San Lorenzo Vacations from $1,030

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your San Lorenzo Vacation

If you're wanting a food-lovers escape, our San Lorenzo vacation packages are what you need. Whether you want to experience its nightlife, bars and pubs or culture, this neighborhood has something on offer for everyone. Some top nearby attractions to visit during your trip to San Lorenzo include Roman Forum, Pantheon and Piazza Navona. Expedia can help you turn your ideal San Lorenzo vacation into reality, whatever your budget or travel plans.

The Latest San Lorenzo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Vibe Nazionale

Vibe Nazionale

Rome City Centre
$1,030
per person
Nov 18 - Nov 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
8.4/10 Very Good! (118 reviews)
Hotel Delle Civette

Hotel Delle Civette

Nomentano
Save 100% on your flight
$1,463
per person
Oct 5 - Oct 10
found 2 days ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (317 reviews)
Staff goes above and beyond to help guests. Every single aspect of the hotel was excellent. We plan to stay there again.

Reviewed on Aug 16, 2026

Relais de la Poste

Relais de la Poste

Rome City Centre
Save 100% on your flight
$1,349
per person
Oct 29 - Nov 3
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (713 reviews)
Fabulous location, really helpful staff. Happy to store our bags so we could go straight off exploring. Lovely big spacious room. No issues with noise.

Reviewed on Aug 28, 2026

ROMEO Roma

ROMEO Roma

Rome City Centre
Save 100% on your flight
$3,000
per person
Nov 22 - Nov 26
found 2 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
10/10 Exceptional! (1 review)
Glorious property, 3-Star food, 5-star service.

Reviewed on May 23, 2026

Hotiday Roma Trevi

Hotiday Roma Trevi

Rome City Centre
$1,495
per person
Sep 29 - Oct 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
No reviews

Where to stay in San Lorenzo

Find the best San Lorenzo areas and neighborhoods for the activities you enjoy most. Learn more about San Lorenzo
A historic building with a dome and columns, surrounded by pedestrians and parked vehicles.

Rome City Centre

9 out of top 10 points of interest in this area

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre
A classical fountain with multiple statues, including a prominent figure holding a staff, surrounded by water.

Rome Historic Centre

Enclosed by Aurelian Walls, this UNESCO-listed historic district boasts numerous museums, including the Capitoline Museums and Scuderie del Quirinale. Well-connected by public transport including the Roma Termini and Roma Ostiense stations which are nearby.

Find hotels in Rome Historic Centre
The Colosseum with its arches and ruins, partially covered by vegetation.

Monti

Relax in wine bars and restaurants, take a walking tour and discover the famous Colosseum and other historic sites in one of Rome’s prominent districts.

Find hotels in Monti
A cobblestone street with graffiti, a restaurant named 'CAGGIO', and people walking.

Trastevere

Narrow cobbled streets lined by ancient houses give this area a charming character. Enjoy lively pubs and restaurants at night, while being close to international academic institutions and the River Tiber.

Find hotels in Trastevere
A variety of cured meats and cheeses displayed in a market.

Trevi

Art galleries, churches, and museums are just a few things travelers like about Trevi. Sights like Trevi Fountain and Piazza di Trevi are spots to explore, and you can get around the greater Rome area at Barberini Station.

Find hotels in Trevi

San Lorenzo Hotel Deals

Hotel Quirinale

Hotel Quirinale

Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$158 nightly
$191 total
Aug 30 - Aug 31
Total with taxes and fees
8.8/10 Excellent! (1,925 reviews)
"This was the 2nd time my family has stayed here it was their excellent service and delicious food that made us come back. Very convenient location"

Reviewed on Aug 28, 2026

Hotel Quirinale
Hilton Rome Airport

Hilton Rome Airport

Via Arturo Ferrarin 2 Fiumicino RM
Fully refundableReserve now, pay when you stay
$252 nightly
$289 total
Sep 4 - Sep 5
Total with taxes and fees
Hilton Rome Airport
Hilton Garden Inn Rome Airport

Hilton Garden Inn Rome Airport

Via Vittorio Bragadin 2 Fiumicino RM
Fully refundableReserve now, pay when you stay
$202 nightly
$233 total
Sep 8 - Sep 9
Total with taxes and fees
Hilton Garden Inn Rome Airport
See all 16,751 properties in San Lorenzo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular San Lorenzo attractions

Teatro Blackgull

Enjoy a performance at Teatro Blackgull, a theater with a story to tell in Rome. Visit the notable monuments and stunning cathedral in this vibrant area.
See properties

Studio d'Arte Contemporanea di Pino Casagrande

You can study the exhibits at Studio d'Arte Contemporanea di Pino Casagrande, a museum with a storied past, during your trip to Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.
See properties

Pastificio Cerere

You can browse the exhibits at Pastificio Cerere, a museum with a story of its own, during your travels to Rome. Discover the fascinating museums and churches in this vibrant area.
See properties

Lupa Romana

10.0/10 (1 review)
Enjoy an outing to Lupa Romana during your stay in Rome. Visit the churches and notable monuments in this vibrant area.
See properties

Wishlist Club

After visiting Wishlist Club, make a plan to see the other sights and activities in Rome. Make time to visit the cathedral and monuments while you're in the area.
See properties

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-line: Colosseum & Forum Tour with Special Gladiator’s Gate & Arena Floor Access

Gladiator’s Gate:Special Access Colosseum Tour & Arena Floor in Small Group

$132
per adult
94% of travellers recommend
Gladiator’s Gate:Special Access Colosseum Tour & Arena Floor in Small Group
Rome in a Day: Small Group Tour with Vatican, Colosseum & Historic Center

Rome in a Day: Small Group Tour with Vatican, Colosseum & Historic Center

$250
per adult
96% of travellers recommend
Rome in a Day: Small Group Tour with Vatican, Colosseum & Historic Center
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.