa at Multiplaza Mall and Tegucigalpa Marriott Hotel.